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Study · In vitro (cells) · 2026

3 results

Arsenic Promotes Intracellular Aβ(1-42) Accumulation via Enhanced APP but Reduced NEP Expression, and Indirectly Stimulates Extracellular Aβ Aggregation through AChE Induction in Differentiated SH-SY5Y Cells.

Leelaprachakul N, Visitnonthachai D, Niyomchan A, Maliphol K, Watcharasit P, Satayavivad J

Biological trace element research22 Mar 2026

PMID41865200 (opens in a new tab)DOI10.1007/s12011-026-05075-9 (opens in a new tab)PepBankPUB-41865200
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In differentiated SH-SY5Y cells exposed to arsenic, humanin G restored neprilysin.

    In plain wordsIn cells exposed to arsenic, humanin G restored levels of neprilysin, an enzyme that breaks down amyloid-β.

    Peptide
    Humanin
    Outcome
    IncreaseNeprilysin level in arsenic-treated cells
    Study

    humann: not reported in source

    Differentiated SH-SY5Y neuroblastoma cells
    Comparator
    Arsenic alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, Aβ(1-42) detection by immunogold transmission electron microscopy revealed that NEP restoration by humanin G (HNG) reduced arsenic-induced intracellular Aβ(1-42).
    1 context sentence
    Summary · context
    This study investigated the effects of arsenic on amyloid-β (Aβ), a peptide linked to AD pathogenesis, in differentiated SH-SY5Y neuroblastoma cells.
  2. 02LabIn vitro (cells)Mechanism

    In differentiated SH-SY5Y cells exposed to arsenic, humanin G reduced intracellular Aβ(1-42) accumulation.

    In plain wordsIn cells exposed to arsenic, humanin G reduced the amyloid-β that built up inside cells.

    Peptide
    Humanin
    Outcome
    DecreaseArsenic-induced intracellular Abeta(1-42)
    Study

    humann: not reported in source

    Differentiated SH-SY5Y neuroblastoma cells
    Comparator
    Arsenic alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, Aβ(1-42) detection by immunogold transmission electron microscopy revealed that NEP restoration by humanin G (HNG) reduced arsenic-induced intracellular Aβ(1-42).
    1 context sentence
    Summary · context
    This study investigated the effects of arsenic on amyloid-β (Aβ), a peptide linked to AD pathogenesis, in differentiated SH-SY5Y neuroblastoma cells.
  3. 03LabIn vitro (cells)Mechanism

    In differentiated SH-SY5Y cells exposed to arsenic, humanin G attenuated extracellular Aβ aggregation.

    In plain wordsIn cells exposed to arsenic, humanin G added to arsenic-exposed cells reduced clumping of amyloid-β outside cells.

    Peptide
    Humanin
    Outcome
    DecreaseArsenic-induced extracellular Abeta aggregation
    Study

    humann: not reported in source

    Differentiated SH-SY5Y neuroblastoma cells
    Comparator
    Arsenic alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Co-treatment with HNG, which reportedly prevented AChE-promoted Aβ aggregation, attenuated Aβ aggregation by arsenic.
    1 context sentence
    Summary · context
    This study investigated the effects of arsenic on amyloid-β (Aβ), a peptide linked to AD pathogenesis, in differentiated SH-SY5Y neuroblastoma cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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