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Study · Animal study (in vivo) · mouse · 2026

12 results

Nicotinamide Mononucleotide Ameliorates Nano-Aluminum Oxide-Induced Cognitive Impairment and Ferroptosis via the GSH/GPX4 Axis.

Yu L, Zhang T, Lou X, Zou H, Xie H, Yan F, Ran Q, Zhou L, Gao X, Hu Y, Gao X

Small (Weinheim an der Bergstrasse, Germany)8 May 2026

PMID42101224 (opens in a new tab)DOI10.1002/smll.202508100 (opens in a new tab)PepBankPUB-42101224
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In exposed mice, NMN alleviated hippocampal neuronal loss.

    In plain wordsIn mice exposed to aluminum oxide nanoparticles, NMN reduced neuron loss in the hippocampus.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseHippocampal neuronal loss
    Study

    mousen: not reported in source

    Nano-aluminum oxide neurotoxicity
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Histological and ultrastructural analyses revealed hippocampal neuronal loss, reduced Nissl body density, and mitochondrial abnormalities, all of which were alleviated by NMN treatment.
    1 context sentence
    Summary · context
    Behavioral tests demonstrated that Nano-Al2O3 exposure impaired learning and memory in mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In exposed mice, NMN alleviated reduced Nissl body density.

    In plain wordsIn mice exposed to aluminum oxide nanoparticles, NMN reduced the loss of Nissl body density.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseNissl body density
    Study

    mousen: not reported in source

    Nano-aluminum oxide neurotoxicity
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Histological and ultrastructural analyses revealed hippocampal neuronal loss, reduced Nissl body density, and mitochondrial abnormalities, all of which were alleviated by NMN treatment.
    1 context sentence
    Summary · context
    Behavioral tests demonstrated that Nano-Al2O3 exposure impaired learning and memory in mice.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In exposed mice, NMN alleviated mitochondrial abnormalities.

    In plain wordsIn mice exposed to aluminum oxide nanoparticles, NMN reduced mitochondrial abnormalities.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseMitochondrial abnormalities
    Study

    mousen: not reported in source

    Nano-aluminum oxide neurotoxicity
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Histological and ultrastructural analyses revealed hippocampal neuronal loss, reduced Nissl body density, and mitochondrial abnormalities, all of which were alleviated by NMN treatment.
    1 context sentence
    Summary · context
    Behavioral tests demonstrated that Nano-Al2O3 exposure impaired learning and memory in mice.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In exposed mice, NMN largely reversed increased lipid peroxidation.

    In plain wordsIn mice exposed to aluminum oxide nanoparticles, NMN largely reversed increased lipid oxidation.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseLipid peroxidation
    Study

    mousen: not reported in source

    Nano-aluminum oxide neurotoxicity
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN largely reversed these alterations, restored redox homeostasis, and improved cognitive performance.
    2 context sentences
    Summary · context
    Nano-Al2O3 exposure also increased lipid peroxidation, malondialdehyde, Fe2+, and reactive oxygen species, while decreasing NAD+, glutathione (GSH), and glutathione peroxidase 4 (GPX4), indicating ferroptosis-related damage.
    Summary · context
    Behavioral tests demonstrated that Nano-Al2O3 exposure impaired learning and memory in mice.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In exposed mice, NMN largely reversed increased malondialdehyde.

    In plain wordsIn mice exposed to aluminum oxide nanoparticles, NMN largely reversed increased malondialdehyde.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseMalondialdehyde
    Study

    mousen: not reported in source

    Nano-aluminum oxide neurotoxicity
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN largely reversed these alterations, restored redox homeostasis, and improved cognitive performance.
    2 context sentences
    Summary · context
    Nano-Al2O3 exposure also increased lipid peroxidation, malondialdehyde, Fe2+, and reactive oxygen species, while decreasing NAD+, glutathione (GSH), and glutathione peroxidase 4 (GPX4), indicating ferroptosis-related damage.
    Summary · context
    Behavioral tests demonstrated that Nano-Al2O3 exposure impaired learning and memory in mice.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In exposed mice, NMN largely reversed increased ferrous iron.

    In plain wordsIn mice exposed to aluminum oxide nanoparticles, NMN largely reversed increased ferrous iron.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseFerrous iron
    Study

    mousen: not reported in source

    Nano-aluminum oxide neurotoxicity
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN largely reversed these alterations, restored redox homeostasis, and improved cognitive performance.
    2 context sentences
    Summary · context
    Nano-Al2O3 exposure also increased lipid peroxidation, malondialdehyde, Fe2+, and reactive oxygen species, while decreasing NAD+, glutathione (GSH), and glutathione peroxidase 4 (GPX4), indicating ferroptosis-related damage.
    Summary · context
    Behavioral tests demonstrated that Nano-Al2O3 exposure impaired learning and memory in mice.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In exposed mice, NMN largely reversed increased reactive oxygen species.

