Postinjury Carnosine Treatment Prevents Neurotrophic Factor Decline in Denervated Muscle and Spinal Cord After Traumatic Injury.

Kucharova K, Kuruc T, Magurova M, Ihnatova L, Ileninova M, Kisucka A, Galik J, Lukacova N

The European journal of neuroscience1 Mar 2026

PMID41853954DOI10.1111/ejn.70461PepBankPUB-41853954

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with spinal cord injury, postinjury carnosine produced better locomotor recovery than preinjury treatment.
In plain wordsIn rats with spinal cord injury, carnosine after injury improved movement recovery more than treatment before injury.
Peptide
L-carnosine
Outcome
IncreaseLocomotor recovery
Study
ratn: not reported in source
Thoracic spinal cord injury
Comparator
Carnosine before injury
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · oral · 6 weeksAs given in this study (rat).
Source sentences
Summary
Six weeks after thoracic SCI, we observed better locomotor recovery in CA-I compared to CB-I treated rats.
2 context sentences(design, population, supporting numbers)
Summary · context
In this study, we investigated whether oral supplementation with antioxidant carnosine, a natural dipeptide, could stimulate endogenous production of these neuroprotective molecules within the neural and muscle microenvironment 6 weeks after SCI.
Summary · context
We assessed the effects of 6-week carnosine treatment in female Zucker rats, administered either before (CB-I) or after injury (CA-I).
Report a problemFND-4185395401
02AnimalAnimal study (in vivo)Mechanism
In injured rats, posttraumatic carnosine prevented reduced hind limb BDNF protein levels.
In plain wordsIn rats with spinal cord injury, carnosine after injury prevented loss of hind limb BDNF protein.
Peptide
L-carnosine
Outcome
IncreaseHind limb BDNF protein
Study
ratn: not reported in source
Thoracic spinal cord injury
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · oral · 6 weeksAs given in this study (rat).
Source sentences
Summary
In the hind limb, posttraumatic carnosine treatment prevented SCI-induced reductions in BDNF and GDNF protein levels.
2 context sentences(design, population, supporting numbers)
Summary · context
In this study, we investigated whether oral supplementation with antioxidant carnosine, a natural dipeptide, could stimulate endogenous production of these neuroprotective molecules within the neural and muscle microenvironment 6 weeks after SCI.
Summary · context
We assessed the effects of 6-week carnosine treatment in female Zucker rats, administered either before (CB-I) or after injury (CA-I).
Report a problemFND-4185395402
03AnimalAnimal study (in vivo)Mechanism
In injured rats, posttraumatic carnosine prevented reduced hind limb GDNF protein levels.
In plain wordsIn rats with spinal cord injury, carnosine after injury prevented loss of hind limb GDNF protein.
Peptide
L-carnosine
Outcome
IncreaseHind limb GDNF protein
Study
ratn: not reported in source
Thoracic spinal cord injury
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · oral · 6 weeksAs given in this study (rat).
Source sentences
Summary
In the hind limb, posttraumatic carnosine treatment prevented SCI-induced reductions in BDNF and GDNF protein levels.
2 context sentences(design, population, supporting numbers)
Summary · context
In this study, we investigated whether oral supplementation with antioxidant carnosine, a natural dipeptide, could stimulate endogenous production of these neuroprotective molecules within the neural and muscle microenvironment 6 weeks after SCI.
Summary · context
We assessed the effects of 6-week carnosine treatment in female Zucker rats, administered either before (CB-I) or after injury (CA-I).
Report a problemFND-4185395403
04AnimalAnimal study (in vivo)Mechanism
In injured rats, postinjury carnosine blocked GDNF protein reductions in lumbar and cervical spinal cord segments.
In plain wordsIn rats with spinal cord injury, carnosine after injury prevented GDNF protein loss in lumbar and cervical spinal cord segments.
Peptide
L-carnosine
Outcome
IncreaseSpinal cord GDNF protein
Study
ratn: not reported in source
Thoracic spinal cord injury
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · oral · 6 weeksAs given in this study (rat).
Source sentences
Summary
