Multi-omic profiling reveals Retatrutide alleviates adipose tissue fibrosis via metabolic reprogramming and tissue repair.

Li Q, Cheng W, Zhang J, Ran S, Yu H, Zhou W, Wang Y, Lin J, Liu Y, Hong X, Li H, Yan S

Diabetology & metabolic syndrome10 Apr 2026Cited by 3 (Europe PMC)

PMID41964043PMCIDPMC13214175DOI10.1186/s13098-026-02116-0PepBankPUB-41964043

Read at source PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study14

14 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In high-fat diet-induced obese mice, retatrutide markedly reduced body weight.
In plain wordsIn obese mice, retatrutide markedly lowered body weight.
Peptide
Retatrutide
Outcome
DecreaseBody weight
Study
mousen: not reported in source
High-fat diet-induced obesity mouse model
Outcome group
Body weight · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Retatrutide markedly reduced body weight and adiposity and improved metabolic parameters including glucose homeostasis and dyslipidemia.
1 context sentence(design, population, supporting numbers)
Summary · context
Using a high-fat diet–induced obesity mouse model, we investigated the effects of Retatrutide on adipose tissue through integrated physiological, histological, transcriptomic, and metabolomic analyses.
Report a problemFND-4196404301
02AnimalAnimal study (in vivo)Efficacy outcome
In high-fat diet-induced obese mice, retatrutide markedly reduced adiposity.
In plain wordsIn obese mice, retatrutide markedly lowered body fat.
Peptide
Retatrutide
Outcome
DecreaseAdiposity
Study
mousen: not reported in source
High-fat diet-induced obesity mouse model
Outcome group
Body weight · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Retatrutide markedly reduced body weight and adiposity and improved metabolic parameters including glucose homeostasis and dyslipidemia.
1 context sentence(design, population, supporting numbers)
Summary · context
Using a high-fat diet–induced obesity mouse model, we investigated the effects of Retatrutide on adipose tissue through integrated physiological, histological, transcriptomic, and metabolomic analyses.
Report a problemFND-4196404302
03AnimalAnimal study (in vivo)Efficacy outcome
In high-fat diet-induced obese mice, retatrutide improved glucose homeostasis.
In plain wordsIn obese mice, retatrutide improved blood sugar control.
Peptide
Retatrutide
Outcome
Direction not reportedGlucose homeostasis
Study
mousen: not reported in source
High-fat diet-induced obesity mouse model
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Retatrutide markedly reduced body weight and adiposity and improved metabolic parameters including glucose homeostasis and dyslipidemia.
1 context sentence(design, population, supporting numbers)
Summary · context
Using a high-fat diet–induced obesity mouse model, we investigated the effects of Retatrutide on adipose tissue through integrated physiological, histological, transcriptomic, and metabolomic analyses.
Report a problemFND-4196404303
04AnimalAnimal study (in vivo)Efficacy outcome
In high-fat diet-induced obese mice, retatrutide improved dyslipidemia.
In plain wordsIn obese mice, retatrutide improved abnormal blood fat levels.
Peptide
Retatrutide
Outcome
Direction not reportedDyslipidemia
Study
mousen: not reported in source
High-fat diet-induced obesity mouse model
Outcome group
Lipids · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Retatrutide markedly reduced body weight and adiposity and improved metabolic parameters including glucose homeostasis and dyslipidemia.
1 context sentence(design, population, supporting numbers)
Summary · context
Using a high-fat diet–induced obesity mouse model, we investigated the effects of Retatrutide on adipose tissue through integrated physiological, histological, transcriptomic, and metabolomic analyses.
Report a problemFND-4196404304
05AnimalAnimal study (in vivo)Mechanism
In high-fat diet-induced obese mice, retatrutide suppressed lipogenesis in epididymal white adipose tissue.
In plain wordsIn obese mice, retatrutide reduced fat production in a type of fat tissue.
Peptide
Retatrutide
Outcome
DecreaseLipogenesis in epididymal white adipose tissue
Study
mousen: not reported in source
High-fat diet-induced obesity mouse model
Outcome group
Gene expression · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Multi-omic profiling revealed a coordinated reprogramming of epididymal white adipose tissue, characterized by suppressed lipogenesis, enhanced fatty acid oxidation and mitochondrial function, restored peroxisomal activity, and downregulated inflammatory/fibrotic pathways while promoting angiogenic/…
1 context sentence(design, population, supporting numbers)
Summary · context
Using a high-fat diet–induced obesity mouse model, we investigated the effects of Retatrutide on adipose tissue through integrated physiological, histological, transcriptomic, and metabolomic analyses.
Report a problemFND-4196404305
