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Study · Animal study (in vivo) · rat · 2026

13 results

Protective effects of BPC 157 in rats with experimentally induced lower extremity ischemia-reperfusion injury.

Yıldırım AK, Demirtaş H, Özer A, Arslan M

Scientific reports28 May 2026

PMID42204242 (opens in a new tab)PMCIDPMC13448812 (opens in a new tab)DOI10.1038/s41598-026-55449-1 (opens in a new tab)PepBankPUB-42204242
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study13

13 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with lower limb ischemia-reperfusion injury, BPC‑157 reduced malondialdehyde (MDA) compared with ischemia-reperfusion alone.

    In plain wordsIn rats with leg reperfusion injury, BPC‑157 lowered a marker of oxidative damage (MDA) compared with no BPC‑157.

    Peptide
    BPC-157
    Outcome
    DecreaseSerum MDA
    Study

    ratn: not reported in source

    Wistar albino rats with lower limb ischemia-reperfusion injury
    Comparator
    I/R without BPC 157 (IR group)
    Outcome group
    Oxidative stress · Musculoskeletal
    Studied dose
    20 µg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    reduced MDA and TOS
    1 context sentence
    Summary · context
    Twenty-four male Wistar albino rats were randomized into four groups (n = 6): SHAM, B (BPC 157 only), IR (I/R), and IRB (I/R + BPC 157). I/R was induced by abdominal aortic clamping for 45 min followed by 2 h of reperfusion. BPC 157 (20 µg/kg, intraperitoneal) was administered at the 45th minute of…
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with lower limb ischemia-reperfusion injury, BPC‑157 reduced total oxidant status (TOS) compared with ischemia-reperfusion alone.

    In plain wordsIn rats with leg reperfusion injury, BPC‑157 lowered total oxidant status compared with no BPC‑157.

    Peptide
    BPC-157
    Outcome
    DecreaseSerum total oxidant status (TOS)
    Study

    ratn: not reported in source

    Wistar albino rats with lower limb ischemia-reperfusion injury
    Comparator
    I/R without BPC 157 (IR group)
    Outcome group
    Oxidative stress · Musculoskeletal
    Studied dose
    20 µg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    reduced MDA and TOS
    1 context sentence
    Summary · context
    Twenty-four male Wistar albino rats were randomized into four groups (n = 6): SHAM, B (BPC 157 only), IR (I/R), and IRB (I/R + BPC 157). I/R was induced by abdominal aortic clamping for 45 min followed by 2 h of reperfusion. BPC 157 (20 µg/kg, intraperitoneal) was administered at the 45th minute of…
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with lower limb ischemia-reperfusion injury, BPC‑157 restored superoxide dismutase (SOD) activity compared with ischemia-reperfusion alone.

    In plain wordsIn rats with leg reperfusion injury, BPC‑157 restored an antioxidant enzyme (SOD) compared with no BPC‑157.

    Peptide
    BPC-157
    Outcome
    IncreaseSerum SOD
    Study

    ratn: not reported in source

    Wistar albino rats with lower limb ischemia-reperfusion injury
    Comparator
    I/R without BPC 157 (IR group)
    Outcome group
    Oxidative stress · Musculoskeletal
    Studied dose
    20 µg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    restored SOD and TAS
    1 context sentence
    Summary · context
    Twenty-four male Wistar albino rats were randomized into four groups (n = 6): SHAM, B (BPC 157 only), IR (I/R), and IRB (I/R + BPC 157). I/R was induced by abdominal aortic clamping for 45 min followed by 2 h of reperfusion. BPC 157 (20 µg/kg, intraperitoneal) was administered at the 45th minute of…
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with lower limb ischemia-reperfusion injury, BPC‑157 restored total antioxidant status (TAS) compared with ischemia-reperfusion alone.

    In plain wordsIn rats with leg reperfusion injury, BPC‑157 restored total antioxidant capacity compared with no BPC‑157.

    Peptide
    BPC-157
    Outcome
    IncreaseSerum total antioxidant status (TAS)
    Study

    ratn: not reported in source

    Wistar albino rats with lower limb ischemia-reperfusion injury
    Comparator
    I/R without BPC 157 (IR group)
    Outcome group
    Oxidative stress · Musculoskeletal
    Studied dose
    20 µg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    restored SOD and TAS
    1 context sentence
    Summary · context
    Twenty-four male Wistar albino rats were randomized into four groups (n = 6): SHAM, B (BPC 157 only), IR (I/R), and IRB (I/R + BPC 157). I/R was induced by abdominal aortic clamping for 45 min followed by 2 h of reperfusion. BPC 157 (20 µg/kg, intraperitoneal) was administered at the 45th minute of…
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with lower limb ischemia-reperfusion injury, BPC‑157 downregulated p53 expression compared with ischemia-reperfusion alone.

