In two adolescents with pathogenic or likely pathogenic MC4R mutations, semaglutide treatment was followed by significant weight improvement.
In plain wordsIn two teenagers with a gene change that causes obesity, weight improved on semaglutide. Two cases cannot show it works generally.
- Peptide
- Semaglutide
- Outcome
- DecreaseWeight improvement in adolescents with MC4R mutations
- Study
n = 2
- Outcome group
- Body weight · Metabolic and weight
- Studied dose
- Dose not stated
Source sentences
We describe significant improvement in weight in three patients with pathogenic or likely pathogenic MC4R mutations; two adolescents treated with semaglutide, and a younger child treated with metformin and topiramate.
1 context sentence(design, population, supporting numbers)
Treatment Approaches for Obesity in Children With Heterozygous MC4R Variants.