Skip to content

Study · Animal study (in vivo) · mouse · 2026

11 results

NMN prevents obesity-induced osteoporosis by promoting mitophagy to restore type H vessels.

Shen M, Yu X, Wang J, Sun K, Xiong W, Li Y, Zhang Q

Biochemical pharmacology20 Feb 2026

PMID41724284 (opens in a new tab)DOI10.1016/j.bcp.2026.117839 (opens in a new tab)PepBankPUB-41724284
Publisher pagePubMedAsk about this study
Jump to 11 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In obese mice, NMN significantly inhibited high-fat-diet-induced osteoporosis.

    In plain wordsIn obese mice, NMN reduced diet-induced osteoporosis.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseOsteoporosis
    Study

    mousen: not reported in source

    high-fat-diet-induced osteoporosis
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN significantly inhibited HFD-induced osteoporosis by restoring impaired type H vessels in obese mice, thereby enhancing angiogenesis-osteogenesis coupling.
    1 context sentence
    Summary · context
    An obesity-induced osteoporosis mouse model was established using a high-fat diet (HFD).
  2. 02AnimalAnimal study (in vivo)Mechanism

    In obese mice, NMN restored impaired type H vessels.

    In plain wordsIn obese mice, NMN restored specialized bone blood vessels.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    MixedType H vessels
    Study

    mousen: not reported in source

    high-fat-diet-induced osteoporosis
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN significantly inhibited HFD-induced osteoporosis by restoring impaired type H vessels in obese mice, thereby enhancing angiogenesis-osteogenesis coupling.
    1 context sentence
    Summary · context
    An obesity-induced osteoporosis mouse model was established using a high-fat diet (HFD).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In obese mice, NMN enhanced angiogenesis-osteogenesis coupling.

    In plain wordsIn obese mice, NMN improved coordination between blood vessel growth and bone formation.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseAngiogenesis-osteogenesis coupling
    Study

    mousen: not reported in source

    high-fat-diet-induced osteoporosis
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN significantly inhibited HFD-induced osteoporosis by restoring impaired type H vessels in obese mice, thereby enhancing angiogenesis-osteogenesis coupling.
    1 context sentence
    Summary · context
    An obesity-induced osteoporosis mouse model was established using a high-fat diet (HFD).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In obese mice, NMN restored high-fat-diet-impaired mitophagy in type H vessels.

    In plain wordsIn obese mice, NMN restored mitochondrial recycling in specialized bone blood vessels.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseType H vessel mitophagy
    Study

    mousen: not reported in source

    high-fat-diet-induced osteoporosis
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mechanistically, NMN rescued HFD-impaired mitophagy in type H vessels via inhibiting Src activation, and inhibited obesity-induced polyamine accumulation.
    1 context sentence
    Summary · context
    An obesity-induced osteoporosis mouse model was established using a high-fat diet (HFD).
  5. 05AnimalAnimal study (in vivo)Mechanism

    In obese mice, NMN inhibited Src activation in the mechanism restoring type H vessel mitophagy.

    In plain wordsIn obese mice, NMN inhibited Src activation during restoration of mitochondrial recycling in bone blood vessels.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseSrc activation
    Study

    mousen: not reported in source

    high-fat-diet-induced osteoporosis
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mechanistically, NMN rescued HFD-impaired mitophagy in type H vessels via inhibiting Src activation, and inhibited obesity-induced polyamine accumulation.
    1 context sentence
    Summary · context
    An obesity-induced osteoporosis mouse model was established using a high-fat diet (HFD).
  6. 06AnimalAnimal study (in vivo)Mechanism

    In obese mice, NMN inhibited obesity-induced polyamine accumulation.

    In plain wordsIn obese mice, NMN reduced obesity-related polyamine accumulation.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreasePolyamine accumulation
    Study

    mousen: not reported in source

    high-fat-diet-induced osteoporosis
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mechanistically, NMN rescued HFD-impaired mitophagy in type H vessels via inhibiting Src activation, and inhibited obesity-induced polyamine accumulation.
    1 context sentence
    Summary · context
    An obesity-induced osteoporosis mouse model was established using a high-fat diet (HFD).
  7. 07LabIn vitro (cells)Efficacy outcome

    In palmitic-acid-stimulated BMSCs, NMN promoted osteogenic differentiation.

    In plain wordsIn cells exposed to palmitic acid, NMN promoted bone-forming differentiation.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseOsteogenic differentiation
    Study

    n: not reported in source

    palmitic-acid-stimulated primary BMSCs
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro, NMN rescued the PA-induced dysfunction in BMSCs and HUVECs, promoting osteogenic differentiation and migratory capacity, respectively.
    1 context sentence
    Summary · context
    In vitro, primary bone marrow mesenchymal stem cells (BMSCs) and human umbilical vein endothelial cells (HUVECs) were stimulated with palmitic acid (PA) to mimic a high-fat environment.
  8. 08LabIn vitro (cells)Efficacy outcome

    In palmitic-acid-stimulated HUVECs, NMN promoted migratory capacity.

    In plain wordsIn endothelial cells exposed to palmitic acid, NMN promoted cell migration.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseEndothelial migratory capacity
    Study

    humann: not reported in source

    palmitic-acid-stimulated HUVECs
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro, NMN rescued the PA-induced dysfunction in BMSCs and HUVECs, promoting osteogenic differentiation and migratory capacity, respectively.
    1 context sentence
    Summary · context
    In vitro, primary bone marrow mesenchymal stem cells (BMSCs) and human umbilical vein endothelial cells (HUVECs) were stimulated with palmitic acid (PA) to mimic a high-fat environment.
  9. 09LabOther designMechanism

    In experimental mitochondrial assays, NMN restored mitochondrial membrane potential.

    In plain wordsIn lab tests, NMN restored mitochondrial membrane potential.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    MixedMitochondrial membrane potential
    Study

    n: not reported in source

    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This effect was supported by restored mitochondrial membrane potential, enhanced LC3/TOMM20 co-localization, and upregulation of mitophagy-related genes.
    1 context sentence
    Summary · context
    Mechanistically, NMN rescued HFD-impaired mitophagy in type H vessels via inhibiting Src activation, and inhibited obesity-induced polyamine accumulation.
  10. 10LabOther designMechanism

    In experimental mitochondrial assays, NMN enhanced LC3/TOMM20 co-localization.

    In plain wordsIn lab tests, NMN increased co-localization of LC3 and TOMM20.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseLC3/TOMM20 co-localization
    Study

    n: not reported in source

    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This effect was supported by restored mitochondrial membrane potential, enhanced LC3/TOMM20 co-localization, and upregulation of mitophagy-related genes.
    1 context sentence
    Summary · context
    Mechanistically, NMN rescued HFD-impaired mitophagy in type H vessels via inhibiting Src activation, and inhibited obesity-induced polyamine accumulation.
  11. 11LabOther designMechanism

    In experimental mitochondrial assays, NMN upregulated mitophagy-related genes.

    In plain wordsIn lab tests, NMN increased expression of genes for mitochondrial recycling.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseMitophagy-related genes
    Study

    n: not reported in source

    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This effect was supported by restored mitochondrial membrane potential, enhanced LC3/TOMM20 co-localization, and upregulation of mitophagy-related genes.
    1 context sentence
    Summary · context
    Mechanistically, NMN rescued HFD-impaired mitophagy in type H vessels via inhibiting Src activation, and inhibited obesity-induced polyamine accumulation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.