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Study · Animal study (in vivo) · mouse · 2026

14 results

Kisspeptin-10 Promotes Hormone Secretion, Ovarian Follicles Development and Fecundity via PI3K/AKT/ERK Signal Pathway in Mice.

Suocheng W, Linglong X, Jingshuang G, Zhenya G, Yuan C

Molecular reproduction and development1 Apr 2026

PMID41952615 (opens in a new tab)DOI10.1002/mrd.70093 (opens in a new tab)PepBankPUB-41952615
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study14

14 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, KP-10 notably increased the number of secondary follicles versus control.

    In plain wordsIn mice, KP-10 increased the number of developing ovarian follicles compared with controls.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseNumber of secondary follicles
    Study

    mousen = 75

    Comparator
    Control group
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    5-40 μg/gAs given in this study (mouse).

    Source sentences

    Summary
    Additionally, the number of secondary follicles, MTD, MLD, FWT, and the serum concentrations of progesterone and estradiol were notably elevated (p < 0.05).
    2 context sentences
    Summary · context
    For in-vivo tests, 0, 5, 10, 20, 40 μg/g of KP-10 were injected into 75 mice allocated into control group (CG) and four KP-10 treated groups (including KP-1, KP-2, KP-3, and KP-4 groups).
    Summary · context
    The present study aimed to comprehensively elucidate how KP-10 modulates hormone secretion, the proliferation and autophagy of ovarian follicles by regulating in-vivo and in-vitro levels of associated genes and proteins.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, KP-10 notably increased the maximum transverse diameter of secondary follicles versus control.

    In plain wordsIn mice, KP-10 made developing ovarian follicles wider compared with controls.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseMaximum transverse diameter of secondary follicles
    Study

    mousen = 75

    Comparator
    Control group
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    5-40 μg/gAs given in this study (mouse).

    Source sentences

    Summary
    Additionally, the number of secondary follicles, MTD, MLD, FWT, and the serum concentrations of progesterone and estradiol were notably elevated (p < 0.05).
    2 context sentences
    Summary · context
    Maximum transverse diameter (MTD), maximum longitudinal diameter (MLD) and follicle-wall thickness (FWT) of secondary follicles were measured in days 0, 5, 10, 15, and 25.
    Summary · context
    The present study aimed to comprehensively elucidate how KP-10 modulates hormone secretion, the proliferation and autophagy of ovarian follicles by regulating in-vivo and in-vitro levels of associated genes and proteins.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice, KP-10 notably increased the maximum longitudinal diameter of secondary follicles versus control.

    In plain wordsIn mice, KP-10 made developing ovarian follicles longer compared with controls.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseMaximum longitudinal diameter of secondary follicles
    Study

    mousen = 75

    Comparator
    Control group
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    5-40 μg/gAs given in this study (mouse).

    Source sentences

    Summary
    Additionally, the number of secondary follicles, MTD, MLD, FWT, and the serum concentrations of progesterone and estradiol were notably elevated (p < 0.05).
    2 context sentences
    Summary · context
    Maximum transverse diameter (MTD), maximum longitudinal diameter (MLD) and follicle-wall thickness (FWT) of secondary follicles were measured in days 0, 5, 10, 15, and 25.
    Summary · context
    The present study aimed to comprehensively elucidate how KP-10 modulates hormone secretion, the proliferation and autophagy of ovarian follicles by regulating in-vivo and in-vitro levels of associated genes and proteins.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice, KP-10 notably increased follicle-wall thickness of secondary follicles versus control.

    In plain wordsIn mice, KP-10 thickened the wall of developing ovarian follicles compared with controls.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseFollicle-wall thickness of secondary follicles
    Study

    mousen = 75

    Comparator
    Control group
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    5-40 μg/gAs given in this study (mouse).

    Source sentences

    Summary
    Additionally, the number of secondary follicles, MTD, MLD, FWT, and the serum concentrations of progesterone and estradiol were notably elevated (p < 0.05).
    2 context sentences
    Summary · context
    Maximum transverse diameter (MTD), maximum longitudinal diameter (MLD) and follicle-wall thickness (FWT) of secondary follicles were measured in days 0, 5, 10, 15, and 25.
    Summary · context
    The present study aimed to comprehensively elucidate how KP-10 modulates hormone secretion, the proliferation and autophagy of ovarian follicles by regulating in-vivo and in-vitro levels of associated genes and proteins.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice, KP-10 notably increased serum progesterone versus control.

