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Study · Animal study (in vivo) · mouse · 2026

15 results

NAD + -Boosting Ameliorates Heme Protein-Mediated Acute Kidney Injury.

Singh RD, Croatt AJ, Grande JP, Ackerman AW, Christensen TA, Juncos LA, Nath KA

Kidney36025 Nov 2025

PMID41289025 (opens in a new tab)PMCIDPMC13065137 (opens in a new tab)DOI10.34067/kid.0000001032 (opens in a new tab)PepBankPUB-41289025
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study15

15 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with heme protein-mediated AKI, NMN preserved kidney NAD content compared with vehicle.

    In plain wordsIn mice with kidney injury, NMN preserved kidney NAD compared with vehicle.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseKidney NAD content
    Study

    mousen: not reported in source

    glycerol-induced heme protein-mediated acute kidney injury
    Comparator
    vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The administration of NMN preserved kidney NAD + content in HP-AKI, and compared with the administration of vehicle in HP-AKI, NMN improved glomerular filtration markers
    1 context sentence
    Summary · context
    NAD + -boosting was achieved by the administration of nicotinamide mononucleotide (NMN) in the glycerol model of HP-AKI. The effect of NMN, compared with vehicle, was examined in mice with HP-AKI and with sham AKI at day 1 after HP-AKI was induced.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with heme protein-mediated AKI, NMN improved glomerular filtration markers compared with vehicle.

    In plain wordsIn mice with kidney injury, NMN improved filtration markers compared with vehicle.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Direction not reportedGlomerular filtration markers
    Study

    mousen: not reported in source

    glycerol-induced heme protein-mediated acute kidney injury
    Comparator
    vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The administration of NMN preserved kidney NAD + content in HP-AKI, and compared with the administration of vehicle in HP-AKI, NMN improved glomerular filtration markers
    1 context sentence
    Summary · context
    NAD + -boosting was achieved by the administration of nicotinamide mononucleotide (NMN) in the glycerol model of HP-AKI. The effect of NMN, compared with vehicle, was examined in mice with HP-AKI and with sham AKI at day 1 after HP-AKI was induced.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with heme protein-mediated AKI, NMN reduced tubular necrosis compared with vehicle.

    In plain wordsIn mice with kidney injury, NMN reduced tubular necrosis compared with vehicle.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseTubular necrosis
    Study

    mousen: not reported in source

    glycerol-induced heme protein-mediated acute kidney injury
    Comparator
    vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    reduced histologic injury as assessed by tubular necrosis, dilation, and cast formation and by assessment of dystrophic calcification
    1 context sentence
    Summary · context
    NAD + -boosting was achieved by the administration of nicotinamide mononucleotide (NMN) in the glycerol model of HP-AKI. The effect of NMN, compared with vehicle, was examined in mice with HP-AKI and with sham AKI at day 1 after HP-AKI was induced.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with heme protein-mediated AKI, NMN reduced tubular dilation compared with vehicle.

    In plain wordsIn mice with kidney injury, NMN reduced tubular dilation compared with vehicle.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseTubular dilation
    Study

    mousen: not reported in source

    glycerol-induced heme protein-mediated acute kidney injury
    Comparator
    vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    reduced histologic injury as assessed by tubular necrosis, dilation, and cast formation and by assessment of dystrophic calcification
    1 context sentence
    Summary · context
    NAD + -boosting was achieved by the administration of nicotinamide mononucleotide (NMN) in the glycerol model of HP-AKI. The effect of NMN, compared with vehicle, was examined in mice with HP-AKI and with sham AKI at day 1 after HP-AKI was induced.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice with heme protein-mediated AKI, NMN reduced cast formation compared with vehicle.

    In plain wordsIn mice with kidney injury, NMN reduced cast formation compared with vehicle.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseCast formation
    Study

    mousen: not reported in source

    glycerol-induced heme protein-mediated acute kidney injury
    Comparator
    vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    reduced histologic injury as assessed by tubular necrosis, dilation, and cast formation and by assessment of dystrophic calcification
    1 context sentence
    Summary · context
    NAD + -boosting was achieved by the administration of nicotinamide mononucleotide (NMN) in the glycerol model of HP-AKI. The effect of NMN, compared with vehicle, was examined in mice with HP-AKI and with sham AKI at day 1 after HP-AKI was induced.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice with heme protein-mediated AKI, NMN reduced dystrophic calcification compared with vehicle.

