Effects and Mechanisms of NAD + on Lung Injury After Cardiac Arrest and Cardiopulmonary Resuscitation in Swine.

Chen M, Hu Y, Yang X, Lai L, Liu M, Liu Y, Xu J, Lan P

Shock (Augusta, Ga.)29 Apr 2026

PMID42053361PMCIDPMC13313473DOI10.1097/shk.0000000000002863PepBankPUB-42053361

Read at source PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study23

23 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In swine after resuscitation, NAD+ improved serum SP-D lung injury indices versus CPR vehicle.
In plain wordsIn swine after resuscitation, NAD+ improved serum SP-D lung injury indices compared with CPR vehicle.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
Direction not reportedSerum SP-D
Study
swinen: not reported in source
cardiac arrest and cardiopulmonary resuscitation
Comparator
CPR vehicle group
Outcome group
Lung injury and fibrosis · Respiratory
Studied dose
20 mg/kg · intravenous · 1 hourAs given in this study (swine).
Source sentences
Summary
Compared with the CPR group, NAD + treatment significantly improved lung injury indices, including SP-D, ELWI, PVPI, and OI.
3 context sentences(design, population, supporting numbers)
Summary · context
Significant differences between the CPR and CPR + NAD + groups were observed in serum SP-D at multiple time points, lung tissue SP-D at 24 hours, and ELWI and PVPI at 4 hours.
Summary · context
The CA/CPR model was established by 10 minutes ventricular fibrillation followed by 6 minutes CPR.
Summary · context
At 5 minutes after successful resuscitation, the CPR + NAD + group received intravenous NAD + (20 mg/kg over 1 hour), while the other groups received a vehicle solution.
Report a problemFND-4205336101
02AnimalAnimal study (in vivo)Efficacy outcome
In swine after resuscitation, lung tissue SP-D differed between NAD+ and CPR vehicle groups at the reported tissue assessment.
In plain wordsIn swine after resuscitation, lung tissue SP-D differed between NAD+ and CPR vehicle groups.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
Direction not reportedLung tissue SP-D
Study
swinen: not reported in source
cardiac arrest and cardiopulmonary resuscitation
Comparator
CPR vehicle group
Outcome group
Lung injury and fibrosis · Respiratory
Studied dose
20 mg/kg · intravenous · 1 hourAs given in this study (swine).
Source sentences
Summary
Significant differences between the CPR and CPR + NAD + groups were observed in serum SP-D at multiple time points, lung tissue SP-D at 24 hours, and ELWI and PVPI at 4 hours.
2 context sentences(design, population, supporting numbers)
Summary · context
The CA/CPR model was established by 10 minutes ventricular fibrillation followed by 6 minutes CPR.
Summary · context
At 5 minutes after successful resuscitation, the CPR + NAD + group received intravenous NAD + (20 mg/kg over 1 hour), while the other groups received a vehicle solution.
Report a problemFND-4205336102
03AnimalAnimal study (in vivo)Efficacy outcome
In swine after resuscitation, NAD+ improved extravascular lung water index versus CPR vehicle.
In plain wordsIn swine after resuscitation, NAD+ improved the lung water index compared with CPR vehicle.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
Direction not reportedExtravascular lung water index
Study
swinen: not reported in source
cardiac arrest and cardiopulmonary resuscitation
Comparator
CPR vehicle group
Outcome group
Lung injury and fibrosis · Respiratory
Studied dose
20 mg/kg · intravenous · 1 hourAs given in this study (swine).
Source sentences
Summary
Compared with the CPR group, NAD + treatment significantly improved lung injury indices, including SP-D, ELWI, PVPI, and OI.
3 context sentences(design, population, supporting numbers)
Summary · context
Significant differences between the CPR and CPR + NAD + groups were observed in serum SP-D at multiple time points, lung tissue SP-D at 24 hours, and ELWI and PVPI at 4 hours.
Summary · context
The CA/CPR model was established by 10 minutes ventricular fibrillation followed by 6 minutes CPR.
