A Systematic Review on GLP-1 Receptor Agonists in Reproductive Health: Integrating IVF Data, Ovarian Physiology and Molecular Mechanisms.

Voros C, Chatzinikolaou F, Papapanagiotou I, Polykalas S, Mavrogianni D, Koulakmanidis AM, Athanasiou D, Kanaka V, Bananis K, Athanasiou A, Athanasiou A, Papadimas G and 10 more

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Tsimpoukelis C, Vaitsis D, Karpouzos A, Daskalaki MA, Kanakas N, Theodora M, Thomakos N, Antsaklis P, Loutradis D, Daskalakis G

International journal of molecular sciences12 Jan 2026Cited by 9 (Europe PMC)

PMID41596408PMCIDPMC12841515DOI10.3390/ijms27020759PepBankPUB-41596408

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Summary

Women of reproductive age, especially those with polycystic ovarian syndrome (PCOS), often use glucagon-like peptide-1 receptor agonists (GLP-1RAs) to improve their metabolic functions. A growing body of evidence suggests that GLP-1R signaling may directly affect ovarian physiology, influencing granulosa cell proliferation, survival pathways, and steroidogenic production, in addition to its systemic metabolic effects. Nonetheless, there is a limited comprehension of the molecular mechanisms that regulate these activities and their correlation with menstrual function, reproductive potential, and assisted reproduction. This comprehensive review focuses on ovarian biology, granulosa cell signaling networks, steroidogenesis, and translational fertility outcomes, integrating clinical, in vivo, and in vitro information to elucidate the effects of GLP-1 receptor agonists on reproductive health. We conducted a thorough search of PubMed, Scopus, and Web of Science for randomized trials, prospective studies, animal models, and cellular experiments evaluating the effects of GLP-1RA on reproductive or ovarian outcomes, in accordance with PRISMA criteria. The retrieved data included metabolic changes, androgen levels, monthly regularity, ovarian structure, granulosa cell growth and death, FOXO1 signaling, FSH-cAMP-BMP pathway activity, and fertility or IVF results. Clinical trials shown that GLP-1 receptor agonists improve menstrual regularity, decrease body weight and central adiposity, increase sex hormone-binding globulin levels, and lower free testosterone in overweight and obese women with PCOS. Liraglutide, when combined with metformin, significantly improved IVF pregnancy rates, whereas exenatide increased natural conception rates. Mechanistic studies demonstrate that GLP-1R activation affects FOXO1 phosphorylation, hence promoting granulosa cell proliferation and anti-apoptotic processes. Incretin signaling altered steroidogenesis by reducing the levels of StAR, P450scc, and 3β-HSD, so inhibiting FSH-induced progesterone synthesis, while simultaneously enhancing BMP-Smad signaling. Animal studies demonstrated both beneficial (enhanced follicular growth, anti-apoptotic effects) and detrimental results (oxidative stress, granulosa cell death, uterine inflammation), indicating a context- and dose-dependent response. GLP-1 receptor agonists influence female reproductive biology by altering overall physiological processes and specifically impacting the ovaries via FOXO1 regulation, steroidogenic enzyme expression, and BMP-mediated FSH signaling. Preliminary clinical data indicate improved reproductive function in PCOS, as seen by increased pregnancy rates in both natural and IVF cycles; nevertheless, animal studies reveal a potential risk of ovarian and endometrial damage. These results highlight the need for controlled human research to clarify reproductive safety, molecular pathways, and optimum therapy timing, particularly in non-PCOS patients and IVF settings.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study19

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone19

In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Liraglutide.

01HumanNot a test of Liraglutide aloneSystematic reviewEfficacy outcome
Across clinical trials, GLP-1 receptor agonists improved menstrual regularity in overweight and obese women with PCOS.
In plain wordsIn overweight or obese women with PCOS, pooled GLP-1 receptor agonists including liraglutide improved menstrual regularity.
Peptide
Liraglutide
Outcome
IncreaseMenstrual regularity
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Clinical trials shown that GLP-1 receptor agonists improve menstrual regularity, decrease body weight and central adiposity, increase sex hormone-binding globulin levels, and lower free testosterone in overweight and obese women with PCOS.
