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Study · Measured the body's own peptide · 2026

10 results

Humanin-G protects septic ARDS by mediating mitochondrial function in lung vascular endothelial cells.

Wu X, Li Y, Lin X, Yu Z, Mu S, Li X, Liu J, Han Y

American journal of respiratory cell and molecular biology18 May 2026

PMID42153337 (opens in a new tab)DOI10.1093/ajrcmb/aanag079 (opens in a new tab)PepBankPUB-42153337
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In patients with septic ARDS, serum HN concentrations rose markedly on Day 1 and then fell progressively from Day 3 to Day 7.

    In plain wordsIn people with septic ARDS, the body's own humanin in blood rose on Day 1 and then fell from Day 3 to Day 7.

    Peptide
    Humanin
    Outcome
    MixedSerum humanin over time in septic ARDS
    Study

    n: not reported in source

    Outcome group
    Inflammation markers · Respiratory

    Source sentences

    Summary
    In septic ARDS patients, serum concentrations of HN increased markedly on Day 1, followed by a progressive decrease from Day 3 to Day 7.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone9

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 02AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In a mouse model of septic ARDS, HNG pretreatment significantly reduced inflammatory factor expression.

    In plain wordsIn mice with septic ARDS, pretreatment with humanin-G reduced the expression of inflammatory factors.

    Peptide
    Humanin
    Outcome
    DecreaseInflammatory factor expression in vivo
    Study

    mousen: not reported in source

    LPS-induced murine septic ARDS model
    Comparator
    No HNG pretreatment
    Outcome group
    Inflammation markers · Respiratory

    Source sentences

    Summary
    The results showed that HNG pretreatment significantly reduced inflammatory factor expression in both in vivo and in vitro settings, as confirmed by qPCR and Western blot.
    1 context sentence
    Summary · context
    A murine model of septic ARDS was established through intraperitoneal injection of lipopolysaccharide.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 03AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In a mouse model of septic ARDS, HNG treatment protected against lung injury.

    In plain wordsIn mice with septic ARDS, treatment with humanin-G protected against lung injury.

    Peptide
    Humanin
    Outcome
    DecreaseLung injury
    Study

    mousen: not reported in source

    LPS-induced murine septic ARDS model
    Outcome group
    Inflammation markers · Respiratory

    Source sentences

    Summary
    HNG treatment conferred protection against lung injury, restored mitochondrial morphology, improved mitochondrial respiratory function, and corrected impaired membrane potential, as assessed by H&E staining, transmission electron microscopy, Seahorse analysis, and JC-1 staining, respectively.
    1 context sentence
    Summary · context
    A murine model of septic ARDS was established through intraperitoneal injection of lipopolysaccharide.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 04AnimalNot a test of Humanin aloneAnimal study (in vivo)Mechanism

    In a septic ARDS model, HNG treatment restored mitochondrial morphology.

    In plain wordsIn a septic ARDS model, humanin-G treatment restored the shape of mitochondria.

    Peptide
    Humanin
    Outcome
    IncreaseMitochondrial morphology
    Study

    mousen: not reported in source

    LPS-induced murine septic ARDS model
    Outcome group
    Mitochondrial function · Respiratory

    Source sentences

    Summary
    restored mitochondrial morphology, improved mitochondrial respiratory function, and corrected impaired membrane potential, as assessed by H&E staining, transmission electron microscopy, Seahorse analysis, and JC-1 staining, respectively.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  4. 05LabNot a test of Humanin aloneIn vitro (cells)Efficacy outcome

    In vitro, HNG pretreatment significantly reduced inflammatory factor expression.

    In plain wordsIn cells, pretreatment with humanin-G reduced the expression of inflammatory factors.

    Peptide
    Humanin
    Outcome
    DecreaseInflammatory factor expression in vitro
    Study

    n: not reported in source

    In vitro lung vascular endothelial cell model of sepsis
    Comparator
    No HNG pretreatment
    Outcome group
    Inflammation markers · Respiratory

    Source sentences

    Summary
    The results showed that HNG pretreatment significantly reduced inflammatory factor expression in both in vivo and in vitro settings, as confirmed by qPCR and Western blot.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  5. 06LabNot a test of Humanin aloneIn vitro (cells)Mechanism

    In the septic ARDS model, HNG treatment improved mitochondrial respiratory function.

    In plain wordsIn a septic ARDS model, humanin-G treatment improved how well mitochondria breathe.

    Peptide
    Humanin
    Outcome
    IncreaseMitochondrial respiratory function
    Study

    n: not reported in source

    Lung vascular endothelial cells in septic ARDS model
    Outcome group
    Mitochondrial function · Respiratory

    Source sentences

    Summary
    improved mitochondrial respiratory function, and corrected impaired membrane potential, as assessed by H&E staining, transmission electron microscopy, Seahorse analysis, and JC-1 staining, respectively.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  6. 07LabNot a test of Humanin aloneIn vitro (cells)Mechanism

    In the septic ARDS model, HNG treatment corrected impaired membrane potential.

    In plain wordsIn a septic ARDS model, humanin-G treatment corrected a damaged mitochondrial membrane potential.

    Peptide
    Humanin
    Outcome
    IncreaseMitochondrial membrane potential
    Study

    n: not reported in source

    Lung vascular endothelial cells in septic ARDS model
    Outcome group
    Mitochondrial function · Respiratory

    Source sentences

    Summary
    corrected impaired membrane potential, as assessed by H&E staining, transmission electron microscopy, Seahorse analysis, and JC-1 staining, respectively.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  7. 08LabNot a test of Humanin aloneIn vitro (cells)Mechanism

    Immunoprecipitation confirmed that HNG competitively interacts with the IL-6 receptor family in comparison to IL-6.

    In plain wordsIn lab tests, humanin-G competed with IL-6 for binding to the IL-6 receptor family.

    Peptide
    Humanin
    Outcome
    Not applicableCompetition with IL-6 for the IL-6 receptor family
    Study

    n: not reported in source

    Immunoprecipitation
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Source sentences

    Summary
    immunoprecipitation confirmed that HNG competitively interacts with the IL-6 receptor family in comparison to IL-6.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  8. 09LabNot a test of Humanin aloneIn vitro (cells)Mechanism

    In septic lung endothelial cells, the protective effects of HNG on mitochondria may be largely due to suppression of STAT3 expression.

    In plain wordsIn septic lung endothelial cells, humanin-G lowered STAT3, which may explain much of its protection of mitochondria.

    Peptide
    Humanin
    Outcome
    DecreaseSTAT3 expression
    Study

    n: not reported in source

    Septic lung endothelial cells
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Source sentences

    Summary
    Furthermore, WB analysis indicated that the protective effects of HNG on mitochondria may be largely due to the suppression of STAT3 expression in septic lung endothelial cells.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  9. 10Computer modelNot a test of Humanin aloneIn silicoMechanism

    Protein-peptide interaction analysis suggested that HNG binds to the interleukin-6 receptor alpha.

    In plain wordsA computer analysis suggested that humanin-G binds to the interleukin-6 receptor alpha.

    Peptide
    Humanin
    Outcome
    Not applicableHNG binding to interleukin-6 receptor alpha
    Study

    n: not reported in source

    Protein-peptide interaction analysis
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Source sentences

    Summary
    protein-peptide interaction analysis suggested that HNG binds to the interleukin-6 receptor alpha

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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