Summary · context
At 5 minutes after successful resuscitation, the CPR + NAD + group received intravenous NAD + (20 mg/kg over 1 hour), while the other groups received a vehicle solution.
Report a problemFND-4205336103
04AnimalAnimal study (in vivo)Efficacy outcome
In swine after resuscitation, NAD+ improved pulmonary vascular permeability index versus CPR vehicle.
In plain wordsIn swine after resuscitation, NAD+ improved the lung vascular permeability index compared with CPR vehicle.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
Direction not reportedPulmonary vascular permeability index
Study
swinen: not reported in source
cardiac arrest and cardiopulmonary resuscitation
Comparator
CPR vehicle group
Outcome group
Lung injury and fibrosis · Respiratory
Studied dose
20 mg/kg · intravenous · 1 hourAs given in this study (swine).
Source sentences
Summary
Compared with the CPR group, NAD + treatment significantly improved lung injury indices, including SP-D, ELWI, PVPI, and OI.
3 context sentences(design, population, supporting numbers)
Summary · context
Significant differences between the CPR and CPR + NAD + groups were observed in serum SP-D at multiple time points, lung tissue SP-D at 24 hours, and ELWI and PVPI at 4 hours.
Summary · context
The CA/CPR model was established by 10 minutes ventricular fibrillation followed by 6 minutes CPR.
Summary · context
At 5 minutes after successful resuscitation, the CPR + NAD + group received intravenous NAD + (20 mg/kg over 1 hour), while the other groups received a vehicle solution.
Report a problemFND-4205336104
05AnimalAnimal study (in vivo)Efficacy outcome
In swine after resuscitation, NAD+ improved oxygenation index versus CPR vehicle.
In plain wordsIn swine after resuscitation, NAD+ improved oxygenation compared with CPR vehicle.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
Direction not reportedOxygenation index
Study
swinen: not reported in source
cardiac arrest and cardiopulmonary resuscitation
Comparator
CPR vehicle group
Outcome group
Lung injury and fibrosis · Respiratory
Studied dose
20 mg/kg · intravenous · 1 hourAs given in this study (swine).
Source sentences
Summary
Compared with the CPR group, NAD + treatment significantly improved lung injury indices, including SP-D, ELWI, PVPI, and OI.
2 context sentences(design, population, supporting numbers)
Summary · context
The CA/CPR model was established by 10 minutes ventricular fibrillation followed by 6 minutes CPR.
Summary · context
At 5 minutes after successful resuscitation, the CPR + NAD + group received intravenous NAD + (20 mg/kg over 1 hour), while the other groups received a vehicle solution.
Report a problemFND-4205336105
06AnimalAnimal study (in vivo)Efficacy outcome
In swine after resuscitation, NAD+ attenuated lung tissue injury versus CPR vehicle.
In plain wordsIn swine after resuscitation, NAD+ reduced lung tissue injury compared with CPR vehicle.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
DecreaseLung tissue injury versus CPR
Study
swinen: not reported in source
cardiac arrest and cardiopulmonary resuscitation
Comparator
CPR vehicle group
Outcome group
Lung injury and fibrosis · Respiratory
Studied dose
20 mg/kg · intravenous · 1 hourAs given in this study (swine).
Source sentences
Summary
Histopathological analysis revealed marked lung tissue injury and increased apoptosis in both intervention groups compared with the Sham group; however, these changes were significantly attenuated in the CPR + NAD + group.
2 context sentences(design, population, supporting numbers)
Summary · context
The CA/CPR model was established by 10 minutes ventricular fibrillation followed by 6 minutes CPR.
Summary · context
At 5 minutes after successful resuscitation, the CPR + NAD + group received intravenous NAD + (20 mg/kg over 1 hour), while the other groups received a vehicle solution.
Report a problemFND-4205336106
07AnimalAnimal study (in vivo)Efficacy outcome
In swine after resuscitation, NAD+ attenuated lung apoptosis versus CPR vehicle.
In plain wordsIn swine after resuscitation, NAD+ reduced lung cell death compared with CPR vehicle.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
DecreaseApoptosis versus CPR
Study
swinen: not reported in source
cardiac arrest and cardiopulmonary resuscitation
Comparator
CPR vehicle group
Outcome group
Lung injury and fibrosis · Respiratory
Studied dose
20 mg/kg · intravenous · 1 hourAs given in this study (swine).