3 context sentences(design, population, supporting numbers)
Summary · context
Liraglutide, when combined with metformin, significantly improved IVF pregnancy rates, whereas exenatide increased natural conception rates.
Summary · context
This comprehensive review focuses on ovarian biology, granulosa cell signaling networks, steroidogenesis, and translational fertility outcomes, integrating clinical, in vivo, and in vitro information to elucidate the effects of GLP-1 receptor agonists on reproductive health.
Summary · context
We conducted a thorough search of PubMed, Scopus, and Web of Science for randomized trials, prospective studies, animal models, and cellular experiments evaluating the effects of GLP-1RA on reproductive or ovarian outcomes, in accordance with PRISMA criteria.
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Show in the study text Report a problemFND-4159640801
02HumanNot a test of Liraglutide aloneSystematic reviewEfficacy outcome
Across clinical trials, GLP-1 receptor agonists decreased body weight in overweight and obese women with PCOS.
In plain wordsIn overweight or obese women with PCOS, pooled GLP-1 receptor agonists including liraglutide decreased body weight.
Peptide
Liraglutide
Outcome
DecreaseBody weight
Study
n: not reported in source
Outcome group
Body weight · Metabolic and weight
Source sentences
Summary
Clinical trials shown that GLP-1 receptor agonists improve menstrual regularity, decrease body weight and central adiposity, increase sex hormone-binding globulin levels, and lower free testosterone in overweight and obese women with PCOS.
3 context sentences(design, population, supporting numbers)
Summary · context
Liraglutide, when combined with metformin, significantly improved IVF pregnancy rates, whereas exenatide increased natural conception rates.
Summary · context
This comprehensive review focuses on ovarian biology, granulosa cell signaling networks, steroidogenesis, and translational fertility outcomes, integrating clinical, in vivo, and in vitro information to elucidate the effects of GLP-1 receptor agonists on reproductive health.
Summary · context
We conducted a thorough search of PubMed, Scopus, and Web of Science for randomized trials, prospective studies, animal models, and cellular experiments evaluating the effects of GLP-1RA on reproductive or ovarian outcomes, in accordance with PRISMA criteria.
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Show in the study text Report a problemFND-4159640802
03HumanNot a test of Liraglutide aloneSystematic reviewEfficacy outcome
Across clinical trials, GLP-1 receptor agonists decreased central adiposity in overweight and obese women with PCOS.
In plain wordsIn overweight or obese women with PCOS, pooled GLP-1 receptor agonists including liraglutide decreased central adiposity.
Peptide
Liraglutide
Outcome
DecreaseCentral adiposity
Study
n: not reported in source
Outcome group
Body weight · Metabolic and weight
Source sentences
Summary
Clinical trials shown that GLP-1 receptor agonists improve menstrual regularity, decrease body weight and central adiposity, increase sex hormone-binding globulin levels, and lower free testosterone in overweight and obese women with PCOS.
3 context sentences(design, population, supporting numbers)
Summary · context
Liraglutide, when combined with metformin, significantly improved IVF pregnancy rates, whereas exenatide increased natural conception rates.
Summary · context
This comprehensive review focuses on ovarian biology, granulosa cell signaling networks, steroidogenesis, and translational fertility outcomes, integrating clinical, in vivo, and in vitro information to elucidate the effects of GLP-1 receptor agonists on reproductive health.
Summary · context
We conducted a thorough search of PubMed, Scopus, and Web of Science for randomized trials, prospective studies, animal models, and cellular experiments evaluating the effects of GLP-1RA on reproductive or ovarian outcomes, in accordance with PRISMA criteria.
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Show in the study text Report a problemFND-4159640803
04HumanNot a test of Liraglutide aloneSystematic reviewEfficacy outcome
Across clinical trials, GLP-1 receptor agonists increased sex hormone-binding globulin in overweight and obese women with PCOS.
In plain wordsIn overweight or obese women with PCOS, pooled GLP-1 receptor agonists including liraglutide increased sex hormone-binding globulin.
Peptide
Liraglutide
Outcome
IncreaseSex hormone-binding globulin
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Clinical trials shown that GLP-1 receptor agonists improve menstrual regularity, decrease body weight and central adiposity, increase sex hormone-binding globulin levels, and lower free testosterone in overweight and obese women with PCOS.
