β-Nicotinamide Mononucleotide Enhances Skin Barrier Function and Attenuates UV-B-Induced Photoaging in Mice.

Kim SJ, Lee S, Choi YJ, Kang M, Lee J, Hwang GS, Roh SS, Jin MH, Park S, Park M, Cho HS, Kang KS

Antioxidants (Basel, Switzerland)27 Nov 2025Cited by 4 (Europe PMC)

PMID41462625PMCIDPMC12729516DOI10.3390/antiox14121424PepBankPUB-41462625

Summary

Ultraviolet B (UV-B) radiation significantly contributes to skin photoaging, which is characterized by epidermal thickening, collagen degradation, wrinkle formation, barrier dysfunction, and oxidative stress. Nicotinamide mononucleotide (NMN), a key precursor of nicotinamide adenine dinucleotide, regulates cellular energy metabolism and antioxidant defense and demonstrates anti-aging effects in animal models. Here, we investigated the protective effects of oral NMN supplementation against UV-B-induced photoaging in SKH-1 hairless mice. Over a 10-week experimental period, oral NMN administration significantly alleviated epidermal hypertrophy, reduced wrinkle formation and skin surface roughness, improved hydration and elasticity, and restored transepidermal water loss to near-normal levels. Histological analyses revealed marked preservation of collagen fiber density and attenuation of dermal matrix degradation. Furthermore, NMN supplementation inhibited the phosphorylation of MAPK signaling components (ERK, JNK, and p38), suppressed pro-inflammatory cytokine (TNF-α and IL-6) and matrix-degrading enzyme (MMP-1) expression, and restored hyaluronan synthase (HAS-1 and HAS-2) expression. Additionally, NMN enhanced the systemic antioxidant defense, as indicated by the restored superoxide dismutase activity. Thus, NMN has multi-layered protective effects against UV-B-induced skin aging by modulating oxidative stress, inflammatory signaling, extracellular matrix remodeling, and hyaluronic acid metabolism.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study17

