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Study · Animal study (in vivo) · rat · 2026

11 results

Unilateral Adrenalectomy, and the Stable Pentadecapeptide BPC 157 as Therapy in Rats-A Cytoprotection Approach.

Smoday IM, Vukovic V, Oroz K, Vranes H, Kalogjera L, Gamulin O, Vlainic J, Milavic M, Sikiric S, Nikolac Gabaj N, Marijancevic D, Koprivanac A and 10 more

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Tomic L, Strbe S, Barisic I, Beketic Oreskovic L, Kordic M, Tvrdeic A, Seiwerth S, Sikiric P, Boban Blagaic A, Skrtic A

Pharmaceuticals (Basel, Switzerland)30 May 2026

PMID42356491 (opens in a new tab)DOI10.3390/ph19060873 (opens in a new tab)PepBankPUB-42356491
Publisher pagePubMedAsk about this study
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Summary

Background. This rat study reveals a new point: the considerable impact of unilateral adrenalectomy, severe vascular and multiorgan failure, occlusion/occlusion-like syndrome, and the stable gastric pentadecapeptide BPC 157 therapy. Based on the recent Fourier transform infrared (FTIR) spectroscopy vascular disturbance studies, particularly those after unilateral adrenalectomy in rats, the noted cytoprotective vascular recovery effect of the BPC 157 therapy may be useful. Methods. In rats, unilateral adrenalectomy (at 15 min, 5 h, 24 h) leads to integrated gross and morphological changes, vascular alterations, oxidative stress parameters, molecular markers and occlusion/occlusion-like syndrome and BPC 157 as useful therapy (/kg ig) (10 µg, 10 ng). Results. Peripherally and centrally, counteraction includes the lesions (adrenal, brain, heart, lung, liver, kidney, gastrointestinal tract), organ hemorrhage, and thrombosis. Attenuated/eliminated were arrhythmias, intracranial (superior sagittal sinus), portal, caval hypertension, and aortic hypotension. Significant resolution occurred via activation of collateral pathways, the azygos vein (direct blood flow delivery), and the recovered peduncle of the inferior suprarenal artery and superior suprarenal vein. Virchow's triad circumstances were reversed. Occlusion/occlusion-like syndrome was counteracted as a whole. Also, BPC 157 counteracted adrenal lesions (lipid depletion, congestion). There were higher cortisol values, but still very low, and a shift toward the left of the adrenal compensatory weight increase. For the indicative conclusion along with previous studies, mechanistically, BPC 157 therapy exhibits the NO-system modulation/oxidative stress balance, increases NO-level, counteracts oxidative stress (malondialdehyde (MDA)), upregulates NOS1-3, and VEGF-A expression. Conclusions. These effects of BPC 157 therapy and its easy applicability deserve further consideration.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats after unilateral adrenalectomy, BPC‑157 therapy counteracted lesions in the adrenal, brain, heart, lung, liver, kidney and gastrointestinal tract.

    In plain wordsIn rats after adrenal gland removal, BPC‑157 reduced organ damage in several organs.

    Peptide
    BPC-157
    Outcome
    DecreaseOrgan lesions (adrenal, brain, heart, lung, liver, kidney, GI tract)
    Study

    ratn: not reported in source

    Rats after unilateral adrenalectomy
    Outcome group
    Organ injury · Whole body
    Studied dose
    10 µg/kg, 10 ng/kg · intragastricAs given in this study (rat).

    Source sentences

    Summary
    Peripherally and centrally, counteraction includes the lesions (adrenal, brain, heart, lung, liver, kidney, gastrointestinal tract), organ hemorrhage, and thrombosis.
    1 context sentence
    Summary · context
    In rats, unilateral adrenalectomy (at 15 min, 5 h, 24 h) leads to integrated gross and morphological changes, vascular alterations, oxidative stress parameters, molecular markers and occlusion/occlusion-like syndrome and BPC 157 as useful therapy (/kg ig) (10 µg, 10 ng).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats after unilateral adrenalectomy, BPC‑157 therapy counteracted organ hemorrhage.

    In plain wordsIn rats after adrenal gland removal, BPC‑157 reduced bleeding in organs.

    Peptide
    BPC-157
    Outcome
    DecreaseOrgan hemorrhage
    Study

    ratn: not reported in source

    Rats after unilateral adrenalectomy
    Outcome group
    Organ injury · Whole body
    Studied dose
    10 µg/kg, 10 ng/kg · intragastricAs given in this study (rat).