Source sentences
Summary
Histopathological analysis revealed marked lung tissue injury and increased apoptosis in both intervention groups compared with the Sham group; however, these changes were significantly attenuated in the CPR + NAD + group.
2 context sentences(design, population, supporting numbers)
Summary · context
The CA/CPR model was established by 10 minutes ventricular fibrillation followed by 6 minutes CPR.
Summary · context
At 5 minutes after successful resuscitation, the CPR + NAD + group received intravenous NAD + (20 mg/kg over 1 hour), while the other groups received a vehicle solution.
Report a problemFND-4205336107
08AnimalAnimal study (in vivo)Efficacy outcome
In swine, lung tissue injury remained increased in the NAD+ CPR group versus Sham.
In plain wordsIn swine, lung tissue injury was higher in the NAD+ CPR group than Sham.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
IncreaseLung injury versus sham
Study
swinen: not reported in source
cardiac arrest and cardiopulmonary resuscitation
Comparator
Sham
Outcome group
Lung injury and fibrosis · Respiratory
Studied dose
20 mg/kg · intravenous · 1 hourAs given in this study (swine).
Source sentences
Summary
Histopathological analysis revealed marked lung tissue injury and increased apoptosis in both intervention groups compared with the Sham group; however, these changes were significantly attenuated in the CPR + NAD + group.
2 context sentences(design, population, supporting numbers)
Summary · context
The CA/CPR model was established by 10 minutes ventricular fibrillation followed by 6 minutes CPR.
Summary · context
At 5 minutes after successful resuscitation, the CPR + NAD + group received intravenous NAD + (20 mg/kg over 1 hour), while the other groups received a vehicle solution.
Report a problemFND-4205336108
09AnimalAnimal study (in vivo)Efficacy outcome
In swine, lung apoptosis remained increased in the NAD+ CPR group versus Sham.
In plain wordsIn swine, lung cell death was higher in the NAD+ CPR group than Sham.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
IncreaseApoptosis versus sham
Study
swinen: not reported in source
cardiac arrest and cardiopulmonary resuscitation
Comparator
Sham
Outcome group
Lung injury and fibrosis · Respiratory
Studied dose
20 mg/kg · intravenous · 1 hourAs given in this study (swine).
Source sentences
Summary
Histopathological analysis revealed marked lung tissue injury and increased apoptosis in both intervention groups compared with the Sham group; however, these changes were significantly attenuated in the CPR + NAD + group.
2 context sentences(design, population, supporting numbers)
Summary · context
The CA/CPR model was established by 10 minutes ventricular fibrillation followed by 6 minutes CPR.
Summary · context
At 5 minutes after successful resuscitation, the CPR + NAD + group received intravenous NAD + (20 mg/kg over 1 hour), while the other groups received a vehicle solution.
Report a problemFND-4205336109
10AnimalAnimal study (in vivo)Mechanism
In swine after resuscitation, NAD+ reversed elevated lung ferrous iron versus CPR vehicle.
In plain wordsIn swine after resuscitation, NAD+ reduced lung ferrous iron compared with CPR vehicle.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
DecreaseFerrous iron versus CPR
Study
swinen: not reported in source
cardiac arrest and cardiopulmonary resuscitation
Comparator
CPR vehicle group
Outcome group
Lung injury and fibrosis · Respiratory
Studied dose
20 mg/kg · intravenous · 1 hourAs given in this study (swine).
Source sentences
Summary
Notably, NAD + administration significantly reversed these ferroptosis-related alterations compared with the CPR group.
3 context sentences(design, population, supporting numbers)
Summary · context
Compared with the Sham group, lung tissue levels of Fe 2+ , MDA, 4-HNE, reactive oxygen species, and ACSL4 expression were significantly increased, whereas GSH levels and YAP expression were significantly decreased in both intervention groups.
Summary · context
The CA/CPR model was established by 10 minutes ventricular fibrillation followed by 6 minutes CPR.