Additionally, this treatment blocked the SCI-induced reduction of GDNF protein levels and the oligodendrocyte-specific gene Olig2 in the lumbar and cervical spinal cord segments.
2 context sentences(design, population, supporting numbers)
Summary · context
In this study, we investigated whether oral supplementation with antioxidant carnosine, a natural dipeptide, could stimulate endogenous production of these neuroprotective molecules within the neural and muscle microenvironment 6 weeks after SCI.
Summary · context
We assessed the effects of 6-week carnosine treatment in female Zucker rats, administered either before (CB-I) or after injury (CA-I).
Report a problemFND-4185395404
05AnimalAnimal study (in vivo)Mechanism
In injured rats, postinjury carnosine blocked Olig2 reductions in lumbar and cervical spinal cord segments.
In plain wordsIn rats with spinal cord injury, carnosine after injury prevented Olig2 reductions in lumbar and cervical spinal cord segments.
Peptide
L-carnosine
Outcome
IncreaseSpinal cord Olig2
Study
ratn: not reported in source
Thoracic spinal cord injury
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · oral · 6 weeksAs given in this study (rat).
Source sentences
Summary
Additionally, this treatment blocked the SCI-induced reduction of GDNF protein levels and the oligodendrocyte-specific gene Olig2 in the lumbar and cervical spinal cord segments.
2 context sentences(design, population, supporting numbers)
Summary · context
In this study, we investigated whether oral supplementation with antioxidant carnosine, a natural dipeptide, could stimulate endogenous production of these neuroprotective molecules within the neural and muscle microenvironment 6 weeks after SCI.
Summary · context
We assessed the effects of 6-week carnosine treatment in female Zucker rats, administered either before (CB-I) or after injury (CA-I).
Report a problemFND-4185395405
06AnimalAnimal study (in vivo)Mechanism
In injured rats, postinjury carnosine increased BDNF receptor-specific gene expression in cervical segments.
In plain wordsIn rats with spinal cord injury, carnosine after injury increased BDNF receptor-specific gene expression in cervical segments.
Peptide
L-carnosine
Outcome
IncreaseBDNF receptor-specific gene expression
Study
ratn: not reported in source
Thoracic spinal cord injury
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · oral · 6 weeksAs given in this study (rat).
Source sentences
Summary
Interestingly, the postinjury treatment elevated the gene expression in BDNF receptor- and astrocyte-specific genes in the cervical segments.
2 context sentences(design, population, supporting numbers)
Summary · context
In this study, we investigated whether oral supplementation with antioxidant carnosine, a natural dipeptide, could stimulate endogenous production of these neuroprotective molecules within the neural and muscle microenvironment 6 weeks after SCI.
Summary · context
We assessed the effects of 6-week carnosine treatment in female Zucker rats, administered either before (CB-I) or after injury (CA-I).
Report a problemFND-4185395406
07AnimalAnimal study (in vivo)Mechanism
In injured rats, postinjury carnosine increased astrocyte-specific gene expression in cervical segments.
In plain wordsIn rats with spinal cord injury, carnosine after injury increased astrocyte-specific gene expression in cervical segments.
Peptide
L-carnosine
Outcome
IncreaseAstrocyte-specific gene expression
Study
ratn: not reported in source
Thoracic spinal cord injury
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · oral · 6 weeksAs given in this study (rat).
Source sentences
Summary
Interestingly, the postinjury treatment elevated the gene expression in BDNF receptor- and astrocyte-specific genes in the cervical segments.
2 context sentences(design, population, supporting numbers)
Summary · context
In this study, we investigated whether oral supplementation with antioxidant carnosine, a natural dipeptide, could stimulate endogenous production of these neuroprotective molecules within the neural and muscle microenvironment 6 weeks after SCI.
Summary · context
We assessed the effects of 6-week carnosine treatment in female Zucker rats, administered either before (CB-I) or after injury (CA-I).
Report a problemFND-4185395407

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

Keywords

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