Effect of Retatrutide, a Novel Triple Receptor Agonist, on Blood Pressure and Lipid Levels: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Simental-Mendía LE, Barragán-Zúñiga LJ, Reyes-Avitia V

High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension29 Jun 2026

PMID42371360DOI10.1007/s40292-026-00812-6PepBankPUB-42371360

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

01HumanSystematic reviewEfficacy outcome
In a meta-analysis of randomized trials, retatrutide significantly lowered systolic blood pressure.
In plain wordsIn a pooled analysis of trials, retatrutide lowered systolic blood pressure.
Peptide
Retatrutide
Outcome
DecreaseSystolic blood pressure
Study
n: not reported in source
Outcome group
Blood pressure · Cardiovascular
Studied dose
Dose not stated
Measurements
Systolic BP WMD
−6.79 mmHg
retatrutide, random-effects
Source sentences
Summary
retatrutide significantly decreases systolic blood pressure (WMD: - 6.79 mmHg, 95% CI: - 8.36, - 5.23, p 2 = 20%
1 context sentence(design, population, supporting numbers)
Summary · context
This meta-analysis aims to investigate the effect of retatrutide on blood pressure and lipid levels through a meta-analysis of randomized controlled trials.
Report a problemFND-4237136001
02HumanSystematic reviewEfficacy outcome
In a meta-analysis of randomized trials, retatrutide significantly lowered diastolic blood pressure.
In plain wordsIn a pooled analysis of trials, retatrutide lowered diastolic blood pressure.
Peptide
Retatrutide
Outcome
DecreaseDiastolic blood pressure
Study
n: not reported in source
Outcome group
Blood pressure · Cardiovascular
Studied dose
Dose not stated
Measurements
Diastolic BP WMD
−2.46 mmHg
retatrutide, random-effects
Source sentences
Summary
diastolic blood pressure (WMD: - 2.46 mmHg, 95% CI: - 3.25, - 1.67, p 2 = 0%
1 context sentence(design, population, supporting numbers)
Summary · context
This meta-analysis aims to investigate the effect of retatrutide on blood pressure and lipid levels through a meta-analysis of randomized controlled trials.
Report a problemFND-4237136002
03HumanSystematic reviewEfficacy outcome
In a meta-analysis of randomized trials, retatrutide significantly reduced total cholesterol.
In plain wordsIn a pooled analysis of trials, retatrutide lowered total cholesterol.
Peptide
Retatrutide
Outcome
DecreaseTotal cholesterol
Study
n: not reported in source
Outcome group
Lipids · Cardiovascular
Studied dose
Dose not stated
Measurements
Total cholesterol WMD
−21.88 mg/dL
retatrutide, random-effects
Source sentences
Summary
total cholesterol (WMD: - 21.88 mg/dL, 95% CI: - 27.79, - 15.97, p 2 = 84%
1 context sentence(design, population, supporting numbers)
Summary · context
This meta-analysis aims to investigate the effect of retatrutide on blood pressure and lipid levels through a meta-analysis of randomized controlled trials.
Report a problemFND-4237136003
04HumanSystematic reviewEfficacy outcome
In a meta-analysis of randomized trials, retatrutide significantly reduced LDL cholesterol.
In plain wordsIn a pooled analysis of trials, retatrutide lowered LDL (bad) cholesterol.
Peptide
Retatrutide
Outcome
DecreaseLDL-C
Study
n: not reported in source
Outcome group
Lipids · Cardiovascular
Studied dose
Dose not stated
Measurements
LDL-C WMD
−13.1 mg/dL
retatrutide, random-effects
Source sentences
Summary
LDL-C (WMD: - 13.10 mg/dL, 95% CI: - 16.10, - 10.10, p 2 = 47%
1 context sentence(design, population, supporting numbers)
Summary · context
This meta-analysis aims to investigate the effect of retatrutide on blood pressure and lipid levels through a meta-analysis of randomized controlled trials.
Report a problemFND-4237136004
05HumanSystematic reviewEfficacy outcome
In a meta-analysis of randomized trials, retatrutide significantly reduced triglycerides.
In plain wordsIn a pooled analysis of trials, retatrutide lowered triglycerides.
Peptide
Retatrutide
Outcome
DecreaseTriglycerides
Study
n: not reported in source
Outcome group
Lipids · Cardiovascular
Studied dose
Dose not stated
Measurements
Triglycerides WMD
−40.9 mg/dL
retatrutide, random-effects
Source sentences
Summary
triglycerides (WMD: - 40.90 mg/dL, 95% CI: - 48.50, - 33.30, p 2 = 53%
1 context sentence(design, population, supporting numbers)
Summary · context
This meta-analysis aims to investigate the effect of retatrutide on blood pressure and lipid levels through a meta-analysis of randomized controlled trials.
Report a problemFND-4237136005
06HumanSystematic reviewEfficacy outcome
In a meta-analysis of randomized trials, retatrutide had no significant effect on HDL cholesterol.
In plain wordsIn a pooled analysis of trials, retatrutide did not change HDL (good) cholesterol.
Peptide
Retatrutide
Outcome
No significant changeHDL-C
Study
n: not reported in source
Outcome group
Lipids · Cardiovascular
Studied dose
Dose not stated
Measurements
HDL-C WMD
−0.01 mg/dL
retatrutide, random-effects
Source sentences
Summary
However, this triple hormone receptor agonist had no significant effect on HDL-C concentrations (WMD: - 0.01 mg/dL, 95% CI: - 1.30, 1.27, p = 0.98, I²= 0%).
1 context sentence(design, population, supporting numbers)
Summary · context
This meta-analysis aims to investigate the effect of retatrutide on blood pressure and lipid levels through a meta-analysis of randomized controlled trials.
Report a problemFND-4237136006

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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Effect of Retatrutide, a Novel Triple Receptor Agonist, on Blood Pressure and Lipid Levels: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Summary

Results from this study6

Version history

Subjects

Publication types

MeSH terms

Keywords