Stable pentadecapeptide therapy counteracts gentamicin-induced nephrotoxicity via nitric oxide-system modulation: evidence from a triple nitric oxide-agent approach in rats.

Vukoja I, Vlainic J, Francina M, Barisic I, Zukanovic G, Miskulin I, Kralj L, Popovic Dolic M, Dulcic D, Tubikanec AM, Sikiric S, Krezic I and 13 more

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Kordic M, Beketic Oreskovic L, Oreskovic I, Strbe S, Staresinic B, Pavelic Turudic T, Perovic D, Bilic V, Stancic Rokotov D, Boban Blagaic A, Seiwerth S, Sikiric P, Skrtic A

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society1 Jun 2026

PMID42533460DOI10.26402/jpp.2026.3.08PepBankPUB-42533460

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with gentamicin nephrotoxicity, BPC‑157 therapy counteracted the clinical presentation, which stayed close to normal.
In plain wordsIn rats with kidney damage from gentamicin, BPC‑157 kept the signs of illness close to normal.
Peptide
BPC-157
Outcome
DecreaseClinical presentation of nephrotoxicity
Study
ratn: not reported in source
Rats with gentamicin-induced nephrotoxicity
Comparator
Gentamicin without BPC 157
Outcome group
Kidney function · Kidney and urinary
Studied dose
10 µg/kg, 10 ng/kg · drinking water or intraperitonealAs given in this study (rat).
Source sentences
Summary
BPC 157 therapy counteracted gentamicin nephrotoxicity clinical presentation
2 context sentences(design, population, supporting numbers)
Summary · context
In rats, stable gastric pentadecapeptide (BPC 157) therapy may resolve severe gentamicin nephrotoxicity (100 mg/kg ip/daily through 8 days) and the nitric oxide (NO)-system relation.
Summary · context
We applied BPC 157 (10 µg/kg, 10 ng/kg, in drinking water or daily intraperitoneally) along with a triple NO-agent approach.
Report a problemFND-4253346001
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with gentamicin nephrotoxicity, BPC‑157 therapy kept serum urea close to normal values.
In plain wordsIn rats with kidney damage from gentamicin, BPC‑157 kept blood urea close to normal.
Peptide
BPC-157
Outcome
DecreaseSerum urea
Study
ratn: not reported in source
Rats with gentamicin-induced nephrotoxicity
Comparator
Gentamicin without BPC 157
Outcome group
Kidney function · Kidney and urinary
Studied dose
10 µg/kg, 10 ng/kg · drinking water or intraperitonealAs given in this study (rat).
Source sentences
Summary
serum urea, and creatinine (i.e., values close to normal preserved)
2 context sentences(design, population, supporting numbers)
Summary · context
In rats, stable gastric pentadecapeptide (BPC 157) therapy may resolve severe gentamicin nephrotoxicity (100 mg/kg ip/daily through 8 days) and the nitric oxide (NO)-system relation.
Summary · context
We applied BPC 157 (10 µg/kg, 10 ng/kg, in drinking water or daily intraperitoneally) along with a triple NO-agent approach.
Report a problemFND-4253346002
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with gentamicin nephrotoxicity, BPC‑157 therapy kept serum creatinine close to normal values.
In plain wordsIn rats with kidney damage from gentamicin, BPC‑157 kept blood creatinine close to normal.
Peptide
BPC-157
Outcome
DecreaseSerum creatinine
Study
ratn: not reported in source
Rats with gentamicin-induced nephrotoxicity
Comparator
Gentamicin without BPC 157
Outcome group
Kidney function · Kidney and urinary
Studied dose
10 µg/kg, 10 ng/kg · drinking water or intraperitonealAs given in this study (rat).
Source sentences
Summary
serum urea, and creatinine (i.e., values close to normal preserved)
2 context sentences(design, population, supporting numbers)
Summary · context
In rats, stable gastric pentadecapeptide (BPC 157) therapy may resolve severe gentamicin nephrotoxicity (100 mg/kg ip/daily through 8 days) and the nitric oxide (NO)-system relation.
Summary · context
We applied BPC 157 (10 µg/kg, 10 ng/kg, in drinking water or daily intraperitoneally) along with a triple NO-agent approach.
Report a problemFND-4253346003
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with gentamicin nephrotoxicity, BPC‑157 therapy maintained diuresis; polyuria and oliguria were completely avoided.
In plain wordsIn rats with kidney damage from gentamicin, BPC‑157 kept urine output normal, with no excess or very low output.
