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Study · Non-randomized trial · n = 46 · 2026

19 results

Effect of Calorie Restricted Diet Versus Liraglutide on Intrapancreatic Fat Deposition in People With Obesity: A Pilot Study.

Cheng H, Jiang X, Zhu X, Zhu X, Li C, Cao M, Zhou Q, Deng S, Wu W

Obesity (Silver Spring, Md.)24 Feb 2026Cited by 1 (Europe PMC)

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study19

7 results from studies that gave the peptide. 7 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In people with obesity, liraglutide and calorie restriction had no significant between-group interaction for pancreatic fat fraction (interaction p = 0.560).

    In plain wordsIn people with obesity, liraglutide and calorie restriction did not differ significantly for pancreatic fat.

    Outcome
    No significant changePancreatic fat fraction
    Study

    n = 46

    Comparator
    Calorie restricted diet
    Analysis
    Primary
    Outcome group
    Body composition · Metabolic and weight
    Studied dose
    Dose not stated · 24 weeksAs given in this study (human).

    Source sentences

    Summary
    Both CRD (n = 23) and liraglutide (n = 23) demonstrated significant and comparable reductions in PFF (time effect: p < 0.001; interaction effect: p = 0.560).
    3 context sentences
    Summary · context
    In this 24-week prospective nonrandomized study, participants with obesity received CRD or liraglutide.
    Summary · context
    Primary endpoint was the change in pancreatic fat fraction (PFF).
    Summary · context
    Secondary endpoints included changes in body weight, liver fat fraction (LFF), visceral fat area (VFA), and glycemic-related parameters.
  2. 02HumanNon-randomized trialEfficacy outcome

    In people with obesity, liraglutide and calorie restriction had no significant between-group interaction for body weight (interaction p > 0.05).

    In plain wordsIn people with obesity, liraglutide and calorie restriction did not differ significantly for body weight.

    Outcome
    No significant changeBody weight
    Study

    n = 46

    Comparator
    Calorie restricted diet
    Analysis
    Secondary
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · 24 weeksAs given in this study (human).

    Source sentences

    Summary
    Significant and similar improvements were also observed in body weight, LFF, VFA, HbA1c, HOMA2-IR, and ISIM (all time effects: p  0.05).
    4 context sentences
    Summary · context
    In this 24-week prospective nonrandomized study, participants with obesity received CRD or liraglutide.
    Summary · context
    Primary endpoint was the change in pancreatic fat fraction (PFF).
    Summary · context
    Secondary endpoints included changes in body weight, liver fat fraction (LFF), visceral fat area (VFA), and glycemic-related parameters.
    Summary · context
    Both CRD (n = 23) and liraglutide (n = 23) demonstrated significant and comparable reductions in PFF (time effect: p < 0.001; interaction effect: p = 0.560).
  3. 03HumanNon-randomized trialEfficacy outcome

    In people with obesity, liraglutide and calorie restriction had no significant between-group interaction for liver fat fraction (interaction p > 0.05).

    In plain wordsIn people with obesity, liraglutide and calorie restriction did not differ significantly for liver fat.

    Outcome
    No significant changeLiver fat fraction
    Study

    n = 46

    Comparator
    Calorie restricted diet
    Analysis
    Secondary
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated · 24 weeksAs given in this study (human).

    Source sentences

    Summary
    Significant and similar improvements were also observed in body weight, LFF, VFA, HbA1c, HOMA2-IR, and ISIM (all time effects: p  0.05).
    4 context sentences
    Summary · context
    In this 24-week prospective nonrandomized study, participants with obesity received CRD or liraglutide.
    Summary · context
    Primary endpoint was the change in pancreatic fat fraction (PFF).
    Summary · context
    Secondary endpoints included changes in body weight, liver fat fraction (LFF), visceral fat area (VFA), and glycemic-related parameters.
    Summary · context
    Both CRD (n = 23) and liraglutide (n = 23) demonstrated significant and comparable reductions in PFF (time effect: p < 0.001; interaction effect: p = 0.560).
  4. 04HumanNon-randomized trialEfficacy outcome

    In people with obesity, liraglutide and calorie restriction had no significant between-group interaction for visceral fat area (interaction p > 0.05).

    In plain wordsIn people with obesity, liraglutide and calorie restriction did not differ significantly for visceral fat.

    Outcome
    No significant changeVisceral fat area
    Study

    n = 46

    Comparator
    Calorie restricted diet
    Analysis
    Secondary
    Outcome group
    Body composition · Metabolic and weight
    Studied dose
    Dose not stated · 24 weeksAs given in this study (human).