3 context sentences(design, population, supporting numbers)
Summary · context
Liraglutide, when combined with metformin, significantly improved IVF pregnancy rates, whereas exenatide increased natural conception rates.
Summary · context
This comprehensive review focuses on ovarian biology, granulosa cell signaling networks, steroidogenesis, and translational fertility outcomes, integrating clinical, in vivo, and in vitro information to elucidate the effects of GLP-1 receptor agonists on reproductive health.
Summary · context
We conducted a thorough search of PubMed, Scopus, and Web of Science for randomized trials, prospective studies, animal models, and cellular experiments evaluating the effects of GLP-1RA on reproductive or ovarian outcomes, in accordance with PRISMA criteria.
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Show in the study text Report a problemFND-4159640804
05HumanNot a test of Liraglutide aloneSystematic reviewEfficacy outcome
Across clinical trials, GLP-1 receptor agonists lowered free testosterone in overweight and obese women with PCOS.
In plain wordsIn overweight or obese women with PCOS, pooled GLP-1 receptor agonists including liraglutide lowered free testosterone.
Peptide
Liraglutide
Outcome
DecreaseFree testosterone
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Clinical trials shown that GLP-1 receptor agonists improve menstrual regularity, decrease body weight and central adiposity, increase sex hormone-binding globulin levels, and lower free testosterone in overweight and obese women with PCOS.
3 context sentences(design, population, supporting numbers)
Summary · context
Liraglutide, when combined with metformin, significantly improved IVF pregnancy rates, whereas exenatide increased natural conception rates.
Summary · context
This comprehensive review focuses on ovarian biology, granulosa cell signaling networks, steroidogenesis, and translational fertility outcomes, integrating clinical, in vivo, and in vitro information to elucidate the effects of GLP-1 receptor agonists on reproductive health.
Summary · context
We conducted a thorough search of PubMed, Scopus, and Web of Science for randomized trials, prospective studies, animal models, and cellular experiments evaluating the effects of GLP-1RA on reproductive or ovarian outcomes, in accordance with PRISMA criteria.
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Show in the study text Report a problemFND-4159640805
06HumanNot a test of Liraglutide aloneSystematic reviewEfficacy outcome
In one clinical study summarized by the review, liraglutide combined with metformin significantly improved IVF pregnancy rates.
In plain wordsIn one clinical study, liraglutide with metformin improved IVF pregnancy rates.
Peptide
Liraglutide
Outcome
IncreaseIVF pregnancy rates
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Liraglutide, when combined with metformin, significantly improved IVF pregnancy rates, whereas exenatide increased natural conception rates.
2 context sentences(design, population, supporting numbers)
Summary · context
This comprehensive review focuses on ovarian biology, granulosa cell signaling networks, steroidogenesis, and translational fertility outcomes, integrating clinical, in vivo, and in vitro information to elucidate the effects of GLP-1 receptor agonists on reproductive health.
Summary · context
We conducted a thorough search of PubMed, Scopus, and Web of Science for randomized trials, prospective studies, animal models, and cellular experiments evaluating the effects of GLP-1RA on reproductive or ovarian outcomes, in accordance with PRISMA criteria.
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Show in the study text Report a problemFND-4159640806
07AnimalNot a test of Liraglutide aloneAnimal study (in vivo)Efficacy outcome
Across animal studies, GLP-1 receptor agonists enhanced follicular growth.
In plain wordsIn animals, pooled GLP-1 receptor agonist results increased follicular growth.
Peptide
Liraglutide
Outcome
IncreaseFollicular growth
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Animal studies demonstrated both beneficial (enhanced follicular growth, anti-apoptotic effects) and detrimental results (oxidative stress, granulosa cell death, uterine inflammation), indicating a context- and dose-dependent response.
3 context sentences(design, population, supporting numbers)
Summary · context
Liraglutide, when combined with metformin, significantly improved IVF pregnancy rates, whereas exenatide increased natural conception rates.
Summary · context
This comprehensive review focuses on ovarian biology, granulosa cell signaling networks, steroidogenesis, and translational fertility outcomes, integrating clinical, in vivo, and in vitro information to elucidate the effects of GLP-1 receptor agonists on reproductive health.
