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Study · Observational study · 2026

3 results

Health Care Costs and Use of Patients Prescribed Four Different Obesity Medications.

Lewis KH, Zhang F, LeCates RF, Argetsinger S, Albert S, Iyer GS, Connolly JG, Wharam JF, Arterburn DE, Ross-Degnan D, Toh S

Obesity (Silver Spring, Md.)12 May 2026

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanObservational studyOther

    In people initiating obesity medications, liraglutide was associated with 73.6% higher first-year total health care costs than phentermine (reported interval 70.9%–76.3%).

    In plain wordsIn people with obesity, liraglutide was linked to 73.6% higher first-year total health care costs than phentermine.

    Outcome
    IncreaseTotal health care costs in year 1
    Study

    n: not reported in source

    Comparator
    Phentermine
    Outcome group
    Healthcare costs and utilization · Whole body
    Studied dose
    Dose not stated

    Measurements

    Total health care cost difference
    73.6%
    year 1 versus phentermine; reported interval 70.9%–76.3%

    Source sentences

    Summary
    Up to 3 years after OM initiation, prescription and total health care costs were higher for all three newer OM cohorts relative to phentermine, with liraglutide having the greatest comparative increase in annual costs (e.g., total costs 73.6% [70.9%, 76.3%] higher in year 1).
    2 context sentences
    Summary · context
    Commercial insurance claims were used to identify new initiators of phentermine (n = 136,788), phentermine-topiramate-ER (n = 13,888), naltrexone-bupropion-SR (n = 28,712), or liraglutide (n = 49,266) for obesity.
    Summary · context
    Multivariable difference-in-differences analyses compared the three newer drugs to phentermine for change in total annual prescription drug and health care costs, outpatient visits, and acute care use (combined emergency department visits and hospital stays).
  2. 02HumanObservational studyOther

    In people initiating obesity medications, liraglutide was associated with 12.6% fewer first-year primary-care physician visits than phentermine (reported interval -13.6% to -11.6%).

    In plain wordsIn people with obesity, liraglutide was linked to 12.6% fewer first-year primary-care visits than phentermine.

    Outcome
    DecreasePrimary care physician visits in year 1
    Study

    n: not reported in source

    Comparator
    Phentermine
    Outcome group
    Healthcare costs and utilization · Whole body
    Studied dose
    Dose not stated

    Measurements

    Primary-care visit frequency difference
    −12.6%
    year 1 versus phentermine; reported interval -13.6% to -11.6%

    Source sentences

    Summary
    Primary care physician visit frequency was slightly lower for the newer OMs (e.g., -12.6% [-13.6%, -11.6%] in year 1 for liraglutide).
    2 context sentences
    Summary · context
    Commercial insurance claims were used to identify new initiators of phentermine (n = 136,788), phentermine-topiramate-ER (n = 13,888), naltrexone-bupropion-SR (n = 28,712), or liraglutide (n = 49,266) for obesity.
    Summary · context
    Multivariable difference-in-differences analyses compared the three newer drugs to phentermine for change in total annual prescription drug and health care costs, outpatient visits, and acute care use (combined emergency department visits and hospital stays).
  3. 03HumanObservational studyOther

    In people initiating obesity medications, liraglutide was associated with higher annual prescription costs than phentermine for up to 3 years after initiation.

    In plain wordsIn people with obesity, liraglutide was linked to higher annual prescription costs than phentermine for up to 3 years.

    Outcome
    IncreaseAnnual prescription drug costs
    Study

    n: not reported in source

    Comparator
    Phentermine
    Outcome group
    Healthcare costs and utilization · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Up to 3 years after OM initiation, prescription and total health care costs were higher for all three newer OM cohorts relative to phentermine, with liraglutide having the greatest comparative increase in annual costs (e.g., total costs 73.6% [70.9%, 76.3%] higher in year 1).
    2 context sentences
    Summary · context
    Commercial insurance claims were used to identify new initiators of phentermine (n = 136,788), phentermine-topiramate-ER (n = 13,888), naltrexone-bupropion-SR (n = 28,712), or liraglutide (n = 49,266) for obesity.
    Summary · context
    Multivariable difference-in-differences analyses compared the three newer drugs to phentermine for change in total annual prescription drug and health care costs, outpatient visits, and acute care use (combined emergency department visits and hospital stays).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 11:11 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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