The effect of a serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate and gluconolactone on skin biomarkers, wrinkles and skin texture: Ex vivo and clinical studies.

Zhu M, He X, Zhu Z, Lynch S, Wang H, Zhou X, Tu Y, Steel A, Hsu KC, Niu Y, Cho A, Hashimoto M, Yan X, Su M, Wang W

International journal of cosmetic science11 Feb 2026

PMID41668671PMCIDPMC13636123DOI10.1111/ics.70087PepBankPUB-41668671

Read at source PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study17

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone17

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

01HumanNot a test of Argireline (acetyl hexapeptide-8) aloneNon-randomized trialEfficacy outcome
In clinical study 1, Formula 1 improved static wrinkles within the first week, with scoring improvements of 35% to 69% after 12 weeks.
In plain wordsThe multi-ingredient serum improved static wrinkles from baseline, with scoring improvements of 35% to 69% after 12 weeks.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
IncreaseStatic wrinkle clinical score
Study
n = 50
Outcome group
Skin and hair · Skin and wound
Measurements
Clinical scoring improvement
35 to 69%
static wrinkle types after 12 weeks
Source sentences
Summary
Meanwhile, Formula 1 significantly improved static wrinkle appearance within the first week, with mean clinical scoring from 35% to 69% for various types of wrinkles after 12 weeks of use (all p < 0.001).
2 context sentences(design, population, supporting numbers)
Summary · context
This study aimed to explore the anti-skin aging efficacy of a novel serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate, gluconolactone, niacinamide and laminaria extract through one ex-vivo study and two clinical studies.
Summary · context
In clinical study 1 (n = 50), the Formula 1's efficacy in reducing static wrinkles and improving skin quality was examined, while study 2 (n = 42) focused on its efficacy against dynamic wrinkles.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-4166867102
02HumanNot a test of Argireline (acetyl hexapeptide-8) aloneNon-randomized trialEfficacy outcome
In clinical study 1, Formula 1 improved skin smoothness scores by 30%.
In plain wordsThe multi-ingredient serum improved skin smoothness scores by 30% from baseline.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
IncreaseSmoothness score
Study
n = 50
Outcome group
Skin and hair · Skin and wound
Measurements
Smoothness improvement
30%
Formula 1
Source sentences
Summary
Additionally, significant improvements were observed in skin quality, indicated by clinical scoring changes of smoothness (30%), radiance (27%), skin pore (43%), elasticity (33%) and firmness (36%) (all p < 0.001).
2 context sentences(design, population, supporting numbers)
Summary · context
This study aimed to explore the anti-skin aging efficacy of a novel serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate, gluconolactone, niacinamide and laminaria extract through one ex-vivo study and two clinical studies.
Summary · context
In clinical study 1 (n = 50), the Formula 1's efficacy in reducing static wrinkles and improving skin quality was examined, while study 2 (n = 42) focused on its efficacy against dynamic wrinkles.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-4166867104
03HumanNot a test of Argireline (acetyl hexapeptide-8) aloneNon-randomized trialEfficacy outcome
In clinical study 1, Formula 1 improved radiance scores by 27%.
In plain wordsThe multi-ingredient serum improved skin radiance scores by 27% from baseline.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
IncreaseRadiance score
Study
n = 50
Outcome group
Skin and hair · Skin and wound
Measurements
Radiance improvement
27%
Formula 1
Source sentences
Summary
Additionally, significant improvements were observed in skin quality, indicated by clinical scoring changes of smoothness (30%), radiance (27%), skin pore (43%), elasticity (33%) and firmness (36%) (all p < 0.001).
2 context sentences(design, population, supporting numbers)
Summary · context
This study aimed to explore the anti-skin aging efficacy of a novel serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate, gluconolactone, niacinamide and laminaria extract through one ex-vivo study and two clinical studies.
Summary · context
In clinical study 1 (n = 50), the Formula 1's efficacy in reducing static wrinkles and improving skin quality was examined, while study 2 (n = 42) focused on its efficacy against dynamic wrinkles.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-4166867105
04HumanNot a test of Argireline (acetyl hexapeptide-8) aloneNon-randomized trialEfficacy outcome
In clinical study 1, Formula 1 improved skin pore scores by 43%.
In plain wordsThe multi-ingredient serum improved skin pore scores by 43% from baseline.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
IncreaseSkin pore score
Study
n = 50
Outcome group
Skin and hair · Skin and wound
Measurements
Skin pore score improvement
43%
Formula 1
Source sentences
Summary
