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Study · Animal study (in vivo) · rat · 2026

10 results

Effects of retatrutide on learning and memory in streptozotocin-induced male diabetic rats.

Keskin U, Altın E, Kara MK, Tekin B, Çakırçoban KN, Özatik FY, Arı NS, Sezgin AK, Güngor E

Behavioural brain research1 Jul 2026

PMID42385950 (opens in a new tab)DOI10.1016/j.bbr.2026.116343 (opens in a new tab)PepBankPUB-42385950
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In streptozotocin-induced diabetic rats, retatrutide reduced blood glucose levels.

    In plain wordsIn diabetic rats, retatrutide lowered blood glucose.

    Peptide
    Retatrutide
    Outcome
    DecreaseBlood glucose
    Study

    ratn: not reported in source

    Streptozotocin-induced diabetic rats
    Comparator
    Untreated diabetic rats
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Retatrutide reduced blood glucose levels but did not prevent diabetes-associated weight loss.
    2 context sentences
    Summary · context
    Male Sprague-Dawley rats were allocated to four groups: control (C), streptozotocin-induced diabetic (STZ), streptozotocin-induced diabetic treated with Retatrutide (STZR), and Retatrutide alone (R).
    Summary · context
    Diabetes was induced with streptozotocin, and spatial learning and memory were assessed using the Morris Water Maze and Passive Avoidance tests.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In streptozotocin-induced diabetic rats, retatrutide did not prevent diabetes-associated weight loss.

    In plain wordsIn diabetic rats, retatrutide did not prevent the weight loss caused by diabetes.

    Peptide
    Retatrutide
    Outcome
    No significant changeBody weight loss in diabetes
    Study

    ratn: not reported in source

    Streptozotocin-induced diabetic rats
    Comparator
    Untreated diabetic rats
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    but did not prevent diabetes-associated weight loss.
    2 context sentences
    Summary · context
    Male Sprague-Dawley rats were allocated to four groups: control (C), streptozotocin-induced diabetic (STZ), streptozotocin-induced diabetic treated with Retatrutide (STZR), and Retatrutide alone (R).
    Summary · context
    Diabetes was induced with streptozotocin, and spatial learning and memory were assessed using the Morris Water Maze and Passive Avoidance tests.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In streptozotocin-induced diabetic rats, retatrutide preserved overall Morris Water Maze performance relative to untreated diabetic rats.

    In plain wordsIn diabetic rats, retatrutide kept maze performance better than no treatment did.

    Peptide
    Retatrutide
    Outcome
    IncreaseMorris Water Maze performance
    Study

    ratn: not reported in source

    Streptozotocin-induced diabetic rats
    Comparator
    Untreated diabetic rats
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Retatrutide-treated diabetic rats showed preserved overall Morris Water Maze performance relative to untreated diabetic rats
    2 context sentences
    Summary · context
    Male Sprague-Dawley rats were allocated to four groups: control (C), streptozotocin-induced diabetic (STZ), streptozotocin-induced diabetic treated with Retatrutide (STZR), and Retatrutide alone (R).
    Summary · context
    Diabetes was induced with streptozotocin, and spatial learning and memory were assessed using the Morris Water Maze and Passive Avoidance tests.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In streptozotocin-induced diabetic rats, retatrutide gave a limited, task-dependent attenuation of short-term avoidance deficits, without full normalisation.

    In plain wordsIn diabetic rats, retatrutide only partly reduced short-term memory deficits.

    Peptide
    Retatrutide
    Outcome
    IncreaseShort-term passive avoidance deficit
    Study

    ratn: not reported in source

    Streptozotocin-induced diabetic rats
    Comparator
    Untreated diabetic rats
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    a limited, task-dependent attenuation of short-term avoidance deficits rather than complete normalisation across all memory measures
    2 context sentences
    Summary · context
    Male Sprague-Dawley rats were allocated to four groups: control (C), streptozotocin-induced diabetic (STZ), streptozotocin-induced diabetic treated with Retatrutide (STZR), and Retatrutide alone (R).
    Summary · context
    Diabetes was induced with streptozotocin, and spatial learning and memory were assessed using the Morris Water Maze and Passive Avoidance tests.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In streptozotocin-induced diabetic rats, retatrutide significantly reduced hippocampal TNF-α.

    In plain wordsIn diabetic rats, retatrutide lowered an inflammation marker (TNF-α) in the hippocampus.

    Peptide
    Retatrutide
    Outcome
    DecreaseHippocampal TNF-α
    Study

    ratn: not reported in source

    Streptozotocin-induced diabetic rats
    Comparator
    Untreated diabetic rats
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    a significant reduction in hippocampal TNF-α, a non-significant trend toward lower IL-1β, and partial preservation of cortical and hippocampal cytoarchitecture.
    2 context sentences
    Summary · context
    Male Sprague-Dawley rats were allocated to four groups: control (C), streptozotocin-induced diabetic (STZ), streptozotocin-induced diabetic treated with Retatrutide (STZR), and Retatrutide alone (R).
    Summary · context
    Diabetes was induced with streptozotocin, and spatial learning and memory were assessed using the Morris Water Maze and Passive Avoidance tests.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In streptozotocin-induced diabetic rats, retatrutide showed a non-significant trend toward lower IL-1β.

