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Study · Animal study (in vivo) · mouse · 2025

5 results

NAD+ attenuates central nervous system demyelination in experimental autoimmune encephalomyelitis mice.

Zheng B, Ma J, Deng X, Pan J, Liao F

Folia neuropathologica1 Jan 2025

PMID41367331 (opens in a new tab)DOI10.5114/fn.2025.147649 (opens in a new tab)PepBankPUB-41367331
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In EAE mice, NAD supplementation promoted regulatory T cell conversion into Th17 cells with increasing NAD concentrations.

    In plain wordsIn mice with EAE, NAD promoted conversion of regulatory T cells into Th17 cells as NAD concentrations increased.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseTreg to Th17 conversion
    Study

    mousen: not reported in source

    Experimental autoimmune encephalomyelitis mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    250 mg/kg/day · injectionAs given in this study (mouse).

    Source sentences

    Summary
    NAD + supplementation promoted the conversion of regulatory T cells (Tregs) into T helper 17 (Th17) cells with increased concentrations of NAD + .
    3 context sentences
    Summary · context
    Mice were divided into 3 groups: EAE, EAE + NAD + , and Control (Ctrl).
    Summary · context
    EAE and EAE + NAD + groups were induced with myelin oligodendrocyte glycoprotein (MOG) to initiate the demyelination process.
    Summary · context
    The EAE + NAD + group received an NAD + injection at a dosage of 250 mg/kg/day.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In EAE mice, NAD alleviated neuroinflammation.

    In plain wordsIn mice with EAE, NAD reduced inflammation in the nervous system.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseNeuroinflammation
    Study

    mousen: not reported in source

    Experimental autoimmune encephalomyelitis mice
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    250 mg/kg/day · injectionAs given in this study (mouse).

    Source sentences

    Summary
    NAD + alleviated neuroinflammation, attenuated central nervous system (CNS) demyelination, and improved the disease score of EAE mice.
    3 context sentences
    Summary · context
    Mice were divided into 3 groups: EAE, EAE + NAD + , and Control (Ctrl).
    Summary · context
    EAE and EAE + NAD + groups were induced with myelin oligodendrocyte glycoprotein (MOG) to initiate the demyelination process.
    Summary · context
    The EAE + NAD + group received an NAD + injection at a dosage of 250 mg/kg/day.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In EAE mice, NAD attenuated central nervous system demyelination.

    In plain wordsIn mice with EAE, NAD reduced loss of myelin in the central nervous system.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseCNS demyelination
    Study

    mousen: not reported in source

    Experimental autoimmune encephalomyelitis mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    250 mg/kg/day · injectionAs given in this study (mouse).

    Source sentences

    Summary
    NAD + alleviated neuroinflammation, attenuated central nervous system (CNS) demyelination, and improved the disease score of EAE mice.
    3 context sentences
    Summary · context
    Mice were divided into 3 groups: EAE, EAE + NAD + , and Control (Ctrl).
    Summary · context
    EAE and EAE + NAD + groups were induced with myelin oligodendrocyte glycoprotein (MOG) to initiate the demyelination process.
    Summary · context
    The EAE + NAD + group received an NAD + injection at a dosage of 250 mg/kg/day.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In EAE mice, NAD improved the disease score.

    In plain wordsIn mice with EAE, NAD improved the disease score.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseDisease score
    Study

    mousen: not reported in source

    Experimental autoimmune encephalomyelitis mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    250 mg/kg/day · injectionAs given in this study (mouse).

    Source sentences

    Summary
    NAD + alleviated neuroinflammation, attenuated central nervous system (CNS) demyelination, and improved the disease score of EAE mice.
    3 context sentences
    Summary · context
    Mice were divided into 3 groups: EAE, EAE + NAD + , and Control (Ctrl).
    Summary · context
    EAE and EAE + NAD + groups were induced with myelin oligodendrocyte glycoprotein (MOG) to initiate the demyelination process.
    Summary · context
    The EAE + NAD + group received an NAD + injection at a dosage of 250 mg/kg/day.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In EAE mice, NAD promoted IL-17A cytokine expression.

    In plain wordsIn mice with EAE, NAD increased IL-17A expression.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseIL-17A expression
    Study

    mousen: not reported in source

    Experimental autoimmune encephalomyelitis mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    250 mg/kg/day · injectionAs given in this study (mouse).

    Source sentences

    Summary
    NAD + promoted expression of the cytokine interleukin 17A (IL-17A).
    3 context sentences
    Summary · context
    Mice were divided into 3 groups: EAE, EAE + NAD + , and Control (Ctrl).
    Summary · context
    EAE and EAE + NAD + groups were induced with myelin oligodendrocyte glycoprotein (MOG) to initiate the demyelination process.
    Summary · context
    The EAE + NAD + group received an NAD + injection at a dosage of 250 mg/kg/day.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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