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Study · Animal study (in vivo) · golden hamster · 2026

6 results

Hexarelin promotes the survival of retinal ganglion cells after optic nerve transection.

Chow KBS

Indian journal of pharmacology2 Mar 2026

PMID41766237 (opens in a new tab)PMCIDPMC13004568 (opens in a new tab)DOI10.4103/ijp.ijp_176_24 (opens in a new tab)PepBankPUB-41766237
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In hamsters with optic nerve transection, single daily doses of hexarelin increased retinal ganglion cell survival dose dependently.

    In plain wordsIn hamsters with a cut optic nerve, daily hexarelin increased survival of retinal ganglion cells, more so at higher doses than saline.

    Peptide
    Hexarelin
    Outcome
    IncreaseRetinal ganglion cell survival after single daily doses
    Study

    golden hamstern: not reported in source

    Optic nerve transection
    Comparator
    Saline
    Outcome group
    Neuroprotection · Eye
    Studied dose
    25, 50 and 100 μg/kg once daily · 5 days of dosing, 7 days after transectionAs given in this study (golden hamster).

    Source sentences

    Summary
    Single daily doses of 25 μg/kg, 50 μg/kg, and 100 μg/kg hexarelin dose dependently and significantly increased the survival of RGC.
    2 context sentences
    Summary · context
    For 7 days following ONT with one dose of drug, hamsters were injected with single dose of saline, 25 μg/kg, 50 μg/kg, and 100 μg/kg hexarelin daily for 5 days.
    Summary · context
    Golden hamsters of 8-9 weeks old were used.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In hamsters with optic nerve transection, 25 μg/kg hexarelin once daily gave 62.4% retinal ganglion cell survival at 7 days, against 51.2% with saline.

    In plain wordsIn hamsters with a cut optic nerve, 25 μg/kg hexarelin daily kept more retinal ganglion cells alive than saline.

    Peptide
    Hexarelin
    Outcome
    IncreaseRetinal ganglion cell survival at 25 μg/kg once daily
    Study

    golden hamstern: not reported in source

    Optic nerve transection
    Comparator
    Saline
    Outcome group
    Neuroprotection · Eye
    Studied dose
    25 μg/kg once daily · 5 days of dosing, 7 days after transectionAs given in this study (golden hamster).

    Measurements

    RGC survival rate
    62.4%
    hexarelin 25 μg/kg once daily
    RGC survival rate
    51.2%
    saline

    Source sentences

    Summary
    The survival rates of RGC in saline, 25 μg/kg, 50 μg/kg, and 100 μg/kg hexarelin-treated hamsters were 51.2%, 62.4%, 68.5%, and 74.6%, respectively, in 7 days ONT.
    2 context sentences
    Summary · context
    For 7 days following ONT with one dose of drug, hamsters were injected with single dose of saline, 25 μg/kg, 50 μg/kg, and 100 μg/kg hexarelin daily for 5 days.
    Summary · context
    Golden hamsters of 8-9 weeks old were used.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In hamsters with optic nerve transection, 50 μg/kg hexarelin once daily gave 68.5% retinal ganglion cell survival at 7 days, against 51.2% with saline.

    In plain wordsIn hamsters with a cut optic nerve, 50 μg/kg hexarelin daily kept more retinal ganglion cells alive than saline.

    Peptide
    Hexarelin
    Outcome
    IncreaseRetinal ganglion cell survival at 50 μg/kg once daily
    Study

    golden hamstern: not reported in source

    Optic nerve transection
    Comparator
    Saline
    Outcome group
    Neuroprotection · Eye
    Studied dose
    50 μg/kg once daily · 5 days of dosing, 7 days after transectionAs given in this study (golden hamster).

    Measurements

    RGC survival rate
    68.5%
    hexarelin 50 μg/kg once daily
    RGC survival rate
    51.2%
    saline

    Source sentences

    Summary
    The survival rates of RGC in saline, 25 μg/kg, 50 μg/kg, and 100 μg/kg hexarelin-treated hamsters were 51.2%, 62.4%, 68.5%, and 74.6%, respectively, in 7 days ONT.
    2 context sentences
    Summary · context
    For 7 days following ONT with one dose of drug, hamsters were injected with single dose of saline, 25 μg/kg, 50 μg/kg, and 100 μg/kg hexarelin daily for 5 days.
    Summary · context
    Golden hamsters of 8-9 weeks old were used.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In hamsters with optic nerve transection, 100 μg/kg hexarelin once daily gave 74.6% retinal ganglion cell survival at 7 days, against 51.2% with saline.

