Study · Animal study (in vivo) · mouse · 2025
7 resultsLiu K, Nong W, Huang H, Wei Y, Wang J, Youzhu L, Huang G, Tang Z, Yu J, Huo P, Hu L, Chen X, Wang X, Lei X
Communications biology26 Nov 2025Cited by 2 (Europe PMC)
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Text rights: CC BY-NC-ND. Results still quote short attributed sentences.
7 results from studies that gave the peptide. No result from this study comes from people.
In obese mice, NMN improved lipid metabolism.
In plain wordsIn obese mice, NMN improved lipid metabolism.
mousen: not reported in source
obese miceSource sentences
In the present study, NMN improved lipid metabolism and enhanced spermatogenesis in obese mice, alleviated SCs dysfunction in vivo and in vitro.
In obese mice, NMN enhanced spermatogenesis.
In plain wordsIn obese mice, NMN increased sperm production.
mousen: not reported in source
obese miceSource sentences
In the present study, NMN improved lipid metabolism and enhanced spermatogenesis in obese mice, alleviated SCs dysfunction in vivo and in vitro.
In obese mice, NMN alleviated Sertoli cell dysfunction.
In plain wordsIn obese mice, NMN reduced Sertoli cell dysfunction.
mousen: not reported in source
obese miceSource sentences
In the present study, NMN improved lipid metabolism and enhanced spermatogenesis in obese mice, alleviated SCs dysfunction in vivo and in vitro.
In obese mice, NMN benefits partly involved changes in acetylation of glycolysis-related proteins.
In plain wordsIn obese mice, NMN benefits partly involved changes in acetylation of proteins involved in glycolysis.
mousen: not reported in source
obese mouse testesSource sentences
The beneficial effects of NMN were due in part to changes in the acetylation of glycolysis-related proteins.
In mice, multi-omics and correlation analyses implicated microbiota, metabolites, spermatogenesis, and LDHC acetylation interactions in NMN benefits.
In plain wordsIn mice, analyses linked NMN benefits to interactions among gut microbes, metabolites, sperm production, and LDHC acetylation.
mousen: not reported in source
obese miceSource sentences
Furthermore, multi-omics and correlation analyses demonstrated that interactions among the gut microbiota, metabolites, spermatogenesis, and LDHC acetylation mediated the beneficial effects of NMN.
In obese mice, NMN reduced LDHC acetylation at lysine residues 5, 17, and 90.
In plain wordsIn obese mice, NMN reduced LDHC acetylation at lysine residues 5, 17, and 90.
mousen: not reported in source
obese mouse testesSource sentences
Importantly, we found that NMN treatment reduced acetylation of the lysine residues 5, 17, and 90 of LDHC, which plays a critical role in SC lactate production in obesity.
In vitro, NMN alleviated Sertoli cell dysfunction.
In plain wordsIn cells, NMN reduced Sertoli cell dysfunction.
n: not reported in source
Sertoli cellsSource sentences
In the present study, NMN improved lipid metabolism and enhanced spermatogenesis in obese mice, alleviated SCs dysfunction in vivo and in vitro.
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Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC
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