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Study · Animal study (in vivo) · mouse · 2026

9 results

High-Fat Diet Promotes Glycolysis in Hepatocellular Carcinoma by Suppressing Hepatic Kisspeptin Signaling in Mice.

Zhao R, Nie L, Shi Y, Jin L, Pan Y, Zhang X, Wang Z, He M, Zhang G, Yuan Q, Xia T, Wang S, Yang J, Yang W, Yuan D

Molecular carcinogenesis2 Dec 2025

PMID41328591 (opens in a new tab)DOI10.1002/mc.70068 (opens in a new tab)PepBankPUB-41328591
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In N-Nitrosodiethylamine-induced hepatocellular carcinoma mice on a high-fat diet, Kisspeptin‑10 attenuated diet-promoted tumor progression.

    In plain wordsIn mice with liver cancer on a high-fat diet, Kisspeptin‑10 slowed tumour progression.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseHigh-fat diet-promoted HCC progression
    Study

    mousen: not reported in source

    NDEA-induced hepatocellular carcinoma mice on high-fat diet
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with kisspeptin-10 attenuated high-fat diet-promoted hepatocellular carcinoma progression and decreased the expression of key glycolytic enzymes HK, PFKM, and PKM2.
    1 context sentence
    Summary · context
    In a N-Nitrosodiethylamine-induced hepatocellular carcinoma mouse model, high-fat diet accelerated tumor progression accompanied by kisspeptin receptor downregulation.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In hepatocellular carcinoma mice on a high-fat diet, Kisspeptin‑10 decreased the glycolytic enzyme HK.

    In plain wordsIn mice with liver cancer, Kisspeptin‑10 lowered a sugar-breakdown enzyme.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseHexokinase (HK) expression
    Study

    mousen: not reported in source

    NDEA-induced hepatocellular carcinoma mice on high-fat diet
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with kisspeptin-10 attenuated high-fat diet-promoted hepatocellular carcinoma progression and decreased the expression of key glycolytic enzymes HK, PFKM, and PKM2.
    1 context sentence
    Summary · context
    In a N-Nitrosodiethylamine-induced hepatocellular carcinoma mouse model, high-fat diet accelerated tumor progression accompanied by kisspeptin receptor downregulation.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In hepatocellular carcinoma mice on a high-fat diet, Kisspeptin‑10 decreased the glycolytic enzyme PFKM.

    In plain wordsIn mice with liver cancer, Kisspeptin‑10 lowered a sugar-breakdown enzyme.

    Peptide
    Kisspeptin-10
    Outcome
    DecreasePFKM expression
    Study

    mousen: not reported in source

    NDEA-induced hepatocellular carcinoma mice on high-fat diet
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with kisspeptin-10 attenuated high-fat diet-promoted hepatocellular carcinoma progression and decreased the expression of key glycolytic enzymes HK, PFKM, and PKM2.
    1 context sentence
    Summary · context
    In a N-Nitrosodiethylamine-induced hepatocellular carcinoma mouse model, high-fat diet accelerated tumor progression accompanied by kisspeptin receptor downregulation.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In hepatocellular carcinoma mice on a high-fat diet, Kisspeptin‑10 decreased the glycolytic enzyme PKM2.

    In plain wordsIn mice with liver cancer, Kisspeptin‑10 lowered a sugar-breakdown enzyme.

    Peptide
    Kisspeptin-10
    Outcome
    DecreasePKM2 expression
    Study

    mousen: not reported in source

    NDEA-induced hepatocellular carcinoma mice on high-fat diet
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with kisspeptin-10 attenuated high-fat diet-promoted hepatocellular carcinoma progression and decreased the expression of key glycolytic enzymes HK, PFKM, and PKM2.
    1 context sentence
    Summary · context
    In a N-Nitrosodiethylamine-induced hepatocellular carcinoma mouse model, high-fat diet accelerated tumor progression accompanied by kisspeptin receptor downregulation.
  5. 05LabIn vitro (cells)Mechanism

    In HepG2 cells, Kisspeptin‑10 inhibited the glycolytic enzyme HK in a dose-dependent manner.

    In plain wordsIn liver cancer cells in the lab, Kisspeptin‑10 lowered a sugar-breakdown enzyme, more so at higher doses.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseHK inhibition in HepG2 cells
    Study

    humann: not reported in source

    HepG2 cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro studies using HepG2 cells further confirmed that kisspeptin-10 inhibited these glycolytic enzymes in a dose-dependent manner.
    1 context sentence
    Summary · context
    Treatment with kisspeptin-10 attenuated high-fat diet-promoted hepatocellular carcinoma progression and decreased the expression of key glycolytic enzymes HK, PFKM, and PKM2.
  6. 06LabIn vitro (cells)Mechanism

    In HepG2 cells, Kisspeptin‑10 inhibited the glycolytic enzyme PFKM in a dose-dependent manner.

    In plain wordsIn liver cancer cells in the lab, Kisspeptin‑10 lowered a sugar-breakdown enzyme, more so at higher doses.

    Peptide
    Kisspeptin-10
    Outcome
    DecreasePFKM inhibition in HepG2 cells
    Study

    humann: not reported in source

    HepG2 cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro studies using HepG2 cells further confirmed that kisspeptin-10 inhibited these glycolytic enzymes in a dose-dependent manner.
    1 context sentence
    Summary · context
    Treatment with kisspeptin-10 attenuated high-fat diet-promoted hepatocellular carcinoma progression and decreased the expression of key glycolytic enzymes HK, PFKM, and PKM2.
  7. 07LabIn vitro (cells)Mechanism

    In HepG2 cells, Kisspeptin‑10 inhibited the glycolytic enzyme PKM2 in a dose-dependent manner.

    In plain wordsIn liver cancer cells in the lab, Kisspeptin‑10 lowered a sugar-breakdown enzyme, more so at higher doses.

    Peptide
    Kisspeptin-10
    Outcome
    DecreasePKM2 inhibition in HepG2 cells
    Study

    humann: not reported in source

    HepG2 cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro studies using HepG2 cells further confirmed that kisspeptin-10 inhibited these glycolytic enzymes in a dose-dependent manner.
    1 context sentence
    Summary · context
    Treatment with kisspeptin-10 attenuated high-fat diet-promoted hepatocellular carcinoma progression and decreased the expression of key glycolytic enzymes HK, PFKM, and PKM2.

Studies that did not test the peptide alone2

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 08AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Mechanism

    In mice, high-fat diet feeding significantly decreased hepatic kisspeptin receptor expression.

    In plain wordsIn mice, a high-fat diet lowered the level of the kisspeptin receptor in the liver.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseHepatic kisspeptin receptor expression
    Study

    mousen: not reported in source

    High-fat diet-fed mice
    Outcome group
    Receptor activity and mechanism · Cancer

    Source sentences

    Summary
    High-fat diet feeding significantly decreased hepatic kisspeptin receptor expression in mice.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  2. 09AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Mechanism

    In N-Nitrosodiethylamine-induced hepatocellular carcinoma mice, a high-fat diet accelerated tumor progression with kisspeptin receptor downregulation.

    In plain wordsIn mice with liver cancer, a high-fat diet sped up tumour growth and lowered the kisspeptin receptor.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseTumor progression and receptor expression on high-fat diet
    Study

    mousen: not reported in source

    NDEA-induced hepatocellular carcinoma mice on high-fat diet
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    In a N-Nitrosodiethylamine-induced hepatocellular carcinoma mouse model, high-fat diet accelerated tumor progression accompanied by kisspeptin receptor downregulation.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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