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Study · Animal study (in vivo) · rat · 2026

2 results

Fourier Transform Infrared Spectroscopic Characterization of Aortic Wall Remodeling by Stable Gastric Pentadecapeptide BPC 157 After Unilateral Adrenalectomy in Rats.

Smoday IM, Vukovic V, Oroz K, Vranes H, Kalogjera L, Gamulin O, Vlainic J, Milavic M, Sikiric S, Nikolac Gabaj N, Marijancevic D, Koprivanac A and 10 more

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Beketic Oreskovic L, Oreskovic I, Strbe S, Barisic I, Kordic M, Tvrdeic A, Seiwerth S, Sikiric P, Boban Blagaic A, Skrtic A

Pharmaceuticals (Basel, Switzerland)22 Jan 2026Cited by 4 (Europe PMC)

PMID41599787 (opens in a new tab)PMCIDPMC12845017 (opens in a new tab)DOI10.3390/ph19010191 (opens in a new tab)PepBankPUB-41599787
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Summary

Background: No Fourier transform infrared (FTIR) spectroscopy studies have directly evaluated adrenalectomy vessels, the technique's established ability to probe collagen/elastin-associated spectral features and lipid peroxidation-related signatures, and protein structural damage. Stable gastric pentadecapeptide BPC 157 therapy was found to maintain the vascular function under severe stress, as FTIR spectroscopy recently demonstrated rapid peptide-induced molecular changes in healthy rat blood vessels, particularly in lipid content and protein secondary structure. Methods: To extend these findings and highlight the BPC 157 vascular background in the special circumstances of the course following unilateral adrenalectomy, abdominal aortas were collected at 15 min, 5 h, and 24 h after unilateral adrenalectomy for the FTIR spectroscopy assessment. Results: FTIR spectra were acquired, preprocessed, and analyzed using principal component analysis (PCA), support vector machine discriminant analysis (SVMDA), and band-specific statistics. BPC 157 (10 ng/kg intragatrically immediately after unilateral adrenalectomy) produced a clear, reproducible separation of aortic spectra from control samples at all time points. The main discriminatory spectral signatures were observed in three regions, including amide I and amide II (protein-related bands, consistent with collagen/elastin contributions) and lipid C-H stretching bands. These spectral signatures are consistent with early extracellular matrix reinforcement and membrane preservation in the vascular wall and align with the recovering effect on the lesions in counteraction of the severe vascular and multiorgan failure, attenuation/elimination of thrombosis and blood pressure disturbances in various occlusion/occlusion-like syndromes. Conclusions: Together, after unilateral adrenalectomy, the FTIR data provide molecular-level spectral signatures consistent with rapid remodeling of the aortic wall toward a more structurally stable and functionally favorable state.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats after unilateral adrenalectomy, BPC‑157 produced a clear, reproducible separation of aortic FTIR spectra from control samples at all time points.

    In plain wordsIn rats after adrenal gland removal, BPC‑157 changed the molecular make-up of the aorta wall compared with controls, as seen by infrared light.

    Peptide
    BPC-157
    Outcome
    Not applicableSeparation of aortic FTIR spectra from controls
    Study

    ratn: not reported in source

    Abdominal aorta after unilateral adrenalectomy (FTIR spectroscopy)
    Comparator
    Control samples
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    10 ng/kg · intragastric · 15 min, 5 h and 24 h (assessment times)As given in this study (rat).

    Source sentences

    Summary
    BPC 157 (10 ng/kg intragatrically immediately after unilateral adrenalectomy) produced a clear, reproducible separation of aortic spectra from control samples at all time points.
    1 context sentence
    Summary · context
    To extend these findings and highlight the BPC 157 vascular background in the special circumstances of the course following unilateral adrenalectomy, abdominal aortas were collected at 15 min, 5 h, and 24 h after unilateral adrenalectomy for the FTIR spectroscopy assessment.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats after unilateral adrenalectomy, the aortic spectral differences with BPC‑157 lay mainly in amide I, amide II and lipid C-H stretching bands.

    In plain wordsIn rats after adrenal gland removal, the aorta differences with BPC‑157 were mainly in protein-related and fat-related signals.

    Peptide
    BPC-157
    Outcome
    Not applicableDiscriminatory spectral regions (amide I, amide II, lipid C-H)
    Study

    ratn: not reported in source

    Abdominal aorta after unilateral adrenalectomy (FTIR spectroscopy)
    Comparator
    Control samples
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    10 ng/kg · intragastric · 15 min, 5 h and 24 h (assessment times)As given in this study (rat).

    Source sentences

    Summary
    The main discriminatory spectral signatures were observed in three regions, including amide I and amide II (protein-related bands, consistent with collagen/elastin contributions) and lipid C-H stretching bands.
    1 context sentence
    Summary · context
    To extend these findings and highlight the BPC 157 vascular background in the special circumstances of the course following unilateral adrenalectomy, abdominal aortas were collected at 15 min, 5 h, and 24 h after unilateral adrenalectomy for the FTIR spectroscopy assessment.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

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