Kisspeptin-10 Ameliorates Obesity-Diabetes with Diverse Effects on Ileal Enteroendocrine Cells and Pancreatic Islet Morphology in High-Fat Fed Female Mice.

Sridhar A, Khan D, Muthukumar R, Sampathkumar S, Irwin N, Flatt PR, Moffett RC

Biomolecules13 Nov 2025

PMID41301510PMCIDPMC12650608DOI10.3390/biom15111591PepBankPUB-41301510

Summary

Kisspeptin is a neuropeptide recognised for a pivotal role within the reproductive system, but potentially important endocrine metabolic effects are less well understood. We examined effects of twice-daily intraperitoneal administration of saline vehicle or kisspeptin-10 (25 nmol/kg), for 21 days, on glucose homeostasis, energy balance, circulating hormones as well as the morphology-function of enteroendocrine and islet cells in high-fat diet (HFD) fed female mice, with normal diet (ND) mice as an additional control group. Kisspeptin-10 decreased body weight, blood glucose and energy intake to ND levels. HFD increased circulating follicle-stimulating hormone (FSH) levels, which were further enhanced by kisspeptin-10 along with luteinising hormone (LH) concentrations. Neither HFD nor kisspeptin-10 affected progesterone or corticosterone. In the ileum, kisspeptin-10 decreased crypt depth and restored villi length to ND control levels, as well as increasing the proportion of glucose-dependent insulinotropic polypeptide (GIP) positive cells when compared to HFD mice and glucagon-like peptide-1 (GLP-1) positive cells compared to ND mice. Peptide YY (PYY) immunoreactivity was unaltered by HFD or kisspeptin-10. Plasma GIP was unchanged but circulating GLP-1 and PYY were reduced to ND levels. Within the pancreas, total islet, beta- and alpha-cell areas were similar in all mice, but kisspeptin-10 intervention restored relative insulin area to ND levels. Glucagon radius, an indicator of peripherally located alpha-cells, was reduced in HFD mice but normalised by kisspeptin-10 alongside elevated glucagon-islet area. Notably, beta-cell proliferation was increased by kisspeptin-10 with no alteration in beta-cell apoptosis. Overall, we reveal a previously uncharacterised diverse metabolic role for kisspeptin in directly modulating the gut-pancreatic axis.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study21

21 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In high-fat fed female mice, kisspeptin‑10 decreased body weight to normal-diet levels.
In plain wordsIn mice on a high-fat diet, kisspeptin‑10 brought body weight down to the level of mice on a normal diet.
Peptide
Kisspeptin-10
Outcome
DecreaseBody weight
Study
mousen: not reported in source
high-fat diet-fed female mice with normal diet control
Comparator
Saline vehicle in high-fat diet mice
Outcome group
Body weight · Metabolic and weight
Studied dose
25 nmol/kg twice daily · intraperitoneal · 21 daysAs given in this study (mouse).
Source sentences
Summary
Kisspeptin-10 decreased body weight, blood glucose and energy intake to ND levels.
1 context sentence(design, population, supporting numbers)
Summary · context
We examined effects of twice-daily intraperitoneal administration of saline vehicle or kisspeptin-10 (25 nmol/kg), for 21 days, on glucose homeostasis, energy balance, circulating hormones as well as the morphology-function of enteroendocrine and islet cells in high-fat diet (HFD) fed female mice, with normal diet (ND) mice as an additional control group.
Show in the study text Report a problemFND-4130151001
02AnimalAnimal study (in vivo)Efficacy outcome
In high-fat fed female mice, kisspeptin‑10 decreased blood glucose to normal-diet levels.
In plain wordsIn mice on a high-fat diet, kisspeptin‑10 brought blood sugar down to the level of mice on a normal diet.
