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Study · Observational study · 2026

2 results

Comparison of Semaglutide and Lifestyle Counselling for Weight Loss Using Multi-Site Electronic Health Records.

Powell WJB, Mazzotti DR, Herrmann SD, Davis AM, Mittendorfer B, Bruce J, Song X, Waitman LR

Clinical obesity1 Apr 2026

PMID41830068 (opens in a new tab)DOI10.1111/cob.70076 (opens in a new tab)PepBankPUB-41830068
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanObservational studyEfficacy outcome

    In adults with obesity and no diabetes, semaglutide was associated with a higher hazard of 10% weight loss than lifestyle counselling alone (HR 1.63).

    In plain wordsIn adults with obesity and no diabetes, semaglutide was linked to more 10% weight loss than lifestyle counselling alone.

    Peptide
    Semaglutide
    Outcome
    Increase10% or greater weight loss (time to event)
    Study

    n: not reported in source

    Comparator
    Lifestyle counselling alone
    Analysis
    Primary
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Measurements

    Hazard ratio
    1.63 ratio
    non-diabetic

    Source sentences

    Summary
    Hazard ratios for 10% weight loss were significantly higher from semaglutide for non-diabetic (1.63 [95% CI: 1.32, 2.01; p < 0.001])
    1 context sentence
    Summary · context
    Participants were adults with obesity receiving semaglutide for a minimum of 16 weeks or lifestyle counselling with at least three sessions within the first 16 weeks.
  2. 02HumanObservational studyEfficacy outcome

    In adults with obesity and diabetes, semaglutide was associated with a higher hazard of 10% weight loss than lifestyle counselling alone (HR 2.45).

    In plain wordsIn adults with obesity and diabetes, semaglutide was linked to more 10% weight loss than lifestyle counselling alone.

    Peptide
    Semaglutide
    Outcome
    Increase10% or greater weight loss (time to event)
    Study

    n: not reported in source

    Comparator
    Lifestyle counselling alone
    Analysis
    Primary
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Measurements

    Hazard ratio
    2.45 ratio
    diabetic

    Source sentences

    Summary
    and diabetic (2.45 [95% CI: 1.47, 4.09; p < 0.001]) populations
    1 context sentence
    Summary · context
    Participants were adults with obesity receiving semaglutide for a minimum of 16 weeks or lifestyle counselling with at least three sessions within the first 16 weeks.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:04 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:06 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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