NMN alleviates oxidative stress damage in alopecia areata by activating SIRT7 and promoting glutamine metabolism.

Cao T, Jiang L, Liu L, Wang N, Zhai D, Liu L

Biochimica et biophysica acta. Gene regulatory mechanisms27 Jul 2026

PMID42508531DOI10.1016/j.bbagrm.2026.195168PepBankPUB-42508531

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study19

18 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In mice, NMN alleviated oxidant-induced hair follicle damage.
In plain wordsIn mice, NMN reduced hair follicle damage caused by oxidative stress.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseHair follicle damage
Study
mousen: not reported in source
H2O2-induced hair follicle damage
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
In vivo, NMN treatment alleviated H₂O₂-induced hair follicle damage, promoted regeneration, and preserved SIRT7 expression in the stem cell niche.
1 context sentence(design, population, supporting numbers)
Summary · context
An in vivo mouse model of H₂O₂-induced hair follicle damage was utilized for validation.
Report a problemFND-4250853117
02AnimalAnimal study (in vivo)Efficacy outcome
In mice with oxidant-induced hair follicle damage, NMN promoted regeneration.
In plain wordsIn mice with oxidative hair follicle damage, NMN promoted regeneration.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseHair follicle regeneration
Study
mousen: not reported in source
H2O2-induced hair follicle damage
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
In vivo, NMN treatment alleviated H₂O₂-induced hair follicle damage, promoted regeneration, and preserved SIRT7 expression in the stem cell niche.
1 context sentence(design, population, supporting numbers)
Summary · context
An in vivo mouse model of H₂O₂-induced hair follicle damage was utilized for validation.
Report a problemFND-4250853118
03AnimalAnimal study (in vivo)Mechanism
In mice with oxidant-induced hair follicle damage, NMN preserved SIRT7 expression in the stem cell niche.
In plain wordsIn mice with hair follicle damage, NMN preserved SIRT7 expression around stem cells.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseStem cell niche SIRT7 expression
Study
mousen: not reported in source
H2O2-induced hair follicle damage
Outcome group
Receptor activity and mechanism · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
In vivo, NMN treatment alleviated H₂O₂-induced hair follicle damage, promoted regeneration, and preserved SIRT7 expression in the stem cell niche.
1 context sentence(design, population, supporting numbers)
Summary · context
An in vivo mouse model of H₂O₂-induced hair follicle damage was utilized for validation.
Report a problemFND-4250853119
04LabIn vitro (cells)Efficacy outcome
In AA-derived and oxidant-exposed hair follicle stem cells, NMN increased viability.
In plain wordsIn cells from alopecia areata and oxidative stress models, NMN increased survival.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseCell viability
Study
humann: not reported in source
AA-derived and H2O2-induced hair follicle stem cells
Outcome group
Cell viability and death · Skin and wound
Studied dose
2 mMAs given in this study (human).
Source sentences
Summary
The results showed that NMN (2 mM) significantly enhanced the viability, migration, and differentiation capacity of both AA-derived and H₂O₂-induced HFSCs, while cell apoptosis and oxidative stress were repressed.
2 context sentences(design, population, supporting numbers)
Summary · context
Scalp tissues from AA patients and healthy controls were collected, and HFSCs were isolated.
Summary · context
An in vitro oxidative stress model was established using H₂O₂.
Report a problemFND-4250853101
05LabIn vitro (cells)Efficacy outcome
In AA-derived and oxidant-exposed hair follicle stem cells, NMN increased migration.
In plain wordsIn cells from alopecia areata and oxidative stress models, NMN increased migration.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseCell migration
Study
humann: not reported in source
AA-derived and H2O2-induced hair follicle stem cells
Outcome group
Skin and hair · Skin and wound
Studied dose
2 mMAs given in this study (human).
Source sentences
Summary
The results showed that NMN (2 mM) significantly enhanced the viability, migration, and differentiation capacity of both AA-derived and H₂O₂-induced HFSCs, while cell apoptosis and oxidative stress were repressed.