Peptide
Kisspeptin-10
Outcome
DecreaseBlood glucose
Study
mousen: not reported in source
high-fat diet-fed female mice with normal diet control
Comparator
Saline vehicle in high-fat diet mice
Outcome group
Glycemic control · Metabolic and weight
Studied dose
25 nmol/kg twice daily · intraperitoneal · 21 daysAs given in this study (mouse).
Source sentences
Summary
Kisspeptin-10 decreased body weight, blood glucose and energy intake to ND levels.
1 context sentence(design, population, supporting numbers)
Summary · context
We examined effects of twice-daily intraperitoneal administration of saline vehicle or kisspeptin-10 (25 nmol/kg), for 21 days, on glucose homeostasis, energy balance, circulating hormones as well as the morphology-function of enteroendocrine and islet cells in high-fat diet (HFD) fed female mice, with normal diet (ND) mice as an additional control group.
Show in the study text Report a problemFND-4130151002
03AnimalAnimal study (in vivo)Efficacy outcome
In high-fat fed female mice, kisspeptin‑10 decreased energy intake to normal-diet levels.
In plain wordsIn mice on a high-fat diet, kisspeptin‑10 brought food energy intake down to the level of mice on a normal diet.
Peptide
Kisspeptin-10
Outcome
DecreaseEnergy intake
Study
mousen: not reported in source
high-fat diet-fed female mice with normal diet control
Comparator
Saline vehicle in high-fat diet mice
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
25 nmol/kg twice daily · intraperitoneal · 21 daysAs given in this study (mouse).
Source sentences
Summary
Kisspeptin-10 decreased body weight, blood glucose and energy intake to ND levels.
1 context sentence(design, population, supporting numbers)
Summary · context
We examined effects of twice-daily intraperitoneal administration of saline vehicle or kisspeptin-10 (25 nmol/kg), for 21 days, on glucose homeostasis, energy balance, circulating hormones as well as the morphology-function of enteroendocrine and islet cells in high-fat diet (HFD) fed female mice, with normal diet (ND) mice as an additional control group.
Show in the study text Report a problemFND-4130151003
04AnimalAnimal study (in vivo)Efficacy outcome
In high-fat fed female mice, kisspeptin‑10 further enhanced the high-fat diet-induced rise in circulating FSH.
In plain wordsIn mice on a high-fat diet, kisspeptin‑10 raised the hormone FSH further.
Peptide
Kisspeptin-10
Outcome
IncreaseCirculating FSH
Study
mousen: not reported in source
high-fat diet-fed female mice with normal diet control
Comparator
Saline vehicle in high-fat diet mice
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
25 nmol/kg twice daily · intraperitoneal · 21 daysAs given in this study (mouse).
Source sentences
Summary
HFD increased circulating follicle-stimulating hormone (FSH) levels, which were further enhanced by kisspeptin-10 along with luteinising hormone (LH) concentrations.
1 context sentence(design, population, supporting numbers)
Summary · context
We examined effects of twice-daily intraperitoneal administration of saline vehicle or kisspeptin-10 (25 nmol/kg), for 21 days, on glucose homeostasis, energy balance, circulating hormones as well as the morphology-function of enteroendocrine and islet cells in high-fat diet (HFD) fed female mice, with normal diet (ND) mice as an additional control group.
Show in the study text Report a problemFND-4130151004
05AnimalAnimal study (in vivo)Efficacy outcome
In high-fat fed female mice, kisspeptin‑10 increased circulating LH concentrations.
In plain wordsIn mice on a high-fat diet, kisspeptin‑10 raised the hormone LH.
Peptide
Kisspeptin-10
Outcome
IncreaseCirculating LH
Study
mousen: not reported in source
high-fat diet-fed female mice with normal diet control
Comparator
Saline vehicle in high-fat diet mice
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
25 nmol/kg twice daily · intraperitoneal · 21 daysAs given in this study (mouse).
Source sentences
Summary
HFD increased circulating follicle-stimulating hormone (FSH) levels, which were further enhanced by kisspeptin-10 along with luteinising hormone (LH) concentrations.
