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Study · Animal study (in vivo) · mouse · 2026

10 results

Kisspeptin-10 attenuates pulmonary arterial hypertension via restoration of mitochondrial function in pulmonary artery smooth muscle cells.

Huang S, Chen Z, Gong W, Song Y, Ding W, Zhang L, Li J

Neuropeptides23 Mar 2026

PMID41955717 (opens in a new tab)DOI10.1016/j.npep.2026.102611 (opens in a new tab)PepBankPUB-41955717
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In the SU5416/hypoxia mouse model of PAH, kisspeptin‑10 considerably reduced right ventricular systolic pressure.

    In plain wordsIn mice with pulmonary arterial hypertension, kisspeptin‑10 lowered the pressure in the right side of the heart.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseRight ventricular systolic pressure
    Study

    mousen: not reported in source

    SU5416/hypoxia mouse model of pulmonary arterial hypertension
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The administration of kisspeptin-10 resulted in a considerable reduction in the systolic pressure of the right ventricle
    1 context sentence
    Summary · context
    Here we show that Kisspeptin-10, acting via its receptor GPR54, markedly attenuates PAH in the SU5416/hypoxia mouse model.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In the SU5416/hypoxia mouse model of PAH, kisspeptin‑10 reduced right ventricular hypertrophy.

    In plain wordsIn mice with pulmonary arterial hypertension, kisspeptin‑10 reduced thickening of the right side of the heart.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseRight ventricular hypertrophy
    Study

    mousen: not reported in source

    SU5416/hypoxia mouse model of pulmonary arterial hypertension
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The administration of kisspeptin-10 resulted in a considerable reduction in the systolic pressure of the right ventricle, as well as in the level of right ventricular hypertrophy
    1 context sentence
    Summary · context
    Here we show that Kisspeptin-10, acting via its receptor GPR54, markedly attenuates PAH in the SU5416/hypoxia mouse model.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In the SU5416/hypoxia mouse model of PAH, kisspeptin‑10 reduced pulmonary vascular remodeling.

    In plain wordsIn mice with pulmonary arterial hypertension, kisspeptin‑10 reduced structural change in lung blood vessels.

    Peptide
    Kisspeptin-10
    Outcome
    DecreasePulmonary vascular remodeling
    Study

    mousen: not reported in source

    SU5416/hypoxia mouse model of pulmonary arterial hypertension
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The administration of kisspeptin-10 resulted in a considerable reduction in the systolic pressure of the right ventricle, as well as in the level of right ventricular hypertrophy and pulmonary vascular remodeling
    1 context sentence
    Summary · context
    Here we show that Kisspeptin-10, acting via its receptor GPR54, markedly attenuates PAH in the SU5416/hypoxia mouse model.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In hypoxic PASMCs and PAH lungs, kisspeptin‑10 restored mitochondrial membrane potential.

    In plain wordsIn mice with pulmonary arterial hypertension, kisspeptin‑10 restored the energy-producing state of mitochondria in lung cells.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseMitochondrial membrane potential
    Study

    mousen: not reported in source

    SU5416/hypoxia mouse model of pulmonary arterial hypertension
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Kisspeptin-10 restored mitochondrial membrane potential
    1 context sentence
    Summary · context
    in hypoxic PASMCs and PAH lungs
  5. 05AnimalAnimal study (in vivo)Mechanism

    In hypoxic PASMCs and PAH lungs, kisspeptin‑10 restored ATP production.

    In plain wordsIn mice with pulmonary arterial hypertension, kisspeptin‑10 restored cell energy production in lung tissue.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseATP production
    Study

    mousen: not reported in source

    SU5416/hypoxia mouse model of pulmonary arterial hypertension
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    ATP production, and cytochrome c oxidase activity in hypoxic PASMCs and PAH lungs
  6. 06AnimalAnimal study (in vivo)Mechanism

    In hypoxic PASMCs and PAH lungs, kisspeptin‑10 restored cytochrome c oxidase activity.

    In plain wordsIn mice with pulmonary arterial hypertension, kisspeptin‑10 restored a key mitochondrial enzyme activity in lung tissue.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseCytochrome c oxidase activity
    Study

    mousen: not reported in source

    SU5416/hypoxia mouse model of pulmonary arterial hypertension
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    cytochrome c oxidase activity in hypoxic PASMCs and PAH lungs
  7. 07AnimalAnimal study (in vivo)Mechanism

    In hypoxic PASMCs and PAH lungs, kisspeptin‑10 normalized excessive accumulation of the mitophagy protein PINK1.

    In plain wordsIn mice with pulmonary arterial hypertension, kisspeptin‑10 brought a mitochondrial clean-up protein, PINK1, back toward normal levels.

    Peptide
    Kisspeptin-10
    Outcome
    DecreasePINK1 accumulation
    Study

    mousen: not reported in source

    SU5416/hypoxia mouse model of pulmonary arterial hypertension
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    while normalizing excessive accumulation of the mitophagy proteins PINK1, Parkin, and FUNDC1
  8. 08AnimalAnimal study (in vivo)Mechanism

    In hypoxic PASMCs and PAH lungs, kisspeptin‑10 normalized excessive accumulation of the mitophagy protein Parkin.

    In plain wordsIn mice with pulmonary arterial hypertension, kisspeptin‑10 brought a mitochondrial clean-up protein, Parkin, back toward normal levels.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseParkin accumulation
    Study

    mousen: not reported in source

    SU5416/hypoxia mouse model of pulmonary arterial hypertension
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    while normalizing excessive accumulation of the mitophagy proteins PINK1, Parkin, and FUNDC1
  9. 09AnimalAnimal study (in vivo)Mechanism

    In hypoxic PASMCs and PAH lungs, kisspeptin‑10 normalized excessive accumulation of the mitophagy protein FUNDC1.

    In plain wordsIn mice with pulmonary arterial hypertension, kisspeptin‑10 brought a mitochondrial clean-up protein, FUNDC1, back toward normal levels.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseFUNDC1 accumulation
    Study

    mousen: not reported in source

    SU5416/hypoxia mouse model of pulmonary arterial hypertension
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    while normalizing excessive accumulation of the mitophagy proteins PINK1, Parkin, and FUNDC1
  10. 10LabIn vitro (cells)Efficacy outcome

    In cultured pulmonary artery smooth muscle cells, kisspeptin‑10 directly inhibited hypoxia-induced proliferation.

    In plain wordsIn cells in the lab, kisspeptin‑10 directly slowed the growth of lung artery muscle cells under low oxygen.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseHypoxia-induced PASMC proliferation
    Study

    n: not reported in source

    Pulmonary artery smooth muscle cells (PASMCs)
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro, Kisspeptin-10 directly inhibited hypoxia-induced PASMC proliferation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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