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Study · Animal study (in vivo) · mouse · 2026

5 results

Nicotinamide mononucleotide attenuates hepatic endoplasmic reticulum stress and modulates circadian rhythms in young mice with diet-induced obesity.

Kwon SY, Na K, Han Y, Song S, Park YJ

Nutrition research and practice23 Jul 2025

PMID41970324 (opens in a new tab)PMCIDPMC13062564 (opens in a new tab)DOI10.4162/nrp.2026.20.2.220 (opens in a new tab)PepBankPUB-41970324
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study5

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In young mice, NMN significantly decreased body weight.

    In plain wordsIn young mice, NMN significantly reduced body weight.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseBody weight
    Study

    mousen: not reported in source

    Lean and obese C57BL/6N mice
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    500 mg/kg/day · 1 monAs given in this study (mouse).

    Source sentences

    Summary
    In mouse study, short-term NMN administration significantly decreased body weight and fat mass.
    1 context sentence
    Summary · context
    Next, 11-week-old lean and obese C57BL/6N mice administrated NMN (500 mg/kg/day) for 1 mon were analyzed for metabolic parameters and gene expression for the target pathways.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In young mice, NMN significantly decreased fat mass.

    In plain wordsIn young mice, NMN significantly reduced fat mass.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseFat mass
    Study

    mousen: not reported in source

    Lean and obese C57BL/6N mice
    Outcome group
    Body composition · Metabolic and weight
    Studied dose
    500 mg/kg/day · 1 monAs given in this study (mouse).

    Source sentences

    Summary
    In mouse study, short-term NMN administration significantly decreased body weight and fat mass.
    1 context sentence
    Summary · context
    Next, 11-week-old lean and obese C57BL/6N mice administrated NMN (500 mg/kg/day) for 1 mon were analyzed for metabolic parameters and gene expression for the target pathways.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In young mice, NMN alleviated hepatic ER stress.

    In plain wordsIn young mice, NMN reduced liver cell stress in the endoplasmic reticulum.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseHepatic ER stress
    Study

    mousen: not reported in source

    Lean and obese C57BL/6N mice
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    500 mg/kg/day · 1 monAs given in this study (mouse).

    Source sentences

    Summary
    NMN also alleviated hepatic ER stress response in vivo and in vitro.
    1 context sentence
    Summary · context
    Next, 11-week-old lean and obese C57BL/6N mice administrated NMN (500 mg/kg/day) for 1 mon were analyzed for metabolic parameters and gene expression for the target pathways.
  4. 04LabIn vitro (cells)Efficacy outcome

    In AML12 cells, NMN alleviated ER stress.

    In plain wordsIn cells, NMN reduced stress in the endoplasmic reticulum.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseHepatic ER stress
    Study

    n: not reported in source

    AML12 cells
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN also alleviated hepatic ER stress response in vivo and in vitro.
    1 context sentence
    Summary · context
    In vitro study using AML12 cell line was then conducted to confirm the effects of NMN.

Studies that did not test the peptide alone1

In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking NMN (nicotinamide mononucleotide).

  1. 05Computer modelNot a test of NMN (nicotinamide mononucleotide) aloneIn silicoMechanism

    Secondary analysis of NMN intervention transcriptome datasets identified potential circadian regulation and hepatic ER stress pathways.

    In plain wordsComputer analysis of NMN study datasets identified potential pathways for body-clock regulation and liver cell stress.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Not applicableCircadian and ER stress pathways
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Liver

    Source sentences

    Summary
    The secondary analysis of hepatic transcriptome datasets revealed potential target pathways related to circadian regulation and hepatic ER stress.
    1 context sentence
    Summary · context
    We first conducted a secondary analysis of hepatic transcriptome datasets from multiple NMN intervention studies to identify target pathways.

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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