1 context sentence(design, population, supporting numbers)
Summary · context
We examined effects of twice-daily intraperitoneal administration of saline vehicle or kisspeptin-10 (25 nmol/kg), for 21 days, on glucose homeostasis, energy balance, circulating hormones as well as the morphology-function of enteroendocrine and islet cells in high-fat diet (HFD) fed female mice, with normal diet (ND) mice as an additional control group.
Show in the study text Report a problemFND-4130151005
06AnimalAnimal study (in vivo)Efficacy outcome
In high-fat fed female mice, kisspeptin‑10 did not affect progesterone.
In plain wordsIn mice on a high-fat diet, kisspeptin‑10 did not change progesterone.
Peptide
Kisspeptin-10
Outcome
No significant changeProgesterone
Study
mousen: not reported in source
high-fat diet-fed female mice with normal diet control
Comparator
Saline vehicle in high-fat diet mice
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
25 nmol/kg twice daily · intraperitoneal · 21 daysAs given in this study (mouse).
Source sentences
Summary
Neither HFD nor kisspeptin-10 affected progesterone or corticosterone.
1 context sentence(design, population, supporting numbers)
Summary · context
We examined effects of twice-daily intraperitoneal administration of saline vehicle or kisspeptin-10 (25 nmol/kg), for 21 days, on glucose homeostasis, energy balance, circulating hormones as well as the morphology-function of enteroendocrine and islet cells in high-fat diet (HFD) fed female mice, with normal diet (ND) mice as an additional control group.
Show in the study text Report a problemFND-4130151006
07AnimalAnimal study (in vivo)Efficacy outcome
In high-fat fed female mice, kisspeptin‑10 did not affect corticosterone.
In plain wordsIn mice on a high-fat diet, kisspeptin‑10 did not change corticosterone.
Peptide
Kisspeptin-10
Outcome
No significant changeCorticosterone
Study
mousen: not reported in source
high-fat diet-fed female mice with normal diet control
Comparator
Saline vehicle in high-fat diet mice
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
25 nmol/kg twice daily · intraperitoneal · 21 daysAs given in this study (mouse).
Source sentences
Summary
Neither HFD nor kisspeptin-10 affected progesterone or corticosterone.
1 context sentence(design, population, supporting numbers)
Summary · context
We examined effects of twice-daily intraperitoneal administration of saline vehicle or kisspeptin-10 (25 nmol/kg), for 21 days, on glucose homeostasis, energy balance, circulating hormones as well as the morphology-function of enteroendocrine and islet cells in high-fat diet (HFD) fed female mice, with normal diet (ND) mice as an additional control group.
Show in the study text Report a problemFND-4130151007
08AnimalAnimal study (in vivo)Efficacy outcome
In high-fat fed female mice, kisspeptin‑10 decreased ileal crypt depth.
In plain wordsIn mice on a high-fat diet, kisspeptin‑10 made the crypts in the small intestine shallower.
Peptide
Kisspeptin-10
Outcome
DecreaseIleal crypt depth
Study
mousen: not reported in source
high-fat diet-fed female mice with normal diet control
Comparator
Saline vehicle in high-fat diet mice
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
25 nmol/kg twice daily · intraperitoneal · 21 daysAs given in this study (mouse).
Source sentences
Summary
In the ileum, kisspeptin-10 decreased crypt depth
1 context sentence(design, population, supporting numbers)
Summary · context
We examined effects of twice-daily intraperitoneal administration of saline vehicle or kisspeptin-10 (25 nmol/kg), for 21 days, on glucose homeostasis, energy balance, circulating hormones as well as the morphology-function of enteroendocrine and islet cells in high-fat diet (HFD) fed female mice, with normal diet (ND) mice as an additional control group.
Show in the study text Report a problemFND-4130151008
09AnimalAnimal study (in vivo)Efficacy outcome
In high-fat fed female mice, kisspeptin‑10 restored ileal villi length to normal-diet levels.