17 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In UV-B-exposed mice, NMN reduced epidermal hypertrophy.
In plain wordsIn mice exposed to UV-B, NMN reduced epidermal thickening.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseEpidermal hypertrophy
Study
mousen: not reported in source
UV-B-exposed SKH-1 hairless mice
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated · oral · 10 weeksAs given in this study (mouse).
Source sentences
Summary
Over a 10-week experimental period, oral NMN administration significantly alleviated epidermal hypertrophy, reduced wrinkle formation and skin surface roughness, improved hydration and elasticity, and restored transepidermal water loss to near-normal levels.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated the protective effects of oral NMN supplementation against UV-B-induced photoaging in SKH-1 hairless mice.
Show in the study text Report a problemFND-4146262501
02AnimalAnimal study (in vivo)Efficacy outcome
In UV-B-exposed mice, NMN reduced wrinkle formation.
In plain wordsIn mice exposed to UV-B, NMN reduced wrinkles.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseWrinkle formation
Study
mousen: not reported in source
UV-B-exposed SKH-1 hairless mice
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated · oral · 10 weeksAs given in this study (mouse).
Source sentences
Summary
Over a 10-week experimental period, oral NMN administration significantly alleviated epidermal hypertrophy, reduced wrinkle formation and skin surface roughness, improved hydration and elasticity, and restored transepidermal water loss to near-normal levels.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated the protective effects of oral NMN supplementation against UV-B-induced photoaging in SKH-1 hairless mice.
Show in the study text Report a problemFND-4146262502
03AnimalAnimal study (in vivo)Efficacy outcome
In UV-B-exposed mice, NMN reduced skin surface roughness.
In plain wordsIn mice exposed to UV-B, NMN reduced skin roughness.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseSkin surface roughness
Study
mousen: not reported in source
UV-B-exposed SKH-1 hairless mice
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated · oral · 10 weeksAs given in this study (mouse).
Source sentences
Summary
Over a 10-week experimental period, oral NMN administration significantly alleviated epidermal hypertrophy, reduced wrinkle formation and skin surface roughness, improved hydration and elasticity, and restored transepidermal water loss to near-normal levels.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated the protective effects of oral NMN supplementation against UV-B-induced photoaging in SKH-1 hairless mice.
Show in the study text Report a problemFND-4146262503
04AnimalAnimal study (in vivo)Efficacy outcome
In UV-B-exposed mice, NMN improved skin hydration.
In plain wordsIn mice exposed to UV-B, NMN improved skin hydration.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseSkin hydration
Study
mousen: not reported in source
UV-B-exposed SKH-1 hairless mice
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated · oral · 10 weeksAs given in this study (mouse).
Source sentences
Summary
Over a 10-week experimental period, oral NMN administration significantly alleviated epidermal hypertrophy, reduced wrinkle formation and skin surface roughness, improved hydration and elasticity, and restored transepidermal water loss to near-normal levels.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated the protective effects of oral NMN supplementation against UV-B-induced photoaging in SKH-1 hairless mice.
Show in the study text Report a problemFND-4146262504
05AnimalAnimal study (in vivo)Efficacy outcome
In UV-B-exposed mice, NMN improved skin elasticity.
In plain wordsIn mice exposed to UV-B, NMN improved skin elasticity.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseSkin elasticity
Study
mousen: not reported in source
UV-B-exposed SKH-1 hairless mice
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated · oral · 10 weeksAs given in this study (mouse).
Source sentences
Summary
Over a 10-week experimental period, oral NMN administration significantly alleviated epidermal hypertrophy, reduced wrinkle formation and skin surface roughness, improved hydration and elasticity, and restored transepidermal water loss to near-normal levels.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated the protective effects of oral NMN supplementation against UV-B-induced photoaging in SKH-1 hairless mice.
Show in the study text Report a problemFND-4146262505
06AnimalAnimal study (in vivo)Efficacy outcome
In UV-B-exposed mice, NMN restored transepidermal water loss to near-normal levels.
In plain wordsIn mice exposed to UV-B, NMN restored water loss through skin to near-normal levels.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseTransepidermal water loss
Study
mousen: not reported in source
UV-B-exposed SKH-1 hairless mice
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated · oral · 10 weeksAs given in this study (mouse).
Source sentences
Summary
