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Study · Animal study (in vivo) · 2026

3 results

An orally active estrogen receptor-related receptor agonist, SLU-PP-915, enhances aerobic exercise capacity.

Billon C, Appourchaux K, Côté I, Burris TP

The Journal of pharmacology and experimental therapeutics1 Dec 2025

PMID41421047 (opens in a new tab)DOI10.1016/j.jpet.2025.103787 (opens in a new tab)PepBankPUB-41421047
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In the exercise model, SLU‑PP‑332 and SLU-PP-915 produced similar improvements in aerobic exercise distance.

    In plain wordsIn animal exercise experiments, SLU‑PP‑332 improved exercise distance to a similar extent as SLU-PP-915.

    Peptide
    SLU-PP-332
    Outcome
    Direction not reportedExercise distance
    Study

    n: not reported in source

    Aerobic exercise model
    Comparator
    SLU-PP-915
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    Dose not stated · intraperitonealAs given in this study.

    Source sentences

    Summary
    Compound 915 enhances aerobic exercise performance (distance and duration) to a similar extent as 332 when administered intraperitoneally
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In the exercise model, SLU‑PP‑332 and SLU-PP-915 produced similar improvements in aerobic exercise duration.

    In plain wordsIn animal exercise experiments, SLU‑PP‑332 improved exercise duration to a similar extent as SLU-PP-915.

    Peptide
    SLU-PP-332
    Outcome
    Direction not reportedExercise duration
    Study

    n: not reported in source

    Aerobic exercise model
    Comparator
    SLU-PP-915
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    Dose not stated · intraperitonealAs given in this study.

    Source sentences

    Summary
    Compound 915 enhances aerobic exercise performance (distance and duration) to a similar extent as 332 when administered intraperitoneally
  3. 03AnimalAnimal study (in vivo)Mechanism

    In examined muscles, SLU‑PP‑332 induced Ddit4 expression to levels matching or exceeding treadmill running, depending on the muscle.

    In plain wordsIn animal muscles, SLU‑PP‑332 induced Ddit4 levels matching or exceeding treadmill running, depending on the muscle.

    Peptide
    SLU-PP-332
    Outcome
    MixedDdit4 expression
    Study

    n: not reported in source

    Aerobic exercise model
    Comparator
    Treadmill running
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both compounds robustly induce the expression of DNA damage-inducible transcript 4 (Ddit4), a gene induced by acute aerobic exercise, with levels matching or exceeding levels induced by treadmill running, depending on the muscle examined.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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