Summary · context
At 5 minutes after successful resuscitation, the CPR + NAD + group received intravenous NAD + (20 mg/kg over 1 hour), while the other groups received a vehicle solution.
Report a problemFND-4205336110
11AnimalAnimal study (in vivo)Mechanism
In swine after resuscitation, NAD+ reversed elevated lung MDA versus CPR vehicle.
In plain wordsIn swine after resuscitation, NAD+ reduced lung MDA compared with CPR vehicle.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
DecreaseMDA versus CPR
Study
swinen: not reported in source
cardiac arrest and cardiopulmonary resuscitation
Comparator
CPR vehicle group
Outcome group
Lung injury and fibrosis · Respiratory
Studied dose
20 mg/kg · intravenous · 1 hourAs given in this study (swine).
Source sentences
Summary
Notably, NAD + administration significantly reversed these ferroptosis-related alterations compared with the CPR group.
3 context sentences(design, population, supporting numbers)
Summary · context
Compared with the Sham group, lung tissue levels of Fe 2+ , MDA, 4-HNE, reactive oxygen species, and ACSL4 expression were significantly increased, whereas GSH levels and YAP expression were significantly decreased in both intervention groups.
Summary · context
The CA/CPR model was established by 10 minutes ventricular fibrillation followed by 6 minutes CPR.
Summary · context
At 5 minutes after successful resuscitation, the CPR + NAD + group received intravenous NAD + (20 mg/kg over 1 hour), while the other groups received a vehicle solution.
Report a problemFND-4205336111
12AnimalAnimal study (in vivo)Mechanism
In swine after resuscitation, NAD+ reversed elevated lung 4-HNE versus CPR vehicle.
In plain wordsIn swine after resuscitation, NAD+ reduced lung 4-HNE compared with CPR vehicle.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
Decrease4-HNE versus CPR
Study
swinen: not reported in source
cardiac arrest and cardiopulmonary resuscitation
Comparator
CPR vehicle group
Outcome group
Lung injury and fibrosis · Respiratory
Studied dose
20 mg/kg · intravenous · 1 hourAs given in this study (swine).
Source sentences
Summary
Notably, NAD + administration significantly reversed these ferroptosis-related alterations compared with the CPR group.
3 context sentences(design, population, supporting numbers)
Summary · context
Compared with the Sham group, lung tissue levels of Fe 2+ , MDA, 4-HNE, reactive oxygen species, and ACSL4 expression were significantly increased, whereas GSH levels and YAP expression were significantly decreased in both intervention groups.
Summary · context
The CA/CPR model was established by 10 minutes ventricular fibrillation followed by 6 minutes CPR.
Summary · context
At 5 minutes after successful resuscitation, the CPR + NAD + group received intravenous NAD + (20 mg/kg over 1 hour), while the other groups received a vehicle solution.
Report a problemFND-4205336112
13AnimalAnimal study (in vivo)Mechanism
In swine after resuscitation, NAD+ reversed elevated lung reactive oxygen species versus CPR vehicle.
In plain wordsIn swine after resuscitation, NAD+ reduced lung reactive oxygen species compared with CPR vehicle.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
DecreaseReactive oxygen species versus CPR
Study
swinen: not reported in source
cardiac arrest and cardiopulmonary resuscitation
Comparator
CPR vehicle group
Outcome group
Lung injury and fibrosis · Respiratory
Studied dose
20 mg/kg · intravenous · 1 hourAs given in this study (swine).
Source sentences
Summary
Notably, NAD + administration significantly reversed these ferroptosis-related alterations compared with the CPR group.
3 context sentences(design, population, supporting numbers)
Summary · context
Compared with the Sham group, lung tissue levels of Fe 2+ , MDA, 4-HNE, reactive oxygen species, and ACSL4 expression were significantly increased, whereas GSH levels and YAP expression were significantly decreased in both intervention groups.
Summary · context
The CA/CPR model was established by 10 minutes ventricular fibrillation followed by 6 minutes CPR.
