A senescent metabolism-modulating hierarchical scaffold restores NAD⁺ homeostasis and redox balance for aged bone repair.

Jiang J, Chen J, Wang X, Zhang X, Lv H, Wu C, Han L, Zhu Y

Bioactive materials27 Jun 2026

PMID42395338PMCIDPMC13324311DOI10.1016/j.bioactmat.2026.06.036PepBankPUB-42395338

Read at source PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study9

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone9

In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking NMN (nicotinamide mononucleotide).

01AnimalNot a test of NMN (nicotinamide mononucleotide) aloneAnimal study (in vivo)Efficacy outcome
In aged rats with femoral condyle defects, the scaffold with NMN and manganese increased new bone formation.
In plain wordsIn aged rats with bone defects, the scaffold with NMN and manganese increased new bone formation.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseNew bone formation
Study
ratn: not reported in source
Aged rats with femoral condyle defects
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
Based on the dual regulatory mechanism, the scaffold implantation significantly promoted new bone formation and maturation in aged rats with femoral condyle defects.
2 context sentences(design, population, supporting numbers)
Summary · context
Here, we propose a senescent metabolism-reprogramming therapeutic strategy by developing a hierarchical bioceramic scaffold, comprising an outer 3D-printed β-tricalcium phosphate (β-TCP) hollow tube and an inner freeze-casting MnTCP ceramic rod with the loading of nicotinamide mononucleotide (NMN).
Summary · context
During aged bone repair, the scaffold enables sustained release of both NMN and manganese (Mn) ions, targeting two core problems of the senescent bone microenvironment: NAD⁺ metabolic imbalance and accumulated oxidative stress.
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-4239533808
02AnimalNot a test of NMN (nicotinamide mononucleotide) aloneAnimal study (in vivo)Efficacy outcome
In aged rats with femoral condyle defects, the scaffold with NMN and manganese increased new bone maturation.
In plain wordsIn aged rats with bone defects, the scaffold with NMN and manganese increased new bone maturation.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseNew bone maturation
Study
ratn: not reported in source
Aged rats with femoral condyle defects
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
Based on the dual regulatory mechanism, the scaffold implantation significantly promoted new bone formation and maturation in aged rats with femoral condyle defects.
2 context sentences(design, population, supporting numbers)
Summary · context
Here, we propose a senescent metabolism-reprogramming therapeutic strategy by developing a hierarchical bioceramic scaffold, comprising an outer 3D-printed β-tricalcium phosphate (β-TCP) hollow tube and an inner freeze-casting MnTCP ceramic rod with the loading of nicotinamide mononucleotide (NMN).
Summary · context
During aged bone repair, the scaffold enables sustained release of both NMN and manganese (Mn) ions, targeting two core problems of the senescent bone microenvironment: NAD⁺ metabolic imbalance and accumulated oxidative stress.
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-4239533809
03LabNot a test of NMN (nicotinamide mononucleotide) aloneIn vitro (cells)Efficacy outcome
In cellular tests, the NMN- and manganese-releasing scaffold restored intracellular NAD+ levels.
In plain wordsIn cells, the scaffold with NMN and manganese restored NAD+ levels.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseIntracellular NAD+ levels
Study
n: not reported in source
Outcome group
Mitochondrial function · Metabolic and weight
Source sentences
Summary
The scaffold was demonstrated to effectively restore intracellular NAD⁺ levels for reversing senescence-induced energy metabolism disorder by improving mitochondrial structure and function, and to scavenge excessive reactive oxygen species (ROS) for regulating cellular redox homeostasis.
2 context sentences(design, population, supporting numbers)
Summary · context
Here, we propose a senescent metabolism-reprogramming therapeutic strategy by developing a hierarchical bioceramic scaffold, comprising an outer 3D-printed β-tricalcium phosphate (β-TCP) hollow tube and an inner freeze-casting MnTCP ceramic rod with the loading of nicotinamide mononucleotide (NMN).
Summary · context
During aged bone repair, the scaffold enables sustained release of both NMN and manganese (Mn) ions, targeting two core problems of the senescent bone microenvironment: NAD⁺ metabolic imbalance and accumulated oxidative stress.
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-4239533801
04LabNot a test of NMN (nicotinamide mononucleotide) aloneIn vitro (cells)Efficacy outcome
In cellular tests, the NMN- and manganese-releasing scaffold improved mitochondrial structure.
In plain wordsIn cells, the scaffold with NMN and manganese improved mitochondrial structure.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseMitochondrial structure
Study
n: not reported in source
Outcome group
Mitochondrial function · Metabolic and weight
Source sentences
Summary
The scaffold was demonstrated to effectively restore intracellular NAD⁺ levels for reversing senescence-induced energy metabolism disorder by improving mitochondrial structure and function, and to scavenge excessive reactive oxygen species (ROS) for regulating cellular redox homeostasis.
2 context sentences(design, population, supporting numbers)
Summary · context
Here, we propose a senescent metabolism-reprogramming therapeutic strategy by developing a hierarchical bioceramic scaffold, comprising an outer 3D-printed β-tricalcium phosphate (β-TCP) hollow tube and an inner freeze-casting MnTCP ceramic rod with the loading of nicotinamide mononucleotide (NMN).
Summary · context
During aged bone repair, the scaffold enables sustained release of both NMN and manganese (Mn) ions, targeting two core problems of the senescent bone microenvironment: NAD⁺ metabolic imbalance and accumulated oxidative stress.
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-4239533802
05LabNot a test of NMN (nicotinamide mononucleotide) aloneIn vitro (cells)Efficacy outcome
In cellular tests, the NMN- and manganese-releasing scaffold improved mitochondrial function.
In plain wordsIn cells, the scaffold with NMN and manganese improved mitochondrial function.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseMitochondrial function