    Source sentences

    Summary
    Peripherally and centrally, counteraction includes the lesions (adrenal, brain, heart, lung, liver, kidney, gastrointestinal tract), organ hemorrhage, and thrombosis.
    1 context sentence
    Summary · context
    In rats, unilateral adrenalectomy (at 15 min, 5 h, 24 h) leads to integrated gross and morphological changes, vascular alterations, oxidative stress parameters, molecular markers and occlusion/occlusion-like syndrome and BPC 157 as useful therapy (/kg ig) (10 µg, 10 ng).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats after unilateral adrenalectomy, BPC‑157 therapy counteracted thrombosis.

    In plain wordsIn rats after adrenal gland removal, BPC‑157 reduced blood clots.

    Peptide
    BPC-157
    Outcome
    DecreaseThrombosis
    Study

    ratn: not reported in source

    Rats after unilateral adrenalectomy
    Outcome group
    Organ injury · Cardiovascular
    Studied dose
    10 µg/kg, 10 ng/kg · intragastricAs given in this study (rat).

    Source sentences

    Summary
    Peripherally and centrally, counteraction includes the lesions (adrenal, brain, heart, lung, liver, kidney, gastrointestinal tract), organ hemorrhage, and thrombosis.
    1 context sentence
    Summary · context
    In rats, unilateral adrenalectomy (at 15 min, 5 h, 24 h) leads to integrated gross and morphological changes, vascular alterations, oxidative stress parameters, molecular markers and occlusion/occlusion-like syndrome and BPC 157 as useful therapy (/kg ig) (10 µg, 10 ng).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats after unilateral adrenalectomy, BPC‑157 therapy attenuated or eliminated arrhythmias.

    In plain wordsIn rats after adrenal gland removal, BPC‑157 reduced or removed heart rhythm problems.

    Peptide
    BPC-157
    Outcome
    DecreaseArrhythmias
    Study

    ratn: not reported in source

    Rats after unilateral adrenalectomy
    Outcome group
    Organ injury · Cardiovascular
    Studied dose
    10 µg/kg, 10 ng/kg · intragastricAs given in this study (rat).

    Source sentences

    Summary
    Attenuated/eliminated were arrhythmias, intracranial (superior sagittal sinus), portal, caval hypertension, and aortic hypotension.
    1 context sentence
    Summary · context
    In rats, unilateral adrenalectomy (at 15 min, 5 h, 24 h) leads to integrated gross and morphological changes, vascular alterations, oxidative stress parameters, molecular markers and occlusion/occlusion-like syndrome and BPC 157 as useful therapy (/kg ig) (10 µg, 10 ng).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats after unilateral adrenalectomy, BPC‑157 therapy attenuated or eliminated intracranial (superior sagittal sinus), portal and caval hypertension.

    In plain wordsIn rats after adrenal gland removal, BPC‑157 reduced or removed high pressure in veins of the head and body.

    Peptide
    BPC-157
    Outcome
    DecreaseIntracranial, portal and caval hypertension
    Study

    ratn: not reported in source

    Rats after unilateral adrenalectomy
    Outcome group
    Organ injury · Cardiovascular
    Studied dose
    10 µg/kg, 10 ng/kg · intragastricAs given in this study (rat).

    Source sentences

    Summary
    Attenuated/eliminated were arrhythmias, intracranial (superior sagittal sinus), portal, caval hypertension, and aortic hypotension.
    1 context sentence
    Summary · context
    In rats, unilateral adrenalectomy (at 15 min, 5 h, 24 h) leads to integrated gross and morphological changes, vascular alterations, oxidative stress parameters, molecular markers and occlusion/occlusion-like syndrome and BPC 157 as useful therapy (/kg ig) (10 µg, 10 ng).
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats after unilateral adrenalectomy, BPC‑157 therapy attenuated or eliminated aortic hypotension.

    In plain wordsIn rats after adrenal gland removal, BPC‑157 reduced or removed low blood pressure in the aorta.

    Peptide
    BPC-157
    Outcome
    DecreaseAortic hypotension
    Study

    ratn: not reported in source

    Rats after unilateral adrenalectomy
    Outcome group
    Organ injury · Cardiovascular
    Studied dose
    10 µg/kg, 10 ng/kg · intragastricAs given in this study (rat).

    Source sentences

    Summary
    Attenuated/eliminated were arrhythmias, intracranial (superior sagittal sinus), portal, caval hypertension, and aortic hypotension.
    1 context sentence
    Summary · context
    In rats, unilateral adrenalectomy (at 15 min, 5 h, 24 h) leads to integrated gross and morphological changes, vascular alterations, oxidative stress parameters, molecular markers and occlusion/occlusion-like syndrome and BPC 157 as useful therapy (/kg ig) (10 µg, 10 ng).
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats after unilateral adrenalectomy, BPC‑157 therapy was linked to significant resolution through activation of collateral pathways, including the azygos vein.

    In plain wordsIn rats after adrenal gland removal, BPC‑157 activated alternative blood routes, including the azygos vein.