    Source sentences

    Summary
    Significant and similar improvements were also observed in body weight, LFF, VFA, HbA1c, HOMA2-IR, and ISIM (all time effects: p  0.05).
    4 context sentences
    Summary · context
    In this 24-week prospective nonrandomized study, participants with obesity received CRD or liraglutide.
    Summary · context
    Primary endpoint was the change in pancreatic fat fraction (PFF).
    Summary · context
    Secondary endpoints included changes in body weight, liver fat fraction (LFF), visceral fat area (VFA), and glycemic-related parameters.
    Summary · context
    Both CRD (n = 23) and liraglutide (n = 23) demonstrated significant and comparable reductions in PFF (time effect: p < 0.001; interaction effect: p = 0.560).
  5. 05HumanNon-randomized trialEfficacy outcome

    In people with obesity, liraglutide and calorie restriction had no significant between-group interaction for HbA1c (interaction p > 0.05).

    In plain wordsIn people with obesity, liraglutide and calorie restriction did not differ significantly for HbA1c.

    Outcome
    No significant changeHbA1c
    Study

    n = 46

    Comparator
    Calorie restricted diet
    Analysis
    Secondary
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · 24 weeksAs given in this study (human).

    Source sentences

    Summary
    Significant and similar improvements were also observed in body weight, LFF, VFA, HbA1c, HOMA2-IR, and ISIM (all time effects: p  0.05).
    4 context sentences
    Summary · context
    In this 24-week prospective nonrandomized study, participants with obesity received CRD or liraglutide.
    Summary · context
    Primary endpoint was the change in pancreatic fat fraction (PFF).
    Summary · context
    Secondary endpoints included changes in body weight, liver fat fraction (LFF), visceral fat area (VFA), and glycemic-related parameters.
    Summary · context
    Both CRD (n = 23) and liraglutide (n = 23) demonstrated significant and comparable reductions in PFF (time effect: p < 0.001; interaction effect: p = 0.560).
  6. 06HumanNon-randomized trialEfficacy outcome

    In people with obesity, liraglutide and calorie restriction had no significant between-group interaction for HOMA2-IR (interaction p > 0.05).

    In plain wordsIn people with obesity, liraglutide and calorie restriction did not differ significantly for HOMA2-IR.

    Outcome
    No significant changeHOMA2-IR
    Study

    n = 46

    Comparator
    Calorie restricted diet
    Analysis
    Secondary
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · 24 weeksAs given in this study (human).

    Source sentences

    Summary
    Significant and similar improvements were also observed in body weight, LFF, VFA, HbA1c, HOMA2-IR, and ISIM (all time effects: p  0.05).
    4 context sentences
    Summary · context
    In this 24-week prospective nonrandomized study, participants with obesity received CRD or liraglutide.
    Summary · context
    Primary endpoint was the change in pancreatic fat fraction (PFF).
    Summary · context
    Secondary endpoints included changes in body weight, liver fat fraction (LFF), visceral fat area (VFA), and glycemic-related parameters.
    Summary · context
    Both CRD (n = 23) and liraglutide (n = 23) demonstrated significant and comparable reductions in PFF (time effect: p < 0.001; interaction effect: p = 0.560).
  7. 07HumanNon-randomized trialEfficacy outcome

    In people with obesity, liraglutide and calorie restriction had no significant between-group interaction for ISIM (interaction p > 0.05).

    In plain wordsIn people with obesity, liraglutide and calorie restriction did not differ significantly for ISIM.

    Outcome
    No significant changeISIM
    Study

    n = 46

    Comparator
    Calorie restricted diet
    Analysis
    Secondary
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · 24 weeksAs given in this study (human).

    Source sentences

    Summary
    Significant and similar improvements were also observed in body weight, LFF, VFA, HbA1c, HOMA2-IR, and ISIM (all time effects: p  0.05).
    4 context sentences
    Summary · context
    In this 24-week prospective nonrandomized study, participants with obesity received CRD or liraglutide.
    Summary · context
    Primary endpoint was the change in pancreatic fat fraction (PFF).
    Summary · context
    Secondary endpoints included changes in body weight, liver fat fraction (LFF), visceral fat area (VFA), and glycemic-related parameters.
    Summary · context
    Both CRD (n = 23) and liraglutide (n = 23) demonstrated significant and comparable reductions in PFF (time effect: p < 0.001; interaction effect: p = 0.560).

Studies that did not test the peptide alone12

In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Liraglutide.

  1. 08HumanNot a test of Liraglutide aloneNon-randomized trialEfficacy outcome

    In people with obesity, pancreatic fat fraction significantly decreased over time across both calorie-restriction and liraglutide groups (time p < 0.001).

