In a man with 26 kg of weight loss on semaglutide and long-term nicotine replacement, acute heart failure with dilated cardiomyopathy and an ejection fraction of 15% occurred; the authors think energy deficit, not direct drug toxicity, contributed.
In plain wordsOne man on semaglutide and long-term nicotine replacement had severe heart failure after fast weight loss; the cause cannot be tied to semaglutide alone.
- Peptide
- Semaglutide
- Outcome
- Not applicableDilated cardiomyopathy with heart failure
- Study
n = 1
- Outcome group
- Adverse events · Cardiovascular
Source sentences
Evaluation showed global left ventricular systolic dysfunction with an ejection fraction of 15%, marked dilation, moderate mitral regurgitation and right ventricular insertion-point fibrosis.
2 context sentences(design, population, supporting numbers)
Pharmacological exposures, such as glucagon-like peptide-1 agonists and chronic NRT, may have contributed indirectly by facilitating prolonged energy imbalance rather than acting as direct cardiotoxic agents.
He had intentionally lost 26 kg over 2 months through 0.25 mg semaglutide therapy, and reports >25 years of chronic nicotine replacement therapy (NRT: 30-40 mg/day).
In this study, Semaglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semaglutide.