Summary · context
We conducted a thorough search of PubMed, Scopus, and Web of Science for randomized trials, prospective studies, animal models, and cellular experiments evaluating the effects of GLP-1RA on reproductive or ovarian outcomes, in accordance with PRISMA criteria.
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Show in the study text Report a problemFND-4159640815
08AnimalNot a test of Liraglutide aloneAnimal study (in vivo)Mechanism
Across animal studies, GLP-1 receptor agonists had anti-apoptotic effects.
In plain wordsIn animals, pooled GLP-1 receptor agonist results had anti-apoptotic effects.
Peptide
Liraglutide
Outcome
Not applicableAnti-apoptotic effects
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Animal studies demonstrated both beneficial (enhanced follicular growth, anti-apoptotic effects) and detrimental results (oxidative stress, granulosa cell death, uterine inflammation), indicating a context- and dose-dependent response.
3 context sentences(design, population, supporting numbers)
Summary · context
Liraglutide, when combined with metformin, significantly improved IVF pregnancy rates, whereas exenatide increased natural conception rates.
Summary · context
This comprehensive review focuses on ovarian biology, granulosa cell signaling networks, steroidogenesis, and translational fertility outcomes, integrating clinical, in vivo, and in vitro information to elucidate the effects of GLP-1 receptor agonists on reproductive health.
Summary · context
We conducted a thorough search of PubMed, Scopus, and Web of Science for randomized trials, prospective studies, animal models, and cellular experiments evaluating the effects of GLP-1RA on reproductive or ovarian outcomes, in accordance with PRISMA criteria.
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Show in the study text Report a problemFND-4159640816
09AnimalNot a test of Liraglutide aloneAnimal study (in vivo)Safety outcome
Across animal studies, GLP-1 receptor agonist results included oxidative stress.
In plain wordsIn animals, pooled GLP-1 receptor agonist results included oxidative stress.
Peptide
Liraglutide
Outcome
Not applicableOxidative stress
Study
n: not reported in source
Outcome group
Inflammation markers · Reproductive and sexual health
Source sentences
Summary
Animal studies demonstrated both beneficial (enhanced follicular growth, anti-apoptotic effects) and detrimental results (oxidative stress, granulosa cell death, uterine inflammation), indicating a context- and dose-dependent response.
3 context sentences(design, population, supporting numbers)
Summary · context
Liraglutide, when combined with metformin, significantly improved IVF pregnancy rates, whereas exenatide increased natural conception rates.
Summary · context
This comprehensive review focuses on ovarian biology, granulosa cell signaling networks, steroidogenesis, and translational fertility outcomes, integrating clinical, in vivo, and in vitro information to elucidate the effects of GLP-1 receptor agonists on reproductive health.
Summary · context
We conducted a thorough search of PubMed, Scopus, and Web of Science for randomized trials, prospective studies, animal models, and cellular experiments evaluating the effects of GLP-1RA on reproductive or ovarian outcomes, in accordance with PRISMA criteria.
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Show in the study text Report a problemFND-4159640817
10AnimalNot a test of Liraglutide aloneAnimal study (in vivo)Safety outcome
Across animal studies, GLP-1 receptor agonist results included granulosa cell death.
In plain wordsIn animals, pooled GLP-1 receptor agonist results included granulosa cell death.
Peptide
Liraglutide
Outcome
Not applicableGranulosa cell death
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Animal studies demonstrated both beneficial (enhanced follicular growth, anti-apoptotic effects) and detrimental results (oxidative stress, granulosa cell death, uterine inflammation), indicating a context- and dose-dependent response.
3 context sentences(design, population, supporting numbers)
Summary · context
Liraglutide, when combined with metformin, significantly improved IVF pregnancy rates, whereas exenatide increased natural conception rates.
Summary · context
This comprehensive review focuses on ovarian biology, granulosa cell signaling networks, steroidogenesis, and translational fertility outcomes, integrating clinical, in vivo, and in vitro information to elucidate the effects of GLP-1 receptor agonists on reproductive health.