    In plain wordsIn rats with leg reperfusion injury, BPC‑157 lowered activity of the cell-death gene p53 compared with no BPC‑157.

    Peptide
    BPC-157
    Outcome
    Decreasep53 gene expression
    Study

    ratn: not reported in source

    Wistar albino rats with lower limb ischemia-reperfusion injury
    Comparator
    I/R without BPC 157 (IR group)
    Outcome group
    Cell viability and death · Musculoskeletal
    Studied dose
    20 µg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    downregulated p53, Bax, and Casp3
    1 context sentence
    Summary · context
    Twenty-four male Wistar albino rats were randomized into four groups (n = 6): SHAM, B (BPC 157 only), IR (I/R), and IRB (I/R + BPC 157). I/R was induced by abdominal aortic clamping for 45 min followed by 2 h of reperfusion. BPC 157 (20 µg/kg, intraperitoneal) was administered at the 45th minute of…
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with lower limb ischemia-reperfusion injury, BPC‑157 downregulated Bax expression compared with ischemia-reperfusion alone.

    In plain wordsIn rats with leg reperfusion injury, BPC‑157 lowered activity of the cell-death gene Bax compared with no BPC‑157.

    Peptide
    BPC-157
    Outcome
    DecreaseBax gene expression
    Study

    ratn: not reported in source

    Wistar albino rats with lower limb ischemia-reperfusion injury
    Comparator
    I/R without BPC 157 (IR group)
    Outcome group
    Cell viability and death · Musculoskeletal
    Studied dose
    20 µg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    downregulated p53, Bax, and Casp3
    1 context sentence
    Summary · context
    Twenty-four male Wistar albino rats were randomized into four groups (n = 6): SHAM, B (BPC 157 only), IR (I/R), and IRB (I/R + BPC 157). I/R was induced by abdominal aortic clamping for 45 min followed by 2 h of reperfusion. BPC 157 (20 µg/kg, intraperitoneal) was administered at the 45th minute of…
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with lower limb ischemia-reperfusion injury, BPC‑157 downregulated Casp3 expression compared with ischemia-reperfusion alone.

    In plain wordsIn rats with leg reperfusion injury, BPC‑157 lowered activity of the cell-death gene Casp3 compared with no BPC‑157.

    Peptide
    BPC-157
    Outcome
    DecreaseCasp3 gene expression
    Study

    ratn: not reported in source

    Wistar albino rats with lower limb ischemia-reperfusion injury
    Comparator
    I/R without BPC 157 (IR group)
    Outcome group
    Cell viability and death · Musculoskeletal
    Studied dose
    20 µg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    downregulated p53, Bax, and Casp3
    1 context sentence
    Summary · context
    Twenty-four male Wistar albino rats were randomized into four groups (n = 6): SHAM, B (BPC 157 only), IR (I/R), and IRB (I/R + BPC 157). I/R was induced by abdominal aortic clamping for 45 min followed by 2 h of reperfusion. BPC 157 (20 µg/kg, intraperitoneal) was administered at the 45th minute of…
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats with lower limb ischemia-reperfusion injury, BPC‑157 significantly increased Bcl-2 expression compared with ischemia-reperfusion alone.

    In plain wordsIn rats with leg reperfusion injury, BPC‑157 raised activity of the protective gene Bcl-2 compared with no BPC‑157.

    Peptide
    BPC-157
    Outcome
    IncreaseBcl-2 gene expression
    Study

    ratn: not reported in source

    Wistar albino rats with lower limb ischemia-reperfusion injury
    Comparator
    I/R without BPC 157 (IR group)
    Outcome group
    Cell viability and death · Musculoskeletal
    Studied dose
    20 µg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    BPC 157 significantly increased Bcl-2 expression compared with IR.
    1 context sentence
    Summary · context
    Twenty-four male Wistar albino rats were randomized into four groups (n = 6): SHAM, B (BPC 157 only), IR (I/R), and IRB (I/R + BPC 157). I/R was induced by abdominal aortic clamping for 45 min followed by 2 h of reperfusion. BPC 157 (20 µg/kg, intraperitoneal) was administered at the 45th minute of…
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In rats with lower limb ischemia-reperfusion injury, BPC‑157 reduced IL-6 immunoreactivity compared with ischemia-reperfusion alone.

    In plain wordsIn rats with leg reperfusion injury, BPC‑157 lowered the inflammation marker IL-6 in tissue compared with no BPC‑157.