In plain wordsIn mice on a high-fat diet, kisspeptin‑10 brought the length of small-intestine villi back to normal-diet levels.
Peptide
Kisspeptin-10
Outcome
IncreaseIleal villi length
Study
mousen: not reported in source
high-fat diet-fed female mice with normal diet control
Comparator
Saline vehicle in high-fat diet mice
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
25 nmol/kg twice daily · intraperitoneal · 21 daysAs given in this study (mouse).
Source sentences
Summary
In the ileum, kisspeptin-10 decreased crypt depth and restored villi length to ND control levels
1 context sentence(design, population, supporting numbers)
Summary · context
We examined effects of twice-daily intraperitoneal administration of saline vehicle or kisspeptin-10 (25 nmol/kg), for 21 days, on glucose homeostasis, energy balance, circulating hormones as well as the morphology-function of enteroendocrine and islet cells in high-fat diet (HFD) fed female mice, with normal diet (ND) mice as an additional control group.
Show in the study text Report a problemFND-4130151009
10AnimalAnimal study (in vivo)Efficacy outcome
In high-fat fed female mice, kisspeptin‑10 increased the proportion of GIP-positive ileal cells versus high-fat diet mice.
In plain wordsIn mice, kisspeptin‑10 raised the share of gut cells that make GIP compared with high-fat diet mice.
Peptide
Kisspeptin-10
Outcome
IncreaseGIP-positive cell proportion in ileum
Study
mousen: not reported in source
high-fat diet-fed female mice with normal diet control
Comparator
High-fat diet mice
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
25 nmol/kg twice daily · intraperitoneal · 21 daysAs given in this study (mouse).
Source sentences
Summary
In the ileum, kisspeptin-10 decreased crypt depth and restored villi length to ND control levels, as well as increasing the proportion of glucose-dependent insulinotropic polypeptide (GIP) positive cells when compared to HFD mice
1 context sentence(design, population, supporting numbers)
Summary · context
We examined effects of twice-daily intraperitoneal administration of saline vehicle or kisspeptin-10 (25 nmol/kg), for 21 days, on glucose homeostasis, energy balance, circulating hormones as well as the morphology-function of enteroendocrine and islet cells in high-fat diet (HFD) fed female mice, with normal diet (ND) mice as an additional control group.
Show in the study text Report a problemFND-4130151010
11AnimalAnimal study (in vivo)Efficacy outcome
In high-fat fed female mice, kisspeptin‑10 increased the proportion of GLP-1-positive ileal cells versus normal-diet mice.
In plain wordsIn mice, kisspeptin‑10 raised the share of gut cells that make GLP-1 compared with normal-diet mice.
Peptide
Kisspeptin-10
Outcome
IncreaseGLP-1-positive cell proportion in ileum
Study
mousen: not reported in source
high-fat diet-fed female mice with normal diet control
Comparator
Normal diet mice
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
25 nmol/kg twice daily · intraperitoneal · 21 daysAs given in this study (mouse).
Source sentences
Summary
In the ileum, kisspeptin-10 decreased crypt depth and restored villi length to ND control levels, as well as increasing the proportion of glucose-dependent insulinotropic polypeptide (GIP) positive cells when compared to HFD mice and glucagon-like peptide-1 (GLP-1) positive cells compared to ND mice
1 context sentence(design, population, supporting numbers)
Summary · context
We examined effects of twice-daily intraperitoneal administration of saline vehicle or kisspeptin-10 (25 nmol/kg), for 21 days, on glucose homeostasis, energy balance, circulating hormones as well as the morphology-function of enteroendocrine and islet cells in high-fat diet (HFD) fed female mice, with normal diet (ND) mice as an additional control group.
Show in the study text Report a problemFND-4130151011
12AnimalAnimal study (in vivo)Efficacy outcome
In high-fat fed female mice, ileal PYY immunoreactivity was not altered by kisspeptin‑10.