Summary · context
We conducted a thorough search of PubMed, Scopus, and Web of Science for randomized trials, prospective studies, animal models, and cellular experiments evaluating the effects of GLP-1RA on reproductive or ovarian outcomes, in accordance with PRISMA criteria.
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Show in the study text Report a problemFND-4159640818
11AnimalNot a test of Liraglutide aloneAnimal study (in vivo)Safety outcome
Across animal studies, GLP-1 receptor agonist results included uterine inflammation.
In plain wordsIn animals, pooled GLP-1 receptor agonist results included uterine inflammation.
Peptide
Liraglutide
Outcome
Not applicableUterine inflammation
Study
n: not reported in source
Outcome group
Inflammation markers · Reproductive and sexual health
Source sentences
Summary
Animal studies demonstrated both beneficial (enhanced follicular growth, anti-apoptotic effects) and detrimental results (oxidative stress, granulosa cell death, uterine inflammation), indicating a context- and dose-dependent response.
3 context sentences(design, population, supporting numbers)
Summary · context
Liraglutide, when combined with metformin, significantly improved IVF pregnancy rates, whereas exenatide increased natural conception rates.
Summary · context
This comprehensive review focuses on ovarian biology, granulosa cell signaling networks, steroidogenesis, and translational fertility outcomes, integrating clinical, in vivo, and in vitro information to elucidate the effects of GLP-1 receptor agonists on reproductive health.
Summary · context
We conducted a thorough search of PubMed, Scopus, and Web of Science for randomized trials, prospective studies, animal models, and cellular experiments evaluating the effects of GLP-1RA on reproductive or ovarian outcomes, in accordance with PRISMA criteria.
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Show in the study text Report a problemFND-4159640819
12AnimalNot a test of Liraglutide aloneOther designMechanism
Across preclinical mechanistic studies in this GLP-1 receptor agonist review including liraglutide, GLP-1 receptor activation affected FOXO1 phosphorylation.
In plain wordsIn preclinical mechanistic studies, pooled GLP-1 receptor activation affected FOXO1 phosphorylation.
Peptide
Liraglutide
Outcome
Direction not reportedFOXO1 phosphorylation
Study
n: not reported in source
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
Mechanistic studies demonstrate that GLP-1R activation affects FOXO1 phosphorylation, hence promoting granulosa cell proliferation and anti-apoptotic processes.
3 context sentences(design, population, supporting numbers)
Summary · context
Liraglutide, when combined with metformin, significantly improved IVF pregnancy rates, whereas exenatide increased natural conception rates.
Summary · context
This comprehensive review focuses on ovarian biology, granulosa cell signaling networks, steroidogenesis, and translational fertility outcomes, integrating clinical, in vivo, and in vitro information to elucidate the effects of GLP-1 receptor agonists on reproductive health.
Summary · context
We conducted a thorough search of PubMed, Scopus, and Web of Science for randomized trials, prospective studies, animal models, and cellular experiments evaluating the effects of GLP-1RA on reproductive or ovarian outcomes, in accordance with PRISMA criteria.
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Show in the study text Report a problemFND-4159640807
13AnimalNot a test of Liraglutide aloneOther designMechanism
Across preclinical mechanistic studies in this GLP-1 receptor agonist review including liraglutide, GLP-1 receptor activation promoted granulosa cell proliferation.
In plain wordsIn preclinical studies, pooled GLP-1 receptor agonist results increased granulosa cell growth.
Peptide
Liraglutide
Outcome
IncreaseGranulosa cell proliferation
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Mechanistic studies demonstrate that GLP-1R activation affects FOXO1 phosphorylation, hence promoting granulosa cell proliferation and anti-apoptotic processes.
3 context sentences(design, population, supporting numbers)
Summary · context
Liraglutide, when combined with metformin, significantly improved IVF pregnancy rates, whereas exenatide increased natural conception rates.
Summary · context
This comprehensive review focuses on ovarian biology, granulosa cell signaling networks, steroidogenesis, and translational fertility outcomes, integrating clinical, in vivo, and in vitro information to elucidate the effects of GLP-1 receptor agonists on reproductive health.
