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Study · Not a test of the peptide alone · 2026

3 results

[Cortexin in the comprehensive therapy of alcoholic encephalopathy].

Masaleva IO, Ivenkov MP

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova1 Jan 2026

PMID42360215 (opens in a new tab)DOI10.17116/jnevro202612606152 (opens in a new tab)PepBankPUB-42360215
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cortexin (cortical polypeptide complex).

  1. 01HumanNot a test of Cortexin (cortical polypeptide complex) aloneNon-randomized trialEfficacy outcome

    In patients with alcoholic encephalopathy, comprehensive therapy including Cortexin increased MMSE scores from 27.3 to 28.9 points across both dose groups.

    In plain wordsIn patients with alcoholic encephalopathy, comprehensive therapy including Cortexin increased MMSE scores compared with baseline.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreaseMMSE score
    Study

    n = 40

    Comparator
    baseline
    Outcome group
    Cognition and memory · Nervous system and cognition

    Measurements

    MMSE
    27.3 points
    baseline in both dose groups
    MMSE
    28.9 points
    after comprehensive therapy in both dose groups

    Source sentences

    Summary
    MMSE scores improved from 27.3 to 28.9 points (p<0.01)
    3 context sentences
    Summary · context
    This study was conducted from April 2025 to November 2025 and included 40 patients (20 females and 20 males), aged 34-72 years (mean age: 52.7±14.2 years).
    Summary · context
    Participants received intramuscular injections of Cortexin at 10 mg (n=20) or 20 mg (n=20) for 10 days.
    Summary · context
    The comprehensive treatment regimen included hepatoprotective, metabolic, and detoxification therapies.

    In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cortexin (cortical polypeptide complex).

  2. 02HumanNot a test of Cortexin (cortical polypeptide complex) aloneNon-randomized trialEfficacy outcome

    In patients with alcoholic encephalopathy, comprehensive therapy including Cortexin increased FAB scores from 15.5 to 17.1 points across both dose groups.

    In plain wordsIn patients with alcoholic encephalopathy, comprehensive therapy including Cortexin increased FAB scores compared with baseline.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreaseFAB score
    Study

    n = 40

    Comparator
    baseline
    Outcome group
    Cognition and memory · Nervous system and cognition

    Measurements

    FAB
    15.5 points
    baseline in both dose groups
    FAB
    17.1 points
    after comprehensive therapy in both dose groups

    Source sentences

    Summary
    FAB scores increased from 15.5 to 17.1 points (p<0.01)
    3 context sentences
    Summary · context
    This study was conducted from April 2025 to November 2025 and included 40 patients (20 females and 20 males), aged 34-72 years (mean age: 52.7±14.2 years).
    Summary · context
    Participants received intramuscular injections of Cortexin at 10 mg (n=20) or 20 mg (n=20) for 10 days.
    Summary · context
    The comprehensive treatment regimen included hepatoprotective, metabolic, and detoxification therapies.

    In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cortexin (cortical polypeptide complex).

  3. 03HumanNot a test of Cortexin (cortical polypeptide complex) aloneNon-randomized trialEfficacy outcome

    In patients with alcoholic encephalopathy, comprehensive therapy including Cortexin reduced Schulte table completion time from 97.5 to 84.5 seconds across both dose groups.

    In plain wordsIn patients with alcoholic encephalopathy, comprehensive therapy including Cortexin reduced Schulte table completion time compared with baseline.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    DecreaseSchulte table completion time
    Study

    n = 40

    Comparator
    baseline
    Outcome group
    Cognition and memory · Nervous system and cognition

    Measurements

    Schulte table time
    97.5 seconds
    baseline in both dose groups
    Schulte table time
    84.5 seconds
    after comprehensive therapy in both dose groups

    Source sentences

    Summary
    performance with the Schulte tables improved from an average of 97.5 seconds to 84.5 seconds (p<0.05) in both patient groups.
    3 context sentences
    Summary · context
    This study was conducted from April 2025 to November 2025 and included 40 patients (20 females and 20 males), aged 34-72 years (mean age: 52.7±14.2 years).
    Summary · context
    Participants received intramuscular injections of Cortexin at 10 mg (n=20) or 20 mg (n=20) for 10 days.
    Summary · context
    The comprehensive treatment regimen included hepatoprotective, metabolic, and detoxification therapies.

    In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cortexin (cortical polypeptide complex).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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