In plain wordsIn mice on a high-fat diet, kisspeptin‑10 did not change PYY staining in the gut.
Peptide
Kisspeptin-10
Outcome
No significant changePYY immunoreactivity in ileum
Study
mousen: not reported in source
high-fat diet-fed female mice with normal diet control
Comparator
Saline vehicle in high-fat diet mice
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
25 nmol/kg twice daily · intraperitoneal · 21 daysAs given in this study (mouse).
Source sentences
Summary
Peptide YY (PYY) immunoreactivity was unaltered by HFD or kisspeptin-10.
1 context sentence(design, population, supporting numbers)
Summary · context
We examined effects of twice-daily intraperitoneal administration of saline vehicle or kisspeptin-10 (25 nmol/kg), for 21 days, on glucose homeostasis, energy balance, circulating hormones as well as the morphology-function of enteroendocrine and islet cells in high-fat diet (HFD) fed female mice, with normal diet (ND) mice as an additional control group.
Show in the study text Report a problemFND-4130151012
13AnimalAnimal study (in vivo)Efficacy outcome
In high-fat fed female mice, plasma GIP was unchanged by kisspeptin‑10.
In plain wordsIn mice on a high-fat diet, kisspeptin‑10 did not change blood GIP.
Peptide
Kisspeptin-10
Outcome
No significant changePlasma GIP
Study
mousen: not reported in source
high-fat diet-fed female mice with normal diet control
Comparator
Saline vehicle in high-fat diet mice
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
25 nmol/kg twice daily · intraperitoneal · 21 daysAs given in this study (mouse).
Source sentences
Summary
Plasma GIP was unchanged but circulating GLP-1 and PYY were reduced to ND levels.
1 context sentence(design, population, supporting numbers)
Summary · context
We examined effects of twice-daily intraperitoneal administration of saline vehicle or kisspeptin-10 (25 nmol/kg), for 21 days, on glucose homeostasis, energy balance, circulating hormones as well as the morphology-function of enteroendocrine and islet cells in high-fat diet (HFD) fed female mice, with normal diet (ND) mice as an additional control group.
Show in the study text Report a problemFND-4130151013
14AnimalAnimal study (in vivo)Efficacy outcome
In high-fat fed female mice, kisspeptin‑10 reduced circulating GLP-1 to normal-diet levels.
In plain wordsIn mice on a high-fat diet, kisspeptin‑10 lowered blood GLP-1 to normal-diet levels.
Peptide
Kisspeptin-10
Outcome
DecreaseCirculating GLP-1
Study
mousen: not reported in source
high-fat diet-fed female mice with normal diet control
Comparator
Saline vehicle in high-fat diet mice
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
25 nmol/kg twice daily · intraperitoneal · 21 daysAs given in this study (mouse).
Source sentences
Summary
but circulating GLP-1 and PYY were reduced to ND levels.
1 context sentence(design, population, supporting numbers)
Summary · context
We examined effects of twice-daily intraperitoneal administration of saline vehicle or kisspeptin-10 (25 nmol/kg), for 21 days, on glucose homeostasis, energy balance, circulating hormones as well as the morphology-function of enteroendocrine and islet cells in high-fat diet (HFD) fed female mice, with normal diet (ND) mice as an additional control group.
Show in the study text Report a problemFND-4130151014
15AnimalAnimal study (in vivo)Efficacy outcome
In high-fat fed female mice, kisspeptin‑10 reduced circulating PYY to normal-diet levels.
In plain wordsIn mice on a high-fat diet, kisspeptin‑10 lowered blood PYY to normal-diet levels.
Peptide
Kisspeptin-10
Outcome
DecreaseCirculating PYY
Study
mousen: not reported in source
high-fat diet-fed female mice with normal diet control
Comparator
Saline vehicle in high-fat diet mice
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
25 nmol/kg twice daily · intraperitoneal · 21 daysAs given in this study (mouse).
Source sentences
Summary
but circulating GLP-1 and PYY were reduced to ND levels.
