In obese GLP-1R knock-out mice, retatrutide normalized body weight.
In plain wordsIn obese mice lacking the GLP-1 receptor, retatrutide brought body weight to normal.
- Peptide
- Retatrutide
- Outcome
- DecreaseBody weight normalization in GLP-1R KO mice
- Study
mousen: not reported in source
GLP-1R knock-out diet-induced obese mice- Outcome group
- Body weight · Metabolic and weight
- Studied dose
- Dose not stated
Source sentences
Retatrutide a balanced GLP-1R:GIPR:GCGR triagonist normalized body weight in obese GLP-1R KO mice.
1 context sentence(design, population, supporting numbers)
Selective, dual, and triple sustained-action agonists at GIPR, GCGR and GLP-1R were used to assess body weight and glucose management in diet-induced obese (DIO) wildtype (WT) and GLP-1R knock-out (KO) mice.