2 context sentences(design, population, supporting numbers)
Summary · context
Scalp tissues from AA patients and healthy controls were collected, and HFSCs were isolated.
Summary · context
An in vitro oxidative stress model was established using H₂O₂.
Report a problemFND-4250853102
06LabIn vitro (cells)Efficacy outcome
In AA-derived and oxidant-exposed hair follicle stem cells, NMN increased differentiation capacity.
In plain wordsIn cells from alopecia areata and oxidative stress models, NMN improved differentiation capacity.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseDifferentiation capacity
Study
humann: not reported in source
AA-derived and H2O2-induced hair follicle stem cells
Outcome group
Skin and hair · Skin and wound
Studied dose
2 mMAs given in this study (human).
Source sentences
Summary
The results showed that NMN (2 mM) significantly enhanced the viability, migration, and differentiation capacity of both AA-derived and H₂O₂-induced HFSCs, while cell apoptosis and oxidative stress were repressed.
2 context sentences(design, population, supporting numbers)
Summary · context
Scalp tissues from AA patients and healthy controls were collected, and HFSCs were isolated.
Summary · context
An in vitro oxidative stress model was established using H₂O₂.
Report a problemFND-4250853103
07LabIn vitro (cells)Efficacy outcome
In AA-derived and oxidant-exposed hair follicle stem cells, NMN reduced apoptosis.
In plain wordsIn cells from alopecia areata and oxidative stress models, NMN reduced cell death.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseCell apoptosis
Study
humann: not reported in source
AA-derived and H2O2-induced hair follicle stem cells
Outcome group
Cell viability and death · Skin and wound
Studied dose
2 mMAs given in this study (human).
Source sentences
Summary
The results showed that NMN (2 mM) significantly enhanced the viability, migration, and differentiation capacity of both AA-derived and H₂O₂-induced HFSCs, while cell apoptosis and oxidative stress were repressed.
2 context sentences(design, population, supporting numbers)
Summary · context
Scalp tissues from AA patients and healthy controls were collected, and HFSCs were isolated.
Summary · context
An in vitro oxidative stress model was established using H₂O₂.
Report a problemFND-4250853104
08LabIn vitro (cells)Efficacy outcome
In AA-derived and oxidant-exposed hair follicle stem cells, NMN reduced oxidative stress.
In plain wordsIn cells from alopecia areata and oxidative stress models, NMN reduced oxidative stress.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseOxidative stress
Study
humann: not reported in source
AA-derived and H2O2-induced hair follicle stem cells
Outcome group
Oxidative stress · Skin and wound
Studied dose
2 mMAs given in this study (human).
Source sentences
Summary
The results showed that NMN (2 mM) significantly enhanced the viability, migration, and differentiation capacity of both AA-derived and H₂O₂-induced HFSCs, while cell apoptosis and oxidative stress were repressed.
2 context sentences(design, population, supporting numbers)
Summary · context
Scalp tissues from AA patients and healthy controls were collected, and HFSCs were isolated.
Summary · context
An in vitro oxidative stress model was established using H₂O₂.
Report a problemFND-4250853105
09LabIn vitro (cells)Efficacy outcome
In hair follicle stem cells, NMN promoted glutamine metabolism.
In plain wordsIn cells, NMN increased glutamine metabolism.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseGlutamine metabolism
Study
humann: not reported in source
AA-derived and H2O2-induced hair follicle stem cells
Outcome group
Metabolic pathways and metabolomics · Skin and wound
Studied dose
2 mMAs given in this study (human).
Source sentences
Summary
NMN also promoted glutamine metabolism with increased GSH, glutamate, glutamine and NAD⁺ levels, as well as elevated GPx and GLS1 activities.
2 context sentences(design, population, supporting numbers)
Summary · context
Scalp tissues from AA patients and healthy controls were collected, and HFSCs were isolated.
Summary · context
An in vitro oxidative stress model was established using H₂O₂.
Report a problemFND-4250853106
10LabIn vitro (cells)Efficacy outcome
In hair follicle stem cells, NMN increased GSH levels.
In plain wordsIn cells, NMN increased GSH levels.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseGSH levels