    In plain wordsIn people with obesity, pancreatic fat fraction decreased over time across both calorie-restriction and liraglutide groups.

    Outcome
    DecreasePancreatic fat fraction
    Study

    n = 46

    Analysis
    Primary
    Outcome group
    Body composition · Metabolic and weight

    Source sentences

    Summary
    Both CRD (n = 23) and liraglutide (n = 23) demonstrated significant and comparable reductions in PFF (time effect: p < 0.001; interaction effect: p = 0.560).
    3 context sentences
    Summary · context
    In this 24-week prospective nonrandomized study, participants with obesity received CRD or liraglutide.
    Summary · context
    Primary endpoint was the change in pancreatic fat fraction (PFF).
    Summary · context
    Secondary endpoints included changes in body weight, liver fat fraction (LFF), visceral fat area (VFA), and glycemic-related parameters.

    In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.

  2. 09HumanNot a test of Liraglutide aloneNon-randomized trialEfficacy outcome

    In people with obesity, body weight significantly improved over time across both calorie-restriction and liraglutide groups (time p < 0.001).

    In plain wordsIn people with obesity, body weight improved over time across both calorie-restriction and liraglutide groups.

    Outcome
    Direction not reportedBody weight
    Study

    n = 46

    Analysis
    Secondary
    Outcome group
    Body weight · Metabolic and weight

    Source sentences

    Summary
    Significant and similar improvements were also observed in body weight, LFF, VFA, HbA1c, HOMA2-IR, and ISIM (all time effects: p  0.05).
    4 context sentences
    Summary · context
    In this 24-week prospective nonrandomized study, participants with obesity received CRD or liraglutide.
    Summary · context
    Primary endpoint was the change in pancreatic fat fraction (PFF).
    Summary · context
    Secondary endpoints included changes in body weight, liver fat fraction (LFF), visceral fat area (VFA), and glycemic-related parameters.
    Summary · context
    Both CRD (n = 23) and liraglutide (n = 23) demonstrated significant and comparable reductions in PFF (time effect: p < 0.001; interaction effect: p = 0.560).

    In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.

  3. 10HumanNot a test of Liraglutide aloneNon-randomized trialEfficacy outcome

    In people with obesity, liver fat fraction significantly improved over time across both calorie-restriction and liraglutide groups (time p < 0.001).

    In plain wordsIn people with obesity, liver fat fraction improved over time across both calorie-restriction and liraglutide groups.

    Outcome
    Direction not reportedLiver fat fraction
    Study

    n = 46

    Analysis
    Secondary
    Outcome group
    Liver fat and liver function · Liver

    Source sentences

    Summary
    Significant and similar improvements were also observed in body weight, LFF, VFA, HbA1c, HOMA2-IR, and ISIM (all time effects: p  0.05).
    4 context sentences
    Summary · context
    In this 24-week prospective nonrandomized study, participants with obesity received CRD or liraglutide.
    Summary · context
    Primary endpoint was the change in pancreatic fat fraction (PFF).
    Summary · context
    Secondary endpoints included changes in body weight, liver fat fraction (LFF), visceral fat area (VFA), and glycemic-related parameters.
    Summary · context
    Both CRD (n = 23) and liraglutide (n = 23) demonstrated significant and comparable reductions in PFF (time effect: p < 0.001; interaction effect: p = 0.560).

    In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.

  4. 11HumanNot a test of Liraglutide aloneNon-randomized trialEfficacy outcome

    In people with obesity, visceral fat area significantly improved over time across both calorie-restriction and liraglutide groups (time p < 0.001).

    In plain wordsIn people with obesity, visceral fat area improved over time across both calorie-restriction and liraglutide groups.

    Outcome
    Direction not reportedVisceral fat area
    Study

    n = 46

    Analysis
    Secondary
    Outcome group
    Body composition · Metabolic and weight

    Source sentences

    Summary
    Significant and similar improvements were also observed in body weight, LFF, VFA, HbA1c, HOMA2-IR, and ISIM (all time effects: p  0.05).
    4 context sentences
    Summary · context
    In this 24-week prospective nonrandomized study, participants with obesity received CRD or liraglutide.
    Summary · context
    Primary endpoint was the change in pancreatic fat fraction (PFF).
    Summary · context
    Secondary endpoints included changes in body weight, liver fat fraction (LFF), visceral fat area (VFA), and glycemic-related parameters.
    Summary · context
    Both CRD (n = 23) and liraglutide (n = 23) demonstrated significant and comparable reductions in PFF (time effect: p < 0.001; interaction effect: p = 0.560).

