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Study · Animal study (in vivo) · mouse · 2026

15 results

Enhancing the anti-ageing capacity of hUC-MSCs via NMN co-treatment in D-galactose-induced ageing mice and cellular senescence models.

Liu K, Cao Y, Gu Y, Wang Y, Jin L, Liu A, Wang J, Chen S

Mechanisms of ageing and development28 Jul 2026

PMID42520895 (opens in a new tab)DOI10.1016/j.mad.2026.112232 (opens in a new tab)PepBankPUB-42520895
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study15

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In D-galactose-induced ageing mice, hUC-MSCs plus NMN alleviated thymic atrophy more than hUC-MSCs alone.

    In plain wordsIn mice, stem cells plus NMN reduced thymus atrophy more than stem cells alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseThymic atrophy
    Study

    mousen: not reported in source

    D-galactose-induced ageing mice
    Comparator
    hUC-MSCs alone
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Compared with either treatment alone, the combined administration exerted enhanced anti-ageing efficacy, as evidenced by marked alleviation of thymic and splenic atrophy, attenuation of body weight loss, and significant improvement in motor and cognitive functions in D-galactose-induced ageing mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In D-galactose-induced ageing mice, hUC-MSCs plus NMN alleviated splenic atrophy more than hUC-MSCs alone.

    In plain wordsIn mice, stem cells plus NMN reduced spleen atrophy more than stem cells alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseSplenic atrophy
    Study

    mousen: not reported in source

    D-galactose-induced ageing mice
    Comparator
    hUC-MSCs alone
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Compared with either treatment alone, the combined administration exerted enhanced anti-ageing efficacy, as evidenced by marked alleviation of thymic and splenic atrophy, attenuation of body weight loss, and significant improvement in motor and cognitive functions in D-galactose-induced ageing mice.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In D-galactose-induced ageing mice, hUC-MSCs plus NMN attenuated body weight loss more than hUC-MSCs alone.

    In plain wordsIn mice, stem cells plus NMN reduced weight loss more than stem cells alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseBody weight loss
    Study

    mousen: not reported in source

    D-galactose-induced ageing mice
    Comparator
    hUC-MSCs alone
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Compared with either treatment alone, the combined administration exerted enhanced anti-ageing efficacy, as evidenced by marked alleviation of thymic and splenic atrophy, attenuation of body weight loss, and significant improvement in motor and cognitive functions in D-galactose-induced ageing mice.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In D-galactose-induced ageing mice, hUC-MSCs plus NMN improved motor function more than hUC-MSCs alone.

    In plain wordsIn mice, stem cells plus NMN improved motor function more than stem cells alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseMotor function
    Study

    mousen: not reported in source

    D-galactose-induced ageing mice
    Comparator
    hUC-MSCs alone
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Compared with either treatment alone, the combined administration exerted enhanced anti-ageing efficacy, as evidenced by marked alleviation of thymic and splenic atrophy, attenuation of body weight loss, and significant improvement in motor and cognitive functions in D-galactose-induced ageing mice.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In D-galactose-induced ageing mice, hUC-MSCs plus NMN improved cognitive function more than hUC-MSCs alone.

    In plain wordsIn mice, stem cells plus NMN improved cognitive function more than stem cells alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseCognitive function
    Study

    mousen: not reported in source

    D-galactose-induced ageing mice
    Comparator
    hUC-MSCs alone
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Compared with either treatment alone, the combined administration exerted enhanced anti-ageing efficacy, as evidenced by marked alleviation of thymic and splenic atrophy, attenuation of body weight loss, and significant improvement in motor and cognitive functions in D-galactose-induced ageing mice.
  6. 06LabIn vitro (cells)Mechanism

    In stressed hUC-MSCs, NMN activated the Nrf2/HO-1 pathway and thereby mitigated senescence.

    In plain wordsIn cells, NMN activated the Nrf2/HO-1 pathway under stress, which reduced stem cell senescence.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseNrf2/HO-1 pathway activation
    Study

    humann: not reported in source

    Stressed hUC-MSCs
    Outcome group
    Receptor activity and mechanism · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mechanistically, activation of the Nrf2/HO-1 pathway by NMN mitigated hUC-MSC senescence under stress conditions, thereby preserving their anti-ageing properties.
  7. 07LabIn vitro (cells)Efficacy outcome

    In stressed hUC-MSCs, NMN mitigated senescence through Nrf2/HO-1 pathway activation.

    In plain wordsIn cells, NMN reduced stem cell senescence under stress through Nrf2/HO-1 pathway activation.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseSenescence of stressed hUC-MSCs after NMN
    Study

    humann: not reported in source

    Stressed hUC-MSCs
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mechanistically, activation of the Nrf2/HO-1 pathway by NMN mitigated hUC-MSC senescence under stress conditions, thereby preserving their anti-ageing properties.

Studies that did not test the peptide alone8

In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking NMN (nicotinamide mononucleotide).

  1. 08AnimalNot a test of NMN (nicotinamide mononucleotide) aloneAnimal study (in vivo)Efficacy outcome

    In D-galactose-induced ageing mice, hUC-MSCs plus NMN alleviated thymic atrophy more than NMN alone.

