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Study · Animal study (in vivo) · mouse · 2026

4 results

Humanin Restores Metabolic Hormone Homeostasis of Leptin, Ghrelin, Irisin and Asprosin in Streptozotocin-Induced Diabetic Mice.

Bulut F, Adam M, Ozgen A, Ozcan M

Metabolites29 May 2026Cited by 1 (Europe PMC)

PMID42346352 (opens in a new tab)DOI10.3390/metabo16060373 (opens in a new tab)PepBankPUB-42346352
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In STZ-induced diabetic mice, repeated HN treatment restored leptin levels versus untreated STZ mice.

    In plain wordsIn diabetic mice, repeated humanin treatment restored leptin levels compared with untreated diabetic mice.

    Peptide
    Humanin
    Outcome
    IncreaseSerum leptin
    Study

    mousen = 20

    Streptozotocin-induced diabetic mice
    Comparator
    Untreated STZ-induced diabetic mice
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    4 mg/kg/day · intraperitoneal · 15 daysAs given in this study (mouse).

    Source sentences

    Summary
    Repeated HN treatment effectively restored leptin levels and suppressed asprosin concentrations, while irisin levels showed a relative increase compared to the STZ animals.
    2 context sentences
    Summary · context
    STZ-induced diabetes markedly disrupted metabolic hormone balance, as indicated by decreased leptin and irisin levels and increased asprosin concentrations.
    Summary · context
    Forty male mice were randomly assigned to four groups (n = 10 for each group): control, HN (4 mg/kg/day), STZ (150 mg/kg), and STZ + HN.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In STZ-induced diabetic mice, repeated HN treatment suppressed asprosin concentrations versus untreated STZ mice.

    In plain wordsIn diabetic mice, repeated humanin treatment lowered asprosin levels compared with untreated diabetic mice.

    Peptide
    Humanin
    Outcome
    DecreaseSerum asprosin
    Study

    mousen = 20

    Streptozotocin-induced diabetic mice
    Comparator
    Untreated STZ-induced diabetic mice
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    4 mg/kg/day · intraperitoneal · 15 daysAs given in this study (mouse).

    Source sentences

    Summary
    suppressed asprosin concentrations, while irisin levels showed a relative increase compared to the STZ animals.
    2 context sentences
    Summary · context
    STZ-induced diabetes markedly disrupted metabolic hormone balance, as indicated by decreased leptin and irisin levels and increased asprosin concentrations.
    Summary · context
    Forty male mice were randomly assigned to four groups (n = 10 for each group): control, HN (4 mg/kg/day), STZ (150 mg/kg), and STZ + HN.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In STZ-induced diabetic mice, irisin levels showed a relative increase with repeated HN treatment compared with untreated STZ mice.

    In plain wordsIn diabetic mice, irisin levels rose somewhat with repeated humanin treatment compared with untreated diabetic mice.

    Peptide
    Humanin
    Outcome
    IncreaseSerum irisin
    Study

    mousen = 20

    Streptozotocin-induced diabetic mice
    Comparator
    Untreated STZ-induced diabetic mice
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    4 mg/kg/day · intraperitoneal · 15 daysAs given in this study (mouse).

    Source sentences

    Summary
    irisin levels showed a relative increase compared to the STZ animals.
    2 context sentences
    Summary · context
    STZ-induced diabetes markedly disrupted metabolic hormone balance, as indicated by decreased leptin and irisin levels and increased asprosin concentrations.
    Summary · context
    Forty male mice were randomly assigned to four groups (n = 10 for each group): control, HN (4 mg/kg/day), STZ (150 mg/kg), and STZ + HN.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In STZ-induced diabetic mice, ghrelin levels were significantly elevated with HN treatment compared with untreated STZ mice.

    In plain wordsIn diabetic mice, humanin treatment raised ghrelin levels compared with untreated diabetic mice.

    Peptide
    Humanin
    Outcome
    IncreaseSerum ghrelin
    Study

    mousen = 20

    Streptozotocin-induced diabetic mice
    Comparator
    Untreated STZ-induced diabetic mice
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    4 mg/kg/day · intraperitoneal · 15 daysAs given in this study (mouse).

    Source sentences

    Summary
    In addition, ghrelin levels were significantly elevated in HN-treated diabetic mice compared to untreated STZ animals.
    2 context sentences
    Summary · context
    STZ-induced diabetes markedly disrupted metabolic hormone balance, as indicated by decreased leptin and irisin levels and increased asprosin concentrations.
    Summary · context
    Forty male mice were randomly assigned to four groups (n = 10 for each group): control, HN (4 mg/kg/day), STZ (150 mg/kg), and STZ + HN.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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