    In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.

  5. 12HumanNot a test of Liraglutide aloneNon-randomized trialEfficacy outcome

    In people with obesity, HbA1c significantly improved over time across both calorie-restriction and liraglutide groups (time p < 0.001).

    In plain wordsIn people with obesity, HbA1c improved over time across both calorie-restriction and liraglutide groups.

    Outcome
    Direction not reportedHbA1c
    Study

    n = 46

    Analysis
    Secondary
    Outcome group
    Glycemic control · Metabolic and weight

    Source sentences

    Summary
    Significant and similar improvements were also observed in body weight, LFF, VFA, HbA1c, HOMA2-IR, and ISIM (all time effects: p  0.05).
    4 context sentences
    Summary · context
    In this 24-week prospective nonrandomized study, participants with obesity received CRD or liraglutide.
    Summary · context
    Primary endpoint was the change in pancreatic fat fraction (PFF).
    Summary · context
    Secondary endpoints included changes in body weight, liver fat fraction (LFF), visceral fat area (VFA), and glycemic-related parameters.
    Summary · context
    Both CRD (n = 23) and liraglutide (n = 23) demonstrated significant and comparable reductions in PFF (time effect: p < 0.001; interaction effect: p = 0.560).

    In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.

  6. 13HumanNot a test of Liraglutide aloneNon-randomized trialEfficacy outcome

    In people with obesity, HOMA2-IR significantly improved over time across both calorie-restriction and liraglutide groups (time p < 0.001).

    In plain wordsIn people with obesity, HOMA2-IR improved over time across both calorie-restriction and liraglutide groups.

    Outcome
    Direction not reportedHOMA2-IR
    Study

    n = 46

    Analysis
    Secondary
    Outcome group
    Glycemic control · Metabolic and weight

    Source sentences

    Summary
    Significant and similar improvements were also observed in body weight, LFF, VFA, HbA1c, HOMA2-IR, and ISIM (all time effects: p  0.05).
    4 context sentences
    Summary · context
    In this 24-week prospective nonrandomized study, participants with obesity received CRD or liraglutide.
    Summary · context
    Primary endpoint was the change in pancreatic fat fraction (PFF).
    Summary · context
    Secondary endpoints included changes in body weight, liver fat fraction (LFF), visceral fat area (VFA), and glycemic-related parameters.
    Summary · context
    Both CRD (n = 23) and liraglutide (n = 23) demonstrated significant and comparable reductions in PFF (time effect: p < 0.001; interaction effect: p = 0.560).

    In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.

  7. 14HumanNot a test of Liraglutide aloneNon-randomized trialEfficacy outcome

    In people with obesity, ISIM significantly improved over time across both calorie-restriction and liraglutide groups (time p < 0.001).

    In plain wordsIn people with obesity, ISIM improved over time across both calorie-restriction and liraglutide groups.

    Outcome
    Direction not reportedISIM
    Study

    n = 46

    Analysis
    Secondary
    Outcome group
    Glycemic control · Metabolic and weight

    Source sentences

    Summary
    Significant and similar improvements were also observed in body weight, LFF, VFA, HbA1c, HOMA2-IR, and ISIM (all time effects: p  0.05).
    4 context sentences
    Summary · context
    In this 24-week prospective nonrandomized study, participants with obesity received CRD or liraglutide.
    Summary · context
    Primary endpoint was the change in pancreatic fat fraction (PFF).
    Summary · context
    Secondary endpoints included changes in body weight, liver fat fraction (LFF), visceral fat area (VFA), and glycemic-related parameters.
    Summary · context
    Both CRD (n = 23) and liraglutide (n = 23) demonstrated significant and comparable reductions in PFF (time effect: p < 0.001; interaction effect: p = 0.560).

    In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.

  8. 15HumanNot a test of Liraglutide aloneNon-randomized trialOther

    In the combined obesity cohort, change in HOMA2-IR was positively associated with change in body weight.

    In plain wordsAcross calorie-restriction and liraglutide groups in people with obesity, HOMA2-IR changes were positively linked to body-weight changes.

    Outcome
    IncreaseAssociation of change in HOMA2-IR and body weight
    Study

    n = 46

    Outcome group
    Glycemic control · Metabolic and weight

    Source sentences

    Summary
    Regression analysis indicated that ΔHOMA2-IR was positively associated with Δweight and ΔLFF but negatively with ΔPFF, while ΔISIM was negatively associated with ΔVFA and positively with ΔPFF.
    2 context sentences
    Summary · context
    In this 24-week prospective nonrandomized study, participants with obesity received CRD or liraglutide.
    Summary · context
    Both CRD (n = 23) and liraglutide (n = 23) demonstrated significant and comparable reductions in PFF (time effect: p < 0.001; interaction effect: p = 0.560).

