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Study · Systematic review · 2026

2 results

Recurrent Weight Gain after Weight Loss Induced by Lifestyle Intervention, Metabolic and Bariatric Surgery, or Semaglutide in Adults with Obesity: A Systematic Review of Randomized Controlled Trials.

Chen H, Guo X, Long T, Li M

Obesity surgery3 Jan 2026

PMID41483046 (opens in a new tab)DOI10.1007/s11695-025-08415-1 (opens in a new tab)PepBankPUB-41483046
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanSystematic reviewEfficacy outcome

    In adults with obesity, a systematic review of randomized trials found that semaglutide may support sustained weight reduction during ongoing therapy.

    In plain wordsIn adults with obesity, trials suggest that semaglutide may help keep weight down while people stay on it.

    Peptide
    Semaglutide
    Outcome
    DecreaseSustained weight reduction during semaglutide therapy
    Study

    n: not reported in source

    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    semaglutide may support sustained weight reduction during ongoing therapy
    1 context sentence
    Summary · context
    We systematically reviewed 29 randomized controlled trials comparing long-term outcomes of lifestyle interventions, semaglutide, and metabolic and bariatric surgery (MBS).
  2. 02HumanSystematic reviewEfficacy outcome

    In adults with obesity, a systematic review of randomized trials found that weight rebound followed semaglutide discontinuation.

    In plain wordsIn adults with obesity, trials suggest that weight tends to come back after people stop semaglutide.

    Peptide
    Semaglutide
    Outcome
    IncreaseWeight rebound after semaglutide discontinuation
    Study

    n: not reported in source

    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    is followed by rebound after discontinuation
    1 context sentence
    Summary · context
    We systematically reviewed 29 randomized controlled trials comparing long-term outcomes of lifestyle interventions, semaglutide, and metabolic and bariatric surgery (MBS).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:04 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:06 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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