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Study · Other design · 2026

1 result

Deacetylation of SRF catalyzed by SIRT7 protects against abdominal aortic aneurysm formation.

Xiong Y, Chen J, Lu W, Liu Y, Sheng C, Liu S, Xu B, Li Y, Pan B, Wang W

Experimental & molecular medicine8 Jul 2026

PMID42420530 (opens in a new tab)PMCIDPMC13434582 (opens in a new tab)DOI10.1038/s12276-026-01787-z (opens in a new tab)PepBankPUB-42420530
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Summary

Abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disease for which no effective pharmacological treatments exist. Histone deacetylases (HDACs) have emerged as critical regulators of cardiovascular pathophysiology; however, the contributions of individual HDAC isoforms to AAA formation remain largely undefined. Here, we identified sirtuin 7 (SIRT7) as the most markedly downregulation isoform among 18 HDAC family members in human AAA tissues. Global and vascular smooth muscle cell (VSMC)-specific Sirt7 knockout exacerbated AAA formation, whereas SIRT7 overexpression attenuated aneurysm progression. Mechanistically, SIRT7 deacetylates serum response factor (SRF) at lysine 154, thereby preventing SRF nuclear-to-cytoplasmic translocation and ubiquitin-mediated degradation and preserving the VSMC contractile phenotype. Consequently, SIRT7 deficiency enhances SRF acetylation, accelerates its degradation, and promotes VSMC phenotypic switching, ultimately facilitating AAA progression. Pharmacological activation of SIRT7 with the NAD⁺ precursor nicotinamide mononucleotide attenuated aortic dilation. Collectively, our findings reveal a crucial role for SIRT7-mediated SRF-K154 deacetylation in limiting AAA progression and suggest that nicotinamide mononucleotide supplementation may represent a promising therapeutic strategy for AAA.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalOther designEfficacy outcome

    In the abdominal aortic aneurysm study, NMN attenuated aortic dilation.

    In plain wordsIn the aneurysm study, NMN reduced aortic dilation.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseAortic dilation
    Study

    n: not reported in source

    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pharmacological activation of SIRT7 with the NAD⁺ precursor nicotinamide mononucleotide attenuated aortic dilation.

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Version history

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  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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