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Study · Measured the body's own peptide · 2026

4 results

Longitudinal Trends of Salivary Oxidized Thymosin β4 and β10 in Preterm Infants with Bronchopulmonary Dysplasia.

Tirone C, Fattore S, Menzella N, De Tomaso D, Giaimo M, Cecere S, Perri A, Messana I, Cabras T, Manconi B, Olianas A, Contini C and 5 more

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Guadalupi G, Faa G, Castagnola M, Iavarone F, Vento G

Children (Basel, Switzerland)2 Jun 2026

PMID42353940 (opens in a new tab)DOI10.3390/children13060770 (opens in a new tab)PepBankPUB-42353940
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In preterm infants born before 30 weeks, salivary total Tβ4 levels correlated significantly with postmenstrual age.

    In plain wordsIn preterm infants, the body's own Tβ4 level in saliva was linked to the infant's postmenstrual age.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Direction not reportedSalivary total Tβ4 versus postmenstrual age
    Study

    n = 18

    Outcome group
    Aging markers · Whole body

    Source sentences

    Summary
    Significant correlations were found between postmenstrual age and total Tβ4 (p = 0.001)
    1 context sentence
    Summary · context
    A total of 149 saliva samples from 18 infants with gestational age < 30 weeks were analyzed.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In preterm infants born before 30 weeks, the percentage of oxidized Tβ4 in saliva correlated significantly with postmenstrual age.

    In plain wordsIn preterm infants, the share of oxidized natural Tβ4 in saliva was linked to the infant's postmenstrual age.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Direction not reportedSalivary oxidized Tβ4 percentage versus postmenstrual age
    Study

    n = 18

    Outcome group
    Aging markers · Whole body

    Source sentences

    Summary
    oxidized Tβ4 percentage (p = 0.025)
    1 context sentence
    Summary · context
    A total of 149 saliva samples from 18 infants with gestational age < 30 weeks were analyzed.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In preterm infants, salivary Tβ4 and Tβ10 showed no early difference between infants who later developed bronchopulmonary dysplasia and those who did not.

    In plain wordsIn preterm infants, natural Tβ4 levels in saliva did not differ early between infants who later had lung disease (BPD) and those who did not.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeSalivary Tβ4 early difference between infants with and without BPD
    Study

    n = 18

    Outcome group
    Oxidative stress · Respiratory

    Source sentences

    Summary
    Although no early differences were detected, longitudinal trajectories of Tβ4 and Tβ10 differed between infants with and without BPD.
    2 context sentences
    Summary · context
    No significant differences were observed during the first week of life between neonates who later developed BPD and those who did not.
    Summary · context
    A total of 149 saliva samples from 18 infants with gestational age < 30 weeks were analyzed.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    In preterm infants, salivary total Tβ4 increased over time in neonates without BPD, but remained stable or decreased in neonates with BPD.

    In plain wordsIn preterm infants, natural Tβ4 in saliva rose over time without lung disease (BPD) but stayed flat or fell with BPD.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    MixedSalivary total Tβ4 trajectory over time, BPD versus no BPD
    Study

    n = 18

    Outcome group
    Oxidative stress · Respiratory

    Source sentences

    Summary
    However, longitudinal analysis showed that in neonates without BPD, total and oxidized Tβ10 and total Tβ4 increased over time, whereas in neonates with BPD, these biomarkers remained stable or decreased.
    1 context sentence
    Summary · context
    A total of 149 saliva samples from 18 infants with gestational age < 30 weeks were analyzed.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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