Summary · context
At 5 minutes after successful resuscitation, the CPR + NAD + group received intravenous NAD + (20 mg/kg over 1 hour), while the other groups received a vehicle solution.
Report a problemFND-4205336113
14AnimalAnimal study (in vivo)Mechanism
In swine after resuscitation, NAD+ reversed elevated lung ACSL4 expression versus CPR vehicle.
In plain wordsIn swine after resuscitation, NAD+ reduced lung ACSL4 expression compared with CPR vehicle.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
DecreaseACSL4 versus CPR
Study
swinen: not reported in source
cardiac arrest and cardiopulmonary resuscitation
Comparator
CPR vehicle group
Outcome group
Lung injury and fibrosis · Respiratory
Studied dose
20 mg/kg · intravenous · 1 hourAs given in this study (swine).
Source sentences
Summary
Notably, NAD + administration significantly reversed these ferroptosis-related alterations compared with the CPR group.
3 context sentences(design, population, supporting numbers)
Summary · context
Compared with the Sham group, lung tissue levels of Fe 2+ , MDA, 4-HNE, reactive oxygen species, and ACSL4 expression were significantly increased, whereas GSH levels and YAP expression were significantly decreased in both intervention groups.
Summary · context
The CA/CPR model was established by 10 minutes ventricular fibrillation followed by 6 minutes CPR.
Summary · context
At 5 minutes after successful resuscitation, the CPR + NAD + group received intravenous NAD + (20 mg/kg over 1 hour), while the other groups received a vehicle solution.
Report a problemFND-4205336114
15AnimalAnimal study (in vivo)Mechanism
In swine after resuscitation, NAD+ reversed reduced lung GSH levels versus CPR vehicle.
In plain wordsIn swine after resuscitation, NAD+ increased lung GSH compared with CPR vehicle.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
IncreaseGSH versus CPR
Study
swinen: not reported in source
cardiac arrest and cardiopulmonary resuscitation
Comparator
CPR vehicle group
Outcome group
Lung injury and fibrosis · Respiratory
Studied dose
20 mg/kg · intravenous · 1 hourAs given in this study (swine).
Source sentences
Summary
Notably, NAD + administration significantly reversed these ferroptosis-related alterations compared with the CPR group.
3 context sentences(design, population, supporting numbers)
Summary · context
Compared with the Sham group, lung tissue levels of Fe 2+ , MDA, 4-HNE, reactive oxygen species, and ACSL4 expression were significantly increased, whereas GSH levels and YAP expression were significantly decreased in both intervention groups.
Summary · context
The CA/CPR model was established by 10 minutes ventricular fibrillation followed by 6 minutes CPR.
Summary · context
At 5 minutes after successful resuscitation, the CPR + NAD + group received intravenous NAD + (20 mg/kg over 1 hour), while the other groups received a vehicle solution.
Report a problemFND-4205336115
16AnimalAnimal study (in vivo)Mechanism
In swine after resuscitation, NAD+ reversed reduced lung YAP expression versus CPR vehicle.
In plain wordsIn swine after resuscitation, NAD+ increased lung YAP expression compared with CPR vehicle.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
IncreaseYAP versus CPR
Study
swinen: not reported in source
cardiac arrest and cardiopulmonary resuscitation
Comparator
CPR vehicle group
Outcome group
Lung injury and fibrosis · Respiratory
Studied dose
20 mg/kg · intravenous · 1 hourAs given in this study (swine).
Source sentences
Summary
Notably, NAD + administration significantly reversed these ferroptosis-related alterations compared with the CPR group.
3 context sentences(design, population, supporting numbers)
Summary · context
Compared with the Sham group, lung tissue levels of Fe 2+ , MDA, 4-HNE, reactive oxygen species, and ACSL4 expression were significantly increased, whereas GSH levels and YAP expression were significantly decreased in both intervention groups.
Summary · context
The CA/CPR model was established by 10 minutes ventricular fibrillation followed by 6 minutes CPR.
Summary · context
At 5 minutes after successful resuscitation, the CPR + NAD + group received intravenous NAD + (20 mg/kg over 1 hour), while the other groups received a vehicle solution.
