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Study · Animal study (in vivo) · mouse · 2026

6 results

L-carnosine attenuates endometrial fibrosis by targeting the ERK/PTGS2 axis.

Zhu Y, Zhang X, Zhang X, Zhuang Q, Wang X, Zhang X, Hu Y, Liu D, Zhao G

European journal of pharmacology24 Jun 2026

PMID42342060 (opens in a new tab)DOI10.1016/j.ejphar.2026.179089 (opens in a new tab)PepBankPUB-42342060
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with intrauterine adhesions, L‑carnosine attenuated uterine fibrosis.

    In plain wordsIn mice with intrauterine adhesions, L‑carnosine reduced uterine fibrosis.

    Peptide
    L-carnosine
    Outcome
    DecreaseUterine fibrosis
    Study

    mousen: not reported in source

    Intrauterine adhesions
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We demonstrated that L-carnosine treatment effectively reversed TGF-β-induced fibrosis in hESCs in vitro and attenuated uterine fibrosis in an IUA mouse model in vivo.
    1 context sentence
    Summary · context
    We evaluated the anti-fibrotic effects of L-carnosine in vitro using TGF-β-induced human endometrial stromal cells (hESCs) and in vivo using a mouse model of IUA.
  2. 02LabIn vitro (cells)Efficacy outcome

    In human endometrial stromal cells, L‑carnosine reversed TGF-β-induced fibrosis.

    In plain wordsIn cells, L‑carnosine reversed fibrosis induced by TGF-β.

    Peptide
    L-carnosine
    Outcome
    DecreaseCell fibrosis
    Study

    humann: not reported in source

    TGF-β-induced human endometrial stromal cells
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We demonstrated that L-carnosine treatment effectively reversed TGF-β-induced fibrosis in hESCs in vitro and attenuated uterine fibrosis in an IUA mouse model in vivo.
    1 context sentence
    Summary · context
    We evaluated the anti-fibrotic effects of L-carnosine in vitro using TGF-β-induced human endometrial stromal cells (hESCs) and in vivo using a mouse model of IUA.
  3. 03LabIn vitro (cells)Mechanism

    In endometrial fibrosis experiments, L‑carnosine inhibited ERK phosphorylation.

    In plain wordsIn cells, L‑carnosine inhibited ERK phosphorylation.

    Peptide
    L-carnosine
    Outcome
    DecreaseERK phosphorylation
    Study

    humann: not reported in source

    TGF-β-induced human endometrial stromal cells
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mechanistically, the anti-fibrotic effects of L-carnosine were mediated by the inhibition of ERK phosphorylation, which subsequently led to increased the expression of prostaglandin-endoperoxide synthase 2 (PTGS2).
    1 context sentence
    Summary · context
    We evaluated the anti-fibrotic effects of L-carnosine in vitro using TGF-β-induced human endometrial stromal cells (hESCs) and in vivo using a mouse model of IUA.
  4. 04LabIn vitro (cells)Mechanism

    In endometrial fibrosis experiments, L‑carnosine increased PTGS2 expression after ERK phosphorylation inhibition.

    In plain wordsIn cells, L‑carnosine increased PTGS2 expression after ERK phosphorylation inhibition.

    Peptide
    L-carnosine
    Outcome
    IncreasePTGS2 expression
    Study

    humann: not reported in source

    TGF-β-induced human endometrial stromal cells
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mechanistically, the anti-fibrotic effects of L-carnosine were mediated by the inhibition of ERK phosphorylation, which subsequently led to increased the expression of prostaglandin-endoperoxide synthase 2 (PTGS2).
    1 context sentence
    Summary · context
    We evaluated the anti-fibrotic effects of L-carnosine in vitro using TGF-β-induced human endometrial stromal cells (hESCs) and in vivo using a mouse model of IUA.
  5. 05LabIn vitro (cells)Mechanism

    In endometrial fibrosis experiments, celecoxib inhibition of PTGS2 abolished the protective effects of L‑carnosine.

    In plain wordsIn cells, blocking PTGS2 with celecoxib abolished the protective effects of L‑carnosine.

    Peptide
    L-carnosine
    Outcome
    Not applicablePTGS2 dependence of antifibrotic effect
    Study

    humann: not reported in source

    TGF-β-induced human endometrial stromal cells
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    whereas inhibition of PTGS2 with celecoxib (a specific PTGS2 inhibitor) abrogated the protective effects of L-carnosine.
    1 context sentence
    Summary · context
    We evaluated the anti-fibrotic effects of L-carnosine in vitro using TGF-β-induced human endometrial stromal cells (hESCs) and in vivo using a mouse model of IUA.
  6. 06LabIn vitro (cells)Mechanism

    In endometrial fibrosis experiments, ERK activation with mSIRK blunted L‑carnosine-induced PTGS2 upregulation.

    In plain wordsIn cells, activating ERK with mSIRK weakened the increase in PTGS2 induced by L‑carnosine.

    Peptide
    L-carnosine
    Outcome
    Not applicableERK dependence of PTGS2 upregulation
    Study

    humann: not reported in source

    TGF-β-induced human endometrial stromal cells
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Conversely, pharmacological activation of ERK using mSIRK (an ERK activator) blunted the L-carnosine-induced upregulation of PTGS2.
    1 context sentence
    Summary · context
    We evaluated the anti-fibrotic effects of L-carnosine in vitro using TGF-β-induced human endometrial stromal cells (hESCs) and in vivo using a mouse model of IUA.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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