Additionally, significant improvements were observed in skin quality, indicated by clinical scoring changes of smoothness (30%), radiance (27%), skin pore (43%), elasticity (33%) and firmness (36%) (all p < 0.001).
2 context sentences(design, population, supporting numbers)
Summary · context
This study aimed to explore the anti-skin aging efficacy of a novel serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate, gluconolactone, niacinamide and laminaria extract through one ex-vivo study and two clinical studies.
Summary · context
In clinical study 1 (n = 50), the Formula 1's efficacy in reducing static wrinkles and improving skin quality was examined, while study 2 (n = 42) focused on its efficacy against dynamic wrinkles.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-4166867106
05HumanNot a test of Argireline (acetyl hexapeptide-8) aloneNon-randomized trialEfficacy outcome
In clinical study 1, Formula 1 improved elasticity scores by 33%.
In plain wordsThe multi-ingredient serum improved skin elasticity scores by 33% from baseline.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
IncreaseElasticity score
Study
n = 50
Outcome group
Skin and hair · Skin and wound
Measurements
Elasticity improvement
33%
Formula 1
Source sentences
Summary
Additionally, significant improvements were observed in skin quality, indicated by clinical scoring changes of smoothness (30%), radiance (27%), skin pore (43%), elasticity (33%) and firmness (36%) (all p < 0.001).
2 context sentences(design, population, supporting numbers)
Summary · context
This study aimed to explore the anti-skin aging efficacy of a novel serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate, gluconolactone, niacinamide and laminaria extract through one ex-vivo study and two clinical studies.
Summary · context
In clinical study 1 (n = 50), the Formula 1's efficacy in reducing static wrinkles and improving skin quality was examined, while study 2 (n = 42) focused on its efficacy against dynamic wrinkles.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-4166867107
06HumanNot a test of Argireline (acetyl hexapeptide-8) aloneNon-randomized trialEfficacy outcome
In clinical study 1, Formula 1 improved firmness scores by 36%.
In plain wordsThe multi-ingredient serum improved skin firmness scores by 36% from baseline.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
IncreaseFirmness score
Study
n = 50
Outcome group
Skin and hair · Skin and wound
Measurements
Firmness improvement
36%
Formula 1
Source sentences
Summary
Additionally, significant improvements were observed in skin quality, indicated by clinical scoring changes of smoothness (30%), radiance (27%), skin pore (43%), elasticity (33%) and firmness (36%) (all p < 0.001).
2 context sentences(design, population, supporting numbers)
Summary · context
This study aimed to explore the anti-skin aging efficacy of a novel serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate, gluconolactone, niacinamide and laminaria extract through one ex-vivo study and two clinical studies.
Summary · context
In clinical study 1 (n = 50), the Formula 1's efficacy in reducing static wrinkles and improving skin quality was examined, while study 2 (n = 42) focused on its efficacy against dynamic wrinkles.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-4166867108
07HumanNot a test of SYN-AKE aloneNon-randomized trialEfficacy outcome
In clinical study 1, Formula 1 significantly improved static wrinkles within the first week, with scoring changes of 35% to 69% after 12 weeks.
In plain wordsThe serum significantly improved static wrinkles within the first week, with scoring changes of 35% to 69% after 12 weeks.
Peptide
SYN-AKE
Outcome
DecreaseStatic wrinkle appearance
Study
n = 50
Outcome group
Skin and hair · Skin and wound
Measurements
Clinical scoring change
35 to 69%
various static wrinkle types after 12 weeks
Source sentences
Summary
Meanwhile, Formula 1 significantly improved static wrinkle appearance within the first week, with mean clinical scoring from 35% to 69% for various types of wrinkles after 12 weeks of use (all p < 0.001).
1 context sentence(design, population, supporting numbers)
Summary · context
In clinical study 1 (n = 50), the Formula 1's efficacy in reducing static wrinkles and improving skin quality was examined, while study 2 (n = 42) focused on its efficacy against dynamic wrinkles.
In this study, SYN-AKE was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking SYN-AKE.
Report a problemFND-4166867111
08HumanNot a test of SYN-AKE aloneNon-randomized trialEfficacy outcome
In clinical study 1, Formula 1 significantly improved skin smoothness, with a clinical scoring change of 30%.
In plain wordsThe serum significantly improved skin smoothness, with a score change of 30%.
Peptide
SYN-AKE
Outcome
IncreaseSkin smoothness
Study
n = 50
Outcome group
Skin and hair · Skin and wound
Measurements
Clinical scoring change
30%
smoothness
Source sentences
Summary
Additionally, significant improvements were observed in skin quality, indicated by clinical scoring changes of smoothness (30%), radiance (27%), skin pore (43%), elasticity (33%) and firmness (36%) (all p < 0.001).
1 context sentence(design, population, supporting numbers)
