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Study · Animal study (in vivo) · rat · 2026

9 results

Investigating the effects of nicotinamide mononucleotide administration on testicular apoptosis, and mitochondrial function in doxorubicin-treated rats.

Yousefi Khiabani P, Badalzadeh R, Shokoohi M, Zoghi E, Alihemmati A

Molecular biology reports18 Jul 2026

PMID42470492 (opens in a new tab)DOI10.1007/s11033-026-12391-9 (opens in a new tab)PepBankPUB-42470492
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In doxorubicin-treated rats, NMN attenuated the decrease in Johnson's score versus doxorubicin alone.

    In plain wordsIn rats, NMN improved Johnson's score compared with doxorubicin alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseJohnson's score
    Study

    ratn: not reported in source

    Doxorubicin-treated male Wistar rats
    Comparator
    Doxorubicin alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    100 mg/kg · intraperitoneal · 28 daysAs given in this study (rat).

    Source sentences

    Summary
    NMN treatment significantly attenuated these alterations by reducing oxidative stress and apoptosis while improving mitochondrial function and histological architecture of the testes.
    3 context sentences
    Summary · context
    Doxorubicin administration significantly decreased Johnson's score, seminiferous tubule diameter, epithelial thickness, antioxidant enzyme activity, and mitochondrial membrane potential,
    Summary · context
    Thirty-two male Wistar rats were randomly assigned into four groups: control, NMN, doxorubicin, and NMN + doxorubicin.
    Summary · context
    NMN (100 mg/kg) was administered intraperitoneally for 28 days, whereas doxorubicin was injected intraperitoneally at a dose of 2 mg/kg every 48 h for 12 days (six injections; cumulative dose 12 mg/kg).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In doxorubicin-treated rats, NMN attenuated the decrease in seminiferous tubule diameter versus doxorubicin alone.

    In plain wordsIn rats, NMN improved seminiferous tubule diameter compared with doxorubicin alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseSeminiferous tubule diameter
    Study

    ratn: not reported in source

    Doxorubicin-treated male Wistar rats
    Comparator
    Doxorubicin alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    100 mg/kg · intraperitoneal · 28 daysAs given in this study (rat).

    Source sentences

    Summary
    NMN treatment significantly attenuated these alterations by reducing oxidative stress and apoptosis while improving mitochondrial function and histological architecture of the testes.
    3 context sentences
    Summary · context
    Doxorubicin administration significantly decreased Johnson's score, seminiferous tubule diameter, epithelial thickness, antioxidant enzyme activity, and mitochondrial membrane potential,
    Summary · context
    Thirty-two male Wistar rats were randomly assigned into four groups: control, NMN, doxorubicin, and NMN + doxorubicin.
    Summary · context
    NMN (100 mg/kg) was administered intraperitoneally for 28 days, whereas doxorubicin was injected intraperitoneally at a dose of 2 mg/kg every 48 h for 12 days (six injections; cumulative dose 12 mg/kg).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In doxorubicin-treated rats, NMN attenuated the decrease in epithelial thickness versus doxorubicin alone.

    In plain wordsIn rats, NMN improved testicular epithelial thickness compared with doxorubicin alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseSeminiferous epithelial thickness
    Study

    ratn: not reported in source

    Doxorubicin-treated male Wistar rats
    Comparator
    Doxorubicin alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    100 mg/kg · intraperitoneal · 28 daysAs given in this study (rat).

    Source sentences

    Summary
    NMN treatment significantly attenuated these alterations by reducing oxidative stress and apoptosis while improving mitochondrial function and histological architecture of the testes.
    3 context sentences
    Summary · context
    Doxorubicin administration significantly decreased Johnson's score, seminiferous tubule diameter, epithelial thickness, antioxidant enzyme activity, and mitochondrial membrane potential,
    Summary · context
    Thirty-two male Wistar rats were randomly assigned into four groups: control, NMN, doxorubicin, and NMN + doxorubicin.
    Summary · context
    NMN (100 mg/kg) was administered intraperitoneally for 28 days, whereas doxorubicin was injected intraperitoneally at a dose of 2 mg/kg every 48 h for 12 days (six injections; cumulative dose 12 mg/kg).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In doxorubicin-treated rats, NMN attenuated the reduction in antioxidant enzyme activity versus doxorubicin alone.

    In plain wordsIn rats, NMN improved antioxidant enzyme activity compared with doxorubicin alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseAntioxidant enzyme activity
    Study

    ratn: not reported in source

    Doxorubicin-treated male Wistar rats
    Comparator
    Doxorubicin alone
    Outcome group
    Oxidative stress · Reproductive and sexual health
    Studied dose
    100 mg/kg · intraperitoneal · 28 daysAs given in this study (rat).

    Source sentences

    Summary
    NMN treatment significantly attenuated these alterations by reducing oxidative stress and apoptosis while improving mitochondrial function and histological architecture of the testes.
    3 context sentences
    Summary · context
    Doxorubicin administration significantly decreased Johnson's score, seminiferous tubule diameter, epithelial thickness, antioxidant enzyme activity, and mitochondrial membrane potential,
    Summary · context
    Thirty-two male Wistar rats were randomly assigned into four groups: control, NMN, doxorubicin, and NMN + doxorubicin.
    Summary · context
    NMN (100 mg/kg) was administered intraperitoneally for 28 days, whereas doxorubicin was injected intraperitoneally at a dose of 2 mg/kg every 48 h for 12 days (six injections; cumulative dose 12 mg/kg).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In doxorubicin-treated rats, NMN attenuated the decrease in mitochondrial membrane potential versus doxorubicin alone.