1 context sentence(design, population, supporting numbers)
Summary · context
We examined effects of twice-daily intraperitoneal administration of saline vehicle or kisspeptin-10 (25 nmol/kg), for 21 days, on glucose homeostasis, energy balance, circulating hormones as well as the morphology-function of enteroendocrine and islet cells in high-fat diet (HFD) fed female mice, with normal diet (ND) mice as an additional control group.
Show in the study text Report a problemFND-4130151015
16AnimalAnimal study (in vivo)Efficacy outcome
In high-fat fed female mice, total islet, beta-cell and alpha-cell areas were similar in all groups.
In plain wordsIn mice, total islet, beta-cell and alpha-cell areas were similar in all groups.
Peptide
Kisspeptin-10
Outcome
No significant changeTotal islet, beta-cell and alpha-cell areas
Study
mousen: not reported in source
high-fat diet-fed female mice with normal diet control
Comparator
Saline vehicle in high-fat diet mice
Outcome group
Islet protection · Endocrine and hormones
Studied dose
25 nmol/kg twice daily · intraperitoneal · 21 daysAs given in this study (mouse).
Source sentences
Summary
Within the pancreas, total islet, beta- and alpha-cell areas were similar in all mice
1 context sentence(design, population, supporting numbers)
Summary · context
We examined effects of twice-daily intraperitoneal administration of saline vehicle or kisspeptin-10 (25 nmol/kg), for 21 days, on glucose homeostasis, energy balance, circulating hormones as well as the morphology-function of enteroendocrine and islet cells in high-fat diet (HFD) fed female mice, with normal diet (ND) mice as an additional control group.
Show in the study text Report a problemFND-4130151016
17AnimalAnimal study (in vivo)Efficacy outcome
In high-fat fed female mice, kisspeptin‑10 restored relative insulin area to normal-diet levels.
In plain wordsIn mice on a high-fat diet, kisspeptin‑10 brought the insulin-positive part of the islets back to normal-diet levels.
Peptide
Kisspeptin-10
Outcome
Direction not reportedRelative insulin area
Study
mousen: not reported in source
high-fat diet-fed female mice with normal diet control
Comparator
Saline vehicle in high-fat diet mice
Outcome group
Islet protection · Endocrine and hormones
Studied dose
25 nmol/kg twice daily · intraperitoneal · 21 daysAs given in this study (mouse).
Source sentences
Summary
but kisspeptin-10 intervention restored relative insulin area to ND levels.
1 context sentence(design, population, supporting numbers)
Summary · context
We examined effects of twice-daily intraperitoneal administration of saline vehicle or kisspeptin-10 (25 nmol/kg), for 21 days, on glucose homeostasis, energy balance, circulating hormones as well as the morphology-function of enteroendocrine and islet cells in high-fat diet (HFD) fed female mice, with normal diet (ND) mice as an additional control group.
Show in the study text Report a problemFND-4130151017
18AnimalAnimal study (in vivo)Efficacy outcome
In high-fat fed female mice, kisspeptin‑10 normalised the glucagon radius, which was reduced by the high-fat diet.
In plain wordsIn mice on a high-fat diet, kisspeptin‑10 brought the position of alpha-cells in the islets back to normal.
Peptide
Kisspeptin-10
Outcome
IncreaseGlucagon radius in islets
Study
mousen: not reported in source
high-fat diet-fed female mice with normal diet control
Comparator
High-fat diet mice
Outcome group
Islet protection · Endocrine and hormones
Studied dose
25 nmol/kg twice daily · intraperitoneal · 21 daysAs given in this study (mouse).
Source sentences
Summary
Glucagon radius, an indicator of peripherally located alpha-cells, was reduced in HFD mice but normalised by kisspeptin-10
1 context sentence(design, population, supporting numbers)
Summary · context
We examined effects of twice-daily intraperitoneal administration of saline vehicle or kisspeptin-10 (25 nmol/kg), for 21 days, on glucose homeostasis, energy balance, circulating hormones as well as the morphology-function of enteroendocrine and islet cells in high-fat diet (HFD) fed female mice, with normal diet (ND) mice as an additional control group.
