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Study · Measured the body's own peptide · 2027

5 results

Kisspeptin-10/basal LH ratio improves differentiation of central precocious puberty and premature thelarche.

Banerjee AA, Bhanarkar SR, Kashikar S, Keshwani R, Walia S, Kavya DR, Bombe S, Pande S, Modi DN, Pathak BR, Joshi B, Tandon D and 5 more

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Patil A, Begum S, Mahale SD, Rao S, Surve SV

Clinica chimica acta; international journal of clinical chemistry27 Jun 2026

PMID42364891 (opens in a new tab)DOI10.1016/j.cca.2026.121207 (opens in a new tab)PepBankPUB-42364891
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In girls aged 6-9 years, plasma Kisspeptin‑10 was higher in both idiopathic central precocious puberty and premature thelarche than in controls.

    In plain wordsIn girls with early puberty signs, the body's own kisspeptin‑10 was higher than in girls without them.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlasma Kp-10 in early puberty versus controls
    Study

    n = 96

    Comparator
    Control girls
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Kp-10 and NKB levels were higher in both early-puberty groups than controls
    2 context sentences
    Summary · context
    In this prospective study, Indian girls aged 6-9 years were enrolled as controls (n = 40), ICPP (n = 33), and PT (n = 23).
    Summary · context
    Anthropometry, basal LH, FSH, estradiol, pelvic ultrasonography, and plasma Kp-10, NKB, and NPY levels were assessed.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In girls aged 6-9 years, plasma Kisspeptin‑10 alone did not discriminate idiopathic central precocious puberty from premature thelarche.

    In plain wordsIn girls with early puberty signs, the body's own kisspeptin‑10 level alone could not tell the two conditions apart.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeKp-10 alone to discriminate ICPP from PT
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    but neither marker alone discriminated ICPP from PT.
    2 context sentences
    Summary · context
    In this prospective study, Indian girls aged 6-9 years were enrolled as controls (n = 40), ICPP (n = 33), and PT (n = 23).
    Summary · context
    Anthropometry, basal LH, FSH, estradiol, pelvic ultrasonography, and plasma Kp-10, NKB, and NPY levels were assessed.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In girls aged 6-9 years, a Kisspeptin‑10/basal LH ratio below 4.07 ng/mIU separated idiopathic central precocious puberty from premature thelarche with 72.7% sensitivity and 87.0% specificity.

    In plain wordsIn girls with early puberty signs, the ratio of the body's own kisspeptin‑10 to LH helped tell two conditions apart.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableKp-10/basal LH ratio diagnostic performance
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Measurements

    Cut-off
    < 4.07 ng/mIU
    Kp-10/basal LH ratio
    Sensitivity
    72.7%
    Kp-10/basal LH ratio
    Specificity
    87%
    Kp-10/basal LH ratio
    Accuracy
    78%
    Kp-10/basal LH ratio

    Source sentences

    Summary
    The composite Kp-10/basal LH ratio showed superior performance, with an ROC-derived cut-off <4.07 ng/mIU (sensitivity 72.7%, specificity 87.0%, accuracy 78%).
    2 context sentences
    Summary · context
    In this prospective study, Indian girls aged 6-9 years were enrolled as controls (n = 40), ICPP (n = 33), and PT (n = 23).
    Summary · context
    Anthropometry, basal LH, FSH, estradiol, pelvic ultrasonography, and plasma Kp-10, NKB, and NPY levels were assessed.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    Adding bone age advancement or basal estradiol to the Kisspeptin‑10/basal LH ratio did not meaningfully improve discrimination (AUC 0.78-0.79 for all three models).

    In plain wordsAdding bone age or estradiol to the ratio of the body's own kisspeptin‑10 to LH did not improve how well it told the conditions apart.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeAdded value of bone age advancement or estradiol
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Measurements

    AUC
    0.78 to 0.79
    Models 1 to 3

    Source sentences

    Summary
    All three models showed similar discrimination (AUC 0.78-0.79), with no meaningful improvement after adding BA-CA or estradiol.
    3 context sentences
    Summary · context
    Logistic regression models assessed incremental predictive value: Model 1 included the Kp-10/basal LH ratio; Model 2 added bone age advancement (BA-CA); and Model 3 further included basal estradiol.
    Summary · context
    In this prospective study, Indian girls aged 6-9 years were enrolled as controls (n = 40), ICPP (n = 33), and PT (n = 23).
    Summary · context
    Anthropometry, basal LH, FSH, estradiol, pelvic ultrasonography, and plasma Kp-10, NKB, and NPY levels were assessed.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  5. 05HumanEndogenous levelObservational studyOther

    Decision curve analysis showed a higher net benefit for the Kisspeptin‑10/basal LH ratio than for treat-all or treat-none strategies.

    In plain wordsA test based on the body's own kisspeptin‑10 to LH ratio gave more clinical benefit than treating all or no girls.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableDecision curve net benefit of Kp-10/basal LH ratio
    Study

    n: not reported in source

    Comparator
    Treat-all or treat-none strategies
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    DCA demonstrated a higher net benefit for the Kp-10/basal LH ratio compared with treat-all or treat-none strategies across clinically relevant thresholds.
    2 context sentences
    Summary · context
    In this prospective study, Indian girls aged 6-9 years were enrolled as controls (n = 40), ICPP (n = 33), and PT (n = 23).
    Summary · context
    Anthropometry, basal LH, FSH, estradiol, pelvic ultrasonography, and plasma Kp-10, NKB, and NPY levels were assessed.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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