Summary · context
In clinical study 1 (n = 50), the Formula 1's efficacy in reducing static wrinkles and improving skin quality was examined, while study 2 (n = 42) focused on its efficacy against dynamic wrinkles.
In this study, SYN-AKE was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking SYN-AKE.
Report a problemFND-4166867113
09HumanNot a test of SYN-AKE aloneNon-randomized trialEfficacy outcome
In clinical study 1, Formula 1 significantly improved skin radiance, with a clinical scoring change of 27%.
In plain wordsThe serum significantly improved skin radiance, with a score change of 27%.
Peptide
SYN-AKE
Outcome
IncreaseSkin radiance
Study
n = 50
Outcome group
Skin and hair · Skin and wound
Measurements
Clinical scoring change
27%
radiance
Source sentences
Summary
Additionally, significant improvements were observed in skin quality, indicated by clinical scoring changes of smoothness (30%), radiance (27%), skin pore (43%), elasticity (33%) and firmness (36%) (all p < 0.001).
1 context sentence(design, population, supporting numbers)
Summary · context
In clinical study 1 (n = 50), the Formula 1's efficacy in reducing static wrinkles and improving skin quality was examined, while study 2 (n = 42) focused on its efficacy against dynamic wrinkles.
In this study, SYN-AKE was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking SYN-AKE.
Report a problemFND-4166867114
10HumanNot a test of SYN-AKE aloneNon-randomized trialEfficacy outcome
In clinical study 1, Formula 1 significantly improved the skin pore clinical score by 43%.
In plain wordsThe serum significantly improved the skin pore score by 43%.
Peptide
SYN-AKE
Outcome
Direction not reportedSkin pore clinical score
Study
n = 50
Outcome group
Skin and hair · Skin and wound
Measurements
Clinical scoring change
43%
skin pore
Source sentences
Summary
Additionally, significant improvements were observed in skin quality, indicated by clinical scoring changes of smoothness (30%), radiance (27%), skin pore (43%), elasticity (33%) and firmness (36%) (all p < 0.001).
1 context sentence(design, population, supporting numbers)
Summary · context
In clinical study 1 (n = 50), the Formula 1's efficacy in reducing static wrinkles and improving skin quality was examined, while study 2 (n = 42) focused on its efficacy against dynamic wrinkles.
In this study, SYN-AKE was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking SYN-AKE.
Report a problemFND-4166867115
11HumanNot a test of SYN-AKE aloneNon-randomized trialEfficacy outcome
In clinical study 1, Formula 1 significantly improved skin elasticity, with a clinical scoring change of 33%.
In plain wordsThe serum significantly improved skin elasticity, with a score change of 33%.
Peptide
SYN-AKE
Outcome
IncreaseSkin elasticity
Study
n = 50
Outcome group
Skin and hair · Skin and wound
Measurements
Clinical scoring change
33%
elasticity
Source sentences
Summary
Additionally, significant improvements were observed in skin quality, indicated by clinical scoring changes of smoothness (30%), radiance (27%), skin pore (43%), elasticity (33%) and firmness (36%) (all p < 0.001).
1 context sentence(design, population, supporting numbers)
Summary · context
In clinical study 1 (n = 50), the Formula 1's efficacy in reducing static wrinkles and improving skin quality was examined, while study 2 (n = 42) focused on its efficacy against dynamic wrinkles.
In this study, SYN-AKE was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking SYN-AKE.
Report a problemFND-4166867116
12HumanNot a test of SYN-AKE aloneNon-randomized trialEfficacy outcome
In clinical study 1, Formula 1 significantly improved skin firmness, with a clinical scoring change of 36%.
In plain wordsThe serum significantly improved skin firmness, with a score change of 36%.
Peptide
SYN-AKE
Outcome
IncreaseSkin firmness
Study
n = 50
Outcome group
Skin and hair · Skin and wound
Measurements
Clinical scoring change
36%
firmness
Source sentences
Summary
Additionally, significant improvements were observed in skin quality, indicated by clinical scoring changes of smoothness (30%), radiance (27%), skin pore (43%), elasticity (33%) and firmness (36%) (all p < 0.001).
1 context sentence(design, population, supporting numbers)
Summary · context
In clinical study 1 (n = 50), the Formula 1's efficacy in reducing static wrinkles and improving skin quality was examined, while study 2 (n = 42) focused on its efficacy against dynamic wrinkles.
In this study, SYN-AKE was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking SYN-AKE.
Report a problemFND-4166867117
13HumanNot a test of Argireline (acetyl hexapeptide-8) aloneNon-randomized trialEfficacy outcome
In clinical study 2, Formula 1 improved dynamic wrinkle clinical scores by 10%-13%.
In plain wordsThe multi-ingredient serum improved dynamic wrinkle scores by 10%-13% from baseline.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
IncreaseDynamic wrinkle clinical score
Study
n = 42
Outcome group
Skin and hair · Skin and wound
Measurements
Clinical scoring improvement
10 to 13%
dynamic wrinkles
Source sentences
Summary
