Humanin peptide ameliorates reproductive dysfunction and restores neuroendocrine mechanisms in SSRI-treated male rats.

Köm Akipek RE, Çoban Ercan E, Akipek ME, Atmaca AT, Özdede MR, Türk G, Akdeniz İncili C, Çevik A, Canpolat S

Reproductive biology21 Jul 2026

PMID42480246DOI10.1016/j.repbio.2026.101254PepBankPUB-42480246

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In paroxetine-treated male rats, humanin co-administration significantly reversed the impairment and restored ejaculatory frequency.
In plain wordsIn male rats given paroxetine, humanin restored ejaculatory frequency.
Peptide
Humanin
Outcome
IncreaseEjaculatory frequency
Study
ratn = 20
Paroxetine-treated male Sprague-Dawley rats
Comparator
Paroxetine alone
Outcome group
Sexual function · Reproductive and sexual health
Studied dose
1 mg/kg/day · subcutaneous infusionAs given in this study (rat).
Source sentences
Summary
Humanin co-administration significantly reversed these adverse effects, restoring ejaculatory frequency, copulatory efficiency, sperm parameters, and hormonal balance.
1 context sentence(design, population, supporting numbers)
Summary · context
In Phase 1, fifty rats were randomized into control, sham, paroxetine (20 mg/kg/day via oral gavage), humanin (1 mg/kg/day via subcutaneous infusion), and paroxetine + humanin groups (n = 10/group) to evaluate sexual behavior, sperm quality, serum hormones, and dopaminergic activity within the nucle…
Report a problemFND-4248024601
02AnimalAnimal study (in vivo)Efficacy outcome
In paroxetine-treated male rats, humanin co-administration significantly reversed the impairment and restored copulatory efficiency.
In plain wordsIn male rats given paroxetine, humanin restored copulatory efficiency.
Peptide
Humanin
Outcome
IncreaseCopulatory efficiency
Study
ratn = 20
Paroxetine-treated male Sprague-Dawley rats
Comparator
Paroxetine alone
Outcome group
Sexual function · Reproductive and sexual health
Studied dose
1 mg/kg/day · subcutaneous infusionAs given in this study (rat).
Source sentences
Summary
Humanin co-administration significantly reversed these adverse effects, restoring ejaculatory frequency, copulatory efficiency, sperm parameters, and hormonal balance.
1 context sentence(design, population, supporting numbers)
Summary · context
In Phase 1, fifty rats were randomized into control, sham, paroxetine (20 mg/kg/day via oral gavage), humanin (1 mg/kg/day via subcutaneous infusion), and paroxetine + humanin groups (n = 10/group) to evaluate sexual behavior, sperm quality, serum hormones, and dopaminergic activity within the nucle…
Report a problemFND-4248024602
03AnimalAnimal study (in vivo)Efficacy outcome
In paroxetine-treated male rats, humanin co-administration significantly reversed the impairment and restored sperm parameters.
In plain wordsIn male rats given paroxetine, humanin restored sperm quality measures.
Peptide
Humanin
Outcome
IncreaseSperm parameters
Study
ratn = 20
Paroxetine-treated male Sprague-Dawley rats
Comparator
Paroxetine alone
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
1 mg/kg/day · subcutaneous infusionAs given in this study (rat).
Source sentences
Summary
Humanin co-administration significantly reversed these adverse effects, restoring ejaculatory frequency, copulatory efficiency, sperm parameters, and hormonal balance.
1 context sentence(design, population, supporting numbers)
Summary · context
Paroxetine significantly impaired sexual motivation and performance, reduced sperm motility, concentration, and mitochondrial membrane potential, elevated prolactin, and suppressed testosterone, luteinizing hormone, and dopamine levels in both the NAc and MPOA (p < 0.05).
Report a problemFND-4248024603
04AnimalAnimal study (in vivo)Efficacy outcome
In paroxetine-treated male rats, humanin co-administration significantly reversed the hormone disruption and restored hormonal balance.
In plain wordsIn male rats given paroxetine, humanin restored the balance of reproductive hormones.
Peptide
Humanin
Outcome
MixedSerum hormonal balance
Study
ratn = 20
Paroxetine-treated male Sprague-Dawley rats
Comparator
Paroxetine alone
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
1 mg/kg/day · subcutaneous infusionAs given in this study (rat).
Source sentences
Summary
Humanin co-administration significantly reversed these adverse effects, restoring ejaculatory frequency, copulatory efficiency, sperm parameters, and hormonal balance.
1 context sentence(design, population, supporting numbers)
Summary · context
Paroxetine significantly impaired sexual motivation and performance, reduced sperm motility, concentration, and mitochondrial membrane potential, elevated prolactin, and suppressed testosterone, luteinizing hormone, and dopamine levels in both the NAc and MPOA (p < 0.05).
Report a problemFND-4248024604
05AnimalAnimal study (in vivo)Mechanism
In paroxetine-treated male rats, humanin counteracted the paroxetine-induced dopaminergic suppression in the MPOA and NAc.
In plain wordsIn male rats given paroxetine, humanin counteracted the drop in dopamine activity in two brain regions.
Peptide
Humanin
Outcome
IncreaseDopaminergic activity in MPOA and NAc
Study
ratn = 20
Paroxetine-treated male Sprague-Dawley rats
Comparator
Paroxetine alone
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
1 mg/kg/day · subcutaneous infusionAs given in this study (rat).
Source sentences
Summary
humanin counteracted the paroxetine-induced dopaminergic suppression in the MPOA and NAc
Report a problemFND-4248024605
06AnimalAnimal study (in vivo)Mechanism
In healthy rats, acute microdialysis revealed a supportive upward trend in dopamine turnover under basal conditions.
In plain wordsIn healthy rats, humanin showed an upward trend in dopamine turnover at baseline.
Peptide
Humanin
Outcome
IncreaseDopamine turnover under basal conditions
Study
ratn = 8
Healthy rats
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
acute microdialysis revealed a supportive upward trend in dopamine turnover under basal conditions.
1 context sentence(design, population, supporting numbers)
Summary · context
In Phase 2, central neurochemical dynamics in a separate cohort of healthy rats (n = 8) were assessed using in vivo microdialysis coupled with HPLC-ECD to measure extracellular dopamine and its metabolites in the NAc.
Report a problemFND-4248024606

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

Keywords

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