Report a problemFND-4205336116
17AnimalAnimal study (in vivo)Mechanism
In swine, lung ferrous iron was increased in the NAD+ CPR group versus Sham.
In plain wordsIn swine, lung ferrous iron was higher in the NAD+ CPR group than Sham.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
IncreaseFerrous iron versus sham
Study
swinen: not reported in source
cardiac arrest and cardiopulmonary resuscitation
Comparator
Sham
Outcome group
Lung injury and fibrosis · Respiratory
Studied dose
20 mg/kg · intravenous · 1 hourAs given in this study (swine).
Source sentences
Summary
Compared with the Sham group, lung tissue levels of Fe 2+ , MDA, 4-HNE, reactive oxygen species, and ACSL4 expression were significantly increased, whereas GSH levels and YAP expression were significantly decreased in both intervention groups.
2 context sentences(design, population, supporting numbers)
Summary · context
The CA/CPR model was established by 10 minutes ventricular fibrillation followed by 6 minutes CPR.
Summary · context
At 5 minutes after successful resuscitation, the CPR + NAD + group received intravenous NAD + (20 mg/kg over 1 hour), while the other groups received a vehicle solution.
Report a problemFND-4205336117
18AnimalAnimal study (in vivo)Mechanism
In swine, lung MDA was increased in the NAD+ CPR group versus Sham.
In plain wordsIn swine, lung MDA was higher in the NAD+ CPR group than Sham.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
IncreaseMDA versus sham
Study
swinen: not reported in source
cardiac arrest and cardiopulmonary resuscitation
Comparator
Sham
Outcome group
Lung injury and fibrosis · Respiratory
Studied dose
20 mg/kg · intravenous · 1 hourAs given in this study (swine).
Source sentences
Summary
Compared with the Sham group, lung tissue levels of Fe 2+ , MDA, 4-HNE, reactive oxygen species, and ACSL4 expression were significantly increased, whereas GSH levels and YAP expression were significantly decreased in both intervention groups.
2 context sentences(design, population, supporting numbers)
Summary · context
The CA/CPR model was established by 10 minutes ventricular fibrillation followed by 6 minutes CPR.
Summary · context
At 5 minutes after successful resuscitation, the CPR + NAD + group received intravenous NAD + (20 mg/kg over 1 hour), while the other groups received a vehicle solution.
Report a problemFND-4205336118
19AnimalAnimal study (in vivo)Mechanism
In swine, lung 4-HNE was increased in the NAD+ CPR group versus Sham.
In plain wordsIn swine, lung 4-HNE was higher in the NAD+ CPR group than Sham.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
Increase4-HNE versus sham
Study
swinen: not reported in source
cardiac arrest and cardiopulmonary resuscitation
Comparator
Sham
Outcome group
Lung injury and fibrosis · Respiratory
Studied dose
20 mg/kg · intravenous · 1 hourAs given in this study (swine).
Source sentences
Summary
Compared with the Sham group, lung tissue levels of Fe 2+ , MDA, 4-HNE, reactive oxygen species, and ACSL4 expression were significantly increased, whereas GSH levels and YAP expression were significantly decreased in both intervention groups.
2 context sentences(design, population, supporting numbers)
Summary · context
The CA/CPR model was established by 10 minutes ventricular fibrillation followed by 6 minutes CPR.
Summary · context
At 5 minutes after successful resuscitation, the CPR + NAD + group received intravenous NAD + (20 mg/kg over 1 hour), while the other groups received a vehicle solution.
Report a problemFND-4205336119
20AnimalAnimal study (in vivo)Mechanism
In swine, lung reactive oxygen species were increased in the NAD+ CPR group versus Sham.
In plain wordsIn swine, lung reactive oxygen species were higher in the NAD+ CPR group than Sham.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
IncreaseReactive oxygen species versus sham
Study
swinen: not reported in source
cardiac arrest and cardiopulmonary resuscitation
Comparator
Sham
Outcome group
Lung injury and fibrosis · Respiratory
Studied dose
20 mg/kg · intravenous · 1 hourAs given in this study (swine).