06AnimalAnimal study (in vivo)Mechanism
In high-fat diet-induced obese mice, retatrutide enhanced fatty acid oxidation in epididymal white adipose tissue.
In plain wordsIn obese mice, retatrutide increased fat burning in a type of fat tissue.
Peptide
Retatrutide
Outcome
IncreaseFatty acid oxidation in epididymal white adipose tissue
Study
mousen: not reported in source
High-fat diet-induced obesity mouse model
Outcome group
Mitochondrial function · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Multi-omic profiling revealed a coordinated reprogramming of epididymal white adipose tissue, characterized by suppressed lipogenesis, enhanced fatty acid oxidation and mitochondrial function, restored peroxisomal activity, and downregulated inflammatory/fibrotic pathways while promoting angiogenic/…
1 context sentence(design, population, supporting numbers)
Summary · context
Using a high-fat diet–induced obesity mouse model, we investigated the effects of Retatrutide on adipose tissue through integrated physiological, histological, transcriptomic, and metabolomic analyses.
Report a problemFND-4196404306
07AnimalAnimal study (in vivo)Mechanism
In high-fat diet-induced obese mice, retatrutide enhanced mitochondrial function in epididymal white adipose tissue.
In plain wordsIn obese mice, retatrutide improved mitochondrial function in a type of fat tissue.
Peptide
Retatrutide
Outcome
IncreaseMitochondrial function in epididymal white adipose tissue
Study
mousen: not reported in source
High-fat diet-induced obesity mouse model
Outcome group
Mitochondrial function · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Multi-omic profiling revealed a coordinated reprogramming of epididymal white adipose tissue, characterized by suppressed lipogenesis, enhanced fatty acid oxidation and mitochondrial function, restored peroxisomal activity, and downregulated inflammatory/fibrotic pathways while promoting angiogenic/…
1 context sentence(design, population, supporting numbers)
Summary · context
Using a high-fat diet–induced obesity mouse model, we investigated the effects of Retatrutide on adipose tissue through integrated physiological, histological, transcriptomic, and metabolomic analyses.
Report a problemFND-4196404307
08AnimalAnimal study (in vivo)Mechanism
In high-fat diet-induced obese mice, retatrutide restored peroxisomal activity in epididymal white adipose tissue.
In plain wordsIn obese mice, retatrutide restored peroxisome activity in a type of fat tissue.
Peptide
Retatrutide
Outcome
IncreasePeroxisomal activity in epididymal white adipose tissue
Study
mousen: not reported in source
High-fat diet-induced obesity mouse model
Outcome group
Mitochondrial function · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Multi-omic profiling revealed a coordinated reprogramming of epididymal white adipose tissue, characterized by suppressed lipogenesis, enhanced fatty acid oxidation and mitochondrial function, restored peroxisomal activity, and downregulated inflammatory/fibrotic pathways while promoting angiogenic/…
1 context sentence(design, population, supporting numbers)
Summary · context
Using a high-fat diet–induced obesity mouse model, we investigated the effects of Retatrutide on adipose tissue through integrated physiological, histological, transcriptomic, and metabolomic analyses.
Report a problemFND-4196404308
09AnimalAnimal study (in vivo)Mechanism
In high-fat diet-induced obese mice, retatrutide downregulated inflammatory and fibrotic pathways in epididymal white adipose tissue.
In plain wordsIn obese mice, retatrutide turned down inflammation and scarring pathways in a type of fat tissue.
Peptide
Retatrutide
Outcome
DecreaseInflammatory and fibrotic pathways in epididymal white adipose tissue
Study
mousen: not reported in source
High-fat diet-induced obesity mouse model
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Multi-omic profiling revealed a coordinated reprogramming of epididymal white adipose tissue, characterized by suppressed lipogenesis, enhanced fatty acid oxidation and mitochondrial function, restored peroxisomal activity, and downregulated inflammatory/fibrotic pathways while promoting angiogenic/…
1 context sentence(design, population, supporting numbers)
Summary · context
Using a high-fat diet–induced obesity mouse model, we investigated the effects of Retatrutide on adipose tissue through integrated physiological, histological, transcriptomic, and metabolomic analyses.
Report a problemFND-4196404309
10AnimalAnimal study (in vivo)Mechanism
In high-fat diet-induced obese mice, retatrutide promoted angiogenic and reparative signaling in epididymal white adipose tissue.
In plain wordsIn obese mice, retatrutide increased blood vessel growth and repair signals in a type of fat tissue.
Peptide
Retatrutide
Outcome
IncreaseAngiogenic and reparative signaling in epididymal white adipose tissue
Study
mousen: not reported in source