Peptide
BPC-157
Outcome
DecreaseDiuresis (polyuria and oliguria)
Study
ratn: not reported in source
Rats with gentamicin-induced nephrotoxicity
Comparator
Gentamicin without BPC 157
Outcome group
Kidney function · Kidney and urinary
Studied dose
10 µg/kg, 10 ng/kg · drinking water or intraperitonealAs given in this study (rat).
Source sentences
Summary
maintained diuresis (polyuria/oliguria completely avoided)
2 context sentences(design, population, supporting numbers)
Summary · context
In rats, stable gastric pentadecapeptide (BPC 157) therapy may resolve severe gentamicin nephrotoxicity (100 mg/kg ip/daily through 8 days) and the nitric oxide (NO)-system relation.
Summary · context
We applied BPC 157 (10 µg/kg, 10 ng/kg, in drinking water or daily intraperitoneally) along with a triple NO-agent approach.
Report a problemFND-4253346004
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with gentamicin nephrotoxicity, BPC‑157 therapy was followed by no renal mass increase.
In plain wordsIn rats with kidney damage from gentamicin, BPC‑157 therapy was followed by no increase in kidney mass.
Peptide
BPC-157
Outcome
No significant changeRenal mass
Study
ratn: not reported in source
Rats with gentamicin-induced nephrotoxicity
Comparator
Gentamicin without BPC 157
Outcome group
Kidney function · Kidney and urinary
Studied dose
10 µg/kg, 10 ng/kg · drinking water or intraperitonealAs given in this study (rat).
Source sentences
Summary
and no renal mass increase.
2 context sentences(design, population, supporting numbers)
Summary · context
In rats, stable gastric pentadecapeptide (BPC 157) therapy may resolve severe gentamicin nephrotoxicity (100 mg/kg ip/daily through 8 days) and the nitric oxide (NO)-system relation.
Summary · context
We applied BPC 157 (10 µg/kg, 10 ng/kg, in drinking water or daily intraperitoneally) along with a triple NO-agent approach.
Report a problemFND-4253346005
06AnimalAnimal study (in vivo)Efficacy outcome
In rats with gentamicin nephrotoxicity, BPC‑157 therapy fully preserved normal tubular epithelium cells and nephron presentation on microscopy.
In plain wordsIn rats with kidney damage from gentamicin, BPC‑157 kept kidney tissue looking normal under the microscope.
Peptide
BPC-157
Outcome
DecreaseKidney histology (tubular epithelium and nephron)
Study
ratn: not reported in source
Rats with gentamicin-induced nephrotoxicity
Comparator
Gentamicin without BPC 157
Outcome group
Kidney function · Kidney and urinary
Studied dose
10 µg/kg, 10 ng/kg · drinking water or intraperitonealAs given in this study (rat).
Source sentences
Summary
Finally, fully preserved normal tubular epithelium cells and nephron presentation were present in the microscopy.
2 context sentences(design, population, supporting numbers)
Summary · context
In rats, stable gastric pentadecapeptide (BPC 157) therapy may resolve severe gentamicin nephrotoxicity (100 mg/kg ip/daily through 8 days) and the nitric oxide (NO)-system relation.
Summary · context
We applied BPC 157 (10 µg/kg, 10 ng/kg, in drinking water or daily intraperitoneally) along with a triple NO-agent approach.
Report a problemFND-4253346006
07AnimalAnimal study (in vivo)Efficacy outcome
In rats with gentamicin nephrotoxicity, BPC‑157 counteracted the gentamicin-induced rise in kidney malondialdehyde (MDA).
In plain wordsIn rats with kidney damage from gentamicin, BPC‑157 countered the rise in a marker of oxidative damage (MDA) in the kidney.
Peptide
BPC-157
Outcome
DecreaseKidney MDA
Study
ratn: not reported in source
Rats with gentamicin-induced nephrotoxicity
Comparator
Gentamicin without BPC 157
Outcome group
Oxidative stress · Kidney and urinary
Studied dose
10 µg/kg, 10 ng/kg · drinking water or intraperitonealAs given in this study (rat).
Source sentences
Summary
Counteracted were in kidney gentamicin-increased malondialdehyde (MDA)-levels, and gentamicin-decreased NO-, and superoxide dismutase (SOD)-levels.
2 context sentences(design, population, supporting numbers)
Summary · context
In rats, stable gastric pentadecapeptide (BPC 157) therapy may resolve severe gentamicin nephrotoxicity (100 mg/kg ip/daily through 8 days) and the nitric oxide (NO)-system relation.
Summary · context