Show in the study text Report a problemFND-4130151018
19AnimalAnimal study (in vivo)Efficacy outcome
In high-fat fed female mice, kisspeptin‑10 was accompanied by an elevated glucagon-islet area.
In plain wordsIn mice on a high-fat diet, kisspeptin‑10 came with a larger glucagon-positive islet area.
Peptide
Kisspeptin-10
Outcome
IncreaseGlucagon-islet area
Study
mousen: not reported in source
high-fat diet-fed female mice with normal diet control
Comparator
Saline vehicle in high-fat diet mice
Outcome group
Islet protection · Endocrine and hormones
Studied dose
25 nmol/kg twice daily · intraperitoneal · 21 daysAs given in this study (mouse).
Source sentences
Summary
alongside elevated glucagon-islet area.
1 context sentence(design, population, supporting numbers)
Summary · context
We examined effects of twice-daily intraperitoneal administration of saline vehicle or kisspeptin-10 (25 nmol/kg), for 21 days, on glucose homeostasis, energy balance, circulating hormones as well as the morphology-function of enteroendocrine and islet cells in high-fat diet (HFD) fed female mice, with normal diet (ND) mice as an additional control group.
Show in the study text Report a problemFND-4130151019
20AnimalAnimal study (in vivo)Efficacy outcome
In high-fat fed female mice, kisspeptin‑10 increased beta-cell proliferation.
In plain wordsIn mice on a high-fat diet, kisspeptin‑10 increased the growth of insulin-making beta cells.
Peptide
Kisspeptin-10
Outcome
IncreaseBeta-cell proliferation
Study
mousen: not reported in source
high-fat diet-fed female mice with normal diet control
Comparator
Saline vehicle in high-fat diet mice
Outcome group
Islet protection · Endocrine and hormones
Studied dose
25 nmol/kg twice daily · intraperitoneal · 21 daysAs given in this study (mouse).
Source sentences
Summary
Notably, beta-cell proliferation was increased by kisspeptin-10 with no alteration in beta-cell apoptosis.
1 context sentence(design, population, supporting numbers)
Summary · context
We examined effects of twice-daily intraperitoneal administration of saline vehicle or kisspeptin-10 (25 nmol/kg), for 21 days, on glucose homeostasis, energy balance, circulating hormones as well as the morphology-function of enteroendocrine and islet cells in high-fat diet (HFD) fed female mice, with normal diet (ND) mice as an additional control group.
Show in the study text Report a problemFND-4130151020
21AnimalAnimal study (in vivo)Efficacy outcome
In high-fat fed female mice, kisspeptin‑10 did not alter beta-cell apoptosis.
In plain wordsIn mice on a high-fat diet, kisspeptin‑10 did not change beta-cell death.
Peptide
Kisspeptin-10
Outcome
No significant changeBeta-cell apoptosis
Study
mousen: not reported in source
high-fat diet-fed female mice with normal diet control
Comparator
Saline vehicle in high-fat diet mice
Outcome group
Islet protection · Endocrine and hormones
Studied dose
25 nmol/kg twice daily · intraperitoneal · 21 daysAs given in this study (mouse).
Source sentences
Summary
with no alteration in beta-cell apoptosis.
1 context sentence(design, population, supporting numbers)
Summary · context
We examined effects of twice-daily intraperitoneal administration of saline vehicle or kisspeptin-10 (25 nmol/kg), for 21 days, on glucose homeostasis, energy balance, circulating hormones as well as the morphology-function of enteroendocrine and islet cells in high-fat diet (HFD) fed female mice, with normal diet (ND) mice as an additional control group.
Show in the study text Report a problemFND-4130151021

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

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PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

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Keywords

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