Summary · context
We conducted a thorough search of PubMed, Scopus, and Web of Science for randomized trials, prospective studies, animal models, and cellular experiments evaluating the effects of GLP-1RA on reproductive or ovarian outcomes, in accordance with PRISMA criteria.
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Show in the study text Report a problemFND-4159640808
14AnimalNot a test of Liraglutide aloneOther designMechanism
Across preclinical mechanistic studies in this GLP-1 receptor agonist review including liraglutide, GLP-1 receptor activation promoted anti-apoptotic processes.
In plain wordsIn preclinical mechanistic studies, pooled GLP-1 receptor agonist results promoted anti-apoptotic processes.
Peptide
Liraglutide
Outcome
IncreaseAnti-apoptotic processes
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Mechanistic studies demonstrate that GLP-1R activation affects FOXO1 phosphorylation, hence promoting granulosa cell proliferation and anti-apoptotic processes.
3 context sentences(design, population, supporting numbers)
Summary · context
Liraglutide, when combined with metformin, significantly improved IVF pregnancy rates, whereas exenatide increased natural conception rates.
Summary · context
This comprehensive review focuses on ovarian biology, granulosa cell signaling networks, steroidogenesis, and translational fertility outcomes, integrating clinical, in vivo, and in vitro information to elucidate the effects of GLP-1 receptor agonists on reproductive health.
Summary · context
We conducted a thorough search of PubMed, Scopus, and Web of Science for randomized trials, prospective studies, animal models, and cellular experiments evaluating the effects of GLP-1RA on reproductive or ovarian outcomes, in accordance with PRISMA criteria.
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Show in the study text Report a problemFND-4159640809
15AnimalNot a test of Liraglutide aloneOther designMechanism
Across preclinical mechanistic studies in this GLP-1 receptor agonist review including liraglutide, incretin signaling reduced StAR levels.
In plain wordsIn preclinical studies, pooled incretin results lowered StAR levels.
Peptide
Liraglutide
Outcome
DecreaseStAR levels
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Incretin signaling altered steroidogenesis by reducing the levels of StAR, P450scc, and 3β-HSD, so inhibiting FSH-induced progesterone synthesis, while simultaneously enhancing BMP-Smad signaling.
3 context sentences(design, population, supporting numbers)
Summary · context
Liraglutide, when combined with metformin, significantly improved IVF pregnancy rates, whereas exenatide increased natural conception rates.
Summary · context
This comprehensive review focuses on ovarian biology, granulosa cell signaling networks, steroidogenesis, and translational fertility outcomes, integrating clinical, in vivo, and in vitro information to elucidate the effects of GLP-1 receptor agonists on reproductive health.
Summary · context
We conducted a thorough search of PubMed, Scopus, and Web of Science for randomized trials, prospective studies, animal models, and cellular experiments evaluating the effects of GLP-1RA on reproductive or ovarian outcomes, in accordance with PRISMA criteria.
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Show in the study text Report a problemFND-4159640810
16AnimalNot a test of Liraglutide aloneOther designMechanism
Across preclinical mechanistic studies in this GLP-1 receptor agonist review including liraglutide, incretin signaling reduced P450scc levels.
In plain wordsIn preclinical studies, pooled incretin results lowered P450scc levels.
Peptide
Liraglutide
Outcome
DecreaseP450scc levels
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Incretin signaling altered steroidogenesis by reducing the levels of StAR, P450scc, and 3β-HSD, so inhibiting FSH-induced progesterone synthesis, while simultaneously enhancing BMP-Smad signaling.
3 context sentences(design, population, supporting numbers)
Summary · context
Liraglutide, when combined with metformin, significantly improved IVF pregnancy rates, whereas exenatide increased natural conception rates.
Summary · context
This comprehensive review focuses on ovarian biology, granulosa cell signaling networks, steroidogenesis, and translational fertility outcomes, integrating clinical, in vivo, and in vitro information to elucidate the effects of GLP-1 receptor agonists on reproductive health.
Summary · context
We conducted a thorough search of PubMed, Scopus, and Web of Science for randomized trials, prospective studies, animal models, and cellular experiments evaluating the effects of GLP-1RA on reproductive or ovarian outcomes, in accordance with PRISMA criteria.