Source sentences
Summary
Compared with the Sham group, lung tissue levels of Fe 2+ , MDA, 4-HNE, reactive oxygen species, and ACSL4 expression were significantly increased, whereas GSH levels and YAP expression were significantly decreased in both intervention groups.
2 context sentences(design, population, supporting numbers)
Summary · context
The CA/CPR model was established by 10 minutes ventricular fibrillation followed by 6 minutes CPR.
Summary · context
At 5 minutes after successful resuscitation, the CPR + NAD + group received intravenous NAD + (20 mg/kg over 1 hour), while the other groups received a vehicle solution.
Report a problemFND-4205336120
21AnimalAnimal study (in vivo)Mechanism
In swine, lung ACSL4 expression was increased in the NAD+ CPR group versus Sham.
In plain wordsIn swine, lung ACSL4 expression was higher in the NAD+ CPR group than Sham.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
IncreaseACSL4 versus sham
Study
swinen: not reported in source
cardiac arrest and cardiopulmonary resuscitation
Comparator
Sham
Outcome group
Lung injury and fibrosis · Respiratory
Studied dose
20 mg/kg · intravenous · 1 hourAs given in this study (swine).
Source sentences
Summary
Compared with the Sham group, lung tissue levels of Fe 2+ , MDA, 4-HNE, reactive oxygen species, and ACSL4 expression were significantly increased, whereas GSH levels and YAP expression were significantly decreased in both intervention groups.
2 context sentences(design, population, supporting numbers)
Summary · context
The CA/CPR model was established by 10 minutes ventricular fibrillation followed by 6 minutes CPR.
Summary · context
At 5 minutes after successful resuscitation, the CPR + NAD + group received intravenous NAD + (20 mg/kg over 1 hour), while the other groups received a vehicle solution.
Report a problemFND-4205336121
22AnimalAnimal study (in vivo)Mechanism
In swine, lung GSH was decreased in the NAD+ CPR group versus Sham.
In plain wordsIn swine, lung GSH was lower in the NAD+ CPR group than Sham.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
DecreaseGSH versus sham
Study
swinen: not reported in source
cardiac arrest and cardiopulmonary resuscitation
Comparator
Sham
Outcome group
Lung injury and fibrosis · Respiratory
Studied dose
20 mg/kg · intravenous · 1 hourAs given in this study (swine).
Source sentences
Summary
Compared with the Sham group, lung tissue levels of Fe 2+ , MDA, 4-HNE, reactive oxygen species, and ACSL4 expression were significantly increased, whereas GSH levels and YAP expression were significantly decreased in both intervention groups.
2 context sentences(design, population, supporting numbers)
Summary · context
The CA/CPR model was established by 10 minutes ventricular fibrillation followed by 6 minutes CPR.
Summary · context
At 5 minutes after successful resuscitation, the CPR + NAD + group received intravenous NAD + (20 mg/kg over 1 hour), while the other groups received a vehicle solution.
Report a problemFND-4205336122
23AnimalAnimal study (in vivo)Mechanism
In swine, lung YAP expression was decreased in the NAD+ CPR group versus Sham.
In plain wordsIn swine, lung YAP expression was lower in the NAD+ CPR group than Sham.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
DecreaseYAP versus sham
Study
swinen: not reported in source
cardiac arrest and cardiopulmonary resuscitation
Comparator
Sham
Outcome group
Lung injury and fibrosis · Respiratory
Studied dose
20 mg/kg · intravenous · 1 hourAs given in this study (swine).
Source sentences
Summary
Compared with the Sham group, lung tissue levels of Fe 2+ , MDA, 4-HNE, reactive oxygen species, and ACSL4 expression were significantly increased, whereas GSH levels and YAP expression were significantly decreased in both intervention groups.
2 context sentences(design, population, supporting numbers)
Summary · context
The CA/CPR model was established by 10 minutes ventricular fibrillation followed by 6 minutes CPR.
Summary · context
At 5 minutes after successful resuscitation, the CPR + NAD + group received intravenous NAD + (20 mg/kg over 1 hour), while the other groups received a vehicle solution.
Report a problemFND-4205336123

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

Keywords

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