    In plain wordsIn mice, KP-10 raised blood progesterone compared with controls.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseSerum progesterone
    Study

    mousen = 75

    Comparator
    Control group
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    5-40 μg/gAs given in this study (mouse).

    Source sentences

    Summary
    Additionally, the number of secondary follicles, MTD, MLD, FWT, and the serum concentrations of progesterone and estradiol were notably elevated (p < 0.05).
    2 context sentences
    Summary · context
    For in-vivo tests, 0, 5, 10, 20, 40 μg/g of KP-10 were injected into 75 mice allocated into control group (CG) and four KP-10 treated groups (including KP-1, KP-2, KP-3, and KP-4 groups).
    Summary · context
    The present study aimed to comprehensively elucidate how KP-10 modulates hormone secretion, the proliferation and autophagy of ovarian follicles by regulating in-vivo and in-vitro levels of associated genes and proteins.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice, KP-10 notably increased serum estradiol versus control.

    In plain wordsIn mice, KP-10 raised blood estradiol compared with controls.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseSerum estradiol
    Study

    mousen = 75

    Comparator
    Control group
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    5-40 μg/gAs given in this study (mouse).

    Source sentences

    Summary
    Additionally, the number of secondary follicles, MTD, MLD, FWT, and the serum concentrations of progesterone and estradiol were notably elevated (p < 0.05).
    2 context sentences
    Summary · context
    For in-vivo tests, 0, 5, 10, 20, 40 μg/g of KP-10 were injected into 75 mice allocated into control group (CG) and four KP-10 treated groups (including KP-1, KP-2, KP-3, and KP-4 groups).
    Summary · context
    The present study aimed to comprehensively elucidate how KP-10 modulates hormone secretion, the proliferation and autophagy of ovarian follicles by regulating in-vivo and in-vitro levels of associated genes and proteins.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In mice, KP-10 significantly increased in-vivo PI3K, AKT and ERK mRNA levels versus control.

    In plain wordsIn mice, KP-10 raised the activity of PI3K, AKT and ERK signalling genes compared with controls.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseIn vivo PI3K, AKT and ERK mRNA
    Study

    mousen = 75

    Comparator
    Control group
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    5-40 μg/gAs given in this study (mouse).

    Source sentences

    Summary
    Moreover, the in-vivo levels of PI3K, AKT, ERK mRNAs, as well as StAR and CYP11A1 genes and proteins, were significantly higher than those in CG.
    2 context sentences
    Summary · context
    For in-vivo tests, 0, 5, 10, 20, 40 μg/g of KP-10 were injected into 75 mice allocated into control group (CG) and four KP-10 treated groups (including KP-1, KP-2, KP-3, and KP-4 groups).
    Summary · context
    The present study aimed to comprehensively elucidate how KP-10 modulates hormone secretion, the proliferation and autophagy of ovarian follicles by regulating in-vivo and in-vitro levels of associated genes and proteins.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In mice, KP-10 significantly increased StAR and CYP11A1 genes and proteins versus control.

    In plain wordsIn mice, KP-10 raised genes and proteins that make sex hormones, compared with controls.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseIn vivo StAR and CYP11A1 genes and proteins
    Study

    mousen = 75

    Comparator
    Control group
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    5-40 μg/gAs given in this study (mouse).

    Source sentences

    Summary
    Moreover, the in-vivo levels of PI3K, AKT, ERK mRNAs, as well as StAR and CYP11A1 genes and proteins, were significantly higher than those in CG.
    2 context sentences
    Summary · context
    For in-vivo tests, 0, 5, 10, 20, 40 μg/g of KP-10 were injected into 75 mice allocated into control group (CG) and four KP-10 treated groups (including KP-1, KP-2, KP-3, and KP-4 groups).
    Summary · context
    The present study aimed to comprehensively elucidate how KP-10 modulates hormone secretion, the proliferation and autophagy of ovarian follicles by regulating in-vivo and in-vitro levels of associated genes and proteins.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In mice, the 10 μg/g KP-10 dose had the best efficacy among the doses tested.

    In plain wordsIn mice, 10 μg/g of KP-10 worked best of the doses tested.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableMost effective KP-10 dose
    Study

    mousen = 75

    Comparator
    Other KP-10 doses
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 μg/gAs given in this study (mouse).