    In plain wordsIn hamsters with a cut optic nerve, 100 μg/kg hexarelin daily kept more retinal ganglion cells alive than saline.

    Peptide
    Hexarelin
    Outcome
    IncreaseRetinal ganglion cell survival at 100 μg/kg once daily
    Study

    golden hamstern: not reported in source

    Optic nerve transection
    Comparator
    Saline
    Outcome group
    Neuroprotection · Eye
    Studied dose
    100 μg/kg once daily · 5 days of dosing, 7 days after transectionAs given in this study (golden hamster).

    Measurements

    RGC survival rate
    74.6%
    hexarelin 100 μg/kg once daily
    RGC survival rate
    51.2%
    saline

    Source sentences

    Summary
    The survival rates of RGC in saline, 25 μg/kg, 50 μg/kg, and 100 μg/kg hexarelin-treated hamsters were 51.2%, 62.4%, 68.5%, and 74.6%, respectively, in 7 days ONT.
    2 context sentences
    Summary · context
    For 7 days following ONT with one dose of drug, hamsters were injected with single dose of saline, 25 μg/kg, 50 μg/kg, and 100 μg/kg hexarelin daily for 5 days.
    Summary · context
    Golden hamsters of 8-9 weeks old were used.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In hamsters with optic nerve transection, 100 μg/kg hexarelin twice daily promoted retinal ganglion cell survival to 91.4% at 7 days, against 72.9% with saline.

    In plain wordsIn hamsters with a cut optic nerve, 100 μg/kg hexarelin twice daily kept more retinal ganglion cells alive than saline.

    Peptide
    Hexarelin
    Outcome
    IncreaseRetinal ganglion cell survival at 100 μg/kg twice daily
    Study

    golden hamstern: not reported in source

    Optic nerve transection
    Comparator
    Saline
    Outcome group
    Neuroprotection · Eye
    Studied dose
    100 μg/kg twice daily · 5 days of dosing, 7 days after transectionAs given in this study (golden hamster).

    Measurements

    RGC survival
    91.4%
    hexarelin 100 μg/kg twice daily
    RGC survival
    72.9%
    saline

    Source sentences

    Summary
    Two daily doses of saline, 100 μg/kg and 150 μg/kg hexarelin promoted survivals to 72.9%, 91.4%, and 109.2%, respectively, in 7 days ONT.
    2 context sentences
    Summary · context
    For 7 days after ONT with two doses of drugs, saline, 100 μg/kg and 150 μg/kg hexarelin were injected twice daily for 5 days.
    Summary · context
    Golden hamsters of 8-9 weeks old were used.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In hamsters with optic nerve transection, 150 μg/kg hexarelin twice daily promoted retinal ganglion cell survival to 109.2% at 7 days, against 72.9% with saline.

    In plain wordsIn hamsters with a cut optic nerve, 150 μg/kg hexarelin twice daily kept more retinal ganglion cells alive than saline.

    Peptide
    Hexarelin
    Outcome
    IncreaseRetinal ganglion cell survival at 150 μg/kg twice daily
    Study

    golden hamstern: not reported in source

    Optic nerve transection
    Comparator
    Saline
    Outcome group
    Neuroprotection · Eye
    Studied dose
    150 μg/kg twice daily · 5 days of dosing, 7 days after transectionAs given in this study (golden hamster).

    Measurements

    RGC survival
    109.2%
    hexarelin 150 μg/kg twice daily
    RGC survival
    72.9%
    saline

    Source sentences

    Summary
    Two daily doses of saline, 100 μg/kg and 150 μg/kg hexarelin promoted survivals to 72.9%, 91.4%, and 109.2%, respectively, in 7 days ONT.
    2 context sentences
    Summary · context
    For 7 days after ONT with two doses of drugs, saline, 100 μg/kg and 150 μg/kg hexarelin were injected twice daily for 5 days.
    Summary · context
    Golden hamsters of 8-9 weeks old were used.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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