    In plain wordsIn mice with kidney injury, NMN reduced abnormal calcification compared with vehicle.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseDystrophic calcification
    Study

    mousen: not reported in source

    glycerol-induced heme protein-mediated acute kidney injury
    Comparator
    vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    reduced histologic injury as assessed by tubular necrosis, dilation, and cast formation and by assessment of dystrophic calcification
    1 context sentence
    Summary · context
    NAD + -boosting was achieved by the administration of nicotinamide mononucleotide (NMN) in the glycerol model of HP-AKI. The effect of NMN, compared with vehicle, was examined in mice with HP-AKI and with sham AKI at day 1 after HP-AKI was induced.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In mice with heme protein-mediated AKI, NMN reduced kidney injury marker 1 expression compared with vehicle.

    In plain wordsIn mice with kidney injury, NMN reduced kidney injury marker 1 compared with vehicle.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseKidney injury marker 1 expression
    Study

    mousen: not reported in source

    glycerol-induced heme protein-mediated acute kidney injury
    Comparator
    vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    reduced expression of kidney injury marker 1, a sensitive marker of AKI
    1 context sentence
    Summary · context
    NAD + -boosting was achieved by the administration of nicotinamide mononucleotide (NMN) in the glycerol model of HP-AKI. The effect of NMN, compared with vehicle, was examined in mice with HP-AKI and with sham AKI at day 1 after HP-AKI was induced.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In mice with heme protein-mediated AKI, NMN preserved mitochondrial ultrastructure compared with vehicle.

    In plain wordsIn mice with kidney injury, NMN preserved mitochondrial structure compared with vehicle.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Direction not reportedMitochondrial ultrastructure
    Study

    mousen: not reported in source

    glycerol-induced heme protein-mediated acute kidney injury
    Comparator
    vehicle
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    preserved mitochondrial ultrastructure and increased expression of proteins that promote mitochondrial integrity
    1 context sentence
    Summary · context
    NAD + -boosting was achieved by the administration of nicotinamide mononucleotide (NMN) in the glycerol model of HP-AKI. The effect of NMN, compared with vehicle, was examined in mice with HP-AKI and with sham AKI at day 1 after HP-AKI was induced.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In mice with heme protein-mediated AKI, NMN increased proteins promoting mitochondrial integrity compared with vehicle.

    In plain wordsIn mice with kidney injury, NMN increased proteins supporting mitochondria compared with vehicle.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseMitochondrial integrity protein expression
    Study

    mousen: not reported in source

    glycerol-induced heme protein-mediated acute kidney injury
    Comparator
    vehicle
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    preserved mitochondrial ultrastructure and increased expression of proteins that promote mitochondrial integrity
    1 context sentence
    Summary · context
    NAD + -boosting was achieved by the administration of nicotinamide mononucleotide (NMN) in the glycerol model of HP-AKI. The effect of NMN, compared with vehicle, was examined in mice with HP-AKI and with sham AKI at day 1 after HP-AKI was induced.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In mice with heme protein-mediated AKI, NMN reduced apoptosis assessed by terminal labeling compared with vehicle.

    In plain wordsIn mice with kidney injury, NMN reduced cell death staining compared with vehicle.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseApoptosis staining
    Study

    mousen: not reported in source

    glycerol-induced heme protein-mediated acute kidney injury
    Comparator
    vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    reduced apoptosis as assessed by terminal deoxynucleotidyl transferase-mediated digoxigenin-deoxyuridine nick-end labeling staining and genes and protein expression that contribute to apoptosis, while increasing expression of an anti-apoptotic gene
    1 context sentence
    Summary · context
    NAD + -boosting was achieved by the administration of nicotinamide mononucleotide (NMN) in the glycerol model of HP-AKI. The effect of NMN, compared with vehicle, was examined in mice with HP-AKI and with sham AKI at day 1 after HP-AKI was induced.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In mice with heme protein-mediated AKI, NMN reduced apoptosis-related gene expression compared with vehicle.