Over a 10-week experimental period, oral NMN administration significantly alleviated epidermal hypertrophy, reduced wrinkle formation and skin surface roughness, improved hydration and elasticity, and restored transepidermal water loss to near-normal levels.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated the protective effects of oral NMN supplementation against UV-B-induced photoaging in SKH-1 hairless mice.
Show in the study text Report a problemFND-4146262506
07AnimalAnimal study (in vivo)Efficacy outcome
In UV-B-exposed mice, NMN preserved collagen fiber density.
In plain wordsIn mice exposed to UV-B, NMN preserved skin collagen density.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseCollagen fiber density
Study
mousen: not reported in source
UV-B-exposed SKH-1 hairless mice
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated · oral · 10 weeksAs given in this study (mouse).
Source sentences
Summary
Histological analyses revealed marked preservation of collagen fiber density and attenuation of dermal matrix degradation.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated the protective effects of oral NMN supplementation against UV-B-induced photoaging in SKH-1 hairless mice.
Show in the study text Report a problemFND-4146262507
08AnimalAnimal study (in vivo)Efficacy outcome
In UV-B-exposed mice, NMN attenuated dermal matrix degradation.
In plain wordsIn mice exposed to UV-B, NMN reduced skin matrix breakdown.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseDermal matrix degradation
Study
mousen: not reported in source
UV-B-exposed SKH-1 hairless mice
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated · oral · 10 weeksAs given in this study (mouse).
Source sentences
Summary
Histological analyses revealed marked preservation of collagen fiber density and attenuation of dermal matrix degradation.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated the protective effects of oral NMN supplementation against UV-B-induced photoaging in SKH-1 hairless mice.
Show in the study text Report a problemFND-4146262508
09AnimalAnimal study (in vivo)Mechanism
In UV-B-exposed mice, NMN inhibited ERK phosphorylation.
In plain wordsIn mice exposed to UV-B, NMN reduced ERK phosphorylation.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseERK phosphorylation
Study
mousen: not reported in source
UV-B-exposed SKH-1 hairless mice
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated · oral · 10 weeksAs given in this study (mouse).
Source sentences
Summary
Furthermore, NMN supplementation inhibited the phosphorylation of MAPK signaling components (ERK, JNK, and p38), suppressed pro-inflammatory cytokine (TNF-α and IL-6) and matrix-degrading enzyme (MMP-1) expression, and restored hyaluronan synthase (HAS-1 and HAS-2) expression.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated the protective effects of oral NMN supplementation against UV-B-induced photoaging in SKH-1 hairless mice.
Show in the study text Report a problemFND-4146262509
10AnimalAnimal study (in vivo)Mechanism
In UV-B-exposed mice, NMN inhibited JNK phosphorylation.
In plain wordsIn mice exposed to UV-B, NMN reduced JNK phosphorylation.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseJNK phosphorylation
Study
mousen: not reported in source
UV-B-exposed SKH-1 hairless mice
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated · oral · 10 weeksAs given in this study (mouse).
Source sentences
Summary
Furthermore, NMN supplementation inhibited the phosphorylation of MAPK signaling components (ERK, JNK, and p38), suppressed pro-inflammatory cytokine (TNF-α and IL-6) and matrix-degrading enzyme (MMP-1) expression, and restored hyaluronan synthase (HAS-1 and HAS-2) expression.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated the protective effects of oral NMN supplementation against UV-B-induced photoaging in SKH-1 hairless mice.
Show in the study text Report a problemFND-4146262510
11AnimalAnimal study (in vivo)Mechanism
In UV-B-exposed mice, NMN inhibited p38 phosphorylation.
In plain wordsIn mice exposed to UV-B, NMN reduced p38 phosphorylation.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
Decreasep38 phosphorylation
Study
mousen: not reported in source
UV-B-exposed SKH-1 hairless mice
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated · oral · 10 weeksAs given in this study (mouse).
Source sentences
Summary
Furthermore, NMN supplementation inhibited the phosphorylation of MAPK signaling components (ERK, JNK, and p38), suppressed pro-inflammatory cytokine (TNF-α and IL-6) and matrix-degrading enzyme (MMP-1) expression, and restored hyaluronan synthase (HAS-1 and HAS-2) expression.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated the protective effects of oral NMN supplementation against UV-B-induced photoaging in SKH-1 hairless mice.
Show in the study text Report a problemFND-4146262511
12AnimalAnimal study (in vivo)Mechanism
In UV-B-exposed mice, NMN suppressed TNF-α expression.
In plain wordsIn mice exposed to UV-B, NMN reduced TNF-α expression.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseTNF-α expression
Study
mousen: not reported in source
UV-B-exposed SKH-1 hairless mice
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated · oral · 10 weeksAs given in this study (mouse).
