In molecular dynamics simulations, adding cardiolipin and elamipretide increased membrane capacitance.
In plain wordsIn computer simulations, adding cardiolipin and elamipretide raised membrane capacitance. These are predictions, not tests in living cells.
- Peptide
- Elamipretide (SS-31)
- Outcome
- IncreaseMembrane capacitance
- Study
n: not reported in source
all-atom molecular dynamics bilayer simulations- Outcome group
- Receptor activity and mechanism · Pharmacology
Source sentences
The addition of cardiolipin (CL) and Elamipretide increased the membrane capacitance, decreasing the ΔΨm for a given transmembrane charge imbalance (δTM) and protecting bilayers against electroporation.
2 context sentences(design, population, supporting numbers)
Here, we use all-atom, double-bilayer MD simulations with explicitly modeled ΔΨm voltages to compare how membranes with homogeneous vs heterogeneous lipid compositions respond to varying degrees of electrochemical stress.
These two bilayer systems were also exposed to a mitochondria-targeted peptide named Elamipretide, which has been shown experimentally to modulate membrane electrostatics.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).