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Show in the study text Report a problemFND-4159640811
17AnimalNot a test of Liraglutide aloneOther designMechanism
Across preclinical mechanistic studies in this GLP-1 receptor agonist review including liraglutide, incretin signaling reduced 3β-HSD levels.
In plain wordsIn preclinical studies, pooled incretin results lowered 3β-HSD levels.
Peptide
Liraglutide
Outcome
Decrease3β-HSD levels
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Incretin signaling altered steroidogenesis by reducing the levels of StAR, P450scc, and 3β-HSD, so inhibiting FSH-induced progesterone synthesis, while simultaneously enhancing BMP-Smad signaling.
3 context sentences(design, population, supporting numbers)
Summary · context
Liraglutide, when combined with metformin, significantly improved IVF pregnancy rates, whereas exenatide increased natural conception rates.
Summary · context
This comprehensive review focuses on ovarian biology, granulosa cell signaling networks, steroidogenesis, and translational fertility outcomes, integrating clinical, in vivo, and in vitro information to elucidate the effects of GLP-1 receptor agonists on reproductive health.
Summary · context
We conducted a thorough search of PubMed, Scopus, and Web of Science for randomized trials, prospective studies, animal models, and cellular experiments evaluating the effects of GLP-1RA on reproductive or ovarian outcomes, in accordance with PRISMA criteria.
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Show in the study text Report a problemFND-4159640812
18AnimalNot a test of Liraglutide aloneOther designMechanism
Across preclinical mechanistic studies in this GLP-1 receptor agonist review including liraglutide, incretin signaling inhibited FSH-induced progesterone synthesis.
In plain wordsIn preclinical studies, pooled incretin results lowered FSH-induced progesterone synthesis.
Peptide
Liraglutide
Outcome
DecreaseFSH-induced progesterone synthesis
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Incretin signaling altered steroidogenesis by reducing the levels of StAR, P450scc, and 3β-HSD, so inhibiting FSH-induced progesterone synthesis, while simultaneously enhancing BMP-Smad signaling.
3 context sentences(design, population, supporting numbers)
Summary · context
Liraglutide, when combined with metformin, significantly improved IVF pregnancy rates, whereas exenatide increased natural conception rates.
Summary · context
This comprehensive review focuses on ovarian biology, granulosa cell signaling networks, steroidogenesis, and translational fertility outcomes, integrating clinical, in vivo, and in vitro information to elucidate the effects of GLP-1 receptor agonists on reproductive health.
Summary · context
We conducted a thorough search of PubMed, Scopus, and Web of Science for randomized trials, prospective studies, animal models, and cellular experiments evaluating the effects of GLP-1RA on reproductive or ovarian outcomes, in accordance with PRISMA criteria.
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Show in the study text Report a problemFND-4159640813
19AnimalNot a test of Liraglutide aloneOther designMechanism
Across preclinical mechanistic studies in this GLP-1 receptor agonist review including liraglutide, incretin signaling enhanced BMP-Smad signaling.
In plain wordsIn preclinical studies, pooled incretin results increased BMP-Smad signaling.
Peptide
Liraglutide
Outcome
IncreaseBMP-Smad signaling
Study
n: not reported in source
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
Incretin signaling altered steroidogenesis by reducing the levels of StAR, P450scc, and 3β-HSD, so inhibiting FSH-induced progesterone synthesis, while simultaneously enhancing BMP-Smad signaling.
3 context sentences(design, population, supporting numbers)
Summary · context
Liraglutide, when combined with metformin, significantly improved IVF pregnancy rates, whereas exenatide increased natural conception rates.
Summary · context
This comprehensive review focuses on ovarian biology, granulosa cell signaling networks, steroidogenesis, and translational fertility outcomes, integrating clinical, in vivo, and in vitro information to elucidate the effects of GLP-1 receptor agonists on reproductive health.
Summary · context
We conducted a thorough search of PubMed, Scopus, and Web of Science for randomized trials, prospective studies, animal models, and cellular experiments evaluating the effects of GLP-1RA on reproductive or ovarian outcomes, in accordance with PRISMA criteria.
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Show in the study text Report a problemFND-4159640814

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 11:11 UTC
Study results updated
Version 1
9 Oct 2026, 03:05 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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