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Study · Not a test of the peptide alone · 2026

3 results

Neuroprotective effect of intraperitoneal Humanin-G in retinal degeneration of Royal College of Surgeons rats.

Lin B, Schneider K, Ozgul M, Ianopol N, Seiler MJ

Scientific reports18 Jul 2026

PMID42471450 (opens in a new tab)DOI10.1038/s41598-026-62834-3 (opens in a new tab)PepBankPUB-42471450
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 01AnimalNot a test of Humanin aloneAnimal study (in vivo)Mechanism

    In RCS rats, high dose HNG at 4 weeks after first injection was associated with the largest change in expression of genes for apoptosis, oxidative stress, inflammation and retinal/RPE function.

    In plain wordsIn rats with retinal degeneration, high dose humanin-G changed the activity of genes linked to cell death, stress, inflammation and retinal function.

    Peptide
    Humanin
    Outcome
    MixedRetinal and RPE gene expression at 4 weeks
    Study

    ratn: not reported in source

    Royal College of Surgeons (RCS) rats with retinal degeneration
    Comparator
    Sham saline
    Outcome group
    Neuroprotection · Eye

    Source sentences

    Summary
    The results showed that high dose HNG at 4 weeks after first injection (WAFI) was associated with the largest change in gene expression in the RPE and retina of treated animals, altering expression of genes involved in apoptosis, oxidative stress, inflammation and retinal/RPE function.
    1 context sentence
    Summary · context
    Starting at postnatal day 21, RCS rats received twice a week intraperitoneal injection of either Low Dose HNG (0.4 mg/kg), High Dose HNG (4 mg/kg), or sham-saline for 1 or 4 weeks.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 02AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In RCS rats at 4 weeks after first injection, ERG showed no difference between low or high dose HNG and sham injection.

    In plain wordsIn rats with retinal degeneration, humanin-G at low or high dose did not change electroretinography results compared with sham injection.

    Peptide
    Humanin
    Outcome
    No significant changeElectroretinography at 4 weeks
    Study

    ratn: not reported in source

    Royal College of Surgeons (RCS) rats with retinal degeneration
    Comparator
    Sham saline
    Outcome group
    Neuroprotection · Eye

    Source sentences

    Summary
    At 4 WAFI, ERG showed no difference between either low or high dose of HNG and sham injection
    1 context sentence
    Summary · context
    Starting at postnatal day 21, RCS rats received twice a week intraperitoneal injection of either Low Dose HNG (0.4 mg/kg), High Dose HNG (4 mg/kg), or sham-saline for 1 or 4 weeks.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 03AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In RCS rats at 4 weeks after first injection, high dose HNG significantly improved visual acuity tested by OKT versus sham injection.

    In plain wordsIn rats with retinal degeneration, high dose humanin-G improved visual acuity compared with sham injection.

    Peptide
    Humanin
    Outcome
    IncreaseVisual acuity by optokinetic testing at 4 weeks
    Study

    ratn: not reported in source

    Royal College of Surgeons (RCS) rats with retinal degeneration
    Comparator
    Sham saline
    Outcome group
    Neuroprotection · Eye

    Source sentences

    Summary
    while the visual acuity tested by OKT in rats treated with high dose HNG showed significant improvement.
    1 context sentence
    Summary · context
    Starting at postnatal day 21, RCS rats received twice a week intraperitoneal injection of either Low Dose HNG (0.4 mg/kg), High Dose HNG (4 mg/kg), or sham-saline for 1 or 4 weeks.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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