    Peptide
    BPC-157
    Outcome
    IncreaseCollateral pathway activation
    Study

    ratn: not reported in source

    Rats after unilateral adrenalectomy
    Outcome group
    Organ injury · Cardiovascular
    Studied dose
    10 µg/kg, 10 ng/kg · intragastricAs given in this study (rat).

    Source sentences

    Summary
    Significant resolution occurred via activation of collateral pathways, the azygos vein (direct blood flow delivery), and the recovered peduncle of the inferior suprarenal artery and superior suprarenal vein.
    1 context sentence
    Summary · context
    In rats, unilateral adrenalectomy (at 15 min, 5 h, 24 h) leads to integrated gross and morphological changes, vascular alterations, oxidative stress parameters, molecular markers and occlusion/occlusion-like syndrome and BPC 157 as useful therapy (/kg ig) (10 µg, 10 ng).
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats after unilateral adrenalectomy, BPC‑157 therapy reversed Virchow's triad circumstances.

    In plain wordsIn rats after adrenal gland removal, BPC‑157 reversed the conditions that favour blood clots.

    Peptide
    BPC-157
    Outcome
    DecreaseVirchow's triad circumstances
    Study

    ratn: not reported in source

    Rats after unilateral adrenalectomy
    Outcome group
    Organ injury · Cardiovascular
    Studied dose
    10 µg/kg, 10 ng/kg · intragastricAs given in this study (rat).

    Source sentences

    Summary
    Virchow's triad circumstances were reversed.
    1 context sentence
    Summary · context
    In rats, unilateral adrenalectomy (at 15 min, 5 h, 24 h) leads to integrated gross and morphological changes, vascular alterations, oxidative stress parameters, molecular markers and occlusion/occlusion-like syndrome and BPC 157 as useful therapy (/kg ig) (10 µg, 10 ng).
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In rats after unilateral adrenalectomy, BPC‑157 therapy counteracted the occlusion/occlusion-like syndrome as a whole.

    In plain wordsIn rats after adrenal gland removal, BPC‑157 countered a blockage-like syndrome of the blood vessels.

    Peptide
    BPC-157
    Outcome
    DecreaseOcclusion/occlusion-like syndrome
    Study

    ratn: not reported in source

    Rats after unilateral adrenalectomy
    Outcome group
    Organ injury · Cardiovascular
    Studied dose
    10 µg/kg, 10 ng/kg · intragastricAs given in this study (rat).

    Source sentences

    Summary
    Occlusion/occlusion-like syndrome was counteracted as a whole.
    1 context sentence
    Summary · context
    In rats, unilateral adrenalectomy (at 15 min, 5 h, 24 h) leads to integrated gross and morphological changes, vascular alterations, oxidative stress parameters, molecular markers and occlusion/occlusion-like syndrome and BPC 157 as useful therapy (/kg ig) (10 µg, 10 ng).
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In rats after unilateral adrenalectomy, BPC‑157 counteracted adrenal lesions such as lipid depletion and congestion.

    In plain wordsIn rats after adrenal gland removal, BPC‑157 reduced damage to the remaining adrenal gland.

    Peptide
    BPC-157
    Outcome
    DecreaseAdrenal lesions (lipid depletion, congestion)
    Study

    ratn: not reported in source

    Rats after unilateral adrenalectomy
    Outcome group
    Organ injury · Endocrine and hormones
    Studied dose
    10 µg/kg, 10 ng/kg · intragastricAs given in this study (rat).

    Source sentences

    Summary
    Also, BPC 157 counteracted adrenal lesions (lipid depletion, congestion).
    1 context sentence
    Summary · context
    In rats, unilateral adrenalectomy (at 15 min, 5 h, 24 h) leads to integrated gross and morphological changes, vascular alterations, oxidative stress parameters, molecular markers and occlusion/occlusion-like syndrome and BPC 157 as useful therapy (/kg ig) (10 µg, 10 ng).
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In rats after unilateral adrenalectomy, BPC‑157 therapy was followed by higher cortisol values, which were still very low.

    In plain wordsIn rats after adrenal gland removal, cortisol was higher with BPC‑157 but still very low.

    Peptide
    BPC-157
    Outcome
    IncreaseCortisol
    Study

    ratn: not reported in source

    Rats after unilateral adrenalectomy
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    10 µg/kg, 10 ng/kg · intragastricAs given in this study (rat).

    Source sentences

    Summary
    There were higher cortisol values, but still very low
    1 context sentence
    Summary · context
    In rats, unilateral adrenalectomy (at 15 min, 5 h, 24 h) leads to integrated gross and morphological changes, vascular alterations, oxidative stress parameters, molecular markers and occlusion/occlusion-like syndrome and BPC 157 as useful therapy (/kg ig) (10 µg, 10 ng).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

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