We applied BPC 157 (10 µg/kg, 10 ng/kg, in drinking water or daily intraperitoneally) along with a triple NO-agent approach.
Report a problemFND-4253346007
08AnimalAnimal study (in vivo)Efficacy outcome
In rats with gentamicin nephrotoxicity, BPC‑157 counteracted the gentamicin-induced fall in kidney nitric oxide (NO).
In plain wordsIn rats with kidney damage from gentamicin, BPC‑157 countered the fall in nitric oxide in the kidney.
Peptide
BPC-157
Outcome
IncreaseKidney nitric oxide level
Study
ratn: not reported in source
Rats with gentamicin-induced nephrotoxicity
Comparator
Gentamicin without BPC 157
Outcome group
Oxidative stress · Kidney and urinary
Studied dose
10 µg/kg, 10 ng/kg · drinking water or intraperitonealAs given in this study (rat).
Source sentences
Summary
Counteracted were in kidney gentamicin-increased malondialdehyde (MDA)-levels, and gentamicin-decreased NO-, and superoxide dismutase (SOD)-levels.
2 context sentences(design, population, supporting numbers)
Summary · context
In rats, stable gastric pentadecapeptide (BPC 157) therapy may resolve severe gentamicin nephrotoxicity (100 mg/kg ip/daily through 8 days) and the nitric oxide (NO)-system relation.
Summary · context
We applied BPC 157 (10 µg/kg, 10 ng/kg, in drinking water or daily intraperitoneally) along with a triple NO-agent approach.
Report a problemFND-4253346008
09AnimalAnimal study (in vivo)Efficacy outcome
In rats with gentamicin nephrotoxicity, BPC‑157 counteracted the gentamicin-induced fall in kidney superoxide dismutase (SOD).
In plain wordsIn rats with kidney damage from gentamicin, BPC‑157 countered the fall in an antioxidant enzyme (SOD) in the kidney.
Peptide
BPC-157
Outcome
IncreaseKidney SOD
Study
ratn: not reported in source
Rats with gentamicin-induced nephrotoxicity
Comparator
Gentamicin without BPC 157
Outcome group
Oxidative stress · Kidney and urinary
Studied dose
10 µg/kg, 10 ng/kg · drinking water or intraperitonealAs given in this study (rat).
Source sentences
Summary
Counteracted were in kidney gentamicin-increased malondialdehyde (MDA)-levels, and gentamicin-decreased NO-, and superoxide dismutase (SOD)-levels.
2 context sentences(design, population, supporting numbers)
Summary · context
In rats, stable gastric pentadecapeptide (BPC 157) therapy may resolve severe gentamicin nephrotoxicity (100 mg/kg ip/daily through 8 days) and the nitric oxide (NO)-system relation.
Summary · context
We applied BPC 157 (10 µg/kg, 10 ng/kg, in drinking water or daily intraperitoneally) along with a triple NO-agent approach.
Report a problemFND-4253346009
10AnimalAnimal study (in vivo)Efficacy outcome
In rats with gentamicin nephrotoxicity, BPC‑157 regimens (peroral or intraperitoneal) overwhelmed the effects of the NO-agents L-NAME and L-arginine.
In plain wordsIn rats with kidney damage from gentamicin, BPC‑157 overcame the effects of drugs that block or boost nitric oxide.
Peptide
BPC-157
Outcome
Not applicableEffect against NO-agent modulation of nephrotoxicity
Study
ratn: not reported in source
Rats with gentamicin-induced nephrotoxicity
Comparator
NO-agents (L-NAME, L-arginine, L-NAME + L-arginine) with gentamicin
Outcome group
Kidney function · Kidney and urinary
Studied dose
10 µg/kg, 10 ng/kg · drinking water or intraperitonealAs given in this study (rat).
Source sentences
Summary
BPC 157 regimens (peroral or intraperitoneal) overwhelmed these NO-agents' effects.
2 context sentences(design, population, supporting numbers)
Summary · context
In rats, stable gastric pentadecapeptide (BPC 157) therapy may resolve severe gentamicin nephrotoxicity (100 mg/kg ip/daily through 8 days) and the nitric oxide (NO)-system relation.
Summary · context
We applied BPC 157 (10 µg/kg, 10 ng/kg, in drinking water or daily intraperitoneally) along with a triple NO-agent approach.
Report a problemFND-4253346010

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 02:56 UTC
First added · source update from Europe PMC

Subjects

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Stable pentadecapeptide therapy counteracts gentamicin-induced nephrotoxicity via nitric oxide-system modulation: evidence from a triple nitric oxide-agent approach in rats.

Summary

Results from this study10

Version history

Subjects

Publication types

MeSH terms

Keywords