    In plain wordsIn diabetic rats, retatrutide showed only a small, non-significant trend toward lower IL-1β.

    Peptide
    Retatrutide
    Outcome
    No significant changeHippocampal IL-1β
    Study

    ratn: not reported in source

    Streptozotocin-induced diabetic rats
    Comparator
    Untreated diabetic rats
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    a non-significant trend toward lower IL-1β, and partial preservation of cortical and hippocampal cytoarchitecture.
    2 context sentences
    Summary · context
    Male Sprague-Dawley rats were allocated to four groups: control (C), streptozotocin-induced diabetic (STZ), streptozotocin-induced diabetic treated with Retatrutide (STZR), and Retatrutide alone (R).
    Summary · context
    Diabetes was induced with streptozotocin, and spatial learning and memory were assessed using the Morris Water Maze and Passive Avoidance tests.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In streptozotocin-induced diabetic rats, retatrutide was accompanied by partial preservation of cortical and hippocampal cytoarchitecture.

    In plain wordsIn diabetic rats, retatrutide partly preserved brain tissue structure.

    Peptide
    Retatrutide
    Outcome
    Direction not reportedCortical and hippocampal cytoarchitecture
    Study

    ratn: not reported in source

    Streptozotocin-induced diabetic rats
    Comparator
    Untreated diabetic rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    partial preservation of cortical and hippocampal cytoarchitecture.
    2 context sentences
    Summary · context
    Male Sprague-Dawley rats were allocated to four groups: control (C), streptozotocin-induced diabetic (STZ), streptozotocin-induced diabetic treated with Retatrutide (STZR), and Retatrutide alone (R).
    Summary · context
    Diabetes was induced with streptozotocin, and spatial learning and memory were assessed using the Morris Water Maze and Passive Avoidance tests.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In non-diabetic rats, retatrutide alone did not improve behavioural performance beyond control levels.

    In plain wordsIn healthy rats, retatrutide alone did not improve behaviour test results beyond control rats.

    Peptide
    Retatrutide
    Outcome
    No significant changeBehavioural performance with retatrutide alone
    Study

    ratn: not reported in source

    Non-diabetic Sprague-Dawley rats given retatrutide alone
    Comparator
    Control rats
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Retatrutide alone did not improve behavioural performance beyond control levels, although BDNF and CREB mRNA expression were increased in the non-diabetic Retatrutide group.
    2 context sentences
    Summary · context
    Male Sprague-Dawley rats were allocated to four groups: control (C), streptozotocin-induced diabetic (STZ), streptozotocin-induced diabetic treated with Retatrutide (STZR), and Retatrutide alone (R).
    Summary · context
    Diabetes was induced with streptozotocin, and spatial learning and memory were assessed using the Morris Water Maze and Passive Avoidance tests.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In non-diabetic rats, retatrutide increased BDNF mRNA expression.

    In plain wordsIn healthy rats, retatrutide increased activity of the BDNF gene.

    Peptide
    Retatrutide
    Outcome
    IncreaseBDNF mRNA expression
    Study

    ratn: not reported in source

    Non-diabetic Sprague-Dawley rats given retatrutide alone
    Comparator
    Control rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    BDNF and CREB mRNA expression were increased in the non-diabetic Retatrutide group.
    2 context sentences
    Summary · context
    Male Sprague-Dawley rats were allocated to four groups: control (C), streptozotocin-induced diabetic (STZ), streptozotocin-induced diabetic treated with Retatrutide (STZR), and Retatrutide alone (R).
    Summary · context
    Diabetes was induced with streptozotocin, and spatial learning and memory were assessed using the Morris Water Maze and Passive Avoidance tests.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In non-diabetic rats, retatrutide increased CREB mRNA expression.

    In plain wordsIn healthy rats, retatrutide increased activity of the CREB gene.

    Peptide
    Retatrutide
    Outcome
    IncreaseCREB mRNA expression
    Study

    ratn: not reported in source

    Non-diabetic Sprague-Dawley rats given retatrutide alone
    Comparator
    Control rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    BDNF and CREB mRNA expression were increased in the non-diabetic Retatrutide group.
    2 context sentences
    Summary · context
    Male Sprague-Dawley rats were allocated to four groups: control (C), streptozotocin-induced diabetic (STZ), streptozotocin-induced diabetic treated with Retatrutide (STZR), and Retatrutide alone (R).
    Summary · context
    Diabetes was induced with streptozotocin, and spatial learning and memory were assessed using the Morris Water Maze and Passive Avoidance tests.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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