Study
humann: not reported in source
AA-derived and H2O2-induced hair follicle stem cells
Outcome group
Oxidative stress · Skin and wound
Studied dose
2 mMAs given in this study (human).
Source sentences
Summary
NMN also promoted glutamine metabolism with increased GSH, glutamate, glutamine and NAD⁺ levels, as well as elevated GPx and GLS1 activities.
2 context sentences(design, population, supporting numbers)
Summary · context
Scalp tissues from AA patients and healthy controls were collected, and HFSCs were isolated.
Summary · context
An in vitro oxidative stress model was established using H₂O₂.
Report a problemFND-4250853107
11LabIn vitro (cells)Efficacy outcome
In hair follicle stem cells, NMN increased glutamate levels.
In plain wordsIn cells, NMN increased glutamate levels.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseGlutamate levels
Study
humann: not reported in source
AA-derived and H2O2-induced hair follicle stem cells
Outcome group
Metabolic pathways and metabolomics · Skin and wound
Studied dose
2 mMAs given in this study (human).
Source sentences
Summary
NMN also promoted glutamine metabolism with increased GSH, glutamate, glutamine and NAD⁺ levels, as well as elevated GPx and GLS1 activities.
2 context sentences(design, population, supporting numbers)
Summary · context
Scalp tissues from AA patients and healthy controls were collected, and HFSCs were isolated.
Summary · context
An in vitro oxidative stress model was established using H₂O₂.
Report a problemFND-4250853108
12LabIn vitro (cells)Efficacy outcome
In hair follicle stem cells, NMN increased glutamine levels.
In plain wordsIn cells, NMN increased glutamine levels.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseGlutamine levels
Study
humann: not reported in source
AA-derived and H2O2-induced hair follicle stem cells
Outcome group
Metabolic pathways and metabolomics · Skin and wound
Studied dose
2 mMAs given in this study (human).
Source sentences
Summary
NMN also promoted glutamine metabolism with increased GSH, glutamate, glutamine and NAD⁺ levels, as well as elevated GPx and GLS1 activities.
2 context sentences(design, population, supporting numbers)
Summary · context
Scalp tissues from AA patients and healthy controls were collected, and HFSCs were isolated.
Summary · context
An in vitro oxidative stress model was established using H₂O₂.
Report a problemFND-4250853109
13LabIn vitro (cells)Efficacy outcome
In hair follicle stem cells, NMN increased NAD+ levels.
In plain wordsIn cells, NMN increased NAD+ levels.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseNAD+ levels
Study
humann: not reported in source
AA-derived and H2O2-induced hair follicle stem cells
Outcome group
Metabolic pathways and metabolomics · Skin and wound
Studied dose
2 mMAs given in this study (human).
Source sentences
Summary
NMN also promoted glutamine metabolism with increased GSH, glutamate, glutamine and NAD⁺ levels, as well as elevated GPx and GLS1 activities.
2 context sentences(design, population, supporting numbers)
Summary · context
Scalp tissues from AA patients and healthy controls were collected, and HFSCs were isolated.
Summary · context
An in vitro oxidative stress model was established using H₂O₂.
Report a problemFND-4250853110
14LabIn vitro (cells)Efficacy outcome
In hair follicle stem cells, NMN increased GPx activity.
In plain wordsIn cells, NMN increased GPx activity.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseGPx activity
Study
humann: not reported in source
AA-derived and H2O2-induced hair follicle stem cells
Outcome group
Oxidative stress · Skin and wound
Studied dose
2 mMAs given in this study (human).
Source sentences
Summary
NMN also promoted glutamine metabolism with increased GSH, glutamate, glutamine and NAD⁺ levels, as well as elevated GPx and GLS1 activities.
2 context sentences(design, population, supporting numbers)
Summary · context
Scalp tissues from AA patients and healthy controls were collected, and HFSCs were isolated.
Summary · context
An in vitro oxidative stress model was established using H₂O₂.
Report a problemFND-4250853111
15LabIn vitro (cells)Efficacy outcome
In hair follicle stem cells, NMN increased GLS1 activity.
In plain wordsIn cells, NMN increased GLS1 activity.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseGLS1 activity
Study
humann: not reported in source
