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Study · Animal study (in vivo) · rat · 2026

11 results

[The effect of neuroprotectors on the level of BDNF, tumor necrosis factor alpha and apoptosis markers, and in acute cerebrovascular accidents].

Shchulkin AV, Chernykh IV, Abalenikhina YV, Gatsanoga MV, Kochetkova DL, Kruzhalov NA, Krestinina EV, Yakusheva EN

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova1 Jan 2026

PMID41782540 (opens in a new tab)DOI10.17116/jnevro2026126021123 (opens in a new tab)PepBankPUB-41782540
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats with MCA occlusion-reperfusion, Cerebrolysin increased ischemic hemisphere BDNF, with a less pronounced effect than Mexidol.

    In plain wordsIn rats with stroke injury, Cerebrolysin increased BDNF, with a smaller effect than Mexidol.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseBDNF level
    Study

    ratn = 10

    male Wistar rat MCA occlusion-reperfusion
    Comparator
    saline control
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    215 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Cerebrolysin had a similar effect, although less pronounced.
    4 context sentences
    Summary · context
    Administration of Mexidol increased the BDNF level in the ischemic hemisphere and reduced the content of Fas, bax, caspase 3, and TNFα.
    Summary · context
    The study was performed on male Wistar rats.
    Summary · context
    Western blotting was used to assess the levels of BDNF, TNFα, and apoptosis markers (Fas, bax, caspase 3) in the ischemic hemisphere.
    Summary · context
    Five animals were included in each group for biochemical studies.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats with MCA occlusion-reperfusion, Cerebrolysin reduced Fas, with a less pronounced effect than Mexidol.

    In plain wordsIn rats with stroke injury, Cerebrolysin reduced Fas, with a smaller effect than Mexidol.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseFas level
    Study

    ratn = 10

    male Wistar rat MCA occlusion-reperfusion
    Comparator
    saline control
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    215 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Cerebrolysin had a similar effect, although less pronounced.
    4 context sentences
    Summary · context
    Administration of Mexidol increased the BDNF level in the ischemic hemisphere and reduced the content of Fas, bax, caspase 3, and TNFα.
    Summary · context
    The study was performed on male Wistar rats.
    Summary · context
    Western blotting was used to assess the levels of BDNF, TNFα, and apoptosis markers (Fas, bax, caspase 3) in the ischemic hemisphere.
    Summary · context
    Five animals were included in each group for biochemical studies.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats with MCA occlusion-reperfusion, Cerebrolysin reduced bax, with a less pronounced effect than Mexidol.

    In plain wordsIn rats with stroke injury, Cerebrolysin reduced bax, with a smaller effect than Mexidol.

    Peptide
    Cerebrolysin
    Outcome
    Decreasebax level
    Study

    ratn = 10

    male Wistar rat MCA occlusion-reperfusion
    Comparator
    saline control
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    215 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Cerebrolysin had a similar effect, although less pronounced.
    4 context sentences
    Summary · context
    Administration of Mexidol increased the BDNF level in the ischemic hemisphere and reduced the content of Fas, bax, caspase 3, and TNFα.
    Summary · context
    The study was performed on male Wistar rats.
    Summary · context
    Western blotting was used to assess the levels of BDNF, TNFα, and apoptosis markers (Fas, bax, caspase 3) in the ischemic hemisphere.
    Summary · context
    Five animals were included in each group for biochemical studies.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats with MCA occlusion-reperfusion, Cerebrolysin reduced caspase 3, with a less pronounced effect than Mexidol.

    In plain wordsIn rats with stroke injury, Cerebrolysin reduced caspase 3, with a smaller effect than Mexidol.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseCaspase 3 level
    Study

    ratn = 10

    male Wistar rat MCA occlusion-reperfusion
    Comparator
    saline control
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    215 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Cerebrolysin had a similar effect, although less pronounced.
    4 context sentences
    Summary · context
    Administration of Mexidol increased the BDNF level in the ischemic hemisphere and reduced the content of Fas, bax, caspase 3, and TNFα.
    Summary · context
    The study was performed on male Wistar rats.
    Summary · context
    Western blotting was used to assess the levels of BDNF, TNFα, and apoptosis markers (Fas, bax, caspase 3) in the ischemic hemisphere.
    Summary · context
    Five animals were included in each group for biochemical studies.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats with MCA occlusion-reperfusion, Cerebrolysin reduced TNFα, with a less pronounced effect than Mexidol.