    In plain wordsIn mice, stem cells plus NMN reduced thymus atrophy more than NMN alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseThymic atrophy
    Study

    mousen: not reported in source

    D-galactose-induced ageing mice
    Comparator
    NMN alone
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Compared with either treatment alone, the combined administration exerted enhanced anti-ageing efficacy, as evidenced by marked alleviation of thymic and splenic atrophy, attenuation of body weight loss, and significant improvement in motor and cognitive functions in D-galactose-induced ageing mice.

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

  2. 09AnimalNot a test of NMN (nicotinamide mononucleotide) aloneAnimal study (in vivo)Efficacy outcome

    In D-galactose-induced ageing mice, hUC-MSCs plus NMN alleviated splenic atrophy more than NMN alone.

    In plain wordsIn mice, stem cells plus NMN reduced spleen atrophy more than NMN alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseSplenic atrophy
    Study

    mousen: not reported in source

    D-galactose-induced ageing mice
    Comparator
    NMN alone
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Compared with either treatment alone, the combined administration exerted enhanced anti-ageing efficacy, as evidenced by marked alleviation of thymic and splenic atrophy, attenuation of body weight loss, and significant improvement in motor and cognitive functions in D-galactose-induced ageing mice.

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

  3. 10AnimalNot a test of NMN (nicotinamide mononucleotide) aloneAnimal study (in vivo)Efficacy outcome

    In D-galactose-induced ageing mice, hUC-MSCs plus NMN attenuated body weight loss more than NMN alone.

    In plain wordsIn mice, stem cells plus NMN reduced weight loss more than NMN alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseBody weight loss
    Study

    mousen: not reported in source

    D-galactose-induced ageing mice
    Comparator
    NMN alone
    Outcome group
    Body weight · Metabolic and weight

    Source sentences

    Summary
    Compared with either treatment alone, the combined administration exerted enhanced anti-ageing efficacy, as evidenced by marked alleviation of thymic and splenic atrophy, attenuation of body weight loss, and significant improvement in motor and cognitive functions in D-galactose-induced ageing mice.

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

  4. 11AnimalNot a test of NMN (nicotinamide mononucleotide) aloneAnimal study (in vivo)Efficacy outcome

    In D-galactose-induced ageing mice, hUC-MSCs plus NMN improved motor function more than NMN alone.

    In plain wordsIn mice, stem cells plus NMN improved motor function more than NMN alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseMotor function
    Study

    mousen: not reported in source

    D-galactose-induced ageing mice
    Comparator
    NMN alone
    Outcome group
    Exercise and physical function · Musculoskeletal

    Source sentences

    Summary
    Compared with either treatment alone, the combined administration exerted enhanced anti-ageing efficacy, as evidenced by marked alleviation of thymic and splenic atrophy, attenuation of body weight loss, and significant improvement in motor and cognitive functions in D-galactose-induced ageing mice.

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

  5. 12AnimalNot a test of NMN (nicotinamide mononucleotide) aloneAnimal study (in vivo)Efficacy outcome

    In D-galactose-induced ageing mice, hUC-MSCs plus NMN improved cognitive function more than NMN alone.

    In plain wordsIn mice, stem cells plus NMN improved cognitive function more than NMN alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseCognitive function
    Study

    mousen: not reported in source

    D-galactose-induced ageing mice
    Comparator
    NMN alone
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    Compared with either treatment alone, the combined administration exerted enhanced anti-ageing efficacy, as evidenced by marked alleviation of thymic and splenic atrophy, attenuation of body weight loss, and significant improvement in motor and cognitive functions in D-galactose-induced ageing mice.

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

  6. 13LabNot a test of NMN (nicotinamide mononucleotide) aloneIn vitro (cells)Efficacy outcome

    In lymphocytes, combined hUC-MSC and NMN treatment alleviated cellular senescence.

    In plain wordsIn cells, stem cells plus NMN reduced lymphocyte senescence.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseLymphocyte senescence
    Study

    n: not reported in source

    Lymphocytes
    Outcome group
    Aging markers · Immune and inflammation

    Source sentences

    Summary
    In vitro results indicated that combined treatment with hUC-MSCs and NMN alleviated cellular senescence in lymphocytes while simultaneously reducing oxidative stress and senescence in hUC-MSCs.

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

  7. 14LabNot a test of NMN (nicotinamide mononucleotide) aloneIn vitro (cells)Efficacy outcome

    In hUC-MSCs, combined hUC-MSC and NMN treatment reduced oxidative stress.

    In plain wordsIn cells, combined stem cell and NMN treatment reduced oxidative stress in stem cells.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreasehUC-MSC oxidative stress
    Study

    humann: not reported in source

    hUC-MSCs
    Outcome group
    Oxidative stress · Whole body

    Source sentences

    Summary
    In vitro results indicated that combined treatment with hUC-MSCs and NMN alleviated cellular senescence in lymphocytes while simultaneously reducing oxidative stress and senescence in hUC-MSCs.

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

  8. 15LabNot a test of NMN (nicotinamide mononucleotide) aloneIn vitro (cells)Efficacy outcome

    In hUC-MSCs, combined hUC-MSC and NMN treatment reduced senescence.

    In plain wordsIn cells, combined stem cell and NMN treatment reduced stem cell senescence.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreasehUC-MSC senescence
    Study

    humann: not reported in source

    hUC-MSCs
    Outcome group
    Aging markers · Aging and longevity

    Source sentences

    Summary
    In vitro results indicated that combined treatment with hUC-MSCs and NMN alleviated cellular senescence in lymphocytes while simultaneously reducing oxidative stress and senescence in hUC-MSCs.

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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