    In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.

  9. 16HumanNot a test of Liraglutide aloneNon-randomized trialOther

    In the combined obesity cohort, change in HOMA2-IR was positively associated with change in liver fat fraction.

    In plain wordsAcross calorie-restriction and liraglutide groups in people with obesity, HOMA2-IR changes were positively linked to liver-fat changes.

    Outcome
    IncreaseAssociation of change in HOMA2-IR and liver fat fraction
    Study

    n = 46

    Outcome group
    Glycemic control · Metabolic and weight

    Source sentences

    Summary
    Regression analysis indicated that ΔHOMA2-IR was positively associated with Δweight and ΔLFF but negatively with ΔPFF, while ΔISIM was negatively associated with ΔVFA and positively with ΔPFF.
    2 context sentences
    Summary · context
    In this 24-week prospective nonrandomized study, participants with obesity received CRD or liraglutide.
    Summary · context
    Both CRD (n = 23) and liraglutide (n = 23) demonstrated significant and comparable reductions in PFF (time effect: p < 0.001; interaction effect: p = 0.560).

    In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.

  10. 17HumanNot a test of Liraglutide aloneNon-randomized trialOther

    In the combined obesity cohort, change in HOMA2-IR was negatively associated with change in pancreatic fat fraction.

    In plain wordsAcross calorie-restriction and liraglutide groups in people with obesity, HOMA2-IR changes were inversely linked to pancreatic-fat changes.

    Outcome
    DecreaseAssociation of change in HOMA2-IR and pancreatic fat fraction
    Study

    n = 46

    Outcome group
    Glycemic control · Metabolic and weight

    Source sentences

    Summary
    Regression analysis indicated that ΔHOMA2-IR was positively associated with Δweight and ΔLFF but negatively with ΔPFF, while ΔISIM was negatively associated with ΔVFA and positively with ΔPFF.
    2 context sentences
    Summary · context
    In this 24-week prospective nonrandomized study, participants with obesity received CRD or liraglutide.
    Summary · context
    Both CRD (n = 23) and liraglutide (n = 23) demonstrated significant and comparable reductions in PFF (time effect: p < 0.001; interaction effect: p = 0.560).

    In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.

  11. 18HumanNot a test of Liraglutide aloneNon-randomized trialOther

    In the combined obesity cohort, change in ISIM was negatively associated with change in visceral fat area.

    In plain wordsAcross calorie-restriction and liraglutide groups in people with obesity, ISIM changes were inversely linked to visceral-fat changes.

    Outcome
    DecreaseAssociation of change in ISIM and visceral fat area
    Study

    n = 46

    Outcome group
    Glycemic control · Metabolic and weight

    Source sentences

    Summary
    Regression analysis indicated that ΔHOMA2-IR was positively associated with Δweight and ΔLFF but negatively with ΔPFF, while ΔISIM was negatively associated with ΔVFA and positively with ΔPFF.
    2 context sentences
    Summary · context
    In this 24-week prospective nonrandomized study, participants with obesity received CRD or liraglutide.
    Summary · context
    Both CRD (n = 23) and liraglutide (n = 23) demonstrated significant and comparable reductions in PFF (time effect: p < 0.001; interaction effect: p = 0.560).

    In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.

  12. 19HumanNot a test of Liraglutide aloneNon-randomized trialOther

    In the combined obesity cohort, change in ISIM was positively associated with change in pancreatic fat fraction.

    In plain wordsAcross calorie-restriction and liraglutide groups in people with obesity, ISIM changes were positively linked to pancreatic-fat changes.

    Outcome
    IncreaseAssociation of change in ISIM and pancreatic fat fraction
    Study

    n = 46

    Outcome group
    Glycemic control · Metabolic and weight

    Source sentences

    Summary
    Regression analysis indicated that ΔHOMA2-IR was positively associated with Δweight and ΔLFF but negatively with ΔPFF, while ΔISIM was negatively associated with ΔVFA and positively with ΔPFF.
    2 context sentences
    Summary · context
    In this 24-week prospective nonrandomized study, participants with obesity received CRD or liraglutide.
    Summary · context
    Both CRD (n = 23) and liraglutide (n = 23) demonstrated significant and comparable reductions in PFF (time effect: p < 0.001; interaction effect: p = 0.560).

    In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 11:11 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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