    In plain wordsIn rats with stroke injury, Cerebrolysin reduced TNFα, with a smaller effect than Mexidol.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseTNFα level
    Study

    ratn = 10

    male Wistar rat MCA occlusion-reperfusion
    Comparator
    saline control
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    215 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Cerebrolysin had a similar effect, although less pronounced.
    4 context sentences
    Summary · context
    Administration of Mexidol increased the BDNF level in the ischemic hemisphere and reduced the content of Fas, bax, caspase 3, and TNFα.
    Summary · context
    The study was performed on male Wistar rats.
    Summary · context
    Western blotting was used to assess the levels of BDNF, TNFα, and apoptosis markers (Fas, bax, caspase 3) in the ischemic hemisphere.
    Summary · context
    Five animals were included in each group for biochemical studies.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats after MCA occlusion-reperfusion, Cortexin did not affect BDNF levels versus control.

    In plain wordsIn rats, Cortexin did not change BDNF levels versus control.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    No significant changeBDNF level
    Study

    ratn = 10

    MCA occlusion-reperfusion
    Comparator
    saline control
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    1 mg/kg · intraperitoneal · single injectionAs given in this study (rat).

    Source sentences

    Summary
    Cortexin did not affect the BDNF level but reduced the content of TNFα, Fas, and bax.
    2 context sentences
    Summary · context
    The study was performed on male Wistar rats.
    Summary · context
    Five animals were included in each group for biochemical studies.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats after MCA occlusion-reperfusion, Cortexin reduced TNF alpha content versus control.

    In plain wordsIn rats, Cortexin reduced brain TNF alpha content versus control.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    DecreaseTNF alpha content
    Study

    ratn = 10

    MCA occlusion-reperfusion
    Comparator
    saline control
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    1 mg/kg · intraperitoneal · single injectionAs given in this study (rat).

    Source sentences

    Summary
    Cortexin did not affect the BDNF level but reduced the content of TNFα, Fas, and bax.
    2 context sentences
    Summary · context
    The study was performed on male Wistar rats.
    Summary · context
    Five animals were included in each group for biochemical studies.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In rats after MCA occlusion-reperfusion, Cortexin reduced Fas content versus control.

    In plain wordsIn rats, Cortexin reduced brain Fas content versus control.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    DecreaseFas content
    Study

    ratn = 10

    MCA occlusion-reperfusion
    Comparator
    saline control
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    1 mg/kg · intraperitoneal · single injectionAs given in this study (rat).

    Source sentences

    Summary
    Cortexin did not affect the BDNF level but reduced the content of TNFα, Fas, and bax.
    2 context sentences
    Summary · context
    The study was performed on male Wistar rats.
    Summary · context
    Five animals were included in each group for biochemical studies.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In rats after MCA occlusion-reperfusion, Cortexin reduced bax content versus control.

    In plain wordsIn rats, Cortexin reduced brain bax content versus control.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    Decreasebax content
    Study

    ratn = 10

    MCA occlusion-reperfusion
    Comparator
    saline control
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    1 mg/kg · intraperitoneal · single injectionAs given in this study (rat).

    Source sentences

    Summary
    Cortexin did not affect the BDNF level but reduced the content of TNFα, Fas, and bax.
    2 context sentences
    Summary · context
    The study was performed on male Wistar rats.
    Summary · context
    Five animals were included in each group for biochemical studies.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In rats with MCA occlusion-reperfusion, Cerebrolysin did not significantly reduce necrosis volume compared with saline control.

    In plain wordsIn rats with stroke injury, Cerebrolysin did not significantly reduce tissue death compared with saline control.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeNecrosis volume
    Study

    ratn: not reported in source

    male Wistar rat MCA occlusion-reperfusion
    Comparator
    saline control
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    215 mg/kg · intraperitonealAs given in this study (rat).

    Measurements

    Necrosis volume
    32.57%
    reported result
    P value
    0.176
    reported result

    Source sentences

    Summary
    Cerebrolysin - to 32.57±3.31% (p=0.176)
    3 context sentences
    Summary · context
    In the MCA occlusion-reperfusion model, the necrosis volume in the affected hemisphere of control animals was 38.16±5.98%.
    Summary · context
    The study was performed on male Wistar rats.
    Summary · context
    Western blotting was used to assess the levels of BDNF, TNFα, and apoptosis markers (Fas, bax, caspase 3) in the ischemic hemisphere.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In rats after MCA occlusion-reperfusion, Cortexin did not significantly reduce necrosis volume versus saline.

    In plain wordsIn rats, Cortexin did not significantly reduce brain necrosis versus saline.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    No significant changeNecrosis volume
    Study

    ratn: not reported in source

    MCA occlusion-reperfusion
    Comparator
    saline control
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    1 mg/kg · intraperitoneal · single injectionAs given in this study (rat).

    Measurements

    Necrosis volume
    32.75%
    Cortexin
    P value
    0.198
    versus control

    Source sentences

    Summary
    Cortexin - to 32.75±4.91% (p=0.198).
    1 context sentence
    Summary · context
    The study was performed on male Wistar rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 18:59 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    14 Oct 2026, 05:02 UTC

    Study results updated

  3. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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