    In plain wordsIn rats, NMN improved mitochondrial membrane potential compared with doxorubicin alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseMitochondrial membrane potential
    Study

    ratn: not reported in source

    Doxorubicin-treated male Wistar rats
    Comparator
    Doxorubicin alone
    Outcome group
    Mitochondrial function · Reproductive and sexual health
    Studied dose
    100 mg/kg · intraperitoneal · 28 daysAs given in this study (rat).

    Source sentences

    Summary
    NMN treatment significantly attenuated these alterations by reducing oxidative stress and apoptosis while improving mitochondrial function and histological architecture of the testes.
    3 context sentences
    Summary · context
    Doxorubicin administration significantly decreased Johnson's score, seminiferous tubule diameter, epithelial thickness, antioxidant enzyme activity, and mitochondrial membrane potential,
    Summary · context
    Thirty-two male Wistar rats were randomly assigned into four groups: control, NMN, doxorubicin, and NMN + doxorubicin.
    Summary · context
    NMN (100 mg/kg) was administered intraperitoneally for 28 days, whereas doxorubicin was injected intraperitoneally at a dose of 2 mg/kg every 48 h for 12 days (six injections; cumulative dose 12 mg/kg).
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In doxorubicin-treated rats, NMN attenuated the increase in reactive oxygen species versus doxorubicin alone.

    In plain wordsIn rats, NMN reduced reactive oxygen species compared with doxorubicin alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseReactive oxygen species
    Study

    ratn: not reported in source

    Doxorubicin-treated male Wistar rats
    Comparator
    Doxorubicin alone
    Outcome group
    Oxidative stress · Reproductive and sexual health
    Studied dose
    100 mg/kg · intraperitoneal · 28 daysAs given in this study (rat).

    Source sentences

    Summary
    NMN treatment significantly attenuated these alterations by reducing oxidative stress and apoptosis while improving mitochondrial function and histological architecture of the testes.
    3 context sentences
    Summary · context
    while markedly increasing ROS levels, lipid peroxidation, and Bax expression (p < 0.05).
    Summary · context
    Thirty-two male Wistar rats were randomly assigned into four groups: control, NMN, doxorubicin, and NMN + doxorubicin.
    Summary · context
    NMN (100 mg/kg) was administered intraperitoneally for 28 days, whereas doxorubicin was injected intraperitoneally at a dose of 2 mg/kg every 48 h for 12 days (six injections; cumulative dose 12 mg/kg).
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In doxorubicin-treated rats, NMN attenuated increased lipid peroxidation versus doxorubicin alone.

    In plain wordsIn rats, NMN reduced lipid peroxidation compared with doxorubicin alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseLipid peroxidation
    Study

    ratn: not reported in source

    Doxorubicin-treated male Wistar rats
    Comparator
    Doxorubicin alone
    Outcome group
    Oxidative stress · Reproductive and sexual health
    Studied dose
    100 mg/kg · intraperitoneal · 28 daysAs given in this study (rat).

    Source sentences

    Summary
    NMN treatment significantly attenuated these alterations by reducing oxidative stress and apoptosis while improving mitochondrial function and histological architecture of the testes.
    3 context sentences
    Summary · context
    while markedly increasing ROS levels, lipid peroxidation, and Bax expression (p < 0.05).
    Summary · context
    Thirty-two male Wistar rats were randomly assigned into four groups: control, NMN, doxorubicin, and NMN + doxorubicin.
    Summary · context
    NMN (100 mg/kg) was administered intraperitoneally for 28 days, whereas doxorubicin was injected intraperitoneally at a dose of 2 mg/kg every 48 h for 12 days (six injections; cumulative dose 12 mg/kg).
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In doxorubicin-treated rats, NMN attenuated increased Bax expression versus doxorubicin alone.

    In plain wordsIn rats, NMN reduced Bax expression compared with doxorubicin alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseBax expression
    Study

    ratn: not reported in source

    Doxorubicin-treated male Wistar rats
    Comparator
    Doxorubicin alone
    Outcome group
    Cell viability and death · Reproductive and sexual health
    Studied dose
    100 mg/kg · intraperitoneal · 28 daysAs given in this study (rat).

    Source sentences

    Summary
    NMN treatment significantly attenuated these alterations by reducing oxidative stress and apoptosis while improving mitochondrial function and histological architecture of the testes.
    3 context sentences
    Summary · context
    while markedly increasing ROS levels, lipid peroxidation, and Bax expression (p < 0.05).
    Summary · context
    Thirty-two male Wistar rats were randomly assigned into four groups: control, NMN, doxorubicin, and NMN + doxorubicin.
    Summary · context
    NMN (100 mg/kg) was administered intraperitoneally for 28 days, whereas doxorubicin was injected intraperitoneally at a dose of 2 mg/kg every 48 h for 12 days (six injections; cumulative dose 12 mg/kg).
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In doxorubicin-treated rats, NMN reduced apoptosis versus doxorubicin alone.

    In plain wordsIn rats, NMN reduced testicular cell death compared with doxorubicin alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseTesticular apoptosis
    Study

    ratn: not reported in source

    Doxorubicin-treated male Wistar rats
    Comparator
    Doxorubicin alone
    Outcome group
    Cell viability and death · Reproductive and sexual health
    Studied dose
    100 mg/kg · intraperitoneal · 28 daysAs given in this study (rat).

    Source sentences

    Summary
    NMN treatment significantly attenuated these alterations by reducing oxidative stress and apoptosis while improving mitochondrial function and histological architecture of the testes.
    2 context sentences
    Summary · context
    Thirty-two male Wistar rats were randomly assigned into four groups: control, NMN, doxorubicin, and NMN + doxorubicin.
    Summary · context
    NMN (100 mg/kg) was administered intraperitoneally for 28 days, whereas doxorubicin was injected intraperitoneally at a dose of 2 mg/kg every 48 h for 12 days (six injections; cumulative dose 12 mg/kg).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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