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Study · Case report or series · n = 1 · 2026

4 results

Prolonged Dysesthesia After Massive Accidental Semaglutide Overdose: A Case Report.

Quarenghi M, Stanga A, Bergamaschi A

Journal of the American College of Emergency Physicians open29 May 2026

PMID42256775 (opens in a new tab)PMCIDPMC13241993 (opens in a new tab)DOI10.1016/j.acepjo.2026.100427 (opens in a new tab)PepBankPUB-42256775
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanCase report or seriesSafety outcome

    In a man with obesity, an accidental 9.6 mg semaglutide dose was followed two days later by generalized burning dysesthesia and marked asthenia.

    In plain wordsIn one man, an accidental semaglutide overdose was followed two days later by burning skin sensations and marked weakness.

    Peptide
    Semaglutide
    Outcome
    IncreaseDysesthesia after overdose
    Study

    n = 1

    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    9.6 mg total accidental dose (prescribed 2.4 mg weekly)As given in this study (human).

    Source sentences

    Summary
    Two days after the injection, he developed generalized burning dysesthesia and marked asthenia in the absence of nausea, vomiting, or abdominal pain.
    1 context sentence
    Summary · context
    We report a case of a 50-year-old man with obesity receiving weekly semaglutide 2.4 mg who accidentally administered a total dose of 9.6 mg due to a pen-device handling error.
  2. 02HumanCase report or seriesSafety outcome

    In a man with obesity, the semaglutide overdose was not accompanied by nausea, vomiting or abdominal pain.

    In plain wordsIn one man, the semaglutide overdose was not accompanied by nausea, vomiting or stomach pain.

    Peptide
    Semaglutide
    Outcome
    No significant changeGastrointestinal symptoms after overdose
    Study

    n = 1

    Outcome group
    Gastrointestinal adverse events · Gastrointestinal
    Studied dose
    9.6 mg total accidental dose (prescribed 2.4 mg weekly)As given in this study (human).

    Source sentences

    Summary
    in the absence of nausea, vomiting, or abdominal pain.
    1 context sentence
    Summary · context
    We report a case of a 50-year-old man with obesity receiving weekly semaglutide 2.4 mg who accidentally administered a total dose of 9.6 mg due to a pen-device handling error.
  3. 03HumanCase report or seriesSafety outcome

    In a man with obesity, laboratory tests 4 days after the semaglutide overdose were unremarkable.

    In plain wordsIn one man, blood tests 4 days after the semaglutide overdose showed nothing unusual.

    Peptide
    Semaglutide
    Outcome
    No significant changeLaboratory tests 4 days after overdose
    Study

    n = 1

    Outcome group
    Adverse events · Whole body
    Studied dose
    9.6 mg total accidental dose (prescribed 2.4 mg weekly)As given in this study (human).

    Source sentences

    Summary
    Laboratory tests performed 4 days after exposure were unremarkable.
    1 context sentence
    Summary · context
    We report a case of a 50-year-old man with obesity receiving weekly semaglutide 2.4 mg who accidentally administered a total dose of 9.6 mg due to a pen-device handling error.
  4. 04HumanCase report or seriesSafety outcome

    In a man with obesity, symptoms after the semaglutide overdose gradually improved and resolved completely within 7 days without specific treatment.

    In plain wordsIn one man, symptoms after the semaglutide overdose went away completely within 7 days without specific treatment.

    Peptide
    Semaglutide
    Outcome
    DecreaseResolution of dysesthesia
    Study

    n = 1

    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    9.6 mg total accidental dose (prescribed 2.4 mg weekly)As given in this study (human).

    Source sentences

    Summary
    Symptoms gradually improved and resolved completely within 7 days without specific treatment.
    1 context sentence
    Summary · context
    We report a case of a 50-year-old man with obesity receiving weekly semaglutide 2.4 mg who accidentally administered a total dose of 9.6 mg due to a pen-device handling error.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:04 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:06 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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