    In plain wordsIn mice with kidney injury, NMN reduced cell death gene expression compared with vehicle.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreasePro-apoptotic gene expression
    Study

    mousen: not reported in source

    glycerol-induced heme protein-mediated acute kidney injury
    Comparator
    vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    reduced apoptosis as assessed by terminal deoxynucleotidyl transferase-mediated digoxigenin-deoxyuridine nick-end labeling staining and genes and protein expression that contribute to apoptosis, while increasing expression of an anti-apoptotic gene
    1 context sentence
    Summary · context
    NAD + -boosting was achieved by the administration of nicotinamide mononucleotide (NMN) in the glycerol model of HP-AKI. The effect of NMN, compared with vehicle, was examined in mice with HP-AKI and with sham AKI at day 1 after HP-AKI was induced.
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In mice with heme protein-mediated AKI, NMN reduced apoptosis-related protein expression compared with vehicle.

    In plain wordsIn mice with kidney injury, NMN reduced cell death proteins compared with vehicle.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreasePro-apoptotic protein expression
    Study

    mousen: not reported in source

    glycerol-induced heme protein-mediated acute kidney injury
    Comparator
    vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    reduced apoptosis as assessed by terminal deoxynucleotidyl transferase-mediated digoxigenin-deoxyuridine nick-end labeling staining and genes and protein expression that contribute to apoptosis, while increasing expression of an anti-apoptotic gene
    1 context sentence
    Summary · context
    NAD + -boosting was achieved by the administration of nicotinamide mononucleotide (NMN) in the glycerol model of HP-AKI. The effect of NMN, compared with vehicle, was examined in mice with HP-AKI and with sham AKI at day 1 after HP-AKI was induced.
  13. 13AnimalAnimal study (in vivo)Efficacy outcome

    In mice with heme protein-mediated AKI, NMN increased an anti-apoptotic gene compared with vehicle.

    In plain wordsIn mice with kidney injury, NMN increased a gene that opposes cell death compared with vehicle.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseAnti-apoptotic gene expression
    Study

    mousen: not reported in source

    glycerol-induced heme protein-mediated acute kidney injury
    Comparator
    vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    reduced apoptosis as assessed by terminal deoxynucleotidyl transferase-mediated digoxigenin-deoxyuridine nick-end labeling staining and genes and protein expression that contribute to apoptosis, while increasing expression of an anti-apoptotic gene
    1 context sentence
    Summary · context
    NAD + -boosting was achieved by the administration of nicotinamide mononucleotide (NMN) in the glycerol model of HP-AKI. The effect of NMN, compared with vehicle, was examined in mice with HP-AKI and with sham AKI at day 1 after HP-AKI was induced.
  14. 14AnimalAnimal study (in vivo)Efficacy outcome

    In mice with heme protein-mediated AKI, NMN reduced renal injury-related gene expression compared with vehicle.

    In plain wordsIn mice with kidney injury, NMN reduced injury-related gene expression compared with vehicle.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseRenal injury-related genes
    Study

    mousen: not reported in source

    glycerol-induced heme protein-mediated acute kidney injury
    Comparator
    vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    reduced expression of several renal injury-related genes; and mitigated the severity of the senescence phenotype, as assessed by multiple markers.
    1 context sentence
    Summary · context
    NAD + -boosting was achieved by the administration of nicotinamide mononucleotide (NMN) in the glycerol model of HP-AKI. The effect of NMN, compared with vehicle, was examined in mice with HP-AKI and with sham AKI at day 1 after HP-AKI was induced.
  15. 15AnimalAnimal study (in vivo)Efficacy outcome

    In mice with heme protein-mediated AKI, NMN mitigated the senescence phenotype compared with vehicle.

    In plain wordsIn mice with kidney injury, NMN reduced cellular aging markers compared with vehicle.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseSenescence phenotype
    Study

    mousen: not reported in source

    glycerol-induced heme protein-mediated acute kidney injury
    Comparator
    vehicle
    Outcome group
    Aging markers · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    and mitigated the severity of the senescence phenotype, as assessed by multiple markers.
    1 context sentence
    Summary · context
    NAD + -boosting was achieved by the administration of nicotinamide mononucleotide (NMN) in the glycerol model of HP-AKI. The effect of NMN, compared with vehicle, was examined in mice with HP-AKI and with sham AKI at day 1 after HP-AKI was induced.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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