Study
n: not reported in source
Outcome group
Mitochondrial function · Metabolic and weight
Source sentences
Summary
The scaffold was demonstrated to effectively restore intracellular NAD⁺ levels for reversing senescence-induced energy metabolism disorder by improving mitochondrial structure and function, and to scavenge excessive reactive oxygen species (ROS) for regulating cellular redox homeostasis.
2 context sentences(design, population, supporting numbers)
Summary · context
Here, we propose a senescent metabolism-reprogramming therapeutic strategy by developing a hierarchical bioceramic scaffold, comprising an outer 3D-printed β-tricalcium phosphate (β-TCP) hollow tube and an inner freeze-casting MnTCP ceramic rod with the loading of nicotinamide mononucleotide (NMN).
Summary · context
During aged bone repair, the scaffold enables sustained release of both NMN and manganese (Mn) ions, targeting two core problems of the senescent bone microenvironment: NAD⁺ metabolic imbalance and accumulated oxidative stress.
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-4239533803
06LabNot a test of NMN (nicotinamide mononucleotide) aloneIn vitro (cells)Efficacy outcome
In cellular tests, the NMN- and manganese-releasing scaffold scavenged excessive reactive oxygen species.
In plain wordsIn cells, the scaffold with NMN and manganese reduced excess reactive oxygen species.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseExcess reactive oxygen species
Study
n: not reported in source
Outcome group
Oxidative stress · Whole body
Source sentences
Summary
The scaffold was demonstrated to effectively restore intracellular NAD⁺ levels for reversing senescence-induced energy metabolism disorder by improving mitochondrial structure and function, and to scavenge excessive reactive oxygen species (ROS) for regulating cellular redox homeostasis.
2 context sentences(design, population, supporting numbers)
Summary · context
Here, we propose a senescent metabolism-reprogramming therapeutic strategy by developing a hierarchical bioceramic scaffold, comprising an outer 3D-printed β-tricalcium phosphate (β-TCP) hollow tube and an inner freeze-casting MnTCP ceramic rod with the loading of nicotinamide mononucleotide (NMN).
Summary · context
During aged bone repair, the scaffold enables sustained release of both NMN and manganese (Mn) ions, targeting two core problems of the senescent bone microenvironment: NAD⁺ metabolic imbalance and accumulated oxidative stress.
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-4239533804
07LabNot a test of NMN (nicotinamide mononucleotide) aloneIn vitro (cells)Efficacy outcome
In cellular tests, the NMN- and manganese-releasing scaffold alleviated cellular senescence.
In plain wordsIn cells, the scaffold with NMN and manganese reduced cellular senescence.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseCellular senescence
Study
n: not reported in source
Outcome group
Aging markers · Aging and longevity
Source sentences
Summary
Therefore, it achieved cellular senescence alleviation by restoring energy metabolism and redox homeostasis.
2 context sentences(design, population, supporting numbers)
Summary · context
Here, we propose a senescent metabolism-reprogramming therapeutic strategy by developing a hierarchical bioceramic scaffold, comprising an outer 3D-printed β-tricalcium phosphate (β-TCP) hollow tube and an inner freeze-casting MnTCP ceramic rod with the loading of nicotinamide mononucleotide (NMN).
Summary · context
During aged bone repair, the scaffold enables sustained release of both NMN and manganese (Mn) ions, targeting two core problems of the senescent bone microenvironment: NAD⁺ metabolic imbalance and accumulated oxidative stress.
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-4239533805
08LabNot a test of NMN (nicotinamide mononucleotide) aloneIn vitro (cells)Efficacy outcome
In the aged bone repair study, the scaffold with NMN and manganese inhibited inflammatory responses.
In plain wordsIn cells, the scaffold with NMN and manganese reduced inflammatory responses.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseInflammatory responses
Study
n: not reported in source
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
This anti-senescence action together with the inhibition of inflammatory responses collectively promoted osteogenic differentiation and enhanced bone regeneration.
2 context sentences(design, population, supporting numbers)
Summary · context
Here, we propose a senescent metabolism-reprogramming therapeutic strategy by developing a hierarchical bioceramic scaffold, comprising an outer 3D-printed β-tricalcium phosphate (β-TCP) hollow tube and an inner freeze-casting MnTCP ceramic rod with the loading of nicotinamide mononucleotide (NMN).
Summary · context
During aged bone repair, the scaffold enables sustained release of both NMN and manganese (Mn) ions, targeting two core problems of the senescent bone microenvironment: NAD⁺ metabolic imbalance and accumulated oxidative stress.
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-4239533806
09LabNot a test of NMN (nicotinamide mononucleotide) aloneIn vitro (cells)Efficacy outcome
In cellular tests, the scaffold with NMN and manganese promoted osteogenic differentiation.
In plain wordsIn cells, the scaffold with NMN and manganese promoted differentiation into bone-forming cells.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseOsteogenic differentiation
Study
n: not reported in source
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
This anti-senescence action together with the inhibition of inflammatory responses collectively promoted osteogenic differentiation and enhanced bone regeneration.
2 context sentences(design, population, supporting numbers)
Summary · context
Here, we propose a senescent metabolism-reprogramming therapeutic strategy by developing a hierarchical bioceramic scaffold, comprising an outer 3D-printed β-tricalcium phosphate (β-TCP) hollow tube and an inner freeze-casting MnTCP ceramic rod with the loading of nicotinamide mononucleotide (NMN).
Summary · context
During aged bone repair, the scaffold enables sustained release of both NMN and manganese (Mn) ions, targeting two core problems of the senescent bone microenvironment: NAD⁺ metabolic imbalance and accumulated oxidative stress.
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-4239533807

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Keywords

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