    Source sentences

    Summary
    Ten microgram per gram KP-10 had the best efficacy.
    2 context sentences
    Summary · context
    For in-vivo tests, 0, 5, 10, 20, 40 μg/g of KP-10 were injected into 75 mice allocated into control group (CG) and four KP-10 treated groups (including KP-1, KP-2, KP-3, and KP-4 groups).
    Summary · context
    The present study aimed to comprehensively elucidate how KP-10 modulates hormone secretion, the proliferation and autophagy of ovarian follicles by regulating in-vivo and in-vitro levels of associated genes and proteins.
  10. 10LabIn vitro (cells)Efficacy outcome

    In follicular granulosa cells, KP-10 treatment increased proliferation versus control.

    In plain wordsIn ovarian cells in the lab, KP-10 increased cell growth compared with controls.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseFGC proliferation
    Study

    n: not reported in source

    Follicular granulosa cells (FGCs)
    Comparator
    Control group
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The KP-10-treated groups exhibited increased FGCs proliferation, accompanied by decreased apoptosis and autophagy rates as compared with the control group (CG)
    1 context sentence
    Summary · context
    The present study aimed to comprehensively elucidate how KP-10 modulates hormone secretion, the proliferation and autophagy of ovarian follicles by regulating in-vivo and in-vitro levels of associated genes and proteins.
  11. 11LabIn vitro (cells)Efficacy outcome

    In follicular granulosa cells, KP-10 treatment decreased the apoptosis rate versus control.

    In plain wordsIn ovarian cells in the lab, KP-10 reduced cell death compared with controls.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseFGC apoptosis rate
    Study

    n: not reported in source

    Follicular granulosa cells (FGCs)
    Comparator
    Control group
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The KP-10-treated groups exhibited increased FGCs proliferation, accompanied by decreased apoptosis and autophagy rates as compared with the control group (CG)
    1 context sentence
    Summary · context
    The present study aimed to comprehensively elucidate how KP-10 modulates hormone secretion, the proliferation and autophagy of ovarian follicles by regulating in-vivo and in-vitro levels of associated genes and proteins.
  12. 12LabIn vitro (cells)Efficacy outcome

    In follicular granulosa cells, KP-10 treatment decreased the autophagy rate versus control.

    In plain wordsIn ovarian cells in the lab, KP-10 reduced autophagy compared with controls.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseFGC autophagy rate
    Study

    n: not reported in source

    Follicular granulosa cells (FGCs)
    Comparator
    Control group
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The KP-10-treated groups exhibited increased FGCs proliferation, accompanied by decreased apoptosis and autophagy rates as compared with the control group (CG)
    1 context sentence
    Summary · context
    The present study aimed to comprehensively elucidate how KP-10 modulates hormone secretion, the proliferation and autophagy of ovarian follicles by regulating in-vivo and in-vitro levels of associated genes and proteins.
  13. 13LabIn vitro (cells)Mechanism

    In follicular granulosa cells, KP-10 significantly increased the expression of KISS1R, Bcl-2, LC3-II, mTOR and p62/Sqstm1 genes and proteins.

    In plain wordsIn ovarian cells in the lab, KP-10 raised the activity of several genes and proteins linked to cell survival and growth.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseKISS1R, Bcl-2, LC3-II, mTOR, p62/Sqstm1 expression in FGCs
    Study

    n: not reported in source

    Follicular granulosa cells (FGCs)
    Comparator
    Control group
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The expression levels of KISS1R, Bcl-2, LC3-II, mTOR, p62/Sqstm1, PI3K, AKT, and ERK genes and proteins in FGCs were significantly enhanced (p < 0.05).
    1 context sentence
    Summary · context
    The present study aimed to comprehensively elucidate how KP-10 modulates hormone secretion, the proliferation and autophagy of ovarian follicles by regulating in-vivo and in-vitro levels of associated genes and proteins.
  14. 14LabIn vitro (cells)Mechanism

    In follicular granulosa cells, KP-10 significantly increased the expression of PI3K, AKT and ERK genes and proteins.

    In plain wordsIn ovarian cells in the lab, KP-10 raised the activity of the PI3K, AKT and ERK signalling genes and proteins.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePI3K, AKT and ERK expression in FGCs
    Study

    n: not reported in source

    Follicular granulosa cells (FGCs)
    Comparator
    Control group
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The expression levels of KISS1R, Bcl-2, LC3-II, mTOR, p62/Sqstm1, PI3K, AKT, and ERK genes and proteins in FGCs were significantly enhanced (p < 0.05).
    1 context sentence
    Summary · context
    The present study aimed to comprehensively elucidate how KP-10 modulates hormone secretion, the proliferation and autophagy of ovarian follicles by regulating in-vivo and in-vitro levels of associated genes and proteins.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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