Source sentences
Summary
Furthermore, NMN supplementation inhibited the phosphorylation of MAPK signaling components (ERK, JNK, and p38), suppressed pro-inflammatory cytokine (TNF-α and IL-6) and matrix-degrading enzyme (MMP-1) expression, and restored hyaluronan synthase (HAS-1 and HAS-2) expression.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated the protective effects of oral NMN supplementation against UV-B-induced photoaging in SKH-1 hairless mice.
Show in the study text Report a problemFND-4146262512
13AnimalAnimal study (in vivo)Mechanism
In UV-B-exposed mice, NMN suppressed IL-6 expression.
In plain wordsIn mice exposed to UV-B, NMN reduced IL-6 expression.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseIL-6 expression
Study
mousen: not reported in source
UV-B-exposed SKH-1 hairless mice
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated · oral · 10 weeksAs given in this study (mouse).
Source sentences
Summary
Furthermore, NMN supplementation inhibited the phosphorylation of MAPK signaling components (ERK, JNK, and p38), suppressed pro-inflammatory cytokine (TNF-α and IL-6) and matrix-degrading enzyme (MMP-1) expression, and restored hyaluronan synthase (HAS-1 and HAS-2) expression.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated the protective effects of oral NMN supplementation against UV-B-induced photoaging in SKH-1 hairless mice.
Show in the study text Report a problemFND-4146262513
14AnimalAnimal study (in vivo)Mechanism
In UV-B-exposed mice, NMN suppressed MMP-1 expression.
In plain wordsIn mice exposed to UV-B, NMN reduced MMP-1 expression.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseMMP-1 expression
Study
mousen: not reported in source
UV-B-exposed SKH-1 hairless mice
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated · oral · 10 weeksAs given in this study (mouse).
Source sentences
Summary
Furthermore, NMN supplementation inhibited the phosphorylation of MAPK signaling components (ERK, JNK, and p38), suppressed pro-inflammatory cytokine (TNF-α and IL-6) and matrix-degrading enzyme (MMP-1) expression, and restored hyaluronan synthase (HAS-1 and HAS-2) expression.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated the protective effects of oral NMN supplementation against UV-B-induced photoaging in SKH-1 hairless mice.
Show in the study text Report a problemFND-4146262514
15AnimalAnimal study (in vivo)Mechanism
In UV-B-exposed mice, NMN restored HAS-1 expression.
In plain wordsIn mice exposed to UV-B, NMN restored HAS-1 expression.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseHAS-1 expression
Study
mousen: not reported in source
UV-B-exposed SKH-1 hairless mice
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated · oral · 10 weeksAs given in this study (mouse).
Source sentences
Summary
Furthermore, NMN supplementation inhibited the phosphorylation of MAPK signaling components (ERK, JNK, and p38), suppressed pro-inflammatory cytokine (TNF-α and IL-6) and matrix-degrading enzyme (MMP-1) expression, and restored hyaluronan synthase (HAS-1 and HAS-2) expression.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated the protective effects of oral NMN supplementation against UV-B-induced photoaging in SKH-1 hairless mice.
Show in the study text Report a problemFND-4146262515
16AnimalAnimal study (in vivo)Mechanism
In UV-B-exposed mice, NMN restored HAS-2 expression.
In plain wordsIn mice exposed to UV-B, NMN restored HAS-2 expression.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseHAS-2 expression
Study
mousen: not reported in source
UV-B-exposed SKH-1 hairless mice
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated · oral · 10 weeksAs given in this study (mouse).
Source sentences
Summary
Furthermore, NMN supplementation inhibited the phosphorylation of MAPK signaling components (ERK, JNK, and p38), suppressed pro-inflammatory cytokine (TNF-α and IL-6) and matrix-degrading enzyme (MMP-1) expression, and restored hyaluronan synthase (HAS-1 and HAS-2) expression.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated the protective effects of oral NMN supplementation against UV-B-induced photoaging in SKH-1 hairless mice.
Show in the study text Report a problemFND-4146262516
17AnimalAnimal study (in vivo)Mechanism
In UV-B-exposed mice, NMN restored superoxide dismutase activity.
In plain wordsIn mice exposed to UV-B, NMN restored an antioxidant enzyme's activity.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseSuperoxide dismutase activity
Study
mousen: not reported in source
UV-B-exposed SKH-1 hairless mice
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated · oral · 10 weeksAs given in this study (mouse).
Source sentences
Summary
Additionally, NMN enhanced the systemic antioxidant defense, as indicated by the restored superoxide dismutase activity.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated the protective effects of oral NMN supplementation against UV-B-induced photoaging in SKH-1 hairless mice.
Show in the study text Report a problemFND-4146262517

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Keywords

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