Antioxidant-Enhanced Nanoparticles Delay the Progression of Osteoarthritis.

Shen C, Yu J, Xiang H, Lin J, Jin K, Liu B, Tao H

ACS omega26 Nov 2025

PMID41502612PMCIDPMC12771239DOI10.1021/acsomega.5c07948PepBankPUB-41502612

Read at source PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone6

In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Elamipretide (SS-31).

01AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Safety outcome
In vivo, PCMS had no malignant effect on chondrocyte viability and proliferation and was degradable.
In plain wordsIn animals, the SS31 nanoparticle did not harm cartilage cell survival or growth. The effect is for the whole product.
Peptide
Elamipretide (SS-31)
Outcome
No significant changeChondrocyte viability and proliferation (in vivo)
Study
n: not reported in source
Outcome group
Adverse events · Musculoskeletal
Source sentences
Summary
In addition, both in vivo and in vitro results demonstrated that PCMS had no malignant effect on chondrocyte viability and proliferation and was degradable.
1 context sentence(design, population, supporting numbers)
Summary · context
SS31, a positively charged peptide, was adsorbed onto the surface of PCMg through the charge interaction to obtain the new nanoparticle platform (PCMS).
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-4150261205
02AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Efficacy outcome
In the destabilization of the medial meniscus osteoarthritis model, PCMS alleviated the progression of osteoarthritis by histological staining.
In plain wordsIn animals with joint damage, a nanoparticle carrying SS31 and other active parts slowed osteoarthritis. The effect is for the whole product.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseOsteoarthritis progression
Study
n: not reported in source
DMM osteoarthritis model
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
Through the destabilization of the medial meniscus (DMM) OA model, hematoxylin-eosin (HE), safranin, fast green (SO), and toluidine blue (TB) staining indicated that PCMS effectively alleviated the progression of OA.
1 context sentence(design, population, supporting numbers)
Summary · context
SS31, a positively charged peptide, was adsorbed onto the surface of PCMg through the charge interaction to obtain the new nanoparticle platform (PCMS).
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-4150261206
03LabNot a test of Elamipretide (SS-31) aloneIn vitro (cells)Efficacy outcome
In chondrocytes, the SS31-loaded nanoparticle PCMS reduced the level of reactive oxygen species caused by TBHP.
In plain wordsIn lab tests on cartilage cells, a nanoparticle carrying SS31 and other active parts lowered oxidative stress. The effect is for the whole product.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseReactive oxygen species level
Study
n: not reported in source
chondrocytes with TBHP-induced stress
Outcome group
Oxidative stress · Musculoskeletal
Source sentences
Summary
In vitro, PCMS effectively reduced the reactive oxygen species (ROS) level and restored mitochondrial dysfunction mediated by tert-butyl hydroperoxide (TBHP) through reducing OS in chondrocytes.
1 context sentence(design, population, supporting numbers)
Summary · context
SS31, a positively charged peptide, was adsorbed onto the surface of PCMg through the charge interaction to obtain the new nanoparticle platform (PCMS).
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-4150261201
04LabNot a test of Elamipretide (SS-31) aloneIn vitro (cells)Efficacy outcome
In chondrocytes, the SS31-loaded nanoparticle PCMS restored mitochondrial dysfunction caused by TBHP.
In plain wordsIn lab tests on cartilage cells, a nanoparticle carrying SS31 and other active parts restored mitochondrial function. The effect is for the whole product.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseTBHP-induced mitochondrial dysfunction
Study
n: not reported in source
chondrocytes with TBHP-induced stress
Outcome group
Mitochondrial function · Musculoskeletal
Source sentences
Summary
In vitro, PCMS effectively reduced the reactive oxygen species (ROS) level and restored mitochondrial dysfunction mediated by tert-butyl hydroperoxide (TBHP) through reducing OS in chondrocytes.
1 context sentence(design, population, supporting numbers)
Summary · context
SS31, a positively charged peptide, was adsorbed onto the surface of PCMg through the charge interaction to obtain the new nanoparticle platform (PCMS).
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-4150261202
05LabNot a test of Elamipretide (SS-31) aloneIn vitro (cells)Mechanism
SS31 gave the PCMS nanoparticle good biocompatibility, rapid uptake by chondrocytes and localisation in mitochondria.
In plain wordsIn lab tests, SS31 helped a nanoparticle enter cartilage cells and reach mitochondria. The nanoparticle has other active parts.
Peptide
Elamipretide (SS-31)
Outcome
Not applicableCell uptake and mitochondrial localisation
Study
n: not reported in source
chondrocytes
Outcome group
Mitochondrial function · Musculoskeletal
Source sentences
Summary
SS31 endowed PCMS with good biocompatibility and enabled it to be rapidly endocytosed by chondrocytes and simultaneously localized in mitochondria.
1 context sentence(design, population, supporting numbers)
Summary · context
SS31, a positively charged peptide, was adsorbed onto the surface of PCMg through the charge interaction to obtain the new nanoparticle platform (PCMS).
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-4150261203
06LabNot a test of Elamipretide (SS-31) aloneIn vitro (cells)Safety outcome
In vitro, PCMS had no malignant effect on chondrocyte viability and proliferation.
In plain wordsIn lab tests, the SS31 nanoparticle did not harm cartilage cell survival or growth. The effect is for the whole product.
Peptide
Elamipretide (SS-31)
Outcome
No significant changeChondrocyte viability and proliferation (in vitro)
Study
n: not reported in source
chondrocytes
Outcome group
Adverse events · Musculoskeletal
Source sentences
Summary
In addition, both in vivo and in vitro results demonstrated that PCMS had no malignant effect on chondrocyte viability and proliferation and was degradable.
1 context sentence(design, population, supporting numbers)
Summary · context
SS31, a positively charged peptide, was adsorbed onto the surface of PCMg through the charge interaction to obtain the new nanoparticle platform (PCMS).
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-4150261204

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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