    In plain wordsIn mice exposed to aluminum oxide nanoparticles, NMN largely reversed increased reactive oxygen species.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseReactive oxygen species
    Study

    mousen: not reported in source

    Nano-aluminum oxide neurotoxicity
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN largely reversed these alterations, restored redox homeostasis, and improved cognitive performance.
    2 context sentences
    Summary · context
    Nano-Al2O3 exposure also increased lipid peroxidation, malondialdehyde, Fe2+, and reactive oxygen species, while decreasing NAD+, glutathione (GSH), and glutathione peroxidase 4 (GPX4), indicating ferroptosis-related damage.
    Summary · context
    Behavioral tests demonstrated that Nano-Al2O3 exposure impaired learning and memory in mice.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In exposed mice, NMN largely reversed reduced NAD levels.

    In plain wordsIn mice exposed to aluminum oxide nanoparticles, NMN largely reversed reduced NAD levels.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseNAD levels
    Study

    mousen: not reported in source

    Nano-aluminum oxide neurotoxicity
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN largely reversed these alterations, restored redox homeostasis, and improved cognitive performance.
    2 context sentences
    Summary · context
    Nano-Al2O3 exposure also increased lipid peroxidation, malondialdehyde, Fe2+, and reactive oxygen species, while decreasing NAD+, glutathione (GSH), and glutathione peroxidase 4 (GPX4), indicating ferroptosis-related damage.
    Summary · context
    Behavioral tests demonstrated that Nano-Al2O3 exposure impaired learning and memory in mice.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In exposed mice, NMN largely reversed reduced glutathione.

    In plain wordsIn mice exposed to aluminum oxide nanoparticles, NMN largely reversed reduced glutathione.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseGlutathione
    Study

    mousen: not reported in source

    Nano-aluminum oxide neurotoxicity
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN largely reversed these alterations, restored redox homeostasis, and improved cognitive performance.
    2 context sentences
    Summary · context
    Nano-Al2O3 exposure also increased lipid peroxidation, malondialdehyde, Fe2+, and reactive oxygen species, while decreasing NAD+, glutathione (GSH), and glutathione peroxidase 4 (GPX4), indicating ferroptosis-related damage.
    Summary · context
    Behavioral tests demonstrated that Nano-Al2O3 exposure impaired learning and memory in mice.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In exposed mice, NMN largely reversed reduced glutathione peroxidase 4.

    In plain wordsIn mice exposed to aluminum oxide nanoparticles, NMN largely reversed reduced glutathione peroxidase 4.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseGlutathione peroxidase 4
    Study

    mousen: not reported in source

    Nano-aluminum oxide neurotoxicity
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN largely reversed these alterations, restored redox homeostasis, and improved cognitive performance.
    2 context sentences
    Summary · context
    Nano-Al2O3 exposure also increased lipid peroxidation, malondialdehyde, Fe2+, and reactive oxygen species, while decreasing NAD+, glutathione (GSH), and glutathione peroxidase 4 (GPX4), indicating ferroptosis-related damage.
    Summary · context
    Behavioral tests demonstrated that Nano-Al2O3 exposure impaired learning and memory in mice.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In exposed mice, NMN restored redox homeostasis.

    In plain wordsIn mice exposed to aluminum oxide nanoparticles, NMN restored redox balance.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Direction not reportedRedox homeostasis
    Study

    mousen: not reported in source

    Nano-aluminum oxide neurotoxicity
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN largely reversed these alterations, restored redox homeostasis, and improved cognitive performance.
    1 context sentence
    Summary · context
    Behavioral tests demonstrated that Nano-Al2O3 exposure impaired learning and memory in mice.
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In exposed mice, NMN improved cognitive performance.

    In plain wordsIn mice exposed to aluminum oxide nanoparticles, NMN improved cognitive performance.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseCognitive performance
    Study

    mousen: not reported in source

    Nano-aluminum oxide neurotoxicity
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN largely reversed these alterations, restored redox homeostasis, and improved cognitive performance.
    1 context sentence
    Summary · context
    Behavioral tests demonstrated that Nano-Al2O3 exposure impaired learning and memory in mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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