    Peptide
    BPC-157
    Outcome
    DecreaseIL-6 immunoreactivity
    Study

    ratn: not reported in source

    Wistar albino rats with lower limb ischemia-reperfusion injury
    Comparator
    I/R without BPC 157 (IR group)
    Outcome group
    Inflammation markers · Musculoskeletal
    Studied dose
    20 µg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    reduced IL-6 and Caspase-3 immunoreactivity
    1 context sentence
    Summary · context
    Twenty-four male Wistar albino rats were randomized into four groups (n = 6): SHAM, B (BPC 157 only), IR (I/R), and IRB (I/R + BPC 157). I/R was induced by abdominal aortic clamping for 45 min followed by 2 h of reperfusion. BPC 157 (20 µg/kg, intraperitoneal) was administered at the 45th minute of…
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In rats with lower limb ischemia-reperfusion injury, BPC‑157 reduced Caspase-3 immunoreactivity compared with ischemia-reperfusion alone.

    In plain wordsIn rats with leg reperfusion injury, BPC‑157 lowered the cell-death marker caspase-3 in tissue compared with no BPC‑157.

    Peptide
    BPC-157
    Outcome
    DecreaseCaspase-3 immunoreactivity
    Study

    ratn: not reported in source

    Wistar albino rats with lower limb ischemia-reperfusion injury
    Comparator
    I/R without BPC 157 (IR group)
    Outcome group
    Cell viability and death · Musculoskeletal
    Studied dose
    20 µg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    reduced IL-6 and Caspase-3 immunoreactivity
    1 context sentence
    Summary · context
    Twenty-four male Wistar albino rats were randomized into four groups (n = 6): SHAM, B (BPC 157 only), IR (I/R), and IRB (I/R + BPC 157). I/R was induced by abdominal aortic clamping for 45 min followed by 2 h of reperfusion. BPC 157 (20 µg/kg, intraperitoneal) was administered at the 45th minute of…
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In rats with lower limb ischemia-reperfusion injury, BPC‑157 partially restored VEGF expression compared with ischemia-reperfusion alone.

    In plain wordsIn rats with leg reperfusion injury, BPC‑157 partly restored the blood-vessel growth factor VEGF compared with no BPC‑157.

    Peptide
    BPC-157
    Outcome
    IncreaseVEGF immunoreactivity
    Study

    ratn: not reported in source

    Wistar albino rats with lower limb ischemia-reperfusion injury
    Comparator
    I/R without BPC 157 (IR group)
    Outcome group
    Angiogenesis · Musculoskeletal
    Studied dose
    20 µg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    partially restored VEGF expression.
    1 context sentence
    Summary · context
    Twenty-four male Wistar albino rats were randomized into four groups (n = 6): SHAM, B (BPC 157 only), IR (I/R), and IRB (I/R + BPC 157). I/R was induced by abdominal aortic clamping for 45 min followed by 2 h of reperfusion. BPC 157 (20 µg/kg, intraperitoneal) was administered at the 45th minute of…
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In rats with lower limb ischemia-reperfusion injury, histology showed improved muscle architecture in BPC‑157-treated rats compared with ischemia-reperfusion alone.

    In plain wordsIn rats with leg reperfusion injury, muscle tissue looked better with BPC‑157 than without it.

    Peptide
    BPC-157
    Outcome
    IncreaseMuscle architecture on histology
    Study

    ratn: not reported in source

    Wistar albino rats with lower limb ischemia-reperfusion injury
    Comparator
    I/R without BPC 157 (IR group)
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    20 µg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Histological analysis confirmed improved muscle architecture and reduced collagen deposition in IRB compared with IR.
    1 context sentence
    Summary · context
    Twenty-four male Wistar albino rats were randomized into four groups (n = 6): SHAM, B (BPC 157 only), IR (I/R), and IRB (I/R + BPC 157). I/R was induced by abdominal aortic clamping for 45 min followed by 2 h of reperfusion. BPC 157 (20 µg/kg, intraperitoneal) was administered at the 45th minute of…
  13. 13AnimalAnimal study (in vivo)Efficacy outcome

    In rats with lower limb ischemia-reperfusion injury, histology showed reduced collagen deposition in BPC‑157-treated rats compared with ischemia-reperfusion alone.

    In plain wordsIn rats with leg reperfusion injury, muscle tissue showed less collagen build-up with BPC‑157 than without it.

    Peptide
    BPC-157
    Outcome
    DecreaseCollagen deposition on histology
    Study

    ratn: not reported in source

    Wistar albino rats with lower limb ischemia-reperfusion injury
    Comparator
    I/R without BPC 157 (IR group)
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    20 µg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Histological analysis confirmed improved muscle architecture and reduced collagen deposition in IRB compared with IR.
    1 context sentence
    Summary · context
    Twenty-four male Wistar albino rats were randomized into four groups (n = 6): SHAM, B (BPC 157 only), IR (I/R), and IRB (I/R + BPC 157). I/R was induced by abdominal aortic clamping for 45 min followed by 2 h of reperfusion. BPC 157 (20 µg/kg, intraperitoneal) was administered at the 45th minute of…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

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