The clinical scoring for dynamic wrinkles improved by 10%-13% (all p < 0.001).
2 context sentences(design, population, supporting numbers)
Summary · context
This study aimed to explore the anti-skin aging efficacy of a novel serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate, gluconolactone, niacinamide and laminaria extract through one ex-vivo study and two clinical studies.
Summary · context
In clinical study 1 (n = 50), the Formula 1's efficacy in reducing static wrinkles and improving skin quality was examined, while study 2 (n = 42) focused on its efficacy against dynamic wrinkles.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-4166867103
14HumanNot a test of SYN-AKE aloneNon-randomized trialEfficacy outcome
In clinical study 2, Formula 1 improved dynamic wrinkle clinical scores by 10%-13% (all p < 0.001).
In plain wordsThe serum improved dynamic wrinkle scores by 10%-13%.
Peptide
SYN-AKE
Outcome
Direction not reportedDynamic wrinkle clinical score
Study
n = 42
Outcome group
Skin and hair · Skin and wound
Measurements
Clinical scoring improvement
10 to 13%
dynamic wrinkles
Source sentences
Summary
The clinical scoring for dynamic wrinkles improved by 10%-13% (all p < 0.001).
1 context sentence(design, population, supporting numbers)
Summary · context
In clinical study 1 (n = 50), the Formula 1's efficacy in reducing static wrinkles and improving skin quality was examined, while study 2 (n = 42) focused on its efficacy against dynamic wrinkles.
In this study, SYN-AKE was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking SYN-AKE.
Report a problemFND-4166867112
15LabNot a test of Argireline (acetyl hexapeptide-8) aloneEx vivo tissueMechanism
In ex vivo skin, the multi-ingredient Formula 1 serum significantly increased elastic fibre levels.
In plain wordsIn lab tests, the multi-ingredient serum increased elastic fibre levels.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
IncreaseElastic fibre levels
Study
humann: not reported in source
skin samples
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
Formula 1 significantly increased levels of anti-aging biomarkers including elastic fibres, collagen fibres, etc.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aimed to explore the anti-skin aging efficacy of a novel serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate, gluconolactone, niacinamide and laminaria extract through one ex-vivo study and two clinical studies.
Summary · context
In ex-vivo study, skin samples were exposed to the serum (Formula 1) and its active ingredient combinations (Formula 2).
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-4166867101
16LabNot a test of Argireline (acetyl hexapeptide-8) aloneEx vivo tissueMechanism
In ex vivo skin, the multi-ingredient Formula 1 serum significantly increased collagen fibre levels.
In plain wordsIn lab tests, the multi-ingredient serum increased collagen fibre levels.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
IncreaseCollagen fibre levels
Study
n: not reported in source
skin samples
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
Formula 1 significantly increased levels of anti-aging biomarkers including elastic fibres, collagen fibres, etc.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aimed to explore the anti-skin aging efficacy of a novel serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate, gluconolactone, niacinamide and laminaria extract through one ex-vivo study and two clinical studies.
Summary · context
In ex-vivo study, skin samples were exposed to the serum (Formula 1) and its active ingredient combinations (Formula 2).
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-4166867109
17LabNot a test of SYN-AKE aloneEx vivo tissueEfficacy outcome
In skin samples, Formula 1 significantly increased anti-aging biomarkers, including elastic fibres and collagen fibres.
In plain wordsIn lab tests, the serum significantly increased skin biomarkers, including elastic fibres and collagen fibres.
Peptide
SYN-AKE
Outcome
IncreaseAnti-aging biomarker levels
Study
n: not reported in source
Skin samples
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
Formula 1 significantly increased levels of anti-aging biomarkers including elastic fibres, collagen fibres, etc.
1 context sentence(design, population, supporting numbers)
Summary · context
In ex-vivo study, skin samples were exposed to the serum (Formula 1) and its active ingredient combinations (Formula 2).
In this study, SYN-AKE was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking SYN-AKE.
Report a problemFND-4166867110

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
27 Oct 2026, 16:32 UTC
Study data updated · source update from Europe PMC
Version 2
22 Oct 2026, 02:25 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

The effect of a serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate and gluconolactone on skin biomarkers, wrinkles and skin texture: Ex vivo and clinical studies.

Summary

Results from this study17

Studies that did not test the peptide alone17

Version history

Subjects

Publication types

MeSH terms

Keywords