AA-derived and H2O2-induced hair follicle stem cells
Outcome group
Receptor activity and mechanism · Skin and wound
Studied dose
2 mMAs given in this study (human).
Source sentences
Summary
NMN also promoted glutamine metabolism with increased GSH, glutamate, glutamine and NAD⁺ levels, as well as elevated GPx and GLS1 activities.
2 context sentences(design, population, supporting numbers)
Summary · context
Scalp tissues from AA patients and healthy controls were collected, and HFSCs were isolated.
Summary · context
An in vitro oxidative stress model was established using H₂O₂.
Report a problemFND-4250853112
16LabIn vitro (cells)Mechanism
In hair follicle stem cells, NMN restored SIRT7 expression.
In plain wordsIn cells, NMN restored SIRT7 expression.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseSIRT7 expression
Study
humann: not reported in source
AA-derived and H2O2-induced hair follicle stem cells
Outcome group
Receptor activity and mechanism · Skin and wound
Studied dose
2 mMAs given in this study (human).
Source sentences
Summary
NMN restored SIRT7 expression and activity, leading to the deacetylation and activation of GLS1.
2 context sentences(design, population, supporting numbers)
Summary · context
Scalp tissues from AA patients and healthy controls were collected, and HFSCs were isolated.
Summary · context
An in vitro oxidative stress model was established using H₂O₂.
Report a problemFND-4250853113
17LabIn vitro (cells)Mechanism
In hair follicle stem cells, NMN restored SIRT7 activity.
In plain wordsIn cells, NMN restored SIRT7 activity.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseSIRT7 activity
Study
humann: not reported in source
AA-derived and H2O2-induced hair follicle stem cells
Outcome group
Receptor activity and mechanism · Skin and wound
Studied dose
2 mMAs given in this study (human).
Source sentences
Summary
NMN restored SIRT7 expression and activity, leading to the deacetylation and activation of GLS1.
2 context sentences(design, population, supporting numbers)
Summary · context
Scalp tissues from AA patients and healthy controls were collected, and HFSCs were isolated.
Summary · context
An in vitro oxidative stress model was established using H₂O₂.
Report a problemFND-4250853114
18LabIn vitro (cells)Mechanism
In hair follicle stem cells, NMN restored SIRT7 and led to GLS1 deacetylation.
In plain wordsIn cells, NMN promoted removal of acetyl groups from GLS1 through SIRT7 restoration.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseGLS1 acetylation
Study
humann: not reported in source
AA-derived and H2O2-induced hair follicle stem cells
Outcome group
Receptor activity and mechanism · Skin and wound
Studied dose
2 mMAs given in this study (human).
Source sentences
Summary
NMN restored SIRT7 expression and activity, leading to the deacetylation and activation of GLS1.
2 context sentences(design, population, supporting numbers)
Summary · context
Scalp tissues from AA patients and healthy controls were collected, and HFSCs were isolated.
Summary · context
An in vitro oxidative stress model was established using H₂O₂.
Report a problemFND-4250853115

Studies that did not test the peptide alone1

In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking NMN (nicotinamide mononucleotide).

19LabNot a test of NMN (nicotinamide mononucleotide) aloneIn vitro (cells)Mechanism
In hair follicle stem cells, SIRT7 or GLS1 knockdown abolished NMN protection, while GLS1-MUT rescued it.
In plain wordsIn cells, SIRT7 or GLS1 gene suppression blocked NMN protection, while mutant GLS1 restored it.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
MixedDependence of protection on SIRT7 and GLS1
Study
humann: not reported in source
AA-derived and H2O2-induced hair follicle stem cells
Outcome group
Receptor activity and mechanism · Skin and wound
Source sentences
Summary
Knockdown of SIRT7 or GLS1 abolished NMN's protective effects, which were rescued by GLS1-MUT, establishing a linear pathway.
2 context sentences(design, population, supporting numbers)
Summary · context
Scalp tissues from AA patients and healthy controls were collected, and HFSCs were isolated.
Summary · context
An in vitro oxidative stress model was established using H₂O₂.
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-4250853116

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

Keywords

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