High-fat diet-induced obesity mouse model
Outcome group
Gene expression · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Multi-omic profiling revealed a coordinated reprogramming of epididymal white adipose tissue, characterized by suppressed lipogenesis, enhanced fatty acid oxidation and mitochondrial function, restored peroxisomal activity, and downregulated inflammatory/fibrotic pathways while promoting angiogenic/…
1 context sentence(design, population, supporting numbers)
Summary · context
Using a high-fat diet–induced obesity mouse model, we investigated the effects of Retatrutide on adipose tissue through integrated physiological, histological, transcriptomic, and metabolomic analyses.
Report a problemFND-4196404310
11AnimalAnimal study (in vivo)Mechanism
In high-fat diet-induced obese mice, metabolomics showed clearance of lipotoxic intermediates with retatrutide.
In plain wordsIn obese mice, retatrutide cleared harmful fat breakdown products from fat tissue.
Peptide
Retatrutide
Outcome
DecreaseLipotoxic intermediates
Study
mousen: not reported in source
High-fat diet-induced obesity mouse model
Outcome group
Lipids · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Metabolomic analysis further demonstrated clearance of lipotoxic intermediates, decreased pro-inflammatory lipids, reduced collagen-derived metabolites, and elevated anti-inflammatory 15-HETE, confirming metabolic restoration at multiple regulatory levels.
1 context sentence(design, population, supporting numbers)
Summary · context
Using a high-fat diet–induced obesity mouse model, we investigated the effects of Retatrutide on adipose tissue through integrated physiological, histological, transcriptomic, and metabolomic analyses.
Report a problemFND-4196404311
12AnimalAnimal study (in vivo)Mechanism
In high-fat diet-induced obese mice, metabolomics showed decreased pro-inflammatory lipids with retatrutide.
In plain wordsIn obese mice, retatrutide lowered fats that promote inflammation.
Peptide
Retatrutide
Outcome
DecreasePro-inflammatory lipids
Study
mousen: not reported in source
High-fat diet-induced obesity mouse model
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Metabolomic analysis further demonstrated clearance of lipotoxic intermediates, decreased pro-inflammatory lipids, reduced collagen-derived metabolites, and elevated anti-inflammatory 15-HETE, confirming metabolic restoration at multiple regulatory levels.
1 context sentence(design, population, supporting numbers)
Summary · context
Using a high-fat diet–induced obesity mouse model, we investigated the effects of Retatrutide on adipose tissue through integrated physiological, histological, transcriptomic, and metabolomic analyses.
Report a problemFND-4196404312
13AnimalAnimal study (in vivo)Mechanism
In high-fat diet-induced obese mice, metabolomics showed reduced collagen-derived metabolites with retatrutide.
In plain wordsIn obese mice, retatrutide lowered collagen-derived molecules in tests of fat tissue.
Peptide
Retatrutide
Outcome
DecreaseCollagen-derived metabolites
Study
mousen: not reported in source
High-fat diet-induced obesity mouse model
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Metabolomic analysis further demonstrated clearance of lipotoxic intermediates, decreased pro-inflammatory lipids, reduced collagen-derived metabolites, and elevated anti-inflammatory 15-HETE, confirming metabolic restoration at multiple regulatory levels.
1 context sentence(design, population, supporting numbers)
Summary · context
Using a high-fat diet–induced obesity mouse model, we investigated the effects of Retatrutide on adipose tissue through integrated physiological, histological, transcriptomic, and metabolomic analyses.
Report a problemFND-4196404313
14AnimalAnimal study (in vivo)Mechanism
In high-fat diet-induced obese mice, metabolomics showed elevated anti-inflammatory 15-HETE with retatrutide.
In plain wordsIn obese mice, retatrutide raised levels of an anti-inflammatory fat molecule, 15-HETE.
Peptide
Retatrutide
Outcome
Increase15-HETE
Study
mousen: not reported in source
High-fat diet-induced obesity mouse model
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Metabolomic analysis further demonstrated clearance of lipotoxic intermediates, decreased pro-inflammatory lipids, reduced collagen-derived metabolites, and elevated anti-inflammatory 15-HETE, confirming metabolic restoration at multiple regulatory levels.
1 context sentence(design, population, supporting numbers)
Summary · context
Using a high-fat diet–induced obesity mouse model, we investigated the effects of Retatrutide on adipose tissue through integrated physiological, histological, transcriptomic, and metabolomic analyses.
Report a problemFND-4196404314

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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Keywords

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