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Study · In vitro (cells) · mouse · 2026

6 results

Dual role of Kisspeptin-10 in modulating neuroinflammation: Downregulation of NLRP3 inflammasome activation and Caspase-1-mediated pyroptosis, and activation of BAG3-dependent aggrephagy in microglial cells.

Kalkan ÖF, Erdem Ş, Erdem M, Ateşer Kalkan S, Şahin Z, Uzun AY, Kurt AK, Karahan SC

Neuropeptides6 Dec 2025Cited by 1 (Europe PMC)

PMID41380532 (opens in a new tab)DOI10.1016/j.npep.2025.102580 (opens in a new tab)PepBankPUB-41380532
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In murine microglial cells stimulated with LPS + ATP, KP-10 significantly reduced NLRP3 expression.

    In plain wordsIn mouse brain immune cells, KP-10 lowered the inflammation sensor NLRP3.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseNLRP3 expression
    Study

    mousen: not reported in source

    Murine microglial cells, LPS + ATP
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    KP-10 treatment significantly reduced NLRP3 expression
    1 context sentence
    Summary · context
    In this study, we investigated the effects of KP-10 on LPS + ATP-induced NLRP3 inflammasome activation and pyroptotic signaling in murine microglial cells.
  2. 02LabIn vitro (cells)Mechanism

    In murine microglial cells stimulated with LPS + ATP, KP-10 inhibited cleavage of caspase-1 into its active p20 subunit.

    In plain wordsIn mouse brain immune cells, KP-10 reduced activation of caspase-1, an inflammation enzyme.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseCaspase-1 cleavage
    Study

    mousen: not reported in source

    Murine microglial cells, LPS + ATP
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    inhibited cleavage of caspase-1 into its active p20 subunit
    1 context sentence
    Summary · context
    In this study, we investigated the effects of KP-10 on LPS + ATP-induced NLRP3 inflammasome activation and pyroptotic signaling in murine microglial cells.
  3. 03LabIn vitro (cells)Mechanism

    In murine microglial cells stimulated with LPS + ATP, KP-10 decreased GSDMD cleavage into GSDMD-N, indicating suppressed pyroptosis.

    In plain wordsIn mouse brain immune cells, KP-10 reduced a step that leads to inflammatory cell death.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseGSDMD cleavage
    Study

    mousen: not reported in source

    Murine microglial cells, LPS + ATP
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    decreased GSDMD cleavage into its pore-forming N-terminal fragment (GSDMD-N)
    1 context sentence
    Summary · context
    In this study, we investigated the effects of KP-10 on LPS + ATP-induced NLRP3 inflammasome activation and pyroptotic signaling in murine microglial cells.
  4. 04LabIn vitro (cells)Mechanism

    In murine microglial cells stimulated with LPS + ATP, KP-10 attenuated secretion of IL-1β.

    In plain wordsIn mouse brain immune cells, KP-10 lowered release of the inflammation signal IL-1β.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseIL-1β secretion
    Study

    mousen: not reported in source

    Murine microglial cells, LPS + ATP
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    KP-10 also attenuated the secretion of IL-1β and IL-18
    1 context sentence
    Summary · context
    In this study, we investigated the effects of KP-10 on LPS + ATP-induced NLRP3 inflammasome activation and pyroptotic signaling in murine microglial cells.
  5. 05LabIn vitro (cells)Mechanism

    In murine microglial cells stimulated with LPS + ATP, KP-10 attenuated secretion of IL-18.

    In plain wordsIn mouse brain immune cells, KP-10 lowered release of the inflammation signal IL-18.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseIL-18 secretion
    Study

    mousen: not reported in source

    Murine microglial cells, LPS + ATP
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    KP-10 also attenuated the secretion of IL-1β and IL-18
    1 context sentence
    Summary · context
    In this study, we investigated the effects of KP-10 on LPS + ATP-induced NLRP3 inflammasome activation and pyroptotic signaling in murine microglial cells.
  6. 06LabIn vitro (cells)Mechanism

    In murine microglial cells, KP-10 markedly upregulated the co-chaperone BAG3.

    In plain wordsIn mouse brain immune cells, KP-10 raised BAG3, a protein that helps clear damaged proteins.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseBAG3 expression
    Study

    mousen: not reported in source

    Murine microglial cells, LPS + ATP
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    KP-10 markedly upregulated Bcl-2-associated athanogene 3 (BAG3)
    1 context sentence
    Summary · context
    In this study, we investigated the effects of KP-10 on LPS + ATP-induced NLRP3 inflammasome activation and pyroptotic signaling in murine microglial cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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